Oxaliplatin (BioDeep_00000614811)
代谢物信息卡片
Oxaliplatin
化学式: C8H14N2O4Pt (397.0601)
中文名称: 奥沙利铂
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(C(C1)N)N.C(=O)(C(=O)[O-])[O-].[Pt+2]
InChI: /q
描述信息
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
C274 - Antineoplastic Agent > C798 - Radiosensitizing Agent > C1450 - Platinum Compound
同义名列表
1 个代谢物同义名
数据库引用编号
5 个数据库交叉引用编号
- KEGGdrug: D01790
- PubChem: 9887054
- Metlin: METLIN85187
- MeSH: Oxaliplatin
- CAS: 63121-00-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhiqiang Feng, Shuai Zhang, Qiurong Han, Tianhao Chu, Huaqing Wang, Li Yu, Weihua Zhang, Jun Liu, Weizheng Liang, Jun Xue, Xueliang Wu, Chunze Zhang, Yijia Wang. Liensinine sensitizes colorectal cancer cells to oxaliplatin by targeting HIF-1α to inhibit autophagy.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155647. doi:
10.1016/j.phymed.2024.155647. [PMID: 38703660] - Jierong Han, Hengzhou Lai, Wenyuan Li, Huarui Liao, Chong Xiao, Xueke Li, Fengming You, Jing Guo. Efficacy and safety of traditional plant-based medicines for preventing chronic oxaliplatin-induced peripheral neurotoxicity in patients with colorectal cancer: A systematic review and meta-analysis with core herb contribution.
Journal of ethnopharmacology.
2024 May; 326(?):117735. doi:
10.1016/j.jep.2024.117735. [PMID: 38211824] - Lihua Shao, Li Zhu, Rong Su, Chunting Yang, Xiaqing Gao, Yan Xu, Hongwei Wang, Chenglong Guo, Hailong Li. Baicalin enhances the chemotherapy sensitivity of oxaliplatin-resistant gastric cancer cells by activating p53-mediated ferroptosis.
Scientific reports.
2024 05; 14(1):10745. doi:
10.1038/s41598-024-60920-y. [PMID: 38730240] - Weiran Cao, Xue Zhang, Rui Li, Zijie Li, An Lu, Fei Yu, Lu Sun, Jiancheng Wang, Zhiyu Wang, Huining He. Lipid core-shell nanoparticles co-deliver FOLFOX regimen and siPD-L1 for synergistic targeted cancer treatment.
Journal of controlled release : official journal of the Controlled Release Society.
2024 Apr; 368(?):52-65. doi:
10.1016/j.jconrel.2024.02.025. [PMID: 38368946] - Qiong Yi, Shumin He, Kai Liao, Zongxiang Yue, Ling Mei. Nanoparticles integrated with mild photothermal therapy and oxaliplatin for tumor chemotherapy and immunotherapy.
Nanomedicine (London, England).
2024 04; 19(10):841-854. doi:
10.2217/nnm-2023-0335. [PMID: 38436253] - Xue Li, Ying Cheng, Zhifu Yang, Qifeng Ji, Menglei Huan, Weiliang Ye, Miao Liu, Bangle Zhang, Daozhou Liu, Siyuan Zhou. Glioma-targeted oxaliplatin/ferritin clathrate reversing the immunosuppressive microenvironment through hijacking Fe2+ and boosting Fenton reaction.
Journal of nanobiotechnology.
2024 Mar; 22(1):93. doi:
10.1186/s12951-024-02376-w. [PMID: 38443927] - Sikai Wang, Hongxia Cheng, Yilan Huang, Miaomiao Li, Dongmei Gao, Huaping Chen, Ruxiong Su, Kun Guo. HSP90a promotes the resistance to oxaliplatin in HCC through regulating IDH1-induced cell competition.
Biochimica et biophysica acta. Molecular cell research.
2024 Mar; 1871(3):119680. doi:
10.1016/j.bbamcr.2024.119680. [PMID: 38280407] - Dekun Cheng, Zhangtie Wang, Xin Guo, Yiwen Guo, Yu Zhang, Yuanhui Zhao, Ruijie Liu, Ming Chang. Acer truncatum Bunge seed oil ameliorated oxaliplatin-induced demyelination by improving mitochondrial dysfunction via the Pink1/Parkin mitophagy pathway.
Food & function.
2024 Feb; 15(3):1355-1368. doi:
10.1039/d3fo03955b. [PMID: 38205834] - Zhikun Liu, Jinyuan Cai, Guiyang Jiang, Meng Wang, Chuang Wu, Kangning Su, Weiwei Hu, Yaxian Huang, Chunhao Yu, Xiaochao Huang, Guoxiu Cao, Hengshan Wang. Novel Platinum(IV) complexes intervene oxaliplatin resistance in colon cancer via inducing ferroptosis and apoptosis.
European journal of medicinal chemistry.
2024 Jan; 263(?):115968. doi:
10.1016/j.ejmech.2023.115968. [PMID: 37995563] - Mustafa Ileriturk, Duygu Ileriturk, Ozge Kandemir, Nurhan Akaras, Hasan Simsek, Ender Erdogan, Fatih M Kandemir. Naringin attenuates oxaliplatin-induced nephrotoxicity and hepatotoxicity: A molecular, biochemical, and histopathological approach in a rat model.
Journal of biochemical and molecular toxicology.
2024 Jan; 38(1):e23604. doi:
10.1002/jbt.23604. [PMID: 38037725] - Cheng Ma, Xiaofang Zhong, Rong Liu, Xiaojia Yang, Zhiqiang Xie, Yongshun Zhang, Yanhua Xu, Hairui Wang, Chunting He, Guangsheng Du, Tao Gong, Xun Sun. Co-delivery of oxaliplatin prodrug liposomes with Bacillus Calmette-Guérin for chemo-immunotherapy of orthotopic bladder cancer.
Journal of controlled release : official journal of the Controlled Release Society.
2024 Jan; 365(?):640-653. doi:
10.1016/j.jconrel.2023.11.050. [PMID: 38042374] - Tyler S Larson, Thomas J DiProspero, Gary L Glish, Matthew R Lockett. Differential lipid analysis of oxaliplatin-sensitive and resistant HCT116 cells reveals different levels of drug-induced lipid droplet formation.
Analytical and bioanalytical chemistry.
2024 Jan; 416(1):151-162. doi:
10.1007/s00216-023-05010-0. [PMID: 37917349] - Kara Chandler, Josh Millar, George Ward, Christopher Boyall, Tom White, Joseph David Ready, Rawan Maani, Keith Chapple, Robert Tempest, Joseph Brealey, Catherine Duckett, Sarah Haywood-Small, Simon Turega, Nick Peake. Imaging of Light-Enhanced Extracellular Vesicle-Mediated Delivery of Oxaliplatin to Colorectal Cancer Cells via Laser Ablation, Inductively Coupled Plasma Mass Spectrometry.
Cells.
2023 12; 13(1):. doi:
10.3390/cells13010024. [PMID: 38201228] - Jing-Chun Zeng, Yue-Xuan Chen, Jing-Jing Li, Xin-Dong Wang, Xi Xiao, Rui-Lin Zhang, Kai-Song Ji, Li-Ming Lu. Mechanism of analgesic effect of fire needle on peripheral sensitization in rats with neuropathic pain induced by chemotherapy.
Zhen ci yan jiu = Acupuncture research.
2023 Nov; 48(11):1095-1102. doi:
10.13702/j.1000-0607.20221165. [PMID: 37984906] - Zhancheng Gu, Chen Chen, Jialin Gu, Ziwei Song, Guoli Wei, Guoxiang Cai, Qijin Shu, Lingjun Zhu, Weiyou Zhu, Haibin Deng, Sheng Li, Aifei Chen, Yue Yin, Qiulan Wu, Hongyu Zhu, Guochun Li, Anwei Dai, Jiege Huo. Development and validation of the chemotherapy-induced peripheral neuropathy integrated assessment - oxaliplatin subscale: a prospective cohort study.
BMC cancer.
2023 Nov; 23(1):1109. doi:
10.1186/s12885-023-11541-7. [PMID: 37964212] - Pan Longci, Q I Chunhui, Shen Xubo, Huang Yixian, Yang Xinrong, Sun Xianjun. Traditional Chinese Medicine syndrome analysis on oxaliplatin-induced peripheral neuropathy and clinical efficacy of Bushen Yiqi formula: a prospective randomized controlled study.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2023 Oct; 43(6):1234-1242. doi:
10.19852/j.cnki.jtcm.20230630.004. [PMID: 37946486] - Kai Xu, Xu Chang, Xue Bai, Hong-Bing Liu, Xu-Bo Chen, Hong-Ping Chen, Yue-Hui Liu. Activation of Nrf2 inhibits ferroptosis and protects against oxaliplatin-induced ototoxicity.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Sep; 165(?):115248. doi:
10.1016/j.biopha.2023.115248. [PMID: 37523980] - Kaixuan Zeng, Weihao Li, Yue Wang, Zifei Zhang, Linjie Zhang, Weili Zhang, Yue Xing, Chi Zhou. Inhibition of CDK1 Overcomes Oxaliplatin Resistance by Regulating ACSL4-mediated Ferroptosis in Colorectal Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2023 09; 10(25):e2301088. doi:
10.1002/advs.202301088. [PMID: 37428466] - Mei-Mei Zhang, Zhi-Cheng Gong, Yan-Yan Chen. [Research progress on oxaliplatin-induced neurotoxicity in traditional Chinese medicine (TCM) and western medical cognition and prevention and treatment by TCM].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2023 Sep; 48(17):4610-4619. doi:
10.19540/j.cnki.cjcmm.20230605.601. [PMID: 37802800] - Zhiping Rao, Yutian Xia, Qian Jia, Yutong Zhu, Lexuan Wang, Guohuan Liu, Xuelan Liu, Peng Yang, Pengbo Ning, Ruili Zhang, Xianghan Zhang, Chaoqiang Qiao, Zhongliang Wang. Iron-based metal-organic framework co-loaded with buthionine sulfoximine and oxaliplatin for enhanced cancer chemo-ferrotherapy via sustainable glutathione elimination.
Journal of nanobiotechnology.
2023 Aug; 21(1):265. doi:
10.1186/s12951-023-01998-w. [PMID: 37563614] - Anne Zebitz Eriksen, Fredrik Melander, Grace De Malona Eriksen, Paul Joseph Kempen, Andreas Kjaer, Thomas Lars Andresen, Andrew James Urquhart. Active Transport and Ocular Distribution of Intravitreally Injected Liposomes.
Translational vision science & technology.
2023 Aug; 12(8):20. doi:
10.1167/tvst.12.8.20. [PMID: 37615641] - Dongsheng Tang, Huiling Zhou, Minhui Cui, Ganghao Liang, Hanchen Zhang, Haihua Xiao. NIR-II Light Accelerated Prodrug Reduction of Pt(IV)-Incorporating Pseudo Semiconducting Polymers for Robust Degradation and Maximized Photothermal/Chemo-Immunotherapy.
Advanced materials (Deerfield Beach, Fla.).
2023 Jul; 35(28):e2300048. doi:
10.1002/adma.202300048. [PMID: 37016274] - Daniel J Farkas, Saadet Inan, Laila N Heydari, Clare T Johnson, Pingwei Zhao, Heather B Bradshaw, Sara Jane Ward, Scott M Rawls. Cannabinoid mechanisms contribute to the therapeutic efficacy of the kratom alkaloid mitragynine against neuropathic, but not inflammatory pain.
Life sciences.
2023 Jun; 328(?):121878. doi:
10.1016/j.lfs.2023.121878. [PMID: 37392779] - Yixiang Zhan, Kemin Ni, Zhaoce Liu, Ran Xin, Qiurong Han, Hangyu Ping, Yaohong Liu, Xuanzhu Zhao, Wanting Wang, Suying Yan, Jing Sun, Qinghuai Zhang, Guihua Wang, Zili Zhang, Xipeng Zhang, Xia Hu, Guoxun Li, Chunze Zhang. Stage III deficient mismatch repair colon patients get greater benefit from earlier starting oxaliplatin-based chemotherapy regimen.
Scientific reports.
2023 06; 13(1):8969. doi:
10.1038/s41598-023-33153-8. [PMID: 37268749] - Meixiao Zhan, Yufeng Ding, Shanzhou Huang, Yuhang Liu, Jing Xiao, Hua Yu, Ligong Lu, Xiongjun Wang. Lysyl oxidase-like 3 restrains mitochondrial ferroptosis to promote liver cancer chemoresistance by stabilizing dihydroorotate dehydrogenase.
Nature communications.
2023 May; 14(1):3123. doi:
10.1038/s41467-023-38753-6. [PMID: 37253718] - Zhiwei Chen, Heyan Chen, Lihui Huang, Baiqun Duan, Sheng Dai, Wenjing Cai, Meng Sun, Zhikai Jiang, Ruijie Lu, Yiling Jiang, Xinyu Jiang, Hailun Zheng, Qing Yao, Kwonseop Kim, Guangyong Lin, Congying Xie, Maoping Chu, Ruijie Chen, Longfa Kou. ATB0,+-targeted nanoparticles initiate autophagy suppression to overcome chemoresistance for enhanced colorectal cancer therapy.
International journal of pharmaceutics.
2023 May; ?(?):123082. doi:
10.1016/j.ijpharm.2023.123082. [PMID: 37244464] - Nada K Sedky, Nour M Abdel-Kader, Marwa Y Issa, Manal M M Abdelhady, Samir N Shamma, Udo Bakowsky, Sherif Ashraf Fahmy. Co-Delivery of Ylang Ylang Oil of Cananga odorata and Oxaliplatin Using Intelligent pH-Sensitive Lipid-Based Nanovesicles for the Effective Treatment of Triple-Negative Breast Cancer.
International journal of molecular sciences.
2023 May; 24(9):. doi:
10.3390/ijms24098392. [PMID: 37176099] - Negin Alavi, Parvaneh Maghami, Azar Fani Pakdel, Majid Rezaei, Amir Avan. The advance anticancer role of polymeric core-shell ZnO nanoparticles containing oxaliplatin in colorectal cancer.
Journal of biochemical and molecular toxicology.
2023 May; 37(5):e23325. doi:
10.1002/jbt.23325. [PMID: 36843533] - Ming Zu, Xinyu Hao, Jing Ning, Xin Zhou, Yueqing Gong, Yanfei Lang, Weichao Xu, Jing Zhang, Shigang Ding. Patient-derived organoid culture of gastric cancer for disease modeling and drug sensitivity testing.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Apr; 163(?):114751. doi:
10.1016/j.biopha.2023.114751. [PMID: 37105073] - Soek-Ying Neo, Yin-Yin Siew, Hui-Chuing Yew, Yaqian He, Keng-Ling Poh, Yi-Chen Tsai, Shu-Ling Ng, Wei-Xun Tan, Teck-Ian Chong, Claire Sophie En-Shen Lim, Samuel Shan-Wei Ho, Deepika Singh, Azhar Ali, Yeh-Ching Linn, Chay-Hoon Tan, See-Voon Seow, Hwee-Ling Koh. Effects of Leea indica leaf extracts and its phytoconstituents on natural killer cell-mediated cytotoxicity in human ovarian cancer.
BMC complementary medicine and therapies.
2023 Mar; 23(1):79. doi:
10.1186/s12906-023-03904-1. [PMID: 36899361] - Qi Zuo, Qimei Xu, Zhen Li, Dixian Luo, Hanwu Peng, Zhi Duan. Kruppel-like factor 5 enhances proliferation, lipid droplet formation and oxaliplatin resistance in colorectal cancer by promoting fatty acid binding protein 6 transcription.
Anti-cancer drugs.
2023 Mar; ?(?):. doi:
10.1097/cad.0000000000001515. [PMID: 37067981] - Aranka Brockmueller, Samson Mathews Samuel, Alena Mazurakova, Dietrich Büsselberg, Peter Kubatka, Mehdi Shakibaei. Curcumin, calebin A and chemosensitization: How are they linked to colorectal cancer?.
Life sciences.
2023 Feb; 318(?):121504. doi:
10.1016/j.lfs.2023.121504. [PMID: 36813082] - Elahe Seyed Hosseini, Marziyeh Alizadeh Zarei, Hossein Tarrahimofrad, Javad Zamani, Hamed Haddad Kashani, Ejaz Ahmad, Hossein Nikzad. Synergistic effects of dendrosomal nanocurcumin and oxaliplatin on oncogenic properties of ovarian cancer cell lines by down-expression of MMPs.
Biological research.
2023 Jan; 56(1):3. doi:
10.1186/s40659-023-00412-x. [PMID: 36658640] - Hanie Mahaki, Mona Mansourian, Zahra Meshkat, Amir Avan, Mohammad Hossein Shafiee, Reihaneh Alsadat Mahmoudian, Elnaz Ghorbani, Gordon A Ferns, Hamed Manoochehri, Shaho Menbari, Mohsen Sheykhhasan, Hamid Tanzadehpanah. Nanoparticles Containing Oxaliplatin and the Treatment of Colorectal Cancer.
Current pharmaceutical design.
2023; 29(38):3018-3039. doi:
10.2174/0113816128274742231103063738. [PMID: 37990895] - Gang Wang, Jun-Jie Wang, Zhu Zhi-Min, Xiao-Na Xu, Feng Shi, Xing-Li Fu. Targeting critical pathways in ferroptosis and enhancing antitumor therapy of Platinum drugs for colorectal cancer.
Science progress.
2023 Jan; 106(1):368504221147173. doi:
10.1177/00368504221147173. [PMID: 36718538] - Zhen-Xiong Zhao, Yan-Qiu Zhang, Hui Sun, Zi-Qi Chen, Jin-Jia Chang, Xin Wang, Xu Wang, Cong Tan, Shu-Juan Ni, Wei-Wei Weng, Meng Zhang, Lei Wang, Dan Huang, Yun Feng, Wei-Qi Sheng, Mi-Die Xu. Calcipotriol abrogates cancer-associated fibroblast-derived IL-8-mediated oxaliplatin resistance in gastric cancer cells via blocking PI3K/Akt signaling.
Acta pharmacologica Sinica.
2023 Jan; 44(1):178-188. doi:
10.1038/s41401-022-00927-1. [PMID: 35676532] - Caifu Lu, Cong Zhang. Oxaliplatin inhibits colorectal cancer progression by inhibiting CXCL11 secreted by cancer-associated fibroblasts and the CXCR3/PI3K/AKT pathway.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.
2023 Jan; 25(1):160-172. doi:
10.1007/s12094-022-02922-8. [PMID: 36129606] - Yi Zhang, Lei Xu, Zeqiang Ren, Xin Liu, Jun Song, Pengbo Zhang, Chong Zhang, Shuai Gong, Nai Wu, Xiuzhong Zhang, Chanbin Xie, Zhixing Lu, Min Ma, Yi Zhang, Yifei Chen, Changwei Lin. LINC01615 maintains cell survival in adaptation to nutrient starvation through the pentose phosphate pathway and modulates chemosensitivity in colorectal cancer.
Cellular and molecular life sciences : CMLS.
2022 Dec; 80(1):20. doi:
10.1007/s00018-022-04675-7. [PMID: 36576581] - Laura Micheli, Valentina Maggini, Clara Ciampi, Eugenia Gallo, Patrizia Bogani, Renato Fani, Luisa Pistelli, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Marinella De Leo, Fabio Firenzuoli. Echinacea purpurea against neuropathic pain: Alkamides versus polyphenols efficacy.
Phytotherapy research : PTR.
2022 Dec; ?(?):. doi:
10.1002/ptr.7709. [PMID: 36578266] - Xiaomin Jiang, Morten Lee, Junjie Xia, Taokun Luo, Jianqiao Liu, Megan Rodriguez, Wenbin Lin. Two-Stage SN38 Release from a Core-Shell Nanoparticle Enhances Tumor Deposition and Antitumor Efficacy for Synergistic Combination with Immune Checkpoint Blockade.
ACS nano.
2022 12; 16(12):21417-21430. doi:
10.1021/acsnano.2c09788. [PMID: 36382721] - Bin Huang, Mengxuan Gui, Zhuona Ni, Yanbin He, Jinyan Zhao, Jun Peng, Jiumao Lin. Chemotherapeutic Drugs Induce Different Gut Microbiota Disorder Pattern and NOD/RIP2/NF-κB Signaling Pathway Activation That Lead to Different Degrees of Intestinal Injury.
Microbiology spectrum.
2022 12; 10(6):e0167722. doi:
10.1128/spectrum.01677-22. [PMID: 36222691] - Lifang Shao, Jiu Chen, Lixiong Ying. Lymphoepithelioma-like Carcinoma of the Stomach: A Case Successfully Treated with Chemotherapy.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2022 12; 32(12):SS227-SS229. doi:
10.29271/jcpsp.2022.supp0.ss227. [PMID: 36597346] - Xiaofeng Qiu, Qihua Xu, Bingling Liao, Sheng Hu, Ying Zhou, Huijun Zhang. Circ-CCS regulates oxaliplatin resistance via targeting miR-874-3p/HK2 axis in colorectal cancer.
Histology and histopathology.
2022 Nov; ?(?):18565. doi:
10.14670/hh-18-565. [PMID: 36519522] - Mengge Wang, Yusen Xiang, Ruyu Wang, Lijun Zhang, Hong Zhang, Hongzhuan Chen, Xin Luan, Lili Chen. Dihydrotanshinone I Inhibits the Proliferation and Growth of Oxaliplatin-Resistant Human HCT116 Colorectal Cancer Cells.
Molecules (Basel, Switzerland).
2022 Nov; 27(22):. doi:
10.3390/molecules27227774. [PMID: 36431875] - Chuangen Li, Yong Wang, Dabin Liu, Chi Chun Wong, Olabisi Oluwabukola Coker, Xiang Zhang, Changan Liu, Yunfei Zhou, Yali Liu, Wei Kang, Ka Fai To, Joseph Jy Sung, Jun Yu. Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis.
Gut.
2022 11; 71(11):2253-2265. doi:
10.1136/gutjnl-2021-325851. [PMID: 35232776] - Morgan Zhang, Min Hu, Sascha R A Alles, Marena A Montera, Ian Adams, Maria D Santi, Kenji Inoue, Nguyen Huu Tu, Karin N Westlund, Yi Ye. Peroxisome proliferator-activated receptor gamma agonist ELB00824 suppresses oxaliplatin-induced pain, neuronal hypersensitivity, and oxidative stress.
Neuropharmacology.
2022 11; 218(?):109233. doi:
10.1016/j.neuropharm.2022.109233. [PMID: 36007855] - Zhifeng Wang, Jingmei Liu, Tao Yang, Qinqin Wang, Rong Liang, Jinliang Tang. Circ_0082182 upregulates the NFIB level via sponging miR-326 to promote oxaliplatin resistance and malignant progression of colorectal cancer cells.
Molecular and cellular biochemistry.
2022 Oct; ?(?):. doi:
10.1007/s11010-022-04551-9. [PMID: 36219357] - Qiumo Zhang, Ting Deng, Hongdian Zhang, Duo Zuo, Qihang Zhu, Ming Bai, Rui Liu, Tao Ning, Le Zhang, Zhentao Yu, Haiyang Zhang, Yi Ba. Adipocyte-Derived Exosomal MTTP Suppresses Ferroptosis and Promotes Chemoresistance in Colorectal Cancer.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2022 10; 9(28):e2203357. doi:
10.1002/advs.202203357. [PMID: 35978266] - Marta Barradas, Adrián Plaza, Gonzalo Colmenarejo, Iolanda Lázaro, Luis Filipe Costa-Machado, Roberto Martín-Hernández, Victor Micó, José Luis López-Aceituno, Jesús Herranz, Cristina Pantoja, Hector Tejero, Alberto Diaz-Ruiz, Fatima Al-Shahrour, Lidia Daimiel, Viviana Loria-Kohen, Ana Ramirez de Molina, Alejo Efeyan, Manuel Serrano, Oscar J Pozo, Aleix Sala-Vila, Pablo J Fernandez-Marcos. Fatty acids homeostasis during fasting predicts protection from chemotherapy toxicity.
Nature communications.
2022 09; 13(1):5677. doi:
10.1038/s41467-022-33352-3. [PMID: 36167809] - Yu Xia, Chenglou Zhu, Lei Xu, Jibin Yao, Mingxu Da. S-1 and oxaliplatin combined with nanoparticle albumin-bound paclitaxel adjuvant chemotherapy for advanced gastric adenocarcinoma.
Chinese medical journal.
2022 09; 135(18):2261-2263. doi:
10.1097/cm9.0000000000002003. [PMID: 35861465] - Feng-Jiao Wang, She Shi, Yong-Qiang Wang, Ke Wang, Shen-Dong Fan, Ya-Nan Zhang, Chen-Chen Feng, Zi-Yong Ju. Protective Mechanism of Electroacupuncture on Peripheral Neurotoxicity Induced by Oxaliplatin in Rats.
Chinese journal of integrative medicine.
2022 Sep; 28(9):833-839. doi:
10.1007/s11655-022-2896-1. [PMID: 35799085] - Jianfeng Guo, Leaf Huang. Formulation of two lipid-based membrane-core nanoparticles for FOLFOX combination therapy.
Nature protocols.
2022 08; 17(8):1818-1831. doi:
10.1038/s41596-022-00698-3. [PMID: 35650451] - Ashwaq A Al-Mutairi, Mayson H Alkhatib. Antitumour effects of a solid lipid nanoparticle loaded with gemcitabine and oxaliplatin on the viability, apoptosis, autophagy, and Hsp90 of ovarian cancer cells.
Journal of microencapsulation.
2022 Aug; 39(5):467-480. doi:
10.1080/02652048.2022.2109218. [PMID: 35916335] - Xiaomin Jiang, Wenbo Han, Jianqiao Liu, Jianming Mao, Morten J Lee, Megan Rodriguez, Youyou Li, Taokun Luo, Ziwan Xu, Kaiting Yang, Marc Bissonnette, Ralph R Weichselbaum, Wenbin Lin. Tumor-Activatable Nanoparticles Target Low-Density Lipoprotein Receptor to Enhance Drug Delivery and Antitumor Efficacy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2022 08; 9(24):e2201614. doi:
10.1002/advs.202201614. [PMID: 35748191] - Xiang Dong, Zewu Zhang, Qin Zhang, Lu Chen, Guangtai Cao, Chen Liu, Tianqiang Song, Wei Lu, Wei Zhang. Triple therapy in biliary tract cancers: GemOX plus immune checkpoint inhibitor in combination with lenvatinib or NGS-guided targeted therapy.
Journal of cancer research and clinical oncology.
2022 Jul; ?(?):. doi:
10.1007/s00432-022-04166-z. [PMID: 35802197] - Mingzhu Li, Zheng Li, Xiande Ma, Shengbo Jin, Yang Cao, Xuebing Wang, Jian Zhao, Jianbo Wang, Xin Wang, Jian Xu. Huangqi Guizhi Wuwu Decoction can prevent and treat oxaliplatin-induced neuropathic pain by TNFα/IL-1β/IL-6/MAPK/NF-kB pathway.
Aging.
2022 Jun; 14(12):5013-5022. doi:
10.18632/aging.203794. [PMID: 35759577] - Cheng Chang, Anrui Zheng, Pinfa Wang, Xiaojun Teng. Circular RNA mitochondrial translation optimization 1 correlates with less lymph node metastasis, longer disease-free survival, and higher chemotherapy sensitivity in gastric cancer.
Journal of clinical laboratory analysis.
2022 Jun; 36(6):e23918. doi:
10.1002/jcla.23918. [PMID: 35478417] - Cheng-Qiong Wang, You-Shu Shen, Xiao-Fan Chen, Hong Jiang, Xue-Mei Yang, Teng-Yang Fan, Shu-Guang Li, Ping Yang, Lin Zhan, Rong Chen, Ji-Hong Feng, Xue Xiao, Zheng Xiao. The intrapleural administration with thymic peptides in malignant pleural effusion: A clusteredsystematicreview and meta-analysis.
International immunopharmacology.
2022 Jun; 107(?):108688. doi:
10.1016/j.intimp.2022.108688. [PMID: 35293322] - Feng Wu, Yaqian Du, Jiani Yang, Boyang Shao, Zhensheng Mi, Yuanfei Yao, Ying Cui, Fei He, Yanqiao Zhang, Piaoping Yang. Peroxidase-like Active Nanomedicine with Dual Glutathione Depletion Property to Restore Oxaliplatin Chemosensitivity and Promote Programmed Cell Death.
ACS nano.
2022 03; 16(3):3647-3663. doi:
10.1021/acsnano.1c06777. [PMID: 35266697] - Youyu Wang, Bo Jiang, Wang Luo. Memantine ameliorates oxaliplatin-induced neurotoxicity via mitochondrial protection.
Bioengineered.
2022 03; 13(3):6688-6697. doi:
10.1080/21655979.2022.2026553. [PMID: 35235756] - Jialei Mao, Yinzhu Bian, Qun Zhang, Linghui Kong, Xiao Shi, Jing Hu, Mi Yang, Li Li, Hanqing Qian, Baorui Liu, Xiaoping Qian. Antitumor activity of iRGD-modified red blood cell membrane nanoparticles loaded with Juglone and Oxaliplatin against colorectal cancer.
Journal of biomaterials applications.
2022 02; 36(7):1301-1316. doi:
10.1177/08853282211052386. [PMID: 34802305] - Dun-Chang Mo, Lang Qin, Lin-Jing Ye. Neoadjuvant Docetaxel, Oxaliplatin, and S-1 in Resectable Advanced Gastric Cancer.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2021 12; 39(34):3883-3884. doi:
10.1200/jco.21.01528. [PMID: 34591655] - Wenlong Du, Xiaoping Yang, Shenfu He, Jia Wang, Yuanxian Guo, Bangguo Kou, Yongjie Jiang, Pan Bian, Bingtai Li, Lanning Yin. Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer.
Drug delivery.
2021 Dec; 28(1):920-929. doi:
10.1080/10717544.2021.1914777. [PMID: 33974471] - Qingguo Li, Huizhen Sun, Dakui Luo, Lu Gan, Shaobo Mo, Weixing Dai, Lei Liang, Yufei Yang, Midie Xu, Jing Li, Peiyong Zheng, Xinxiang Li, Yan Li, Ziliang Wang. Lnc-RP11-536 K7.3/SOX2/HIF-1α signaling axis regulates oxaliplatin resistance in patient-derived colorectal cancer organoids.
Journal of experimental & clinical cancer research : CR.
2021 Nov; 40(1):348. doi:
10.1186/s13046-021-02143-x. [PMID: 34740372] - Davut Aydın, Korhan Özkan, Ali Aydın. The Combination of Amygdalin with Some Anticancer, Antiparasitic, and Antigout Drugs Against MG63, Saos2, SW1353, and FL Cells In Vitro.
Journal of medicinal food.
2021 Nov; 24(11):1230-1234. doi:
10.1089/jmf.2020.0143. [PMID: 33733877] - Yang Yang, Bing Zhao, Xuejiao Gao, Jinbing Sun, Juan Ye, Jun Li, Peng Cao. Targeting strategies for oxaliplatin-induced peripheral neuropathy: clinical syndrome, molecular basis, and drug development.
Journal of experimental & clinical cancer research : CR.
2021 Oct; 40(1):331. doi:
10.1186/s13046-021-02141-z. [PMID: 34686205] - Ketlyn P da Motta, Briana B Lemos, Jaini J Paltian, Angélica S Dos Reis, Gustavo B Blödorn, Diego Alves, Cristiane Luchese, Ethel A Wilhelm. 7-Chloro-4-(phenylselanyl) quinoline reduces renal oxidative stress induced by oxaliplatin in mice.
Canadian journal of physiology and pharmacology.
2021 Oct; 99(10):1102-1111. doi:
10.1139/cjpp-2021-0090. [PMID: 34015230] - Nobuaki Egashira, Yu Goto, Ryota Takahashi, Hikari Iba, Shota Yamamoto, Takuya Watanabe, Kaori Kubota, Takehiro Kawashiri, Chise Taniguchi, Shutaro Katsurabayashi, Katsunori Iwasaki. Ibudilast suppresses oxaliplatin-induced mechanical allodynia and neurodegeneration in rats.
Journal of pharmacological sciences.
2021 Sep; 147(1):114-117. doi:
10.1016/j.jphs.2021.06.004. [PMID: 34294361] - Joshua D Greenlee, Maria Lopez-Cavestany, Nerymar Ortiz-Otero, Kevin Liu, Tejas Subramanian, Burt Cagir, Michael R King. Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization.
eLife.
2021 08; 10(?):. doi:
10.7554/elife.67750. [PMID: 34342264] - Limei Wen, Junping Hu, Jiawei Zhang, Jianhua Yang. Phenylethanol glycosides from Herba Cistanche improve the hypoxic tumor microenvironment and enhance the effects of oxaliplatin via the HIF‑1α signaling pathway.
Molecular medicine reports.
2021 07; 24(1):. doi:
10.3892/mmr.2021.12156. [PMID: 34013363] - Tianjiao Zeng, Mingshi Xu, Wanli Zhang, Xiaofan Gu, Fangqing Zhao, Xuan Liu, Xiongwen Zhang. Autophagy inhibition and microRNA‑199a‑5p upregulation in paclitaxel‑resistant A549/T lung cancer cells.
Oncology reports.
2021 07; 46(1):. doi:
10.3892/or.2021.8100. [PMID: 34080652] - Jing Yu, Dongli Hu, Yu Cheng, Jiwei Guo, Yicheng Wang, Zhirong Tan, Jingbo Peng, Honghao Zhou. Lipidomics and transcriptomics analyses of altered lipid species and pathways in oxaliplatin-treated colorectal cancer cells.
Journal of pharmaceutical and biomedical analysis.
2021 Jun; 200(?):114077. doi:
10.1016/j.jpba.2021.114077. [PMID: 33892396] - Briana B Lemos, Ketlyn P da Motta, Jaini J Paltian, Angélica S Reis, Gustavo B Blödorn, Mauro P Soares, Diego Alves, Cristiane Luchese, Ethel A Wilhelm. Role of 7-chloro-4-(phenylselanyl) quinoline in the treatment of oxaliplatin-induced hepatic toxicity in mice.
Canadian journal of physiology and pharmacology.
2021 Apr; 99(4):378-388. doi:
10.1139/cjpp-2020-0134. [PMID: 32810410] - Guoli Wei, Zhancheng Gu, Jialin Gu, Jialin Yu, Xiaofei Huang, Fengxia Qin, Lingchang Li, Rong Ding, Jiege Huo. Platinum accumulation in oxaliplatin-induced peripheral neuropathy.
Journal of the peripheral nervous system : JPNS.
2021 Mar; 26(1):35-42. doi:
10.1111/jns.12432. [PMID: 33462873] - Ziyuan Wang, Xiaoting Sun, Yuanyuan Feng, Yang Wang, Lu Zhang, Yan Wang, Zhen Fang, Nisma Lena Bahaji Azami, Mingyu Sun, Qi Li. Dihydromyricetin reverses MRP2-induced multidrug resistance by preventing NF-κB-Nrf2 signaling in colorectal cancer cell.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Feb; 82(?):153414. doi:
10.1016/j.phymed.2020.153414. [PMID: 33461143] - Ji Hwan Lee, Daeun Min, Donghun Lee, Woojin Kim. Zingiber officinale Roscoe Rhizomes Attenuate Oxaliplatin-Induced Neuropathic Pain in Mice.
Molecules (Basel, Switzerland).
2021 Jan; 26(3):. doi:
10.3390/molecules26030548. [PMID: 33494465] - Xiangdong Cheng, Dan Wu, Nong Xu, Luchuan Chen, Zhilong Yan, Ping Chen, Lei Zhou, Jianfa Yu, Jiuwei Cui, Wei Li, Chang Wang, Wenming Feng, Yunhai Wei, Pengfei Yu, Yian Du, Jieer Ying, Zhiyuan Xu, Litao Yang, Yunli Zhang. Adjuvant albumin-bound paclitaxel combined with S-1 vs. oxaliplatin combined with capecitabine after D2 gastrectomy in patients with stage III gastric adenocarcinoma: a phase III multicenter, open-label, randomized controlled clinical trial protocol.
BMC cancer.
2021 Jan; 21(1):56. doi:
10.1186/s12885-020-07772-7. [PMID: 33435909] - Mahmoud Ashry, Doaa Galal El-Sahra, Dalia A Gaber, Mohamed A Mustafa, Khaled G Abdel-Wahhab. Nephroprotective Effect of Costus (Saussurea costus) Ethanolic Extract on Oxaliplatin®-induced Nephrotoxicity in Adult Male Wistar Rats.
Pakistan journal of biological sciences : PJBS.
2021 Jan; 24(8):830-839. doi:
10.3923/pjbs.2021.830.839. [PMID: 34486350] - Jingyu Xu, Zhenbiao Guan, Xiaowei Wang, Dazhi Sun, Yongjin Li, Bei Pei, Ye Lu, Liangxi Yuan, Xuan Zhang. Network Pharmacology and Experimental Evidence Identify the Mechanism of Astragaloside IV in Oxaliplatin Neurotoxicity.
Drug design, development and therapy.
2021; 15(?):99-110. doi:
10.2147/dddt.s262818. [PMID: 33469263] - Yeqing Xu, Aizhu Qiu, Feng Peng, Xiangyun Tan, Jin Wang, Xiaosong Gong. Exosomal transfer of circular RNA FBXW7 ameliorates the chemoresistance to oxaliplatin in colorectal cancer by sponging miR-18b-5p.
Neoplasma.
2021 Jan; 68(1):108-118. doi:
10.4149/neo_2020_200417n414. [PMID: 33147048] - Rong Ding, Yue Wang, Ji-Ping Zhu, Wu-Guang Lu, Guo-Li Wei, Zhan-Cheng Gu, Zhen-Tao An, Jie-Ge Huo. Danggui Sini decoction protects against oxaliplatin-induced peripheral neuropathy in rats.
Journal of integrative neuroscience.
2020 Dec; 19(4):663-671. doi:
10.31083/j.jin.2020.04.1154. [PMID: 33378840] - Xinjie Zhang, Haitao Chen, Yi Lu, Chao Xu, Wang Yao, Lu Xu, Runzhe Zhang, Liping Zhang, Qinghua Yao. Prevention of oxaliplatin-related neurotoxicity by ω-3 PUFAs: A double-blind randomized study of patients receiving oxaliplatin combined with capecitabine for colon cancer.
Medicine.
2020 Dec; 99(50):e23564. doi:
10.1097/md.0000000000023564. [PMID: 33327312] - Vittoria Rimola, Lisa Hahnefeld, Junli Zhao, Changyu Jiang, Carlo Angioni, Yannick Schreiber, Tabea Osthues, Sandra Pierre, Gerd Geisslinger, Ru-Rong Ji, Klaus Scholich, Marco Sisignano. Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2020 12; 40(49):9519-9532. doi:
10.1523/jneurosci.1223-20.2020. [PMID: 33158961] - Y Yao, R Deng, D Liao, H Xie, J Zuo, Y Jia, F Kong. Maintenance treatment in advanced HER2-negative gastric cancer.
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico.
2020 Dec; 22(12):2206-2212. doi:
10.1007/s12094-020-02379-7. [PMID: 32562198] - Kuldeep Rajpoot, Sunil K Jain. 99mTc-labelled and pH-awakened microbeads entrapping surface-modified lipid nanoparticles for the augmented effect of oxaliplatin in the therapy of colorectal cancer.
Journal of microencapsulation.
2020 Dec; 37(8):609-623. doi:
10.1080/02652048.2020.1829141. [PMID: 32985297] - Jelena S Katanic Stankovic, Dragica Selakovic, Vladimir Mihailovic, Gvozden Rosic. Antioxidant Supplementation in the Treatment of Neurotoxicity Induced by Platinum-Based Chemotherapeutics-A Review.
International journal of molecular sciences.
2020 Oct; 21(20):. doi:
10.3390/ijms21207753. [PMID: 33092125] - Weixing Dai, Ye Xu, Shaobo Mo, Qingguo Li, Jun Yu, Renjie Wang, Yanlei Ma, Yan Ni, Wenqiang Xiang, Lingyu Han, Long Zhang, Sanjun Cai, Jun Qin, Wen-Lian Chen, Wei Jia, Guoxiang Cai. GLUT3 induced by AMPK/CREB1 axis is key for withstanding energy stress and augments the efficacy of current colorectal cancer therapies.
Signal transduction and targeted therapy.
2020 09; 5(1):177. doi:
10.1038/s41392-020-00220-9. [PMID: 32873793] - Hamit Celik, Sefa Kucukler, Selcuk Ozdemir, Selim Comakli, Cihan Gur, Fatih Mehmet Kandemir, Ahmet Yardim. Lycopene protects against central and peripheral neuropathy by inhibiting oxaliplatin-induced ATF-6 pathway, apoptosis, inflammation and oxidative stress in brains and sciatic tissues of rats.
Neurotoxicology.
2020 09; 80(?):29-40. doi:
10.1016/j.neuro.2020.06.005. [PMID: 32544411] - Yuan Fang, Juan Ye, Bing Zhao, Jinbing Sun, Na Gu, Xi Chen, Lingli Ren, Jiao Chen, Xueting Cai, Wenjuan Zhang, Yang Yang, Peng Cao. Formononetin ameliorates oxaliplatin-induced peripheral neuropathy via the KEAP1-NRF2-GSTP1 axis.
Redox biology.
2020 09; 36(?):101677. doi:
10.1016/j.redox.2020.101677. [PMID: 32823168] - Mária Macejová, Veronika Sačková, Petra Hradická, Rastislav Jendželovský, Vlasta Demečková, Peter Fedoročko. Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2020 Aug; 66(?):104860. doi:
10.1016/j.tiv.2020.104860. [PMID: 32298799] - Xuhui Wang, Man Li, Kebai Ren, Chunyu Xia, Jianping Li, Qianwen Yu, Yue Qiu, Zhengze Lu, Yang Long, Zhirong Zhang, Qin He. On-Demand Autophagy Cascade Amplification Nanoparticles Precisely Enhanced Oxaliplatin-Induced Cancer Immunotherapy.
Advanced materials (Deerfield Beach, Fla.).
2020 Aug; 32(32):e2002160. doi:
10.1002/adma.202002160. [PMID: 32596861] - Weimin Wang, Haibo Wang, Liangliang Xiang, Tengyang Ni, Feng Jin, Jianliang Deng, Yunlei Zhang, Ishikawa Shintaro, Yan Zhou, Yanqing Liu. DJ‑1 is a new prognostic marker and predicts chemotherapy efficacy in colorectal cancer.
Oncology reports.
2020 07; 44(1):77-90. doi:
10.3892/or.2020.7593. [PMID: 32627002] - Yan Zhang, Hongyin Zhai. Bilobalide assuages morphine-induced addiction in hippocampal neuron cells through upregulation of microRNA-101.
Journal of biochemical and molecular toxicology.
2020 Jul; 34(7):e22493. doi:
10.1002/jbt.22493. [PMID: 32319158] - Samineh Dehghanpour, Hamid Reza Pourzamani, Mohammad Mehdi Amin, Karim Ebrahimpour. Evaluation of toxic effects of platinum-based antineoplastic drugs (cisplatin, carboplatin and oxaliplatin) on green alga Chlorella vulgaris.
Aquatic toxicology (Amsterdam, Netherlands).
2020 Jun; 223(?):105495. doi:
10.1016/j.aquatox.2020.105495. [PMID: 32371336] - Jia -Lu Zheng, Shuang-Shuang Wang, Ke-Ping Shen, Xiao-Wei Huang, Miao Li, Lei Chen, Xiao Peng, Hong-Mei An, Bing Hu. Ursolic acid potentiated oxaliplatin to induce apoptosis in colorectal cancer RKO cells.
Die Pharmazie.
2020 06; 75(6):246-249. doi:
10.1691/ph.2020.0417. [PMID: 32539919] - Xiao-Man Wei, Xiao-Feng Chen, Peng Shu, Zhi-Wei Jiang, Xiao-Yu Wu, Xi Zou, Kai Chen, Bo Shen, Wen-Wei Hu, Wei Lu, Wei-Xing Shen, Liu Li, Jun-Yi Wang, Feng-Jiao Zhao, Qing-Feng Yin, Hai-Bo Cheng, Yan-Hong Gu. Study on efficacy and safety of Huangqi Guizhi Wuwu decoction treatment for oxaliplatin induced peripheral neurotoxicity: A protocol for a randomized, controlled, double-blind, multicenter trial.
Medicine.
2020 May; 99(22):e19923. doi:
10.1097/md.0000000000019923. [PMID: 32481364] - Marta Woźniak, Sebastian Makuch, Kinga Winograd, Jerzy Wiśniewski, Piotr Ziółkowski, Siddarth Agrawal. 6-Shogaol enhances the anticancer effect of 5-fluorouracil, oxaliplatin, and irinotecan via increase of apoptosis and autophagy in colon cancer cells in hypoxic/aglycemic conditions.
BMC complementary medicine and therapies.
2020 May; 20(1):141. doi:
10.1186/s12906-020-02913-8. [PMID: 32393373] - Sung-Chul Lim, Keshab Raj Parajuli, Song Iy Han. Role of Death Receptors-associated Lipid Rafts in Oxaliplatin-induced Death Mode Regulation of HepG2 Cells.
Anticancer research.
2020 May; 40(5):2573-2582. doi:
10.21873/anticanres.14228. [PMID: 32366402] - Jianfeng Guo, Zhuo Yu, Manisit Das, Leaf Huang. Nano Codelivery of Oxaliplatin and Folinic Acid Achieves Synergistic Chemo-Immunotherapy with 5-Fluorouracil for Colorectal Cancer and Liver Metastasis.
ACS nano.
2020 04; 14(4):5075-5089. doi:
10.1021/acsnano.0c01676. [PMID: 32283007]
