Fluocortolone (BioDeep_00000614722)

代谢物信息卡片

Fluocortolone

化学式: C22H29FO4 (376.2049766)
中文名称: 氟可龙
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC2C3CC(C4=CC(=O)C=CC4(C3C(CC2(C1C(=O)CO)C)O)C)F
InChI: InChI=1S/C22H29FO4/c1-11-6-14-13-8-16(23)15-7-12(25)4-5-21(15,2)20(13)17(26)9-22(14,3)19(11)18(27)10-24/h4-5,7,11,13-14,16-17,19-20,24,26H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19-,20-,21+,22+/m1/s1

描述信息

H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AB - Glucocorticoids
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07X - Corticosteroids, other combinations > D07XC - Corticosteroids, potent, other combinations
C - Cardiovascular system > C05 - Vasoprotectives > C05A - Agents for treatment of hemorrhoids and anal fissures for topical use > C05AA - Corticosteroids
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AC - Corticosteroids, potent (group iii)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D005938 - Glucocorticoids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents

同义名列表

1 个代谢物同义名

Fluocortolone

数据库引用编号

8 个数据库交叉引用编号

ChEBI: CHEBI:135581
KEGGdrug: D04218
PubChem: 9053
Metlin: METLIN85045
DrugBank: DB08971
ChEMBL: CHEMBL251634
MeSH: Fluocortolone
CAS: 152-97-6

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Leon H Kircik. A study to assess the occlusivity and moisturization potential of three topical corticosteroid products using the skin trauma after razor shaving (STARS) bioassay. Journal of drugs in dermatology : JDD. 2014 May; 13(5):582-5. doi: ". [PMID: 24809882]
Daniel Böhringer, Frieder Daub, Johannes Schwartzkopff, Philip Maier, Florian Birnbaum, Rainer Sundmacher, Thomas Reinhard. Operational post-keratopasty graft tolerance due to differential HLAMatchmaker matching. Molecular vision. 2010 Nov; 16(?):2362-7. doi: NULL. [PMID: 21152438]
R J B Peters, J E Oosterink, A A M Stolker, C Georgakopoulos, M W F Nielen. Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. Analytical and bioanalytical chemistry. 2010 Apr; 396(7):2583-98. doi: 10.1007/s00216-010-3484-3. [PMID: 20155493]
I Madhusudhana Reddy, Alka Beotra, S Jain, S Ahi. A simple and rapid ESI-LC-MS/MS method for simultaneous screening of doping agents in urine samples. Indian journal of pharmacology. 2009 Apr; 41(2):80-6. doi: 10.4103/0253-7613.51347. [PMID: 20336223]
Stephanie Maxine Ross. An integrative approach to eczema (atopic dermatitis). Holistic nursing practice. 2003 Jan; 17(1):56-62. doi: 10.1097/00004650-200301000-00011. [PMID: 12597676]
J Hillenkamp, A Kersten, C Althaus, R Sundmacher. [Cyclosporin A therapy in severe anterior scleritis. 5 severe courses without verification of associated systemic disease treated with cyclosporin A]. Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. 2000 Dec; 97(12):863-9. doi: 10.1007/s003470070010. [PMID: 11227160]
L Pascalis, G Aresu, G Pia. Long-term efficacy and toxicity of cyclosporin A + fluocortolone + methotrexate in the treatment of rheumatoid arthritis. Clinical and experimental rheumatology. 1999 Nov; 17(6):679-88. doi: NULL. [PMID: 10609066]
J Krutmann, T L Diepgen, T A Luger, S Grabbe, H Meffert, N Sönnichsen, W Czech, A Kapp, H Stege, M Grewe, E Schöpf. High-dose UVA1 therapy for atopic dermatitis: results of a multicenter trial. Journal of the American Academy of Dermatology. 1998 Apr; 38(4):589-93. doi: 10.1016/s0190-9622(98)70123-9. [PMID: 9555799]
P A Miescher, H Favre, R Lemoine, P Tamagnini. Drug-combination therapy of rheumatoid arthritis. Springer seminars in immunopathology. 1998; 20(1-2):309-18. doi: 10.1007/bf00832014. [PMID: 9836384]
S Rohatagi, U Täuber, K Richter, H Derendorf. Pharmacokinetic/pharmacodynamic modeling of cortisol suppression after oral administration of fluocortolone. Journal of clinical pharmacology. 1996 Apr; 36(4):311-4. doi: 10.1002/j.1552-4604.1996.tb04206.x. [PMID: 8728344]
K H Lew, W J Jusko. Pharmacodynamic modeling of cortisol suppression from fluocortolone. European journal of clinical pharmacology. 1993; 45(6):581-3. doi: 10.1007/bf00315319. [PMID: 8157047]
S Korsten, H E Reis. [Acquired protein C deficiency in ulcerative colitis. The cause of thromboembolic complications]. Deutsche medizinische Wochenschrift (1946). 1992 Mar; 117(11):419-24. doi: 10.1055/s-2008-1062328. [PMID: 1347501]
H A Orgel, E O Meltzer, C W Bierman, E Bronsky, J T Connell, P L Lieberman, R Nathan, D S Pearlman, H L Pence, R G Slavin. Intranasal fluocortin butyl in patients with perennial rhinitis: a 12-month efficacy and safety study including nasal biopsy. The Journal of allergy and clinical immunology. 1991 Aug; 88(2):257-64. doi: 10.1016/0091-6749(91)90336-m. [PMID: 1880325]
C Althaus, R Sundmacher. [Chronic recurrent polychondritis. The spectrum of eye involvement]. Fortschritte der Ophthalmologie : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft. 1991; 88(4):396-400. doi: NULL. [PMID: 1786930]
H Krickeberg. [Development of multiple precancerous conditions and malignant skin tumors in immunosuppressive therapy]. Zeitschrift fur Hautkrankheiten. 1988 Sep; 63(9):773-5. doi: NULL. [PMID: 3059708]
R A Neumann, J B Schmidt, J Spona. [Effect of topical glucocorticoids on endogenous cortisol production]. Zeitschrift fur Hautkrankheiten. 1988 Apr; 63(4):302-8. doi: NULL. [PMID: 3291439]
U F Legler. Lack of impairment of fluocortolone disposition in oral contraceptive users. European journal of clinical pharmacology. 1988; 35(1):101-3. doi: 10.1007/bf00555517. [PMID: 3220090]
U Tüber, U Posern, U Bickel, H Matthes, K Voigt. Fluocortolone: pharmacokinetics and effect on ACTH and cortisol secretion during daily and alternate-day administration. European journal of clinical pharmacology. 1988; 35(2):177-81. doi: 10.1007/bf00609249. [PMID: 2847930]
P Beris, P A Miescher. [Treatment of severe aplastic anemia with a cyclosporin-corticosteroid combination]. Schweizerische medizinische Wochenschrift. 1987 Nov; 117(45):1751-5. doi: NULL. [PMID: 3423763]
P A Miescher, H Favre, F Chatelanat, M J Mihatsch. Combined steroid-cyclosporin treatment of chronic autoimmune diseases. Clinical results and assessment of nephrotoxicity by renal biopsy. Klinische Wochenschrift. 1987 Aug; 65(15):727-36. doi: 10.1007/bf01736809. [PMID: 3626435]
F Lopatta, P Vecsei, U Täuber, D Haack. [Pharmacokinetics of fluocortolone in long term therapy of patients with rheumatic and hematologic diseases]. Arzneimittel-Forschung. 1986 Aug; 36(8):1268-71. doi: NULL. [PMID: 3490855]
P Beris, A Burger, L Favre, A Riondel, P A Miescher. Adrenocortical responsiveness after discontinuous corticosteroid therapy. Klinische Wochenschrift. 1986 Jan; 64(2):70-5. doi: 10.1007/bf01784132. [PMID: 3005756]
U Täuber, K Richter, H Matthes. Fluocortolone: pharmacokinetics and effect on plasma cortisol level. European journal of clinical pharmacology. 1986; 30(4):433-8. doi: 10.1007/bf00607956. [PMID: 3743619]
U F Legler. Pharmacokinetics of fluocortolone in man. European journal of clinical pharmacology. 1986; 30(5):615-7. doi: 10.1007/bf00542423. [PMID: 3758149]
H Brunn, P Fister, E Eigenbrodt, V Stojanowić. False-positive results in the radioimmunoassay detection of stilbene derivatives after administration of fluorinated corticosteroids to animals. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1985 Oct; 23(10):931-5. doi: 10.1016/0278-6915(85)90110-3. [PMID: 4065768]
P Aertgeerts, M Albring, F Klaschka, T Nasemann, R Patzelt-Wenczler, K Rauhut, B Weigl. [Comparative testing of Kamillosan cream and steroidal (0.25\% hydrocortisone, 0.75\% fluocortin butyl ester) and non-steroidal (5\% bufexamac) dermatologic agents in maintenance therapy of eczematous diseases]. Zeitschrift fur Hautkrankheiten. 1985 Feb; 60(3):270-7. doi: ". [PMID: 3158124]
T Koziol, M L Grayeski, R Weinberger. Determination of trace levels of steroids in blood plasma by liquid chromatography with peroxyoxalate chemiluminescence detection. Journal of chromatography. 1984 Dec; 317(?):355-66. doi: 10.1016/s0021-9673(01)91675-9. [PMID: 6530443]
U Täuber, D Haack, B Nieuweboer, G Kloss, P Vecsei, H Wendt. The pharmacokinetics of fluocortolone and prednisolone after intravenous and oral administration. International journal of clinical pharmacology, therapy, and toxicology. 1984 Jan; 22(1):48-55. doi: NULL. [PMID: 6698661]
C Queille, R Pommarede, J H Saurat. Efficacy versus systemic effects of six topical steroids in the treatment of atopic dermatitis of childhood. Pediatric dermatology. 1984 Jan; 1(3):246-53. doi: 10.1111/j.1525-1470.1984.tb01124.x. [PMID: 6494068]
B Emmerich, M Pemsl, I Wüst, W E Berdel, S Lechner, E Thiel, A Georgii, W Gössner, J Rastetter. Conversion of an IGM secreting immunocytoma in a high grade malignant lymphoma of immunoblastic type. Blut. 1983 Feb; 46(2):81-4. doi: 10.1007/bf00320662. [PMID: 6401437]
B Sherman, M Weinberger, H Chen-Walden, H Wendt. Further studies of the effects of inhaled glucocorticoids on pituitary-adrenal function in healthy adults. The Journal of allergy and clinical immunology. 1982 Feb; 69(2):208-12. doi: 10.1016/0091-6749(82)90101-4. [PMID: 7056952]
F Hartmann. Clinical application of corticoids. International dental journal. 1981 Dec; 31(4):273-85. doi: NULL. [PMID: 6946974]
H Gleispach, S Porta. [The metabolism of hydrocortisone, prednisolone and fluocortolone (author's transl)]. Wiener klinische Wochenschrift. 1981 Nov; 93(21):671-3. doi: NULL. [PMID: 7324480]
P H Vlasses, R K Ferguson, J R Koplin, R A Clementi, P J Green. Adrenocortical function after chronic inhalation of fluocortinbutyl and beclomethasone dipropionate. Clinical pharmacology and therapeutics. 1981 May; 29(5):643-9. doi: 10.1038/clpt.1981.89. [PMID: 7214795]
H Chen-Walden. Clinical data of fluocortin butylester (FCB) - a new inhalable corticoid. Zeitschrift fur Erkrankungen der Atmungsorgane. 1981; 157(3):287-90. doi: NULL. [PMID: 7340214]
H Flasch, E Hofferber. [Penetration kinetics of fluocortolone from a new base for ointment and creme (author's transl)]. Arzneimittel-Forschung. 1980; 30(4):652-6. doi: NULL. [PMID: 7190408]
P A Bürkle. [Primary chronic polyarthritis with kidney involvement (mesangiocapillary glomerulonephritis)]. Zeitschrift fur Rheumatologie. 1979 Mar; 38(3-4):71-80. doi: NULL. [PMID: 155958]
A S Bhargava, P Staben, F Siegmund, C Schöbel, P Günzel. Effect of intratracheal and oral application of corticosteroids on the adrenal function test in beagle dogs after ACTH-stimulation. Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement. 1979; ?(2):425-9. doi: 10.1007/978-3-642-67265-1_50. [PMID: 223526]
R W Motson, D N Glass, D A Smith, J R Daly. The effect of short-and long-term corticosteroid treatment on sleep-associated growth hormone secretion. Clinical endocrinology. 1978 Apr; 8(4):315-26. doi: 10.1111/j.1365-2265.1978.tb02774.x. [PMID: 647985]
K H Kolb, R Latza, O Hepp-Latza, P W Lücker, W Rindt, B Simon. [Human-pharmacokinetic Studies on Penetration Kinetics of a 6 alpha-Fluoro-9 alpha-chloro-16 alpha-methyl-delta 1,4-pregnadiene-11 beta-dihydroxy-3,20-dione-21-trimethyl-acetic acid (Clocortolone Trimethyl-acetic acid) after e picutaneous application]. Arzneimittel-Forschung. 1978; 28(9):1648-51. doi: NULL. [PMID: 582571]
A S Bhargava, P Staben, F Siegmund, C Schöbel, P Günzel. Effect of fluocortin butylester and beclomethasone dipropionate on the adrenal gland in beagle dogs. Arzneimittel-Forschung. 1978; 28(9):1638-41. doi: NULL. [PMID: 224887]
H Fellier, H Gleispach, H Esterbauer. [Binding of cortisol, fluocortolone and difluocortolone to human plasma proteins (author's transl)]. Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie. 1977 Oct; 15(10):545-8. doi: NULL. [PMID: 925615]
H Wendt. [The effect of fluocortin butylester on adrenal function in man (author's transl)]. Arzneimittel-Forschung. 1977; 27(11a):2236-8. doi: NULL. [PMID: 580036]
W Mützel. [Pharmacolinetics and biotransformation of fluocortin butylester in man (author's transl)]. Arzneimittel-Forschung. 1977; 27(11a):2230-3. doi: NULL. [PMID: 580034]
J F Kapp, B Gliwitzki, P Josefiuk, W Weishaupt. [Dermal and systemic side effects of fluocortin butylester. Comparative skin tearing experiments with active principles from commercial preparations]. Arzneimittel-Forschung. 1977; 27(11a):2206-13. doi: NULL. [PMID: 580030]
P A Bürkle, E Tönnesmann, H E Franz, K Federlin. [Mesangiocapillary glomerulonephritis and rheumatoid arthritis. A case with diagnostic and therapeutic questions (author's transl)]. Immunitat und Infektion. 1976 Apr; 4(2):79-83. doi: NULL. [PMID: 61163]
W Hallauer, J Schirmeister, P Keller, G Krieger, H Schirrmeister. [Collagen disease with pure red cell anemia and perimembraneous glomerulonephritis (author's transl)]. Medizinische Klinik. 1976 Jan; 71(3):101-3. doi: NULL. [PMID: 1082537]
V J Kapp, H Koch, J Casals-Stenzel, M Töpert, E Gerhards. [Studies on the Pharmacology of 6alpha,9-difluoro-11beta-hydroxy-16alpha-methyl-21-valeryloxy-1,4-pregnadiene-3,20-dione (diflucortolon valerate) (author's transl)]. Arzneimittel-Forschung. 1976; 26(7b):1463-75. doi: NULL. [PMID: 188428]