Cholanic acid (BioDeep_00000614483)

 

Secondary id: BioDeep_00000860567


代谢物信息卡片


5alpha-Cholan-24-oic Acid

化学式: C24H40O2 (360.302814)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@]([H])([C@]([H])(C)CCC(O)=O)CC[C@@]4([H])[C@]3([H])CC[C@@]2([H])CCC1
InChI: InChI=1S/C24H40O2/c1-16(7-12-22(25)26)19-10-11-20-18-9-8-17-6-4-5-14-23(17,2)21(18)13-15-24(19,20)3/h16-21H,4-15H2,1-3H3,(H,25,26)/t16-,17+,18+,19-,20+,21+,23+,24-/m1/s1

描述信息

D005765 - Gastrointestinal Agents > D001647 - Bile Acids and Salts
D005765 - Gastrointestinal Agents > D002793 - Cholic Acids

同义名列表

6 个代谢物同义名

Cholanic acid; 5beta-Cholan-24-oic Acid; 5beta-Cholanoic acid; ST 24:1;O2; 5alpha-Cholan-24-oic Acid; 5alpha-Cholanoic acid



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Julia F Nepper, Yin C Lin, Douglas B Weibel. Rcs Phosphorelay Activation in Cardiolipin-Deficient Escherichia coli Reduces Biofilm Formation. Journal of bacteriology. 2019 05; 201(9):. doi: 10.1128/jb.00804-18. [PMID: 30782633]
  • Simon Chewchuk, Tyler Boorman, Derek Edwardson, Amadeo M Parissenti. Bile Acids Increase Doxorubicin Sensitivity in ABCC1-expressing Tumour Cells. Scientific reports. 2018 04; 8(1):5413. doi: 10.1038/s41598-018-23496-y. [PMID: 29615646]
  • Claudia Luengo-Alonso, Juan José Torrado, Maria Paloma Ballesteros, Alessio Malfanti, Sara Bersani, Stefano Salmaso, Paolo Caliceti. A novel performing PEG-cholane nanoformulation for Amphotericin B delivery. International journal of pharmaceutics. 2015 Nov; 495(1):41-51. doi: 10.1016/j.ijpharm.2015.08.070. [PMID: 26319629]
  • Joo In Jung, Ashleigh R Price, Thomas B Ladd, Yong Ran, Hyo-Jin Park, Carolina Ceballos-Diaz, Lisa A Smithson, Günther Hochhaus, Yufei Tang, Rajender Akula, Saritha Ba, Edward H Koo, Gideon Shapiro, Kevin M Felsenstein, Todd E Golde. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator. Molecular neurodegeneration. 2015 Jul; 10(?):29. doi: 10.1186/s13024-015-0021-z. [PMID: 26169917]
  • Michal Ciborowski, Joanna Teul, Jose Luis Martin-Ventura, Jesús Egido, Coral Barbas. Metabolomics with LC-QTOF-MS permits the prediction of disease stage in aortic abdominal aneurysm based on plasma metabolic fingerprint. PloS one. 2012; 7(2):e31982. doi: 10.1371/journal.pone.0031982. [PMID: 22384120]
  • Karsten Suhre, Christa Meisinger, Angela Döring, Elisabeth Altmaier, Petra Belcredi, Christian Gieger, David Chang, Michael V Milburn, Walter E Gall, Klaus M Weinberger, Hans-Werner Mewes, Martin Hrabé de Angelis, H-Erich Wichmann, Florian Kronenberg, Jerzy Adamski, Thomas Illig. Metabolic footprint of diabetes: a multiplatform metabolomics study in an epidemiological setting. PloS one. 2010 Nov; 5(11):e13953. doi: 10.1371/journal.pone.0013953. [PMID: 21085649]
  • Tieshi Li, Lara Longobardi, Froilan Granero-Molto, Timothy J Myers, Yun Yan, Anna Spagnoli. Use of glycol chitosan modified by 5beta-cholanic acid nanoparticles for the sustained release of proteins during murine embryonic limb skeletogenesis. Journal of controlled release : official journal of the Controlled Release Society. 2010 May; 144(1):101-8. doi: 10.1016/j.jconrel.2010.01.021. [PMID: 20116406]
  • Junichi Fukuchi, Ching Song, Qing Dai, Richard A Hiipakka, Shutsung Liao. 5beta-Cholane activators of the farnesol X receptor. The Journal of steroid biochemistry and molecular biology. 2005 Mar; 94(4):311-8. doi: 10.1016/j.jsbmb.2004.11.012. [PMID: 15857750]
  • Ryutaro Adachi, Yoshio Honma, Hiroyuki Masuno, Katsuyoshi Kawana, Iichiro Shimomura, Sachiko Yamada, Makoto Makishima. Selective activation of vitamin D receptor by lithocholic acid acetate, a bile acid derivative. Journal of lipid research. 2005 Jan; 46(1):46-57. doi: 10.1194/jlr.m400294-jlr200. [PMID: 15489543]
  • A Berger, D Rein, E Kratky, I Monnard, H Hajjaj, I Meirim, C Piguet-Welsch, J Hauser, K Mace, P Niederberger. Cholesterol-lowering properties of Ganoderma lucidum in vitro, ex vivo, and in hamsters and minipigs. Lipids in health and disease. 2004 Feb; 3(?):2. doi: 10.1186/1476-511x-3-2. [PMID: 14969592]
  • H Sqalli-Houssaini, C Pierlot, J P Kusnierz, B Parmentier, F Martin-Nizard, S Lestavel-Delattre, A Tartar, J C Fruchart, C Sergheraert, P Duriez. Preparation of anti-HIV-low-density lipoprotein complexes for delivery of anti-HIV drugs via the low-density lipoprotein pathways. Biotechnology therapeutics. 1994; 5(1-2):69-85. doi: ". [PMID: 7703834]
  • K Sawada, A Kawaura, N Tanida, T Shimoyama, T Narisawa. Promoting effect of 5 beta-chol-3-en-24-oic acid on N-methyl-N-nitrosourea-induced colonic tumorigenesis in rats. Japanese journal of cancer research : Gann. 1987 Sep; 78(9):908-14. doi: NULL. [PMID: 3117746]
  • A M Lawson, M J Madigan, D Shortland, P T Clayton. Rapid diagnosis of Zellweger syndrome and infantile Refsum's disease by fast atom bombardment--mass spectrometry of urine bile salts. Clinica chimica acta; international journal of clinical chemistry. 1986 Dec; 161(2):221-31. doi: 10.1016/0009-8981(86)90215-9. [PMID: 2433077]
  • D V Waterhous, S Barnes, D D Muccio. Nuclear magnetic resonance spectroscopy of bile acids. Development of two-dimensional NMR methods for the elucidation of proton resonance assignments for five common hydroxylated bile acids, and their parent bile acid, 5 beta-cholanoic acid. Journal of lipid research. 1985 Sep; 26(9):1068-78. doi: ". [PMID: 4067429]
  • H F Mower, R M Ray, G N Stemmermann, A Nomura, G A Glober. Analysis of fecal bile acids and diet among the Japanese in Hawaii. The Journal of nutrition. 1978 Aug; 108(8):1289-96. doi: 10.1093/jn/108.8.1289. [PMID: 671097]
  • A M Díaz, V M Varela-Díaz. Detection of antigenic differences among street and fixed rabies virus strains by the counterimmunoelectrophoresis test. Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie. 1976 Nov; 236(2-3):185-90. doi: NULL. [PMID: 65070]
  • H DANIELSSON, A KALLNER, J SJOEVALL. ON THE COMPOSITION OF THE BILE ACID FRACTION OF RABBIT FECES AND THE ISOLATION OF A NEW BILE ACID: 3-ALPHA, 12-ALPHA-DIHYDROXY-5-ALPHA-CHOLANIC ACID. BILE ACIDS AND STEROIDS. 136. The Journal of biological chemistry. 1963 Dec; 238(?):3840-52. doi: NULL. [PMID: 14086715]
  • H DANIELSSON, P ENEROTH, K HELLSTROM, J SJOVALL. Synthesis of some 3beta-hydroxylated bile acids and the isolation of 3beta, 12alpha-dihydroxy-5beta-cholanic acid from feces. The Journal of biological chemistry. 1962 Dec; 237(?):3657-9. doi: NULL. [PMID: 14024950]
  • L PERIC-GOLIA, R S JONES. Conversion of mevalonic acid-2-C14 to biliary cholesterol and cholanic acids in the guinea pig. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1961 Aug; 107(?):856-8. doi: 10.3181/00379727-107-26777. [PMID: 14485335]
  • D RUDMAN, F E KENDALL. Bile acid content of human serum. II. The binding of cholanic acids by human plasma proteins. The Journal of clinical investigation. 1957 Apr; 36(4):538-42. doi: 10.1172/jci103451. [PMID: 13416382]