AM2201 (BioDeep_00000614735)

   


代谢物信息卡片


(1-(5-Fluoropentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone

化学式: C24H22FNO (359.1685334)
中文名称: [1-(5-氟戊基)-1H-吲哚-3-基]-1-萘基甲酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC=C2C(=C1)C=CC=C2C(=O)C3=CN(C4=CC=CC=C43)CCCCCF
InChI: InChI=1S/C24H22FNO/c25-15-6-1-7-16-26-17-22(20-12-4-5-14-23(20)26)24(27)21-13-8-10-18-9-2-3-11-19(18)21/h2-5,8-14,17H,1,6-7,15-16H2

描述信息

同义名列表

2 个代谢物同义名

(1-(5-Fluoropentyl)-1H-indol-3-yl)(naphthalen-1-yl)methanone; AM2201



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jeremy Carlier, Ariane Wohlfarth, Bonita D Salmeron, Karl B Scheidweiler, Marilyn A Huestis, Michael H Baumann. Pharmacodynamic Effects, Pharmacokinetics, and Metabolism of the Synthetic Cannabinoid AM-2201 in Male Rats. The Journal of pharmacology and experimental therapeutics. 2018 12; 367(3):543-550. doi: 10.1124/jpet.118.250530. [PMID: 30266766]
  • Melanie Hutter, Sebastian Broecker, Stefan Kneisel, Florian Franz, Simon D Brandt, Volker Auwarter. Metabolism of Nine Synthetic Cannabinoid Receptor Agonists Encountered in Clinical Casework: Major in vivo Phase I Metabolites of AM-694, AM-2201, JWH-007, JWH-019, JWH-203, JWH-307, MAM-2201, UR-144 and XLR-11 in Human Urine Using LC-MS/MS. Current pharmaceutical biotechnology. 2018; 19(2):144-162. doi: 10.2174/1389201019666180509163114. [PMID: 29745330]
  • Katherine N Moore, Demetra Garvin, Brian F Thomas, Megan Grabenauer. Identification of Eight Synthetic Cannabinoids, Including 5F-AKB48 in Seized Herbal Products Using DART-TOF-MS and LC-QTOF-MS as Nontargeted Screening Methods. Journal of forensic sciences. 2017 Sep; 62(5):1151-1158. doi: 10.1111/1556-4029.13367. [PMID: 28597943]
  • Jeremy Carlier, Karl B Scheidweiler, Ariane Wohlfarth, Bonita D Salmeron, Michael H Baumann, Marilyn A Huestis. Quantification of [1-(5-fluoropentyl)-1H-indol-3-yl](naphthalene-1-yl)methanone (AM-2201) and 13 metabolites in human and rat plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. A. 2016 Jun; 1451(?):97-106. doi: 10.1016/j.chroma.2016.05.020. [PMID: 27208987]
  • Shimpei Watanabe, Unnikrishnan Kuzhiumparambil, Zofia Winiarski, Shanlin Fu. Biotransformation of synthetic cannabinoids JWH-018, JWH-073 and AM2201 by Cunninghamella elegans. Forensic science international. 2016 Apr; 261(?):33-42. doi: 10.1016/j.forsciint.2015.12.023. [PMID: 26907475]
  • Kei Zaitsu, Hiroshi Nakayama, Mayumi Yamanaka, Kazuaki Hisatsune, Kentaro Taki, Tomomi Asano, Tooru Kamata, Munehiro Katagai, Yumi Hayashi, Maiko Kusano, Hitoshi Tsuchihashi, Akira Ishii. High-resolution mass spectrometric determination of the synthetic cannabinoids MAM-2201, AM-2201, AM-2232, and their metabolites in postmortem plasma and urine by LC/Q-TOFMS. International journal of legal medicine. 2015 Nov; 129(6):1233-45. doi: 10.1007/s00414-015-1257-4. [PMID: 26349566]
  • Karl B Scheidweiler, Michael J Y Jarvis, Marilyn A Huestis. Nontargeted SWATH acquisition for identifying 47 synthetic cannabinoid metabolites in human urine by liquid chromatography-high-resolution tandem mass spectrometry. Analytical and bioanalytical chemistry. 2015 Jan; 407(3):883-97. doi: 10.1007/s00216-014-8118-8. [PMID: 25224637]
  • Albert A Elian, Jeffery Hackett. Analysis of AM-2201 and metabolites in a drugs and driving case. Drug testing and analysis. 2014 Apr; 6(4):389-95. doi: 10.1002/dta.1535. [PMID: 24574312]
  • Moonhee Jang, Wonkyung Yang, Ilchung Shin, Hyeyoung Choi, Hyejin Chang, Eunmi Kim. Determination of AM-2201 metabolites in urine and comparison with JWH-018 abuse. International journal of legal medicine. 2014 Mar; 128(2):285-94. doi: 10.1007/s00414-013-0884-x. [PMID: 23884698]
  • Amy L Patton, Kathryn A Seely, Krishna C Chimalakonda, Johnny P Tran, Matthew Trass, Art Miranda, William E Fantegrossi, Paul D Kennedy, Paul Dobrowolski, Anna Radominska-Pandya, Keith R McCain, Laura P James, Gregory W Endres, Jeffery H Moran. Targeted metabolomic approach for assessing human synthetic cannabinoid exposure and pharmacology. Analytical chemistry. 2013 Oct; 85(19):9390-9. doi: 10.1021/ac4024704. [PMID: 23987522]
  • Melanie Hutter, Bjoern Moosmann, Stefan Kneisel, Volker Auwärter. Characteristics of the designer drug and synthetic cannabinoid receptor agonist AM-2201 regarding its chemistry and metabolism. Journal of mass spectrometry : JMS. 2013 Jul; 48(7):885-94. doi: 10.1002/jms.3229. [PMID: 23832945]
  • Krishna C Chimalakonda, Kathryn A Seely, Stacie M Bratton, Lisa K Brents, Cindy L Moran, Gregory W Endres, Laura P James, Paul F Hollenberg, Paul L Prather, Anna Radominska-Pandya, Jeffery H Moran. Cytochrome P450-mediated oxidative metabolism of abused synthetic cannabinoids found in K2/Spice: identification of novel cannabinoid receptor ligands. Drug metabolism and disposition: the biological fate of chemicals. 2012 Nov; 40(11):2174-84. doi: 10.1124/dmd.112.047530. [PMID: 22904561]
  • Tim Sobolevsky, Ilya Prasolov, Grigory Rodchenkov. Detection of urinary metabolites of AM-2201 and UR-144, two novel synthetic cannabinoids. Drug testing and analysis. 2012 Oct; 4(10):745-53. doi: 10.1002/dta.1418. [PMID: 23042760]
  • Karoline Simolka, Rainer Lindigkeit, Hans-Martin Schiebel, Uli Papke, Ludger Ernst, Till Beuerle. Analysis of synthetic cannabinoids in 'spice-like' herbal highs: snapshot of the German market in summer 2011. Analytical and bioanalytical chemistry. 2012 Jul; 404(1):157-71. doi: 10.1007/s00216-012-6122-4. [PMID: 22710567]