2-Oxoclopidogrel (BioDeep_00000614904)

   


代谢物信息卡片


methyl (2S)-2-(2-chlorophenyl)-2-{2-oxo-2H,4H,5H,6H,7H,7aH-thieno[3,2-c]pyridin-5-yl}acetate

化学式: C16H16ClNO3S (337.05393760000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: COC(=O)C(C1=CC=CC=C1Cl)N2CCC3C(=CC(=O)S3)C2
InChI: InChI=1S/C16H16ClNO3S/c1-21-16(20)15(11-4-2-3-5-12(11)17)18-7-6-13-10(9-18)8-14(19)22-13/h2-5,8,13,15H,6-7,9H2,1H3/t13?,15-/m0/s1

描述信息

Clopidogrel thiolactone is an important intermediate in the metabolism of clopidogrel (HY-15283). Clopidogrel thiolactone has antiplatelet aggregatione effects. Clopidogrel is a P2Y12 receptor inhibitor that exerts antiplatelet effects[1][2].

同义名列表

3 个代谢物同义名

methyl (2S)-2-(2-chlorophenyl)-2-{2-oxo-2H,4H,5H,6H,7H,7aH-thieno[3,2-c]pyridin-5-yl}acetate; 2-Oxoclopidogrel; Clopidogrel thiolactone



数据库引用编号

5 个数据库交叉引用编号

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代谢反应

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  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
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文献列表

  • S Casey Laizure, Zhe-Yi Hu, Philip M Potter, Robert B Parker. Inhibition of carboxylesterase-1 alters clopidogrel metabolism and disposition. Xenobiotica; the fate of foreign compounds in biological systems. 2020 Mar; 50(3):245-251. doi: 10.1080/00498254.2019.1612535. [PMID: 31039046]
  • Milan Pavlovic, Svetlana Apostolovic, Dragana Stokanovic, Jelena Lilic, Sandra S Konstantinovic, Jelena B Zvezdanovic, Valentina Marinkovic, Valentina N Nikolic. The association of clopidogrel and 2-oxo-clopidogrel plasma levels and the 40 months clinical outcome after primary PCI. International journal of clinical pharmacy. 2018 Dec; 40(6):1482-1489. doi: 10.1007/s11096-018-0730-9. [PMID: 30367373]
  • Janne G Lyngby, Michael H Court, Pamela M Lee. Validation of a method for quantitation of the clopidogrel active metabolite, clopidogrel, clopidogrel carboxylic acid, and 2-oxo-clopidogrel in feline plasma. Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology. 2017 Aug; 19(4):384-395. doi: 10.1016/j.jvc.2017.03.004. [PMID: 28602635]
  • C F Zhou, Y H Ren, Y Q Song, J Yi, B S Han, Q Xue, Z H Fu, D Y Li. [Relationship between ATP-binding cassette subfamily B member 1 and cytochrome P450 2C19 polymorphisms and the effect of clopidogrel post percutaneous coronary intervention in patients with acute coronary syndrome]. Zhonghua xin xue guan bing za zhi. 2016 Apr; 44(4):309-14. doi: 10.3760/cma.j.issn.0253-3758.2016.04.007. [PMID: 27112608]
  • Dragana Stokanovic, Valentina N Nikolic, Sandra S Konstantinovic, Jelena B Zvezdanovic, Jelena Lilic, Svetlana R Apostolovic, Milan Pavlovic, Vladimir S Zivkovic, Tatjana Jevtovic-Stoimenov, Slobodan M Jankovic. P-Glycoprotein Polymorphism C3435T Is Associated with Dose-Adjusted Clopidogrel and 2-Oxo-Clopidogrel Concentration. Pharmacology. 2016; 97(3-4):101-6. doi: 10.1159/000442712. [PMID: 26695516]
  • Zhixia Qiu, Ning Li, Ling Song, Yang Lu, Jing Jing, Harendra S Parekha, Wenchao Gao, Fengjie Tian, Xin Wang, Shuangxia Ren, Xijing Chen. Contributions of intestine and plasma to the presystemic bioconversion of vicagrel, an acetate of clopidogrel. Pharmaceutical research. 2014 Jan; 31(1):238-51. doi: 10.1007/s11095-013-1158-5. [PMID: 24037619]
  • Hao-Jie Zhu, Xinwen Wang, Brian E Gawronski, Bryan J Brinda, Dominick J Angiolillo, John S Markowitz. Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation. The Journal of pharmacology and experimental therapeutics. 2013 Mar; 344(3):665-72. doi: 10.1124/jpet.112.201640. [PMID: 23275066]
  • Patrick M Dansette, Julien Rosi, Gildas Bertho, Daniel Mansuy. Cytochromes P450 catalyze both steps of the major pathway of clopidogrel bioactivation, whereas paraoxonase catalyzes the formation of a minor thiol metabolite isomer. Chemical research in toxicology. 2012 Feb; 25(2):348-56. doi: 10.1021/tx2004085. [PMID: 22103858]
  • Lynn M Abell, Eddie C-K Liu. Dissecting the activation of thienopyridines by cytochromes P450 using a pharmacodynamic assay in vitro. The Journal of pharmacology and experimental therapeutics. 2011 Nov; 339(2):589-96. doi: 10.1124/jpet.111.184895. [PMID: 21828263]