Pentagastrin (BioDeep_00000614928)
代谢物信息卡片
(3S)-3-{[(1S)-1-carbamoyl-2-phenylethyl]carbamoyl}-3-[(2S)-2-[(2S)-3-(1H-indol-3-yl)-2-(3-{[(2-methylpropoxy)carbonyl]amino}propanamido)propanamido]-4-(methylsulfanyl)butanamido]propanoic acid
化学式: C37H49N7O9S (767.3312304000001)
中文名称: 五肽胃泌素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(C)OC(=O)NCCC(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)NC(CCSC)C(=O)NC(CC(=O)O)C(=O)NC(CC3=CC=CC=C3)C(=O)N
InChI: InChI=1S/C37H49N7O9S/c1-37(2,3)53-36(52)39-16-14-30(45)41-28(19-23-21-40-25-13-9-8-12-24(23)25)34(50)42-26(15-17-54-4)33(49)44-29(20-31(46)47)35(51)43-27(32(38)48)18-22-10-6-5-7-11-22/h5-13,21,26-29,40H,14-20H2,1-4H3,(H2,38,48)(H,39,52)(H,41,45)(H,42,50)(H,43,51)(H,44,49)(H,46,47)/t26-,27-,28-,29-/m0/s1
描述信息
V - Various > V04 - Diagnostic agents > V04C - Other diagnostic agents > V04CG - Tests for gastric secretion
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005755 - Gastrins
Pentagastrin (ICI-50123) is a potent, selective Cholecystokinin B (CCKB) receptor antagonists with IC50 values of 11 nM and 1100 nM for CCKB and CCKA, respectively. Pentagastrin enhances gastric mucosal defense mechanisms against acid and protects the gastric mucosa from experimental injury[1].[2].
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31974
- KEGGdrug: D01631
- PubChem: 9853654
- Metlin: METLIN85340
- DrugBank: DB00183
- ChEMBL: CHEMBL1328
- MeSH: Pentagastrin
- CAS: 5534-95-2
- medchemexpress: HY-A0261
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Emine Kartal Baykan, Mehmet Erdoğan. Basal and pentagastrin-stimulated calcitonin cut-off values in diagnosis of preoperative medullary thyroid cancer.
Turkish journal of medical sciences.
2021 04; 51(2):650-656. doi:
10.3906/sag-2003-182. [PMID: 33128357] - Ikechukwu Achilonu, Emmanuel Amarachi Iwuchukwu, Okechinyere Juliet Achilonu, Manuel Antonio Fernandes, Yasien Sayed. Targeting the SARS-CoV-2 main protease using FDA-approved Isavuconazonium, a P2-P3 α-ketoamide derivative and Pentagastrin: An in-silico drug discovery approach.
Journal of molecular graphics & modelling.
2020 12; 101(?):107730. doi:
10.1016/j.jmgm.2020.107730. [PMID: 32920239] - Nobuyuki Takahashi, Yukinori Take. Tegoprazan, a Novel Potassium-Competitive Acid Blocker to Control Gastric Acid Secretion and Motility.
The Journal of pharmacology and experimental therapeutics.
2018 02; 364(2):275-286. doi:
10.1124/jpet.117.244202. [PMID: 29180359] - M R Pelizzo, F Torresan, A Da Roit, I Merante Boschin, S Chondrogiannis, L Rampin, P M Colletti, S Vinjamury, A J Perkins, D Rubello. Mild to moderate increase of serum calcitonin levels only in presence of large medullary thyroid cancer deposits.
Revista espanola de medicina nuclear e imagen molecular.
2015 Nov; 34(6):378-82. doi:
10.1016/j.remn.2015.05.007. [PMID: 26420439] - Ursula Thiem, Rodrig Marculescu, Daniel Cejka, Alois Gessl, Kyra Borchhardt. Low-dose calcium versus pentagastrin for stimulation of calcitonin in chronic hemodialysis patients: a pilot study.
The Journal of clinical endocrinology and metabolism.
2014 Dec; 99(12):4704-11. doi:
10.1210/jc.2014-1869. [PMID: 25215555] - Isabella Merante Boschin, Francesca Torresan, Antonio Toniato, Mariangela Zane, Eric Casal Ide, Gianmaria Pennelli, Lucia Rampin, Patrick M Colletti, Domenico Rubello, Maria Rosa Pelizzo. Incidental medullary thyroid microcarcinoma revealed by mild increase of preoperative serum calcitonin levels: therapeutic implications.
Endocrine.
2014 Apr; 45(3):448-53. doi:
10.1007/s12020-013-0019-7. [PMID: 23884895] - Shoukri A Wakim, Mona A Ahmed, Radwa H Ali. Gastric acid secretion in experimental acute uremia.
Canadian journal of physiology and pharmacology.
2013 Sep; 91(9):693-9. doi:
10.1139/cjpp-2013-0052. [PMID: 23984953] - Luca Giovanella, Frederik A Verburg, Mauro Imperiali, Stefano Valabrega, Pierpaolo Trimboli, Luca Ceriani. Comparison of serum calcitonin and procalcitonin in detecting medullary thyroid carcinoma among patients with thyroid nodules.
Clinical chemistry and laboratory medicine.
2013 Jul; 51(7):1477-81. doi:
10.1515/cclm-2012-0610. [PMID: 23314540] - Kerstin Lorenz, Malik Elwerr, Andreas Machens, Mohammed Abuazab, Hans-Jürgen Holzhausen, Henning Dralle. Hypercalcitoninemia in thyroid conditions other than medullary thyroid carcinoma: a comparative analysis of calcium and pentagastrin stimulation of serum calcitonin.
Langenbeck's archives of surgery.
2013 Mar; 398(3):403-9. doi:
10.1007/s00423-013-1049-6. [PMID: 23408061] - Géraldine Pina, Séverine Dubois, Arnaud Murat, Nicole Berger, Patricia Niccoli, Jean-Louis Peix, Régis Cohen, Claudine Guillausseau, Anne Charrie, Olivier Chabre, Catherine Cornu, Françoise Borson-Chazot, Vincent Rohmer. Is basal ultrasensitive measurement of calcitonin capable of substituting for the pentagastrin-stimulation test?.
Clinical endocrinology.
2013 Mar; 78(3):358-64. doi:
10.1111/cen.12001. [PMID: 22913268] - Makoto Inada, Jun-ichi Kunizaki, Kazuki Tobita, Suguru Akamatsu, Hitoshi Sato. Calcium [¹³C]carbonate breath test for quantitative measurement of total gastric acid in rats.
Scandinavian journal of gastroenterology.
2012 Feb; 47(2):148-54. doi:
10.3109/00365521.2011.647066. [PMID: 22214404] - Gilbert H Daniels. Screening for medullary thyroid carcinoma with serum calcitonin measurements in patients with thyroid nodules in the United States and Canada.
Thyroid : official journal of the American Thyroid Association.
2011 Nov; 21(11):1199-207. doi:
10.1089/thy.2010.0297. [PMID: 21936671] - Jürgen Kratzsch, Anne Petzold, Friedhelm Raue, Walter Reinhardt, Martina Bröcker-Preuss, Rainer Görges, Klaus Mann, Wolfram Karges, Nils Morgenthaler, Markus Luster, Christoph Reiners, Joachim Thiery, Henning Dralle, Dagmar Fuhrer. Basal and stimulated calcitonin and procalcitonin by various assays in patients with and without medullary thyroid cancer.
Clinical chemistry.
2011 Mar; 57(3):467-74. doi:
10.1373/clinchem.2010.151688. [PMID: 21159900] - Jean Michel Le Melledo, Jorge Perez-Parada, Jarret Morrow, Francois Bellavance, Nathalie Lara, Farideh Jahandar, Robert Granger, Glendon Tait, Karen McManus. Pentagastrin-induced hemoconcentration in healthy volunteers and patients with panic disorder: effect of pretreatment with ethinyl estradiol.
Journal of psychopharmacology (Oxford, England).
2011 Jan; 25(1):71-7. doi:
10.1177/0269881109106922. [PMID: 19825898] - Constantin S Jianu, Reidar Fossmark, Unni Syversen, Øyvind Hauso, Helge L Waldum. A meal test improves the specificity of chromogranin A as a marker of neuroendocrine neoplasia.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2010 Oct; 31(5):373-80. doi:
10.1007/s13277-010-0045-5. [PMID: 20480408] - R Schneider, A E Heverhagen, R Moll, D K Bartsch, K Schlosser. Differentiation between thyroidal and ectopic calcitonin secretion in patients with coincidental thyroid nodules and pancreatic tumors - a report of two cases.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2010 Aug; 118(8):520-3. doi:
10.1055/s-0029-1231083. [PMID: 19691012] - B L Herrmann, K W Schmid, R Goerges, M Kemen, K Mann. Calcitonin screening and pentagastrin testing: predictive value for the diagnosis of medullary carcinoma in nodular thyroid disease.
European journal of endocrinology.
2010 Jun; 162(6):1141-5. doi:
10.1530/eje-10-0111. [PMID: 20332126] - Yung-Chih Lai, Yih Ho, Kai-Han Huang, Li Hsueh Tsai. Effects of serotonin on acid secretion in isolated rat stomach: the role of 5-HT3 receptors.
The Chinese journal of physiology.
2009 Nov; 52(5 Suppl):395-405. doi:
10.4077/cjp.2009.amk037. [PMID: 20359130] - Patricia Doyle, Christian Düren, Kai Nerlich, Frederik A Verburg, Inge Grelle, Hanne Jahn, Martin Fassnacht, Uwe Mäder, Christoph Reiners, Markus Luster. Potency and tolerance of calcitonin stimulation with high-dose calcium versus pentagastrin in normal adults.
The Journal of clinical endocrinology and metabolism.
2009 Aug; 94(8):2970-4. doi:
10.1210/jc.2008-2403. [PMID: 19491231] - Tobias Rudholm, Per-Mikael Hellstrom, Elvar Theodorsson, Colin-Allan Campbell, Peter-Geoffrey McLean, Erik Naslund. Bravo capsule system optimizes intragastric pH monitoring over prolonged time: effects of ghrelin on gastric acid and hormone secretion in the rat.
World journal of gastroenterology.
2008 Oct; 14(40):6180-7. doi:
10.3748/wjg.14.6180. [PMID: 18985808] - Peter Vestergaard, Asa Lina Jönsson, Peer Christiansen, Juliana Frohnert. [Can measurement of basal calcitonin replace the pentagastrin test?].
Ugeskrift for laeger.
2008 Oct; 170(41):3238-42. doi:
NULL. [PMID: 18940156] - Cristina S Freitas, Cristiane H Baggio, Jaqueline Finau, Margano Anginoni, Moacir G Pizzolatti, Adair R S Santos, Maria C A Marques. Inhibition of H+/K+ ATPase in the gastroprotective effect of Baccharis illinita DC.
The Journal of pharmacy and pharmacology.
2008 Aug; 60(8):1105-10. doi:
10.1211/jpp.60.8.0017. [PMID: 18644203] - Fatemeh Nabavizadeh Rafsanjani, Mehrdad Shahrani, Zakieh Vahedian Ardakani, Mohammad Vahedian Ardakani. Marjoram increases basal gastric acid and pepsin secretions in rat.
Phytotherapy research : PTR.
2007 Nov; 21(11):1036-8. doi:
10.1002/ptr.2203. [PMID: 17639551] - Bin Yao, Xue Liu, Xiong Chen, Ting-ting Dong, Hua Liang, Jian-ping Weng. [Mutation of the RET proto-oncogene in type 2A multiple endocrine neoplasia Chinese families and the application of pentagastrin stimulation test in diagnosis and follow-up].
Zhonghua nei ke za zhi.
2007 Nov; 46(11):914-8. doi:
NULL. [PMID: 18261274] - Matthias Schott, Holger S Willenberg, Cornelia Sagert, Thi-Bang-Tam Nguyen, Sven Schinner, Mathias Cohnen, Kenko Cupisti, Claus F Eisenberger, Wolfram T Knoefel, Werner A Scherbaum. Identification of occult metastases of medullary thyroid carcinoma by pentagastrin-stimulated intravenous calcitonin sampling followed by targeted surgery.
Clinical endocrinology.
2007 Mar; 66(3):405-9. doi:
10.1111/j.1365-2265.2007.02747.x. [PMID: 17302876] - Giuseppe Costante, Domenico Meringolo, Cosimo Durante, Davide Bianchi, Maria Nocera, Salvatore Tumino, Umberto Crocetti, Marco Attard, Marianna Maranghi, Massimo Torlontano, Sebastiano Filetti. Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules.
The Journal of clinical endocrinology and metabolism.
2007 Feb; 92(2):450-5. doi:
10.1210/jc.2006-1590. [PMID: 17119000] - K A Borchhardt, H Heinzl, A Gessl, W H Hörl, K Kaserer, G Sunder-Plassmann. Calcitonin concentrations in patients with chronic kidney disease and medullary thyroid carcinoma or c-cell hyperplasia.
Kidney international.
2006 Dec; 70(11):2014-20. doi:
10.1038/sj.ki.5001888. [PMID: 17051143] - M F Erdogan, A Gursoy, M Kulaksizoglu. Long-term effects of elevated gastrin levels on calcitonin secretion.
Journal of endocrinological investigation.
2006 Oct; 29(9):771-5. doi:
10.1007/bf03347369. [PMID: 17114906] - M Dorababu, M C Joshi, G Bhawani, M Mohan Kumar, Aditi Chaturvedi, R K Goel. Effect of aqueous extract of neem (Azadirachta indica) leaves on offensive and diffensive gastric mucosal factors in rats.
Indian journal of physiology and pharmacology.
2006 Jul; 50(3):241-9. doi:
NULL. [PMID: 17193895] - Paolo Colombo, Fabiana Locatelli, Pietro Travaglini. [Useful and limits of the biochemical markers for the diagnosis of thyroid carcinoma].
Annali italiani di chirurgia.
2006 May; 77(3):209-14. doi:
NULL. [PMID: 17137035] - G Papi, S M Corsello, K Cioni, A M Pizzini, S Corrado, C Carapezzi, G Fadda, A Baldini, C Carani, A Pontecorvi, E Roti. Value of routine measurement of serum calcitonin concentrations in patients with nodular thyroid disease: A multicenter study.
Journal of endocrinological investigation.
2006 May; 29(5):427-37. doi:
10.1007/bf03344126. [PMID: 16794366] - M Volante. [Sporadic C-cell hyperplasia associated with multinodular goiter].
Pathologica.
2006 Apr; 98(2):160-3. doi:
NULL. [PMID: 16929791] - Juris J Meier, Michael A Nauck, Bartholomaeus Kask, Jens J Holst, Carolyn F Deacon, Wolfgang E Schmidt, Baptist Gallwitz. Influence of gastric inhibitory polypeptide on pentagastrin-stimulated gastric acid secretion in patients with type 2 diabetes and healthy controls.
World journal of gastroenterology.
2006 Mar; 12(12):1874-80. doi:
10.3748/wjg.v12.i12.1874. [PMID: 16609993] - William B Kinlaw, Sarah M Scott, Robert A Maue, Vincent A Memoli, Robert D Harris, Gilbert H Daniels, Donna M Porter, Dorothy R Belloni, Edward T Spooner, Manfred M Ernesti, Walter W Noll. Multiple endocrine neoplasia 2A due to a unique C609S RET mutation presents with pheochromocytoma and reduced penetrance of medullary thyroid carcinoma.
Clinical endocrinology.
2005 Dec; 63(6):676-82. doi:
10.1111/j.1365-2265.2005.02400.x. [PMID: 16343103] - Ildiko M Buck, James W Black, Tracey Cooke, David J Dunstone, John D Gaffen, Eric P Griffin, Elaine A Harper, Robert A D Hull, S Barret Kalindjian, Elliot J Lilley, Ian D Linney, Caroline M R Low, Iain M McDonald, Michael J Pether, Sonia P Roberts, Nigel P Shankley, Mark E Shaxted, Katherine I M Steel, David A Sykes, Matthew J Tozer, Gillian F Watt, Martin K Walker, Laurence Wright, Paul T Wright. Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists.
Journal of medicinal chemistry.
2005 Nov; 48(22):6803-12. doi:
10.1021/jm0490686. [PMID: 16250639] - H Vierhapper, B Niederle, C Bieglmayer, K Kaserer, S Baumgartner-Parzer. Early diagnosis and curative therapy of medullary thyroid carcinoma by routine measurement of serum calcitonin in patients with thyroid disorders.
Thyroid : official journal of the American Thyroid Association.
2005 Nov; 15(11):1267-72. doi:
10.1089/thy.2005.15.1267. [PMID: 16356091] - Fredrik Levin, Therese Edholm, Marcus Ehrström, Berndt Wallin, Peter T Schmidt, Annette M Kirchgessner, Linda M Hilsted, Per M Hellström, Erik Näslund. Effect of peripherally administered ghrelin on gastric emptying and acid secretion in the rat.
Regulatory peptides.
2005 Nov; 131(1-3):59-65. doi:
10.1016/j.regpep.2005.06.001. [PMID: 16040140] - H Vierhapper, S Rondot, E Schulze, L Wagner, S Hanslik, B Niederle, C Bieglmayer, K Kaserer, S Baumgartner-Parzer. Primary hyperparathyroidism as the leading symptom in a patient with a Y791F RET mutation.
Thyroid : official journal of the American Thyroid Association.
2005 Nov; 15(11):1303-8. doi:
10.1089/thy.2005.15.1303. [PMID: 16356097] - P S Morpurgo, V Cappiello, U Verga, L Vicentini, I Vaghi, E Lauri, M Nebuloni, P Beck-Peccoz, A Spada. Ghrelin in human medullary thyroid carcinomas.
Clinical endocrinology.
2005 Oct; 63(4):437-41. doi:
10.1111/j.1365-2265.2005.02360.x. [PMID: 16181236] - Kyra A Borchhardt, Walter H Hörl, Gere Sunder-Plassmann. Reversibility of 'secondary hypercalcitoninemia' after kidney transplantation.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2005 Jul; 5(7):1757-63. doi:
10.1111/j.1600-6143.2005.00908.x. [PMID: 15943636] - R Fossmark, G Johnsen, E Johanessen, H L Waldum. Rebound acid hypersecretion after long-term inhibition of gastric acid secretion.
Alimentary pharmacology & therapeutics.
2005 Jan; 21(2):149-54. doi:
10.1111/j.1365-2036.2004.02271.x. [PMID: 15679764] - Full-Young Chang, Tseng-Shing Chen, Shou-Dong Lee, Ming-Luen Doong, Guey-Hwa Yeh, Paulus S Wang. Pentagastrin-induced gastric acid secretion in the diabetic rats: role of insulin.
The Chinese journal of physiology.
2004 Dec; 47(4):175-81. doi:
NULL. [PMID: 15803750] - H Vierhapper, C Bieglmayer, G Heinze, S Baumgartner-Parzer. Frequency of RET proto-oncogene mutations in patients with normal and with moderately elevated pentagastrin-stimulated serum concentrations of calcitonin.
Thyroid : official journal of the American Thyroid Association.
2004 Aug; 14(8):580-3. doi:
10.1089/1050725041692990. [PMID: 15320968] - Yasutaka Kato, Hiroshi Fukamachi, Masumi Takano-Maruyama, Tomohiko Aoe, Yasuaki Murahashi, Syunji Horie, Yasuo Suzuki, Yasushi Saito, Haruhiko Koseki, Hiroshi Ohno. Reduction of SNAP25 in acid secretion defect of Foxl1-/- gastric parietal cells.
Biochemical and biophysical research communications.
2004 Jul; 320(3):766-72. doi:
10.1016/j.bbrc.2004.05.209. [PMID: 15240114] - Georgios Karanikas, Abbas Moameni, Christian Poetzi, Georg Zettinig, Klaus Kaserer, Christian Bieglmayer, Bruno Niederle, Robert Dudczak, Christian Pirich. Frequency and relevance of elevated calcitonin levels in patients with neoplastic and nonneoplastic thyroid disease and in healthy subjects.
The Journal of clinical endocrinology and metabolism.
2004 Feb; 89(2):515-9. doi:
10.1210/jc.2003-030709. [PMID: 14764755] - W Karges, H Dralle, F Raue, K Mann, C Reiners, M Grussendorf, M Hüfner, B Niederle, G Brabant. Calcitonin measurement to detect medullary thyroid carcinoma in nodular goiter: German evidence-based consensus recommendation.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2004 Jan; 112(1):52-8. doi:
10.1055/s-2004-815727. [PMID: 14758572] - Kazuki Yokoi, Tsuneo Imai, Arihiro Shibata, Yatsuka Hibi, Toyone Kikumori, Hiroomi Funahashi, Akimasa Nakao. Mild persistent hypercalcitoninemia after total thyroidectomy in patients with papillary thyroid carcinoma.
Endocrine journal.
2003 Aug; 50(4):453-8. doi:
10.1507/endocrj.50.453. [PMID: 14599120] - Farhad Zangeneh, Hossein Gharib, John R Goellner, Pai Chih Kao. Potential absence of prognostic implications of severe preoperative hypercalcitoninemia in medullary thyroid carcinoma.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2003 Jul; 9(4):284-9. doi:
10.4158/ep.9.4.284. [PMID: 14561572] - Larry S Barak, Robert H Oakley, Michael A Shetzline. G protein-coupled receptor desensitization as a measure of signaling: modeling of arrestin recruitment to activated CCK-B receptors.
Assay and drug development technologies.
2003 Jun; 1(3):409-24. doi:
10.1089/154065803322163722. [PMID: 15090178] - Jarret D Morrow, Karen McManus, Glendon R Tait, Francois Bellavance, Wendy Chrapko, Nathalie Lara, Jean-Michel Le Mellédo. Pentagastrin-induced release of free fatty acids in healthy volunteers and patients with panic disorder: effect of pretreatment with ethinyl estradiol.
Journal of psychiatry & neuroscience : JPN.
2003 Mar; 28(2):127-33. doi:
NULL. [PMID: 12670129] - Diana Radu, Arne Ahlin, Pär Svanborg, Nils Lindefors. Pentagastrin test for anxiety--psychophysiology and personality.
Psychopharmacology.
2003 Mar; 166(2):139-45. doi:
10.1007/s00213-002-1316-7. [PMID: 12529809] - B Hunyady, A Zólyomi, J Czimmer, G Mózsik, T Kozicz, E Buzás, S Tanaka, A Ichikawa, A Nagy, M Palkovits, A Falus. Expanded parietal cell pool in transgenic mice unable to synthesize histamine.
Scandinavian journal of gastroenterology.
2003 Feb; 38(2):133-40. doi:
10.1080/gas.38.2.133. [PMID: 12678328] - J Dent. Review article: pharmacology of esomeprazole and comparisons with omeprazole.
Alimentary pharmacology & therapeutics.
2003 Feb; 17 Suppl 1(?):5-9. doi:
10.1046/j.1365-2036.17.s1.2.x. [PMID: 12614299] - F Cioppi, A Falchetti, L Masi, M L Brandi. Dynamic investigation for evaluation of calcium metabolism and parathyroid function.
Journal of endocrinological investigation.
2003; 26(7 Suppl):83-91. doi:
NULL. [PMID: 14604070] - Michal Yael Chowers, Nathan Keller, Simon Bar-Meir, Yehuda Chowers. A defined human gastrin sequence stimulates the growth of Helicobacter pylori.
FEMS microbiology letters.
2002 Dec; 217(2):231-6. doi:
10.1111/j.1574-6968.2002.tb11480.x. [PMID: 12480109] - Marilla Geraci, Todd S Anderson, Shiyoko Slate-Cothren, Robert M Post, Una D McCann. Pentagastrin-induced sleep panic attacks: panic in the absence of elevated baseline arousal.
Biological psychiatry.
2002 Dec; 52(12):1183-9. doi:
10.1016/s0006-3223(02)01402-6. [PMID: 12488064] - Giovanni Vitale, Antonio Ciccarelli, Michele Caraglia, Maurizio Galderisi, Riccardo Rossi, Salvatore Del Prete, Alberto Abbruzzese, Giovanni Lupoli. Comparison of two provocative tests for calcitonin in medullary thyroid carcinoma: omeprazole vs pentagastrin.
Clinical chemistry.
2002 Sep; 48(9):1505-10. doi:
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World journal of surgery.
2002 Aug; 26(8):886-90. doi:
10.1007/s00268-002-6613-0. [PMID: 12016469] - Diana Radu, Arne Ahlin, Pär Svanborg, Nils Lindefors. Anxiogenic effects of the CCK(B) agonist pentagastrin in humans and dose-dependent increase in plasma C-peptide levels.
Psychopharmacology.
2002 Jun; 161(4):396-403. doi:
10.1007/s00213-002-1044-z. [PMID: 12073167] - Glendon R Tait, Karen McManus, François Bellavance, Nathalie Lara, Wendy Chrapko, Jean-Michel Le Mellédo. Neuroactive steroid changes in response to challenge with the panicogenic agent pentagastrin.
Psychoneuroendocrinology.
2002 May; 27(4):417-29. doi:
10.1016/s0306-4530(01)00051-8. [PMID: 11911996] - Iradj Sobhani, Sergio Canedo, Beatriz Alchepo, Christiane Vissuzaine, Catherine Chevalier, Marion Buyse, Laurent Moizo, J Pierre Laigneau, Michel Mignon, J Miguel Lewin, André Bado. Putative effect of Helicobacter pylori and gastritis on gastric acid secretion in cat.
American journal of physiology. Gastrointestinal and liver physiology.
2002 Apr; 282(4):G727-34. doi:
10.1152/ajpgi.00282.2001. [PMID: 11897633] - O Zwermann, B Piepkorn, M Engelbach, J Beyer, P Kann. Abnormal pentagastrin response in a patient with pseudohypoparathyroidism.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2002 Apr; 110(2):86-91. doi:
10.1055/s-2002-23492. [PMID: 11928072] - Iradj Sobhani, Marion Buyse, Hélène Goïot, Nina Weber, Jean-Pierre Laigneau, Dominique Henin, Jean-Claude Soul, André Bado. Vagal stimulation rapidly increases leptin secretion in human stomach.
Gastroenterology.
2002 Feb; 122(2):259-63. doi:
10.1053/gast.2002.31385. [PMID: 11832440] - Zi-Li Zhang, Wei-Wen Chen. Proliferation of intestinal crypt cells by gastrin-induced ornithine decarboxylase.
World journal of gastroenterology.
2002 Feb; 8(1):183-7. doi:
10.3748/wjg.v8.i1.183. [PMID: 11833100] - Gabriela E Sanso, Horacio M Domene, RudazMariaC Garcia, Eduardo Pusiol, MondinoAnaK de, Maria Roque, Alejandro Ring, Hector Perinetti, Boris Elsner, Sonia Iorcansky, Marta Barontini. Very early detection of RET proto-oncogene mutation is crucial for preventive thyroidectomy in multiple endocrine neoplasia type 2 children: presence of C-cell malignant disease in asymptomatic carriers.
Cancer.
2002 Jan; 94(2):323-30. doi:
10.1002/cncr.10228. [PMID: 11900218] - V Vlaeminck-Guillem, M D'herbomez, P Pigny, A Fayard, C Bauters, M Decoulx, J L Wémeau. Pseudohypoparathyroidism Ia and hypercalcitoninemia.
The Journal of clinical endocrinology and metabolism.
2001 Jul; 86(7):3091-6. doi:
10.1210/jcem.86.7.7690. [PMID: 11443172] - M Tommasi, A Brocchi, A Cappellini, S Raspanti, M Mannelli. False serum calcitonin high levels using a non-competitive two-site IRMA.
Journal of endocrinological investigation.
2001 May; 24(5):356-60. doi:
10.1007/bf03343873. [PMID: 11407656] - A Regev, R Drori, G M Fraser, Y Niv. Abolition of pentagastrin-stimulated alkaline tide using the carbonic anhydrase inhibitor acetazolamide.
The Israel Medical Association journal : IMAJ.
2001 Apr; 3(4):247-50. doi:
NULL. [PMID: 11344834] - L Nguyen, P Niccoli-Sire, P Caron, D Bastie, B Maes, G Chabrier, O Chabre, V Rohmer, P Lecomte, J F Henry, B Conte-Devolx. Pheochromocytoma in multiple endocrine neoplasia type 2: a prospective study.
European journal of endocrinology.
2001 Jan; 144(1):37-44. doi:
10.1530/eje.0.1440037. [PMID: 11174835] - A Hochól, R de Caro, N Jedrzejczak, A Markowska, M Trejter, G G Nussdorfer, L K Malendowicz. Effect of pentagastrin on steroid secretion and proliferative activity of regenerating rat adrenal cortex.
Cytobios.
2001; 106 Suppl 1(?):119-24. doi:
NULL. [PMID: 11534823] - K Jacobson, N Chiba, Y Chen, M Barrientos, C James, R H Riddell , R H Hunt. Gastric acid secretory response in Helicobacter pylori-positive patients with duodenal ulcer disease.
Canadian journal of gastroenterology = Journal canadien de gastroenterologie.
2001 Jan; 15(1):29-39. doi:
10.1155/2001/764615. [PMID: 11173324] - N Bell, M D Karol, G Sachs, P Greski-Rose, D E Jennings, R H Hunt. Duration of effect of lansoprazole on gastric pH and acid secretion in normal male volunteers.
Alimentary pharmacology & therapeutics.
2001 Jan; 15(1):105-13. doi:
10.1046/j.1365-2036.2001.00831.x. [PMID: 11136283] - K Kordás, G Szalmay, S Bardocz, A Pusztai, G Varga. Phytohaemagglutinin inhibits gastric acid but not pepsin secretion in conscious rats.
Journal of physiology, Paris.
2001 Jan; 95(1-6):309-14. doi:
10.1016/s0928-4257(01)00043-2. [PMID: 11595455] - A Machens, J Haedecke, H J Holzhausen, O Thomusch, U Schneyer, H Dralle. Differential diagnosis of calcitonin-secreting neuroendocrine carcinoma of the foregut by pentagastrin stimulation.
Langenbeck's archives of surgery.
2000 Oct; 385(6):398-401. doi:
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American journal of physiology. Gastrointestinal and liver physiology.
2000 Aug; 279(2):G448-53. doi:
10.1152/ajpgi.2000.279.2.g448. [PMID: 10915655] - I Sobhani, A Bado, C Vissuzaine, M Buyse, S Kermorgant, J P Laigneau, S Attoub, T Lehy, D Henin, M Mignon, M J Lewin. Leptin secretion and leptin receptor in the human stomach.
Gut.
2000 Aug; 47(2):178-83. doi:
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Thyroid : official journal of the American Thyroid Association.
2000 May; 10(5):413-6. doi:
10.1089/thy.2000.10.413. [PMID: 10884188] - N Sasaki, K Matsuno, S Okabe. Selective action of a CCK-B/gastrin receptor antagonist, S-0509, on pentagastrin-, peptone meal- and beer-stimulated gastric acid secretion in dogs.
Alimentary pharmacology & therapeutics.
2000 Apr; 14(4):479-88. doi:
10.1046/j.1365-2036.2000.00732.x. [PMID: 10759628] - P Li, T M Chang, D Coy, W Y Chey. Inhibition of gastric acid secretion in rat stomach by PACAP is mediated by secretin, somatostatin, and PGE(2).
American journal of physiology. Gastrointestinal and liver physiology.
2000 Jan; 278(1):G121-7. doi:
10.1152/ajpgi.2000.278.1.g121. [PMID: 10644570] - V D Corleto, S Minisola, A Moretti, C Damiani, C Grossi, S Ciardi, G D'Ambra, C Bordi, R Strom, G Spagna, G Delle Fave, B Annibale. Prevalence and causes of hypergastrinemia in primary hyperparathyroidism: a prospective study.
The Journal of clinical endocrinology and metabolism.
1999 Dec; 84(12):4554-8. doi:
10.1210/jcem.84.12.6193. [PMID: 10599718] - M Y Chowers, N Keller, R Tal, I Barshack, R Lang, S Bar-Meir, Y Chowers. Human gastrin: a Helicobacter pylori--specific growth factor.
Gastroenterology.
1999 Nov; 117(5):1113-8. doi:
10.1016/s0016-5085(99)70396-3. [PMID: 10535874] - B Mayr, G Brabant, A von zur Mühlen. Incidental detection of familial medullary thyroid carcinoma by calcitonin screening for nodular thyroid disease.
European journal of endocrinology.
1999 Sep; 141(3):286-9. doi:
10.1530/eje.0.1410286. [PMID: 10474127] - H Kotzmann, A Schmidt, C Scheuba, K Kaserer, B Watschinger, G Söregi, B Niederle, H Vierhapper. Basal calcitonin levels and the response to pentagastrin stimulation in patients after kidney transplantation or on chronic hemodialysis as indicators of medullary carcinoma.
Thyroid : official journal of the American Thyroid Association.
1999 Sep; 9(9):943-7. doi:
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Acta physiologica Scandinavica.
1999 Mar; 165(3):277-81. doi:
10.1046/j.1365-201x.1999.00514.x. [PMID: 10192177] - B J Grabau, Y Zavros, K J Hardy, A Shulkes. Developmental regulation of gastric somatostatin secretion in the sheep.
Endocrinology.
1999 Feb; 140(2):603-8. doi:
10.1210/endo.140.2.6497. [PMID: 9927283] - J P Gisbert, D Boixeda, A Al-Mostafa, T Vila, L de Rafael, I Alvarez Baleriola, C M de Argila, V Abraira. Basal and stimulated gastrin and pepsinogen levels after eradication of Helicobacter pylori: a 1-year follow-up study.
European journal of gastroenterology & hepatology.
1999 Feb; 11(2):189-200. doi:
10.1097/00042737-199902000-00022. [PMID: 10102232] - M Engelbach, S Heerdt, R Görges, T Kunt, A Pfützner, T Forst, K Diefenbach, S Walgenbach, J Beyer. Is there an ectopic secretion of monomeric calcitonin in the human being?.
Langenbeck's archives of surgery.
1998 Dec; 383(6):456-9. doi:
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General pharmacology.
1998 Oct; 31(4):625-31. doi:
10.1016/s0306-3623(98)00068-8. [PMID: 9792227] - H Kanerva, I Klebovich, S Drabant, A Urtti, T Nevalainen. Different absorption profiles of deramciclane in man and in dog.
The Journal of pharmacy and pharmacology.
1998 Oct; 50(10):1087-93. doi:
10.1111/j.2042-7158.1998.tb03317.x. [PMID: 9821653] - S Hurlimann, S Dür, P Schwab, L Varga, L Mazzucchelli, R Brand, F Halter. Effects of Helicobacter pylori on gastritis, pentagastrin-stimulated gastric acid secretion, and meal-stimulated plasma gastrin release in the absence of peptic ulcer disease.
The American journal of gastroenterology.
1998 Aug; 93(8):1277-85. doi:
10.1111/j.1572-0241.1998.409_x.x. [PMID: 9707051] - B Stoschus, G Hamscher, S Ikonomou, G Partoulas, C Eberle, T Sauerbruch, G E Feurle. Effect of omeprazole treatment on plasma concentrations of the gastric peptides, xenin, gastrin and somatostatin, and of pepsinogen.
The journal of peptide research : official journal of the American Peptide Society.
1998 Jul; 52(1):27-33. doi:
10.1111/j.1399-3011.1998.tb00649.x. [PMID: 9716248] - P Li, T M Chang, W Y Chey. Secretin inhibits gastric acid secretion via a vagal afferent pathway in rats.
The American journal of physiology.
1998 07; 275(1):G22-8. doi:
10.1152/ajpgi.1998.275.1.g22. [PMID: 9655680] - M F Borges, N M Abelin, F O Menezes, P L Dahia, S P Toledo. Calcitonin deficiency in early stages of chronic autoimmune thyroiditis.
Clinical endocrinology.
1998 Jul; 49(1):69-75. doi:
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The American journal of gastroenterology.
1998 Jul; 93(7):1073-9. doi:
10.1111/j.1572-0241.1998.332_a.x. [PMID: 9672333] - M Feldman, B Cryer, E Lee. Effects of Helicobacter pylori gastritis on gastric secretion in healthy human beings.
The American journal of physiology.
1998 06; 274(6):G1011-7. doi:
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Gastroenterology.
1998 Jun; 114(6):1125-32. doi:
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The American journal of surgical pathology.
1998 Jun; 22(6):722-8. doi:
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Acta physiologica Scandinavica.
1998 May; 163(1):113-9. doi:
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Arzneimittel-Forschung.
1998 Apr; 48(4):403-7. doi:
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