Bendamustine (BioDeep_00000614810)
代谢物信息卡片
Bendamustine
化学式: C16H21Cl2N3O2 (357.1010746)
中文名称: 宾达氮芥
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O
InChI: InChI=1S/C16H21Cl2N3O2/c1-20-14-6-5-12(21(9-7-17)10-8-18)11-13(14)19-15(20)3-2-4-16(22)23/h5-6,11H,2-4,7-10H2,1H3,(H,22,23)
描述信息
L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01A - Alkylating agents > L01AA - Nitrogen mustard analogues
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C2842 - DNA Binding Agent
D009676 - Noxae > D000477 - Alkylating Agents
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135515
- KEGGdrug: D07501
- PubChem: 65628
- Metlin: METLIN85186
- DrugBank: DB06769
- ChEMBL: CHEMBL487253
- MeSH: Bendamustine Hydrochloride
- CAS: 16506-27-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Akie Hirata, Kaname Miyashita, Takafumi Tanaka, Kiyoko Hirata, Taisuke Narazaki, Hayato Utsunomiya, Hirofumi Ohno, Eriko Nakashima, Yoshimichi Tachikawa, Ilseung Choi, Kenichi Taguchi, Youko Suehiro. Serum immunoglobulin G as a discriminator of infection in follicular lymphoma patients undergoing chemotherapy with bendamustine in combination with rituximab.
Hematology (Amsterdam, Netherlands).
2022 Dec; 27(1):384-395. doi:
10.1080/16078454.2022.2051863. [PMID: 35344477] - Honglu Yin, Yuepeng Chen, Qiu Zhong, Shilong Zheng, Guangdi Wang, Ling He. Design, synthesis, and antitumor study of a series of novel 1-Oxa-4-azaspironenone derivatives.
Bioorganic & medicinal chemistry letters.
2022 10; 74(?):128925. doi:
10.1016/j.bmcl.2022.128925. [PMID: 35944852] - Harsha K Tripathy, S V Nair Manju, Rama Murthy Bestha, Vinay Kiran, Sreekanth Dittakavi, Ramesh Mullangi. Validated liquid chromatography-tandem mass spectrometry method for simultaneous quantitation of bendamustine and copanlisib in mouse plasma: Application to a pharmacokinetic study in mice.
Biomedical chromatography : BMC.
2022 Aug; 36(8):e5387. doi:
10.1002/bmc.5387. [PMID: 35470912] - Kohei Kamegai, Noriko Iwamoto, Tomiteru Togano, Kenji Maeda, Yuki Takamatsu, Yusuke Miyazato, Masahiro Ishikane, Masashi Mizokami, Masaya Sugiyama, Shun Iida, Sho Miyamoto, Tadaki Suzuki, Norio Ohmagari. A Fatal Breakthrough COVID-19 Case Following Bendamustine-Rituximab Therapy.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
2022 Aug; 121(?):85-88. doi:
10.1016/j.ijid.2022.04.058. [PMID: 35500795] - Jingjing Jia, Honglu Yin, Chen Chen, Mingli Hu, Qiu Zhong, Shilong Zheng, Wei Zhang, Haibo Li, Liang Xu, Guangdi Wang, Ling He. Design, synthesis, and evaluation of a novel series of mono-indolylbenzoquinones derivatives for the potential treatment of breast cancer.
European journal of medicinal chemistry.
2022 Jul; 237(?):114375. doi:
10.1016/j.ejmech.2022.114375. [PMID: 35477142] - Manabu Suzuki, Daisuke Koyama, Shohei Ikeda, Masumi Sukegawa, Mayumi Teshirogi, Kyohei Misawa, Saburo Tsunoda. Serum IgG and lymphocyte counts are useful for the early detection of infection in patients receiving bendamustine-rituximab therapy.
Journal of clinical and experimental hematopathology : JCEH.
2022 Jun; 62(2):91-98. doi:
10.3960/jslrt.21031. [PMID: 35153257] - Tatsuya Arai, Satoru Mukai, Ryo Kazama, Yoshihiko Ogawa, Koji Nishida, Kazuo Hatanaka, Iwao Gohma. Persistent viral shedding of severe acute respiratory syndrome coronavirus 2 after treatment with bendamustine and rituximab: A case report.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy.
2022 Jun; 28(6):810-813. doi:
10.1016/j.jiac.2022.01.014. [PMID: 35115239] - Guy Pratt, Dima El-Sharkawi, Jaimal Kothari, Shirley D'Sa, Rebecca Auer, Helen McCarthy, Rajesh Krishna, Oliver Miles, Charalampia Kyriakou, Roger Owen. Diagnosis and management of Waldenström macroglobulinaemia-A British Society for Haematology guideline.
British journal of haematology.
2022 04; 197(2):171-187. doi:
10.1111/bjh.18036. [PMID: 35020191] - Qinhong Xu, Jieni Yu, Xiaoyan Lin, Youli Li, Kejie Zhang. CB-LPD, MGUS, T-LGLL, and PRCA: A rare case report of 4 concomitant hematological disorders.
Medicine.
2021 Nov; 100(47):e27874. doi:
10.1097/md.0000000000027874. [PMID: 34964755] - Yunjiang Zhou, Yaxin Chen, Xing Huang, Yingying Tan, Rong Hu, Chong Li, Miao-Miao Niu. A Supramolecular Nanomedicine Based on Bendamustine and MDM2-Targeted D-peptide Inhibitor for Breast Cancer Therapy.
Advanced healthcare materials.
2021 11; 10(21):e2100980. doi:
10.1002/adhm.202100980. [PMID: 34558228] - Shinya Rai, Hiroaki Inoue, Hitoshi Hanamoto, Mitsuhiro Matsuda, Yasuhiro Maeda, Yusuke Wada, Takahiro Haeno, Yosaku Watatani, Takahiro Kumode, Chikara Hirase, J Luis Espinoza, Yasuyoshi Morita, Hirokazu Tanaka, Yoichi Tatsumi, Itaru Matsumura. Low absolute lymphocyte count is a poor prognostic factor for untreated advanced follicular lymphoma treated with rituximab plus bendamustine: results of the prospective phase 2 CONVERT trial.
International journal of hematology.
2021 Aug; 114(2):205-216. doi:
10.1007/s12185-021-03148-0. [PMID: 33864623] - Lan Luo, Jing Jing Jia, Qiu Zhong, Xue Zhong, Shilong Zheng, Guangdi Wang, Ling He. Synthesis and anticancer activity evaluation of naphthalene-substituted triazole spirodienones.
European journal of medicinal chemistry.
2021 Mar; 213(?):113039. doi:
10.1016/j.ejmech.2020.113039. [PMID: 33261898] - Cécile Dumas, Lucile Baseggio. Crystal-storing histiocytosis in Bing-Neel syndrome.
Blood.
2021 02; 137(7):1000. doi:
10.1182/blood.2020009307. [PMID: 33599762] - Griffin J Reed, Antonious Z Hazim, Catalina Sanchez-Alvarez, Kenneth J Warrington. Type II cryoglobulinemic vasculitis in the setting of MALT lymphoma.
BMJ case reports.
2021 Jan; 14(1):. doi:
10.1136/bcr-2020-236267. [PMID: 33436357] - Aurelia Zimmerli, Matteo Monti, Craig Fenwick, Isabella Eckerle, Catherine Beigelman-Aubry, Céline Pellaton, Katia Jaton, Dominique Dumas, Gian-Marco Stamm, Laura Infanti, Heidrun Andreu-Ullrich, Daphné Germann, Marie Mean, Peter Vollenweider, Raphael Stadelmann, Maura Prella, Denis Comte, Benoit Guery, David Gachoud, Nathalie Rufer. Case Report: Stepwise Anti-Inflammatory and Anti-SARS-CoV-2 Effects Following Convalescent Plasma Therapy With Full Clinical Recovery.
Frontiers in immunology.
2021; 12(?):613502. doi:
10.3389/fimmu.2021.613502. [PMID: 33968017] - Andrew N Minzenmayer, Roberto N Miranda, Priscilla R Powell, Palak K Parekh. An unusual case of cutaneous Waldenström macroglobulinemia with the MYD88 L265P mutation.
Journal of cutaneous pathology.
2020 Sep; 47(9):850-853. doi:
10.1111/cup.13722. [PMID: 32335928] - Sigbjørn Berentsen, Wilma Barcellini, Shirley D'Sa, Ulla Randen, Tor Henrik Anderson Tvedt, Bruno Fattizzo, Einar Haukås, Megan Kell, Robert Brudevold, Anders E A Dahm, Jakob Dalgaard, Hege Frøen, Randi Fykse Hallstensen, Pernille H Jæger, Henrik Hjorth-Hansen, Agnieszka Małecka, Markku Oksman, Jürgen Rolke, Mallika Sekhar, Jon Hjalmar Sørbø, Eirik Tjønnfjord, Galina Tsykunova, Geir E Tjønnfjord. Cold agglutinin disease revisited: a multinational, observational study of 232 patients.
Blood.
2020 07; 136(4):480-488. doi:
10.1182/blood.2020005674. [PMID: 32374875] - Emelie Curovic Rotbain, Henrik Frederiksen, Henrik Hjalgrim, Klaus Rostgaard, Gudrun Jakubsdottir Egholm, Banafsheh Zahedi, Christian Bjørn Poulsen, Lisbeth Enggard, Caspar da Cunha-Bang, Carsten Utoft Niemann. IGHV mutational status and outcome for patients with chronic lymphocytic leukemia upon treatment: a Danish nationwide population-based study.
Haematologica.
2020 06; 105(6):1621-1629. doi:
10.3324/haematol.2019.220194. [PMID: 31582540] - Irene Prediletto, Sarah A Farag, Ulrike Bacher, Barbara Jeker, Behrouz Mansouri Taleghani, Rachel Brégy, Thilo Zander, Daniel Betticher, Thomas Egger, Urban Novak, Thomas Pabst. High incidence of reversible renal toxicity of dose-intensified bendamustine-based high-dose chemotherapy in lymphoma and myeloma patients.
Bone marrow transplantation.
2019 12; 54(12):1923-1925. doi:
10.1038/s41409-019-0508-2. [PMID: 30890768] - M Dumont, C Ram-Wolff, M Roelens, P Brice, R Peffault de Latour, M Battistella, I Madelaine, J Delyon, F Herms, J-D Bouaziz, H Moins-Teisserenc, C Lebbé, M Bagot, A de Masson. Efficacy and safety of brentuximab vedotin plus bendamustine in advanced-stage primary cutaneous T-cell lymphomas.
The British journal of dermatology.
2019 12; 181(6):1315-1317. doi:
10.1111/bjd.18215. [PMID: 31206589] - Michael Steurer, Marco Montillo, Lydia Scarfò, Francesca R Mauro, Johannes Andel, Sophie Wildner, Livio Trentin, Ann Janssens, Sonja Burgstaller, Anna Frömming, Thomas Dümmler, Kai Riecke, Matthias Baumann, Diana Beyer, Stéphanie Vauléon, Paolo Ghia, Robin Foà, Federico Caligaris-Cappio, Marco Gobbi. Olaptesed pegol (NOX-A12) with bendamustine and rituximab: a phase IIa study in patients with relapsed/refractory chronic lymphocytic leukemia.
Haematologica.
2019 10; 104(10):2053-2060. doi:
10.3324/haematol.2018.205930. [PMID: 31097627] - Tais Susane Pereira, Juliane Rocha de Sant'anna, Janicelle Fernandes Morais, Joana Paula Rocha de Sant'anna Yajima, Paulo Cezar de Freitas Mathias, Claudinéia Conationi da Silva Franco, Marialba Avezum Alves de Castro-Prado. Assessment of bendamustine-induced genotoxicity in eukaryotic cells.
Drug and chemical toxicology.
2019 Jul; 42(4):394-402. doi:
10.1080/01480545.2018.1458236. [PMID: 29681187] - Silvia Maria Lavezzi, Jan de Jong, Martine Neyens, Paula Cramer, Fatih Demirkan, Graeme Fraser, Nancy Bartlett, Marie-Sarah Dilhuydy, Javier Loscertales, Abraham Avigdor, Simon Rule, Olga Samoilova, Andre Goy, Siddhartha Ganguly, Mariya Salman, Angela Howes, Michelle Mahler, Giuseppe De Nicolao, Italo Poggesi. Systemic Exposure of Rituximab Increased by Ibrutinib: Pharmacokinetic Results and Modeling Based on the HELIOS Trial.
Pharmaceutical research.
2019 May; 36(7):93. doi:
10.1007/s11095-019-2605-8. [PMID: 31044267] - Alessandro Isidori, Federica Loscocco, Barbara Guiducci, Giuseppe Visani. Benda-EAM prior to ASCT and renal toxicity: Much ado about nothing.
American journal of hematology.
2019 04; 94(4):E104-E105. doi:
10.1002/ajh.25413. [PMID: 30663798] - Matthew Ettleson, Kale S Bongers, Kaitlyn Vitale, Anthony J Perissinotti, Tycel Phillips, Bernard L Marini. Successful use of cytarabine and bendamustine in a patient with mantle cell lymphoma and acute renal failure using intermittent hemodialysis: A case report.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2019 Apr; 25(3):731-734. doi:
10.1177/1078155217754244. [PMID: 29385883] - Andrew Rogers, Pulkit Gandhi, Joseph Bautista, Jie Tang. Acquired Gitelman Syndrome Secondary to Bendamustine Use.
Rhode Island medical journal (2013).
2018 Nov; 101(9):36-38. doi:
NULL. [PMID: 30384518] - Therasa Kim, He Yun Choi, Hyun-Seo Lee, Sung-Hoon Jung, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee, Hee-Doo Yoo, Deok-Hwan Yang. Clinical response and pharmacokinetics of bendamustine as a component of salvage R-B(O)AD therapy for the treatment of primary central nervous system lymphoma (PCNSL).
BMC cancer.
2018 Jul; 18(1):729. doi:
10.1186/s12885-018-4632-y. [PMID: 29986691] - Sylvain P Chantepie, Sylvain Garciaz, Emmanuelle Tchernonog, Frederic Peyrade, Marie-Virginie Larcher, Momar Diouf, Luc-Mathieu Fornecker, Roch Houot, Thomas Gastinne, Carole Soussain, Sandra Malak, Richard Lemal, Caroline Delette, Ahmad Ibrahim, Anne-Claire Gac, Emilie Reboursière, Jean-Pierre Vilque, Mohamed-Amine Bekadja, Rene-Olivier Casasnovas, Remy Gressin, Stéphanie Guidez, Diane Coso, Charles Herbaux, Ibrahim Yakoub-Agha, Krimo Bouabdallah, Eric Durot, Gandhi Damaj. Bendamustine-based conditioning prior to autologous stem cell transplantation (ASCT): Results of a French multicenter study of 474 patients from LYmphoma Study Association (LYSA) centers.
American journal of hematology.
2018 Jun; 93(6):729-735. doi:
10.1002/ajh.25077. [PMID: 29473209] - David Ribes, Hélène E L Hachem, Lucie Oberic, François Vergez, Audrey Delas, Julie Belliere, Caroline Protin, Nassim Kamar, Inès Ferrandiz, Suzanne Tavitian, Camille Laurent, Antoine Huart, Dominique Chauveau, Loïc Ysebaert, Stanislas Faguer. Bendamustine plus rituximab for indolent B-cell lymphoma of renal significance.
American journal of hematology.
2018 03; 93(3):356-362. doi:
10.1002/ajh.24984. [PMID: 29168251] - S Oscoz-Jaime, A D Agulló-Pérez, C Llanos-Chavarri, J I Yanguas-Bayona. Cutaneous Infiltration due to Waldenström Macroglobulinemia.
Actas dermo-sifiliograficas.
2018 Jan; 109(1):75-78. doi:
10.1016/j.ad.2017.04.021. [PMID: 28784233] - Anat Gafter-Gvili, Ronit Gurion, Pia Raanani, Ofer Shpilberg, Liat Vidal. Bendamustine-associated infections-systematic review and meta-analysis of randomized controlled trials.
Hematological oncology.
2017 Dec; 35(4):424-431. doi:
10.1002/hon.2350. [PMID: 27734524] - Eric M Cheung, William J Edenfield, Bassam Mattar, Stephen P Anthony, Peter J Mutch, Brian Chanas, Mark Smith, Adrian Hepner. Safety and Pharmacokinetics of Bendamustine Rapid-Infusion Formulation.
Journal of clinical pharmacology.
2017 Nov; 57(11):1400-1408. doi:
10.1002/jcph.942. [PMID: 28561902] - Prashant Kapoor, Stephen M Ansell, Rafael Fonseca, Asher Chanan-Khan, Robert A Kyle, Shaji K Kumar, Joseph R Mikhael, Thomas E Witzig, Michelle Mauermann, Angela Dispenzieri, Sikander Ailawadhi, A Keith Stewart, Martha Q Lacy, Carrie A Thompson, Francis K Buadi, David Dingli, William G Morice, Ronald S Go, Dragan Jevremovic, Taimur Sher, Rebecca L King, Esteban Braggio, Ann Novak, Vivek Roy, Rhett P Ketterling, Patricia T Greipp, Martha Grogan, Ivana N Micallef, P Leif Bergsagel, Joseph P Colgan, Nelson Leung, Wilson I Gonsalves, Yi Lin, David J Inwards, Suzanne R Hayman, Grzegorz S Nowakowski, Patrick B Johnston, Steven J Russell, Svetomir N Markovic, Steven R Zeldenrust, Yi L Hwa, John A Lust, Luis F Porrata, Thomas M Habermann, S Vincent Rajkumar, Morie A Gertz, Craig B Reeder. Diagnosis and Management of Waldenström Macroglobulinemia: Mayo Stratification of Macroglobulinemia and Risk-Adapted Therapy (mSMART) Guidelines 2016.
JAMA oncology.
2017 Sep; 3(9):1257-1265. doi:
10.1001/jamaoncol.2016.5763. [PMID: 28056114] - Devaraj V Chandrashekar, Ponnayyan S Suresh, Rajnish Kumar, Ravi Kanth Bhamidipati, Ramesh Mullangi, Wolfgang Richter, Nuggehally R Srinivas. Sensitive LC-MS/MS Method for the Simultaneous Determination of Bendamustine and its Active Metabolite, γ-Hydroxybendamustine in Small Volume Mice and Dog Plasma and its Application to a Pharmacokinetic Study in Mice and Dogs.
Drug research.
2017 Sep; 67(9):497-508. doi:
10.1055/s-0043-108124. [PMID: 28561238] - Nsabimana A Uwumugambi, Vaishali Sanchorawala, Anthony C Shelton, Lauren Stern, Craig E Gordon. Bendamustine-Induced Nephrogenic Diabetes Insipidus in a Patient With AL Amyloidosis.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2017 Feb; 69(2):317-319. doi:
10.1053/j.ajkd.2016.07.037. [PMID: 27780577] - Pheophet Lamaningao, Seiji Kanda, Sakhone Laimanivong, Takaki Shimono, Andrew Waleluma Darcy, Amphay Phyaluanglath, Nobuyuki Mishima, Toshimasa Nishiyama. Development of a PCR Assay for Diagnosing Trematode (Opisthorchis and Haplorchis) Infections in Human Stools.
The American journal of tropical medicine and hygiene.
2017 Jan; 96(1):221-228. doi:
10.4269/ajtmh.16-0165. [PMID: 27821695] - Dipti Talaulikar, Constantine S Tam, Douglas Joshua, Joy Phoebe Ho, Jeff Szer, Hang Quach, Andrew Spencer, Simon Harrison, Peter Mollee, Andrew W Roberts, Noemi Horvath, Cindy Lee, Andrew Zannettino, Ross Brown, Bradley Augustson, Wilfrid Jaksic, John Gibson, Anna Kalff, Anna Johnston, Judith Trotman, Akash Kalro, George Grigoriadis, Chris Ward, H Miles Prince. Treatment of patients with Waldenström macroglobulinaemia: clinical practice guidelines from the Myeloma Foundation of Australia Medical and Scientific Advisory Group.
Internal medicine journal.
2017 Jan; 47(1):35-49. doi:
10.1111/imj.13311. [PMID: 28076910] - Benjamin A Derman, Milli Jain, Elizabeth A McAninch, Casey Gashti. Bendamustine-induced nephrogenic diabetes insipidus
.
Clinical nephrology.
2017 Jan; 87 (2017)(1):47-50. doi:
10.5414/cn108908. [PMID: 27719738] - Yuvraj Singh, Anumandla Chandrashekar, Vivek K Pawar, Veeramuthu Saravanakumar, Jayagopal Meher, Kavit Raval, Pankaj Singh, R Dinesh Kumar, Manish K Chourasia. Novel Validated RP-HPLC Method for Bendamustine Hydrochloride Based on Ion-pair Chromatography: Application in Determining Infusion Stability and Pharmacokinetics.
Journal of chromatographic science.
2017 01; 55(1):30-39. doi:
10.1093/chromsci/bmw145. [PMID: 27993861] - Farrukh T Awan, Lia Gore, Lei Gao, Jyoti Sharma, Joanne Lager, Luciano J Costa. Phase Ib trial of the PI3K/mTOR inhibitor voxtalisib (SAR245409) in combination with chemoimmunotherapy in patients with relapsed or refractory B-cell malignancies.
British journal of haematology.
2016 Oct; 175(1):55-65. doi:
10.1111/bjh.14181. [PMID: 27293194] - Jonathan J Hogan, Brendan M Weiss. Bridging the Divide: An Onco-Nephrologic Approach to the Monoclonal Gammopathies of Renal Significance.
Clinical journal of the American Society of Nephrology : CJASN.
2016 09; 11(9):1681-91. doi:
10.2215/cjn.03160316. [PMID: 27416775] - N R Srinivas, W Richter, V C Devaraj, P S Suresh, R K Bhamdipati, R Mullangi. Infusion Rate Dependent Pharmacokinetics of Bendamustine with Altered Formation of γ-hydroxybendamustine (M3) Metabolite Following 30- and 60-min Infusion of Bendamustine in Rats.
Drug research.
2016 Jul; 66(7):351-6. doi:
10.1055/s-0042-105745. [PMID: 27120083] - Anna Caldini, Chiara Nozzoli, Alessandro Terreni, Michela Staderini, Margherita Berardi, Tiziana Biagioli, Marco Brogi, Alberto Bosi. New patterns of relapse in multiple myeloma: a case of 'light chain escape' in which FLC predicted relapse earlier than urine and serum immunofixation.
Clinical chemistry and laboratory medicine.
2016 Jun; 54(6):991-5. doi:
10.1515/cclm-2015-0689. [PMID: 26581069] - Marco Aurelio Santo, Daniel Riccioppo, Denis Pajecki, Flavio Kawamoto, Roberto de Cleva, Leila Antonangelo, Lia Marçal, Ivan Cecconello. Weight Regain After Gastric Bypass: Influence of Gut Hormones.
Obesity surgery.
2016 May; 26(5):919-25. doi:
10.1007/s11695-015-1908-z. [PMID: 26450709] - S Garciaz, D Coso, J-M Schiano de Collela, F Broussais, A-M Stoppa, T Aurran, C Chabannon, A Helvig, L Xerri, D Blaise, R Bouabdallah. Bendamustine-based conditioning for non-Hodgkin lymphoma autologous transplantation: an increasing risk of renal toxicity.
Bone marrow transplantation.
2016 Feb; 51(2):319-21. doi:
10.1038/bmt.2015.257. [PMID: 26524266] - Asher Chanan-Khan, Paula Cramer, Fatih Demirkan, Graeme Fraser, Rodrigo Santucci Silva, Sebastian Grosicki, Aleksander Pristupa, Ann Janssens, Jiri Mayer, Nancy L Bartlett, Marie-Sarah Dilhuydy, Halyna Pylypenko, Javier Loscertales, Abraham Avigdor, Simon Rule, Diego Villa, Olga Samoilova, Panagiots Panagiotidis, Andre Goy, Anthony Mato, Miguel A Pavlovsky, Claes Karlsson, Michelle Mahler, Mariya Salman, Steven Sun, Charles Phelps, Sriram Balasubramanian, Angela Howes, Michael Hallek. Ibrutinib combined with bendamustine and rituximab compared with placebo, bendamustine, and rituximab for previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (HELIOS): a randomised, double-blind, phase 3 study.
The Lancet. Oncology.
2016 Feb; 17(2):200-211. doi:
10.1016/s1470-2045(15)00465-9. [PMID: 26655421] - Liang-Tsai Hsiao, Hwei-Fang Tien, Ching-Yuan Kuo, Jin-Hou Wu, Hsin-An Hou, Ming-Chung Wang, Chun-Yu Liu, Po-Min Chen, Tzeon-Jye Chiou. Pharmacokinetic profile and first preliminary clinical evaluation of bendamustine in Taiwanese patients with heavily pretreated indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma.
Hematological oncology.
2015 Dec; 33(4):136-44. doi:
10.1002/hon.2161. [PMID: 25111959] - Steven P Treon. How I treat Waldenström macroglobulinemia.
Blood.
2015 Aug; 126(6):721-32. doi:
10.1182/blood-2015-01-553974. [PMID: 26002963] - C Arimany-Nardi, A Montraveta, E Lee-Vergés, X S Puente, H Koepsell, E Campo, D Colomer, M Pastor-Anglada. Human organic cation transporter 1 (hOCT1) as a mediator of bendamustine uptake and cytotoxicity in chronic lymphocytic leukemia (CLL) cells.
The pharmacogenomics journal.
2015 Aug; 15(4):363-71. doi:
10.1038/tpj.2014.77. [PMID: 25582574] - John M Burke, Richard H C van der Jagt, Ian W Flinn, Michael D Craig, Ling Chen, Joel Morganroth, Mihaela C Munteanu, David A MacDonald. Effect of bendamustine in combination with rituximab on QT interval duration in patients with advanced de novo indolent non-Hodgkin or mantle cell lymphoma.
Cancer chemotherapy and pharmacology.
2015 Jul; 76(1):211-6. doi:
10.1007/s00280-015-2776-x. [PMID: 26006703] - Morie A Gertz. The role of bendamustine in the management of plasma cell myeloma.
Leukemia & lymphoma.
2015 May; 56(5):1195-6. doi:
10.3109/10428194.2014.977888. [PMID: 25347428] - Venkata V V R Marada, Saskia Flörl, Annett Kühne, Gerhard Burckhardt, Yohannes Hagos. Interaction of human organic anion transporter polypeptides 1B1 and 1B3 with antineoplastic compounds.
European journal of medicinal chemistry.
2015 Mar; 92(?):723-31. doi:
10.1016/j.ejmech.2015.01.011. [PMID: 25618019] - Antonio Palumbo, Massimo Offidani, Francesca Patriarca, Maria Teresa Petrucci, Michele Cavo. Bendamustine for the treatment of multiple myeloma in first-line and relapsed-refractory settings: a review of clinical trial data.
Leukemia & lymphoma.
2015 Mar; 56(3):559-67. doi:
10.3109/10428194.2014.915545. [PMID: 24884319] - Yohannes Hagos, Philip Hundertmark, Volodymyr Shnitsar, Venkata V V R Marada, Gerald Wulf, Gerhard Burckhardt. Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake.
American journal of physiology. Renal physiology.
2015 Feb; 308(4):F330-8. doi:
10.1152/ajprenal.00467.2014. [PMID: 25477469] - S Huber, F Antoni, C Schickaneder, H Schickaneder, G Bernhardt, A Buschauer. Stabilities of neutral and basic esters of bendamustine in plasma compared to the parent compound: kinetic investigations by HPLC.
Journal of pharmaceutical and biomedical analysis.
2015 Feb; 104(?):137-43. doi:
10.1016/j.jpba.2014.11.038. [PMID: 25499654] - Philipp Zimmer, Andreas Mierau, Wilhelm Bloch, Heiko K Strüder, Thorben Hülsdünker, Alexander Schenk, Leonie Fiebig, Freek T Baumann, Moritz Hahn, Nina Reinart, Michael Hallek, Thomas Elter. Post-chemotherapy cognitive impairment in patients with B-cell non-Hodgkin lymphoma: a first comprehensive approach to determine cognitive impairments after treatment with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisone or rituximab and bendamustine.
Leukemia & lymphoma.
2015 Feb; 56(2):347-52. doi:
10.3109/10428194.2014.915546. [PMID: 24738942] - Pasquale Esposito, Carmelo Libetta, Teresa Rampino, Marilena Gregorini, Elisa Margiotta, Antonio Dal Canton. Huge kidneys in a patient with chronic lymphocytic leukaemia.
British journal of haematology.
2015 Feb; 168(4):470. doi:
10.1111/bjh.13218. [PMID: 25384540] - B T Dzhumabaeva, L S Biryukova, E P Golitsyna, V A Varshavsky. [Minimal-change glomerulonephritis in chronic lymphocytic leukemia: A clinical case].
Terapevticheskii arkhiv.
2015; 87(12):85-88. doi:
10.17116/terarkh2015871285-88. [PMID: 26978424] - Venkata V V R Marada, Saskia Flörl, Annett Kühne, Judith Müller, Gerhard Burckhardt, Yohannes Hagos. Interaction of human organic anion transporter 2 (OAT2) and sodium taurocholate cotransporting polypeptide (NTCP) with antineoplastic drugs.
Pharmacological research.
2015 Jan; 91(?):78-87. doi:
10.1016/j.phrs.2014.11.002. [PMID: 25481222] - Mona Darwish, Gail Megason, Mary Bond, Edward Hellriegel, Philmore Robertson, Thaddeus Grasela, Luann Phillips. Population pharmacokinetics and pharmacokinetics/pharmacodynamics of bendamustine in pediatric patients with relapsed/refractory acute leukemia.
Current medical research and opinion.
2014 Nov; 30(11):2305-15. doi:
10.1185/03007995.2014.941976. [PMID: 25105914] - Edward Pan, Daohai Yu, Xiuhua Zhao, Anthony Neuger, Pamela Smith, Prakash Chinnaiyan, Hsiang-Hsuan Michael Yu. Phase I study of bendamustine with concurrent whole brain radiation therapy in patients with brain metastases from solid tumors.
Journal of neuro-oncology.
2014 Sep; 119(2):413-20. doi:
10.1007/s11060-014-1510-6. [PMID: 24965340] - A Oestmann, D Aujesky. [Hyperammonemic encephalopathy in multiple myeloma].
Deutsche medizinische Wochenschrift (1946).
2014 Jul; 139(30):1518-20. doi:
10.1055/s-0034-1370132. [PMID: 25072861] - Beth L Nordstrom, Kevin B Knopf, Dana Y Teltsch, Robert Engle, Hooman Beygi, James A Sterchele. The safety of bendamustine in patients with chronic lymphocytic leukemia or non-Hodgkin lymphoma and concomitant renal impairment: a retrospective electronic medical record database analysis.
Leukemia & lymphoma.
2014 Jun; 55(6):1266-73. doi:
10.3109/10428194.2013.836600. [PMID: 23987821] - Feifan Xie, Zeneng Cheng, Hang Cheng, Peng Yu. Simultaneous determination of bendamustine and its active metabolite, gamma-hydroxy-bendamustine in human plasma and urine using HPLC-fluorescence detector: application to a pharmacokinetic study in Chinese cancer patients.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2014 Jun; 960(?):98-104. doi:
10.1016/j.jchromb.2014.04.027. [PMID: 24793082] - Yong Wang, Ruirui Zhu, Yongnian Ni, Serge Kokot. Competitive interactions of anti-carcinogens with serum albumin: a spectroscopic study of bendamustine and dexamethasone with the aid of chemometrics.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2014 Apr; 123(?):241-8. doi:
10.1016/j.saa.2013.12.063. [PMID: 24398467] - G Pratt, S Bowcock, M Lai, S Bell, J Bird, S D'Sa, J Cavenagh, G Cook, G Morgan, R Owen, J A Snowden, K Yong, F Davies. United Kingdom Myeloma Forum (UKMF) position statement on the use of bendamustine in myeloma.
International journal of laboratory hematology.
2014 Feb; 36(1):20-8. doi:
10.1111/ijlh.12097. [PMID: 23615178] - B T Dzhumbaeva, L S Biriukova, E G Gemdzhian, S K Kravchenko, A L Melikian, L S Roshtina. [Chronic lymphocytic leukemia accompanied by renal failure].
Terapevticheskii arkhiv.
2014; 86(12):37-41. doi:
10.17116/terarkh2014861237-41. [PMID: 25804038] - Chenglong Sun, Juan Li, Jingli Gu, Junru Liu, Beihui Huang. Proteomic studies of multiple myeloma in RPMI8226 cell line treated with bendamustine.
Journal of B.U.ON. : official journal of the Balkan Union of Oncology.
2013 Oct; 18(4):996-1005. doi:
NULL. [PMID: 24344029] - Jun Shoji, Susie Q Lew. The use of rituximab and bendamustine in treating chronic lymphocytic leukaemia (CLL) in end-stage renal disease (ESRD).
BMJ case reports.
2013 May; 2013(?):. doi:
10.1136/bcr-2013-009637. [PMID: 23645657] - Mauro Cives, Sabino Ciavarella, Francesca Maria Rizzo, Monica De Matteo, Franco Dammacco, Franco Silvestris. Bendamustine overcomes resistance to melphalan in myeloma cell lines by inducing cell death through mitotic catastrophe.
Cellular signalling.
2013 May; 25(5):1108-17. doi:
10.1016/j.cellsig.2013.01.020. [PMID: 23380051] - Anne-Charlotte Dubbelman, Hilde Rosing, Mona Darwish, Denise D'Andrea, Mary Bond, Edward Hellriegel, Philmore Robertson, Jos H Beijnen, Jan H M Schellens. Pharmacokinetics and excretion of 14C-bendamustine in patients with relapsed or refractory malignancy.
Drugs in R&D.
2013 Mar; 13(1):17-28. doi:
10.1007/s40268-012-0001-5. [PMID: 23322528] - Amanda F Baker, Denise J Roe, Cynthia Laughren, Janice L Cohen, Heather M Wright, Mary C Clouser, Haiyan Cui, David S Alberts, Setsuko K Chambers. Investigation of bendamustine HCL in a phase 2 study in women with resistant ovarian cancer.
Investigational new drugs.
2013 Feb; 31(1):160-6. doi:
10.1007/s10637-012-9827-5. [PMID: 22580577] - Jeanne Held-Warmkessel. A patient with tumor lysis syndrome.
Oncology (Williston Park, N.Y.).
2012 Aug; 26(8 Suppl Nurse Ed):16-21. doi:
NULL. [PMID: 25375006] - Anne-Charlotte Dubbelman, Robert S Jansen, Hilde Rosing, Mona Darwish, Edward Hellriegel, Philmore Robertson, Jan H M Schellens, Jos H Beijnen. Metabolite profiling of bendamustine in urine of cancer patients after administration of [14C]bendamustine.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jul; 40(7):1297-307. doi:
10.1124/dmd.112.045229. [PMID: 22492615] - A C Dubbelman, M Tibben, H Rosing, A Gebretensae, L Nan, S H Gorman, P Robertson, J H M Schellens, J H Beijnen. Development and validation of LC-MS/MS assays for the quantification of bendamustine and its metabolites in human plasma and urine.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Apr; 893-894(?):92-100. doi:
10.1016/j.jchromb.2012.02.039. [PMID: 22426286] - Prasanth Krish, Kenar D Jhaveri. The Case ∣ Hyperbicarbonatemia in a patient with Waldenstrom's macroglobulinemia. Pseudohyperbicarbonatemia due to paraproteinemia.
Kidney international.
2012 Mar; 81(6):603-5. doi:
10.1038/ki.2011.427. [PMID: 22373713] - Karthik Ramasamy, Beth Hazel, Shameem Mahmood, Sophie Corderoy, Stephen Schey. Bendamustine in combination with thalidomide and dexamethasone is an effective therapy for myeloma patients with end stage renal disease.
British journal of haematology.
2011 Dec; 155(5):632-4. doi:
10.1111/j.1365-2141.2011.08754.x. [PMID: 21689088] - Michinori Ogura, Toshiki Uchida, Masafumi Taniwaki, Kiyoshi Ando, Takashi Watanabe, Masanobu Kasai, Yosuke Matsumoto, Daisuke Shimizu, Yoshiaki Ogawa, Ken Ohmachi, Hiroki Yokoyama, Kensei Tobinai. Phase I and pharmacokinetic study of bendamustine hydrochloride in relapsed or refractory indolent B-cell non-Hodgkin lymphoma and mantle cell lymphoma.
Cancer science.
2010 Sep; 101(9):2054-8. doi:
10.1111/j.1349-7006.2010.01633.x. [PMID: 20594195] - Leander Gaul, Sonja Mandl-Weber, Philipp Baumann, Bertold Emmerich, Ralf Schmidmaier. Bendamustine induces G2 cell cycle arrest and apoptosis in myeloma cells: the role of ATM-Chk2-Cdc25A and ATM-p53-p21-pathways.
Journal of cancer research and clinical oncology.
2008 Feb; 134(2):245-53. doi:
10.1007/s00432-007-0278-x. [PMID: 17653574] - M Wiedmann, J Zeh, K Schoppmeyer, C Moebius, M Niederhagen, C Wittekind, J Mossner, K Caca. Bendamustine--a new approach to the treatment of advanced hepatocellular carcinoma?.
Journal of chemotherapy (Florence, Italy).
2008 Feb; 20(1):112-8. doi:
10.1179/joc.2008.20.1.112. [PMID: 18343753] - James P Chovan, Feng Li, Erya Yu, Steven C Ring. Metabolic profile of [(14)C]bendamustine in rat urine and bile: preliminary structural identification of metabolites.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Oct; 35(10):1744-53. doi:
10.1124/dmd.107.015958. [PMID: 17600082] - Konrad Schoppmeyer, Florian Kreth, Marcus Wiedmann, Joachim Mössner, Rainer Preiss, Karel Caca. A pilot study of bendamustine in advanced bile duct cancer.
Anti-cancer drugs.
2007 Jul; 18(6):697-702. doi:
10.1097/cad.0b013e32803d36e6. [PMID: 17762399] - M Rasschaert, D Schrijvers, J Van den Brande, J Dyck, J Bosmans, K Merkle, J B Vermorken. A phase I study of bendamustine hydrochloride administered day 1+2 every 3 weeks in patients with solid tumours.
British journal of cancer.
2007 Jun; 96(11):1692-8. doi:
10.1038/sj.bjc.6603776. [PMID: 17486132] - Marika Rasschaert, Dirk Schrijvers, Jan Van den Brande, Joke Dyck, Johan Bosmans, Karlheinz Merkle, Jan B Vermorken. A phase I study of bendamustine hydrochloride administered once every 3 weeks in patients with solid tumors.
Anti-cancer drugs.
2007 Jun; 18(5):587-95. doi:
10.1097/cad.0b013e3280149eb1. [PMID: 17414628] - Jens Teichert, Frank Baumann, Qi Chao, Craig Franklin, Brandy Bailey, Lothar Hennig, Karel Caca, Konrad Schoppmeyer, Ulrich Patzak, Rainer Preiss. Characterization of two phase I metabolites of bendamustine in human liver microsomes and in cancer patients treated with bendamustine hydrochloride.
Cancer chemotherapy and pharmacology.
2007 May; 59(6):759-70. doi:
10.1007/s00280-006-0331-5. [PMID: 16957931] - Margit Hummel, Dieter Buchheidt, Sebastian Reiter, Jörg Bergmann, Katja Adam, Rüdiger Hehlmann. Recurrent chemotherapy-induced tumor lysis syndrome (TLS) with renal failure in a patient with chronic lymphocytic leukemia - successful treatment and prevention of TLS with low-dose rasburicase.
European journal of haematology.
2005 Dec; 75(6):518-21. doi:
10.1111/j.1600-0609.2005.00550.x. [PMID: 16313266] - Jens Teichert, Reinhard Sohr, Frank Baumann, Lothar Hennig, Karlheinz Merkle, Karel Caca, Rainer Preiss. Synthesis and characterization of some new phase II metabolites of the alkylator bendamustine and their identification in human bile, urine, and plasma from patients with cholangiocarcinoma.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Jul; 33(7):984-92. doi:
10.1124/dmd.105.003624. [PMID: 15845750] - Wolfram Pönisch, Dietger Niederwieser. Bendamustine in the treatment of multiple myeloma: results and future perspectives.
Seminars in oncology.
2002 Aug; 29(4 Suppl 13):23-6. doi:
10.1053/sonc.2002.34876. [PMID: 12170429] - Varsha Gandhi. Metabolism and mechanisms of action of bendamustine: rationales for combination therapies.
Seminars in oncology.
2002 Aug; 29(4 Suppl 13):4-11. doi:
10.1053/sonc.2002.34872. [PMID: 12170425] - S Bezek, M Kukan, V Scasnár, M Lukácsová, T Trnovec. Selective uptake of the anticancer drug bendamustine by liver and kidney tissues following its intravenous administration to mice.
Methods and findings in experimental and clinical pharmacology.
1996 Mar; 18(2):117-22. doi:
NULL. [PMID: 8740243] - R Amlacher, H Weber, R Preiss, H Hoffmann. Influence of leukemia P388 on plasma concentration-time profiles of bendamustine in B6D2F1 mice.
Die Pharmazie.
1992 May; 47(5):378-81. doi:
NULL. [PMID: 1409829] - S Bezek, V Scasnár, T Trnovec, R Grupe. Hepatobiliary elimination of bendamustin (Cytostasan) in rats.
Die Pharmazie.
1991 Nov; 46(11):810-1. doi:
NULL. [PMID: 1811234] - H Weber, R Amlacher, R Preiss, H Hoffmann. [Pharmacokinetics of bendamustin (Cytostasan) in B6D2F1-mice].
Die Pharmazie.
1991 Aug; 46(8):589-91. doi:
NULL. [PMID: 1798713] - H Weber, V Marko, Z Kállay, T Trnovec, R Amlacher. Determination of a cytostatic agent, bendamustine, in plasma using capillary gas chromatography with nitrogen-selective detection.
Journal of chromatography.
1990 Feb; 525(2):459-63. doi:
10.1016/s0378-4347(00)83424-6. [PMID: 2329172] - H Bräunlich, G Stolze, R Stolze. [Renal actions of bendamustin (Cytostasan) in rats].
Die Pharmazie.
1988 Apr; 43(4):265-8. doi:
NULL. [PMID: 3413216] - R Preiss, R Sohr, M Matthias, B Brockmann, H Hüller. [The pharmacokinetics of bendamustine (Cytostasane) in humans].
Die Pharmazie.
1985 Nov; 40(11):782-4. doi:
NULL. [PMID: 4095129] - U Horn, A Härtl, J Güttner, H Hoffmann. Toxicity of the alkylating agent bendamustin.
Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement.
1985; 8(?):504-6. doi:
10.1007/978-3-642-69928-3_120. [PMID: 3868382] - A Przełecka, R S Fritsch, L Wollweber, A Sobota. Effect of a membrane-stabilizing compound on calcium binding to the plasma membrane of Acanthamoeba castellanii.
Acta histochemica.
1980; 66(2):181-91. doi:
10.1016/s0065-1281(80)80001-8. [PMID: 6774578]