Decitabine (BioDeep_00000614808)

   

Antitumor activity


代谢物信息卡片


Decitabine

化学式: C8H12N4O4 (228.08585119999998)
中文名称: 5-氮杂-2-脱氧胞苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(OC1N2C=NC(=NC2=O)N)CO)O
InChI: InChI=1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)/t4-,5+,6+/m0/s1

描述信息

L - Antineoplastic and immunomodulating agents > L01 - Antineoplastic agents > L01B - Antimetabolites > L01BC - Pyrimidine analogues
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C2083 - DNA Methyltransferase Inhibitor
C274 - Antineoplastic Agent > C132686 - Demethylating Agent
D009676 - Noxae > D000963 - Antimetabolites
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity[1][2].

同义名列表

4 个代谢物同义名

Decitabine; 5-Aza-2'-deoxycytidine; 5-AZA-CdR; NSC 127716



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(3)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • W U Jieya, Hou Li, Zhang Xiaoyuan, Elizabeth Gullen, Gao Chong, Wang Jing. Efficacy of Yisui granule on myelodysplastic syndromes in SKM-1 mouse xenograft model through suppressing Wnt/β-catenin signaling pathway. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan. 2024 Feb; 44(1):78-87. doi: 10.19852/j.cnki.jtcm.20231204.003. [PMID: 38213242]
  • Liu Liu, Yaqiong Zhou, Dan Luo, Xiaoying Sun, Hongjin Li, Yi Lu, Jiao Wang, Miao Zhang, Naixuan Lin, Chengqian Yin, Xin Li. Aberrant promoter methylation of Wnt inhibitory factor-1 gene is a potential target for treating psoriasis. Clinical immunology (Orlando, Fla.). 2023 Mar; 250(?):109294. doi: 10.1016/j.clim.2023.109294. [PMID: 36925027]
  • Yadi Xu, Zelin Li, Tian Huai, Xiuhao Huo, Hongliang Wang, Erbao Bian, Bing Zhao. DNMT1 Mediated CAHM Repression Promotes Glioma Invasion via SPAK/JNK Pathway. Cellular and molecular neurobiology. 2022 Nov; 42(8):2643-2653. doi: 10.1007/s10571-021-01125-z. [PMID: 34227028]
  • Yanlong Zhao, Xiaorong Zeng, Xinli Xu, Wenjing Wang, Lei Xu, Yiying Wu, Hang Li. Low-dose 5-aza-2'-deoxycytidine protects against early renal injury by increasing klotho expression. Epigenomics. 2022 11; 14(22):1411-1425. doi: 10.2217/epi-2022-0430. [PMID: 36695107]
  • Congmeng Lin, Yongxin Xie, Wenwen Huang, Dayi Lin, Luhui Lin. 5-Aza-dC promotes T-cell acute lymphoblastic leukemia cell invasion via downregulation of DNMT1 and upregulation of MMP-2 and MMP-9. Experimental hematology. 2022 10; 114(?):43-53.e2. doi: 10.1016/j.exphem.2022.07.301. [PMID: 35908628]
  • Pawan Upadhyay, Jeremy Beales, Nakul M Shah, Agata Gruszczynska, Christopher A Miller, Allegra A Petti, Sai Mukund Ramakrishnan, Daniel C Link, Timothy J Ley, John S Welch. Recurrent transcriptional responses in AML and MDS patients treated with decitabine. Experimental hematology. 2022 Jul; 111(?):50-65. doi: 10.1016/j.exphem.2022.04.002. [PMID: 35429619]
  • Sankalp Arora, Carl Zainaldin, Srilakshmi Bathini, Udita Gupta, Sarah Worth, Kimo Bachiashvili, Ravi Bhatia, Kelly Godby, Omer Jamy, Sravanti Rangaraju, Barry Diamond, Josh D Oliver, Donna Salzman, Antonio Di Stasi, Pankit Vachhani. Tumor lysis syndrome and infectious complications during treatment with venetoclax combined with azacitidine or decitabine in patients with acute myeloid leukemia. Leukemia research. 2022 06; 117(?):106844. doi: 10.1016/j.leukres.2022.106844. [PMID: 35487134]
  • Jonathan Wong, Emily Gruber, Belinda Maher, Mark Waltham, Zahra Sabouri-Thompson, Ian Jong, Quinton Luong, Sidney Levy, Beena Kumar, Daniella Brasacchio, Wendy Jia, Joan So, Hugh Skinner, Alexander Lewis, Simon J Hogg, Stephin Vervoort, Carmen DiCorleto, Micheleine Uhe, Jeanette Gamgee, Stephen Opat, Gareth P Gregory, Galina Polekhina, John Reynolds, Eliza A Hawkes, Gajan Kailainathan, Robin Gasiorowski, Lev M Kats, Jake Shortt. Integrated clinical and genomic evaluation of guadecitabine (SGI-110) in peripheral T-cell lymphoma. Leukemia. 2022 06; 36(6):1654-1665. doi: 10.1038/s41375-022-01571-8. [PMID: 35459873]
  • Roxane Verdikt, Maryam Bendoumou, Sophie Bouchat, Lorena Nestola, Alexander O Pasternak, Gilles Darcis, Véronique Avettand-Fenoel, Caroline Vanhulle, Amina Aït-Ammar, Marion Santangelo, Estelle Plant, Valentin Le Douce, Nadège Delacourt, Aurelija Cicilionytė, Coca Necsoi, Francis Corazza, Caroline Pereira Bittencourt Passaes, Christian Schwartz, Martin Bizet, François Fuks, Asier Sáez-Cirión, Christine Rouzioux, Stéphane De Wit, Ben Berkhout, Virginie Gautier, Olivier Rohr, Carine Van Lint. Novel role of UHRF1 in the epigenetic repression of the latent HIV-1. EBioMedicine. 2022 May; 79(?):103985. doi: 10.1016/j.ebiom.2022.103985. [PMID: 35429693]
  • Bei Zhang, Zhixin Pei, Hongxia Wang, Huimin Wu, Junjie Wang, Junjun Bai, Qinglin Song. Chidamide and Decitabine in Combination with a HAG Priming Regimen for Acute Myeloid Leukemia with TP53 Mutation. Acta medica Okayama. 2022 Feb; 76(1):63-70. doi: 10.18926/amo/63213. [PMID: 35237000]
  • Meghali Goswami, Gege Gui, Laura W Dillon, Katherine E Lindblad, Julie Thompson, Janet Valdez, Dong-Yun Kim, Jack Y Ghannam, Karolyn A Oetjen, Christin B Destefano, Dana M Smith, Hanna Tekleab, Yeusheng Li, Pradeep Dagur, Thomas Hughes, Jennifer L Marté, Jaydira Del Rivero, Joanna Klubo-Gwiezdzinksa, James L Gulley, Katherine R Calvo, Catherine Lai, Christopher S Hourigan. Pembrolizumab and decitabine for refractory or relapsed acute myeloid leukemia. Journal for immunotherapy of cancer. 2022 01; 10(1):. doi: 10.1136/jitc-2021-003392. [PMID: 35017151]
  • Chun Tong, Fang Ye, Ning-Ning Li, Huan Wang, Ya-Nan Shu, Ling Wang, Li-Nan Zhang. [Efficacy and Safety of Different Dosages of Decitabine in the Treatment of High-Risk Patients with Myelodysplastic Syndrome]. Zhongguo shi yan xue ye xue za zhi. 2021 Dec; 29(6):1845-1850. doi: 10.19746/j.cnki.issn.1009-2137.2021.06.026. [PMID: 34893121]
  • Peipei Han, Yifang Wang, Wenqi Luo, Yunliang Lu, Xiaohui Zhou, Yanping Yang, Qian Zheng, Danping Li, Shu Wu, Limei Li, Haishan Zhang, Jun Zhao, Zhe Zhang, Liudmila Matskova, Ping Li, Xiaoying Zhou. Epigenetic inactivation of hydroxymethylglutaryl CoA synthase reduces ketogenesis and facilitates tumor cell motility in clear cell renal carcinoma. Pathology, research and practice. 2021 Nov; 227(?):153622. doi: 10.1016/j.prp.2021.153622. [PMID: 34624592]
  • Nemat Ali, Kartikay Prasad, Abdullah F AlAsmari, Metab Alharbi, Summya Rashid, Vijay Kumar. Genomics-guided targeting of stress granule proteins G3BP1/2 to inhibit SARS-CoV-2 propagation. International journal of biological macromolecules. 2021 Nov; 190(?):636-648. doi: 10.1016/j.ijbiomac.2021.09.018. [PMID: 34517025]
  • Hiroshi Ureshino, Yuki Kurahashi, Tatsuro Watanabe, Satoshi Yamashita, Kazuharu Kamachi, Yuta Yamamoto, Yuki Fukuda-Kurahashi, Nao Yoshida-Sakai, Naoko Hattori, Yoshihiro Hayashi, Atsushi Kawaguchi, Kaoru Tohyama, Seiji Okada, Hironori Harada, Toshikazu Ushijima, Shinya Kimura. Silylation of Deoxynucleotide Analog Yields an Orally Available Drug with Antileukemia Effects. Molecular cancer therapeutics. 2021 08; 20(8):1412-1421. doi: 10.1158/1535-7163.mct-20-1125. [PMID: 34045225]
  • Akemi Kosaka, Yuki Yajima, Mayumi Hatayama, Katsuya Ikuta, Takaaki Sasaki, Noriko Hirai, Syunsuke Yasuda, Marino Nagata, Ryusuke Hayashi, Shohei Harabuchi, Kenzo Ohara, Mizuho Ohara, Takumi Kumai, Kei Ishibashi, Yui Hirata-Nozaki, Toshihiro Nagato, Kensuke Oikawa, Yasuaki Harabuchi, Esteban Celis, Toshikatsu Okumura, Yoshinobu Ohsaki, Hiroya Kobayashi, Takayuki Ohkuri. A stealth antigen SPESP1, which is epigenetically silenced in tumors, is a suitable target for cancer immunotherapy. Cancer science. 2021 Jul; 112(7):2705-2713. doi: 10.1111/cas.14973. [PMID: 34009705]
  • Rueyhung R Weng, Hsuan-Hsuan Lu, Chien-Ting Lin, Chia-Chi Fan, Rong-Shan Lin, Tai-Chung Huang, Shu-Yung Lin, Yi-Jhen Huang, Yi-Hsiu Juan, Yi-Chieh Wu, Zheng-Ci Hung, Chi Liu, Xuan-Hui Lin, Wan-Chen Hsieh, Tzu-Yuan Chiu, Jung-Chi Liao, Yen-Ling Chiu, Shih-Yu Chen, Chong-Jen Yu, Hsing-Chen Tsai. Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer. Nature communications. 2021 04; 12(1):2163. doi: 10.1038/s41467-021-22433-4. [PMID: 33846331]
  • Xiumin Chen, Mingjie Xing. Effects of 5-Aza-2'-deoxycytidine on hormone secretion and epigenetic regulation in sika deer ovarian granulosa cells. Reproduction in domestic animals = Zuchthygiene. 2021 Feb; 56(2):360-369. doi: 10.1111/rda.13873. [PMID: 33254280]
  • Chaoyang Li, Lizhen Li, Meng Sun, Jianzhi Sun, Linlin Shao, Miao Xu, Yu Hou, Jun Peng, Lin Wang, Ming Hou. Predictive Value of High ICAM-1 Level for Poor Treatment Response to Low-Dose Decitabine in Adult Corticosteroid Resistant ITP Patients. Frontiers in immunology. 2021; 12(?):689663. doi: 10.3389/fimmu.2021.689663. [PMID: 34326842]
  • Jian-Ping Shao, Feng Su, Shu-Peng Zhang, He-Kai Chen, Zhao-Jin Li, Guo-Qiang Xing, Hong-Jie Liu, Yong-Yuan Li. miR-212 as potential biomarker suppresses the proliferation of gastric cancer via targeting SOX4. Journal of clinical laboratory analysis. 2020 Dec; 34(12):e23511. doi: 10.1002/jcla.23511. [PMID: 32862489]
  • Tze-Hong Wong, Ting-Yu Chen, Kuo-Yun Tseng, Zih-Ying Chen, Chung-Hsing Chen, Feng-Huei Lin, Hung-Ming Wu, Shankung Lin. Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans. Aging. 2020 11; 13(1):578-597. doi: 10.18632/aging.202166. [PMID: 33257596]
  • Ai-Bo Qin, Ying Tan, Tao Su. Decitabine-induced kidney thrombotic microangiopathy with glomerular crescents formation and tubular necrosis: A case report. Medicine. 2020 Oct; 99(43):e22901. doi: 10.1097/md.0000000000022901. [PMID: 33120841]
  • Xinping Zhou, Chen Mei, Jin Zhang, Ying Lu, Jianping Lan, Shengyun Lin, Yuefeng Zhang, Yuemin Kuang, Yanling Ren, Liya Ma, Juying Wei, Li Ye, Weilai Xu, Kongfei Li, Chenxi Lu, Jie Jin, Hongyan Tong. Epigenetic priming with decitabine followed by low dose idarubicin and cytarabine in acute myeloid leukemia evolving from myelodysplastic syndromes and higher-risk myelodysplastic syndromes: a prospective multicenter single-arm trial. Hematological oncology. 2020 Oct; 38(4):531-540. doi: 10.1002/hon.2755. [PMID: 32469434]
  • Blanca L Valle, Sebastian Rodriguez-Torres, Elisabetta Kuhn, Teresa Díaz-Montes, Edgardo Parrilla-Castellar, Fahcina P Lawson, Oluwasina Folawiyo, Carmen Ili-Gangas, Priscilla Brebi-Mieville, James R Eshleman, James Herman, Ie-Ming Shih, David Sidransky, Rafael Guerrero-Preston. HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer. Cancer prevention research (Philadelphia, Pa.). 2020 09; 13(9):783-794. doi: 10.1158/1940-6207.capr-19-0412. [PMID: 32581010]
  • Chang Su, Shaoqun Liu, Xiaoying Ma, Xiaotong Yang, Jianwen Liu, Peiyong Zheng, Yiou Cao. Decitabine attenuates dextran sodium sulfate‑induced ulcerative colitis through regulation of immune regulatory cells and intestinal barrier. International journal of molecular medicine. 2020 Aug; 46(2):583-594. doi: 10.3892/ijmm.2020.4605. [PMID: 32468024]
  • Anna Nowicka, Barbara Tokarz, Jana Zwyrtková, Eva Dvořák Tomaštíková, Klára Procházková, Ugur Ercan, Andreas Finke, Wilfried Rozhon, Brigitte Poppenberger, Miroslav Otmar, Igor Niezgodzki, Marcela Krečmerová, Ingo Schubert, Ales Pecinka. Comparative analysis of epigenetic inhibitors reveals different degrees of interference with transcriptional gene silencing and induction of DNA damage. The Plant journal : for cell and molecular biology. 2020 04; 102(1):68-84. doi: 10.1111/tpj.14612. [PMID: 31733119]
  • Jingyi Wang, Na He, Ruiqing Wang, Tian Tian, Fengjiao Han, Chaoqin Zhong, Chen Zhang, Mingqiang Hua, Chunyan Ji, Daoxin Ma. Analysis of TET2 and EZH2 gene functions in chromosome instability in acute myeloid leukemia. Scientific reports. 2020 02; 10(1):2706. doi: 10.1038/s41598-020-59365-w. [PMID: 32066746]
  • Jing Xiao, Yankun Liu, Fuxia Wu, Ruiyan Liu, Yongli Xie, Qian Yang, Yufeng Li, Min Liu, Shengping Li, Hua Tang. miR-639 Expression Is Silenced by DNMT3A-Mediated Hypermethylation and Functions as a Tumor Suppressor in Liver Cancer Cells. Molecular therapy : the journal of the American Society of Gene Therapy. 2020 02; 28(2):587-598. doi: 10.1016/j.ymthe.2019.11.021. [PMID: 31843451]
  • Daniel Chen, Daniel L Chao, Lorena Rocha, Matthew Kolar, Viet Anh Nguyen Huu, Michal Krawczyk, Manish Dasyani, Tina Wang, Maryam Jafari, Mary Jabari, Kevin D Ross, Alan Saghatelian, Bruce A Hamilton, Kang Zhang, Dorota Skowronska-Krawczyk. The lipid elongation enzyme ELOVL2 is a molecular regulator of aging in the retina. Aging cell. 2020 02; 19(2):e13100. doi: 10.1111/acel.13100. [PMID: 31943697]
  • Luxi Cao, Tingting Zhu, Xiabing Lang, Sha Jia, Yi Yang, Chaohong Zhu, Yucheng Wang, Shi Feng, Cuili Wang, Ping Zhang, Jianghua Chen, Hong Jiang. Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-κB Pathway. Frontiers in immunology. 2020; 11(?):1360. doi: 10.3389/fimmu.2020.01360. [PMID: 32714333]
  • Lu Chen, Zeyang Wang, Qingwen Xu, Yuxi Liu, Le Chen, Suhang Guo, Hua Wang, Kui Zeng, Junqing Liu, Su Zeng, Lushan Yu. The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma. Theranostics. 2020; 10(8):3562-3578. doi: 10.7150/thno.39944. [PMID: 32206108]
  • Pei-Min Shi, Chun-Mei Ye, Zheng-Dong Wu, Zhi-Chao Zhang. [Relation of miR-140 Expression Level with Therapeutic Effect of Decitabine and Its Mechanism]. Zhongguo shi yan xue ye xue za zhi. 2019 Oct; 27(5):1424-1430. doi: 10.19746/j.cnki.issn.1009-2137.2019.05.011. [PMID: 31607293]
  • Juan Chen, Xuan Chen, Jianfeng Yao, Ming Li, Xiaoyu Yang. The combination of Decitabine and EPZ-6438 effectively facilitate adipogenic differentiation of induced pluripotent stem cell-derived mesenchymal stem cells. Biochemical and biophysical research communications. 2019 08; 516(1):307-312. doi: 10.1016/j.bbrc.2019.06.093. [PMID: 31256938]
  • Qianying Zhu, Lushan Yu, Zhiyuan Qin, Lu Chen, Haihong Hu, Xiaoli Zheng, Su Zeng. Regulation of OCT2 transcriptional repression by histone acetylation in renal cell carcinoma. Epigenetics. 2019 08; 14(8):791-803. doi: 10.1080/15592294.2019.1615354. [PMID: 31088315]
  • Taoyan Yuan, Wanqiu Zhao, Yifan Niu, Yan Fu, Lizhi Lu, Dong Niu. Exploration of the temporal-spatial expression pattern and DNA methylation-related regulation of the duck telomerase reverse transcriptase gene. Poultry science. 2019 Aug; 98(8):3257-3267. doi: 10.3382/ps/pez240. [PMID: 31064004]
  • Yulong Jin, Li Xu, Xiaodong Wu, Juan Feng, Mimi Shu, Hongtao Gu, Guangxun Gao, Jinyi Zhang, Baoxia Dong, Xiequn Chen. Synergistic Efficacy of the Demethylation Agent Decitabine in Combination With the Protease Inhibitor Bortezomib for Treating Multiple Myeloma Through the Wnt/β-Catenin Pathway. Oncology research. 2019 Jun; 27(6):729-737. doi: 10.3727/096504018x15443011011637. [PMID: 30837032]
  • Janis Szeremeta, Jessica Karlsson, Mireille Alhouayek, Christopher J Fowler. Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells. Prostaglandins & other lipid mediators. 2019 06; 142(?):59-67. doi: 10.1016/j.prostaglandins.2019.04.003. [PMID: 30978461]
  • Gao-Yan Tang, Guo-Jun Tang, Lu Yin, Chen Chao, Ren Zhou, Guo-Ping Ren, Jia-Yu Chen, Wei Zhang. ECRG4 acts as a tumor suppressor gene frequently hypermethylated in human breast cancer. Bioscience reports. 2019 05; 39(5):. doi: 10.1042/bsr20190087. [PMID: 30918105]
  • Bumjun Kim, Caroline D Pena, Debra T Auguste. Targeted Lipid Nanoemulsions Encapsulating Epigenetic Drugs Exhibit Selective Cytotoxicity on CDH1-/FOXM1+ Triple Negative Breast Cancer Cells. Molecular pharmaceutics. 2019 05; 16(5):1813-1826. doi: 10.1021/acs.molpharmaceut.8b01065. [PMID: 30883132]
  • Yuan Wei, Xiang-Ming Lao, Xiao Xiao, Xu-Yan Wang, Zong-Jian Wu, Qiu-Hui Zeng, Cai-Yuan Wu, Rui-Qi Wu, Zhen-Xin Chen, Limin Zheng, Bo Li, Dong-Ming Kuang. Plasma Cell Polarization to the Immunoglobulin G Phenotype in Hepatocellular Carcinomas Involves Epigenetic Alterations and Promotes Hepatoma Progression in Mice. Gastroenterology. 2019 05; 156(6):1890-1904.e16. doi: 10.1053/j.gastro.2019.01.250. [PMID: 30711627]
  • Michael R Savona, Olatoyosi Odenike, Philip C Amrein, David P Steensma, Amy E DeZern, Laura C Michaelis, Stefan Faderl, Wael Harb, Hagop Kantarjian, James Lowder, Aram Oganesian, Mohammad Azab, Guillermo Garcia-Manero. An oral fixed-dose combination of decitabine and cedazuridine in myelodysplastic syndromes: a multicentre, open-label, dose-escalation, phase 1 study. The Lancet. Haematology. 2019 Apr; 6(4):e194-e203. doi: 10.1016/s2352-3026(19)30030-4. [PMID: 30926081]
  • Ramya T Kolli, Travis C Glenn, Bradley T Brown, Sukhneeraj P Kaur, Lillie M Barnett, Lawrence H Lash, Brian S Cummings. Bromate-induced Changes in p21 DNA Methylation and Histone Acetylation in Renal Cells. Toxicological sciences : an official journal of the Society of Toxicology. 2019 04; 168(2):460-473. doi: 10.1093/toxsci/kfz016. [PMID: 30649504]
  • Yu-Wei Chang, Kamaleshwar P Singh. Arsenic induces fibrogenic changes in human kidney epithelial cells potentially through epigenetic alterations in DNA methylation. Journal of cellular physiology. 2019 04; 234(4):4713-4725. doi: 10.1002/jcp.27244. [PMID: 30191986]
  • Fang Gan, Xuan Zhou, Yajiao Zhou, Lili Hou, Xingxiang Chen, Cuiling Pan, Kehe Huang. Nephrotoxicity instead of immunotoxicity of OTA is induced through DNMT1-dependent activation of JAK2/STAT3 signaling pathway by targeting SOCS3. Archives of toxicology. 2019 04; 93(4):1067-1082. doi: 10.1007/s00204-019-02434-5. [PMID: 30923867]
  • Jeroen Roosendaal, Kai Wang, Hilde Rosing, Luc Lucas, Abadi Gebretensae, Aram Oganesian, Jan H M Schellens, Jos H Beijnen, Zhongping John Lin. Development and validation of LC-MS/MS methods for the quantification of the novel anticancer agent guadecitabine and its active metabolite β‑decitabine in human plasma, whole blood and urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2019 Mar; 1109(?):132-141. doi: 10.1016/j.jchromb.2019.01.011. [PMID: 30754019]
  • Shouli Wu, Weimin Yan, Bing Qiu, Yongfang Liao, Junying Gu, Shaofeng Wei, Aihua Zhang, Xueli Pan. Aberrant methylation-induced dysfunction of p16 is associated with osteoblast activation caused by fluoride. Environmental toxicology. 2019 Jan; 34(1):37-47. doi: 10.1002/tox.22655. [PMID: 30259626]
  • Thomas Briot, Emilie Roger, Naila Bou Haidar, Jerome Bejaud, Nolwenn Lautram, Catherine Guillet, Sylvain Thépot, Samuel Legeay, Frederic Lagarce. Di-O-lauroyl-decitabine-lipid nanocapsules: toward extending decitabine activity. International journal of nanomedicine. 2019; 14(?):2091-2102. doi: 10.2147/ijn.s190482. [PMID: 30988610]
  • Huilin Li, Weijia Zhang, Fang Zhong, Gokul C Das, Yifan Xie, Zhengzhe Li, Weijing Cai, Gengru Jiang, Jae Choi, Mohamad Sidani, Deborah P Hyink, Kyung Lee, Paul E Klotman, John Cijiang He. Epigenetic regulation of RCAN1 expression in kidney disease and its role in podocyte injury. Kidney international. 2018 12; 94(6):1160-1176. doi: 10.1016/j.kint.2018.07.023. [PMID: 30366682]
  • Changqing Ma, Bowen Liang, Bo Chang, Li Liu, Jiuying Yan, Yazhou Yang, Zhengyang Zhao. Transcriptome Profiling Reveals Transcriptional Regulation by DNA Methyltransferase Inhibitor 5-Aza-2'-Deoxycytidine Enhancing Red Pigmentation in Bagged 'Granny Smith' Apples (Malus domestica). International journal of molecular sciences. 2018 Oct; 19(10):. doi: 10.3390/ijms19103133. [PMID: 30322020]
  • Ying-Tzu Huang, Ting-Shuan Wu, Chuan-Chen Lu, Feng-Yih Yu, Biing-Hui Liu. Aristolochic acid I interferes with the expression of BLCAP tumor suppressor gene in human cells. Toxicology letters. 2018 Jul; 291(?):129-137. doi: 10.1016/j.toxlet.2018.03.032. [PMID: 29655784]
  • Yu Yuan Li, Dan Tang, Yan Lei Du, Chuang Yu Cao, Yu Qiang Nie, Jie Cao, Yong Jian Zhou. Fatty liver mediated by peroxisome proliferator-activated receptor-α DNA methylation can be reversed by a methylation inhibitor and curcumin. Journal of digestive diseases. 2018 Jul; 19(7):421-430. doi: 10.1111/1751-2980.12610. [PMID: 29802754]
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