Alfacalcidol (BioDeep_00000614262)
代谢物信息卡片
Alfacalcidol
化学式: C27H44O2 (400.3341124)
中文名称: 阿法骨化醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CC(C3=C)O)O)C
InChI: InChI=1S/C27H44O2/c1-18(2)8-6-9-19(3)24-13-14-25-21(10-7-15-27(24,25)5)11-12-22-16-23(28)17-26(29)20(22)4/h11-12,18-19,23-26,28-29H,4,6-10,13-17H2,1-3,5H3/b21-11+,22-12-/t19-,23-,24-,25+,26+,27-/m1/s1
描述信息
A - Alimentary tract and metabolism > A11 - Vitamins > A11C - Vitamin a and d, incl. combinations of the two > A11CC - Vitamin d and analogues
D018977 - Micronutrients > D014815 - Vitamins > D006887 - Hydroxycholecalciferols
D050071 - Bone Density Conservation Agents
同义名列表
1 个代谢物同义名
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:31186
- ChEBI: CHEBI:94779
- KEGGdrug: D01518
- PubChem: 5282181
- Metlin: METLIN823
- DrugBank: DB01436
- ChEMBL: CHEMBL1601669
- CAS: 65445-14-9
- CAS: 41294-56-8
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qiang Fu, Ming-Fang Shi, Ying Chen. Clinical effect of alfacalcidol in children with Henoch-Schönlein purpura: a prospective randomized controlled trial.
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics.
2021 Aug; 23(8):797-801. doi:
10.7499/j.issn.1008-8830.2105136. [PMID: 34511168] - Tim Hurley, Zunera Zareen, Philip Stewart, Ciara McDonnell, Denise McDonald, Eleanor Molloy. Bisphosphonate use in children with cerebral palsy.
The Cochrane database of systematic reviews.
2021 07; 7(?):CD012756. doi:
10.1002/14651858.cd012756.pub2. [PMID: 34224134] - Daisuke Harada, Kaoru Ueyama, Kyoko Oriyama, Yoshihito Ishiura, Hiroko Kashiwagi, Hiroyuki Yamada, Yoshiki Seino. Switching from conventional therapy to burosumab injection has the potential to prevent nephrocalcinosis in patients with X-linked hypophosphatemic rickets.
Journal of pediatric endocrinology & metabolism : JPEM.
2021 Jun; 34(6):791-798. doi:
10.1515/jpem-2020-0734. [PMID: 33837680] - Soma Saha, Vishnubhatla Sreenivas, Ravinder Goswami. Alfacalcidol vs Calcitriol in the Management of Patient With Hypoparathyroidism: A Randomized Controlled Trial.
The Journal of clinical endocrinology and metabolism.
2021 06; 106(7):2092-2102. doi:
10.1210/clinem/dgab114. [PMID: 33616655] - Radoslav Omelka, Monika Martiniakova, Karol Svik, Lukas Slovak, Juraj Payer, Ingrid Oppenbergerova, Veronika Kovacova, Martina Babikova, Marta Soltesova-Prnova. The effects of eggshell calcium (Biomin H® ) and its combinations with alfacalcidol (1α-hydroxyvitamin D3) and menaquinone-7 (vitamin K2) on ovariectomy-induced bone loss in a rat model of osteoporosis.
Journal of animal physiology and animal nutrition.
2021 Mar; 105(2):336-344. doi:
10.1111/jpn.13458. [PMID: 33012134] - Jian Zhou, Bo Liu, Ming-Zhao Qin, Jin-Ping Liu. Fall Prevention and Anti-Osteoporosis in Osteopenia Patients of 80 Years of Age and Older: A Randomized Controlled Study.
Orthopaedic surgery.
2020 Jun; 12(3):890-899. doi:
10.1111/os.12701. [PMID: 32495521] - Xiaohan You, Ying Zhou, Jianna Zhang, Qiongxiu Zhou, Yanling Shi, Zhen Su, Chaoshen Chen, Rongrong Shao, Ji Zhang. Effects of parathyroid hormone and vitamin D supplementation on stroke among patients receiving peritoneal dialysis.
BMC nephrology.
2020 05; 21(1):183. doi:
10.1186/s12882-020-01817-6. [PMID: 32423377] - Jin Li, Saroj Rai, Renhao Ze, Xin Tang, Ruikang Liu, Pan Hong. Rotational and translational osteotomy for treatment of severe deformity in hypophosphatemic rickets: A case report.
Medicine.
2020 Jan; 99(3):e18425. doi:
10.1097/md.0000000000018425. [PMID: 32011435] - Piotr Skrzypczyk, Magdalena Okarska-Napierała, Anna Stelmaszczyk-Emmel, Elżbieta Górska, Małgorzata Pańczyk-Tomaszewska. Renalase in children with chronic kidney disease.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2019 Nov; 24(7):638-644. doi:
10.1080/1354750x.2019.1642957. [PMID: 31293181] - Lobna M Abdel Moneim, Maged W Helmy, Hanan S El-Abhar. Co-targeting of endothelin-A and vitamin D receptors: a novel strategy to ameliorate cisplatin-induced nephrotoxicity.
Pharmacological reports : PR.
2019 Oct; 71(5):917-925. doi:
10.1016/j.pharep.2019.04.018. [PMID: 31430707] - Yusuke Nakazawa, Shinya Inoue, Yuka Nakamura, Yasuo Iida, Yasuhito Ishigaki, Katsuhito Miyazawa. High-salt diet promotes crystal deposition through hypertension in Dahl salt-sensitive rat model.
International journal of urology : official journal of the Japanese Urological Association.
2019 08; 26(8):839-846. doi:
10.1111/iju.14035. [PMID: 31257672] - Soma Saha, Ravinder Goswami. Auditing the Efficacy and Safety of Alfacalcidol and Calcium Therapy in Idiopathic Hypoparathyroidism.
The Journal of clinical endocrinology and metabolism.
2019 04; 104(4):1325-1335. doi:
10.1210/jc.2018-02228. [PMID: 30608544] - Ramya Bhargava, Philip A Kalra, Mark Hann, Paul Brenchley, Helen Hurst, Alastair J Hutchison. A randomized controlled trial of different serum phosphate ranges in subjects on hemodialysis.
BMC nephrology.
2019 02; 20(1):37. doi:
10.1186/s12882-019-1216-2. [PMID: 30717691] - Wafaa M Abdel-Rehim, Rasha A El-Tahan, Mennatullah A El-Tarawy, Rowaida R Shehata, Maher A Kamel. The possible antidiabetic effects of vitamin D receptors agonist in rat model of type 2 diabetes.
Molecular and cellular biochemistry.
2019 Jan; 450(1-2):105-112. doi:
10.1007/s11010-018-3377-x. [PMID: 29909574] - Tetsuo Shoji, Masaaki Inaba, Masafumi Fukagawa, Ryoichi Ando, Masanori Emoto, Hisako Fujii, Akira Fujimori, Mitsuru Fukui, Hiroki Hase, Tetsuya Hashimoto, Hideki Hirakata, Hirokazu Honda, Tatsuo Hosoya, Yuji Ikari, Daijo Inaguma, Toru Inoue, Yoshitaka Isaka, Kunitoshi Iseki, Eiji Ishimura, Noritomo Itami, Chiharu Ito, Toshitaka Kakuta, Toru Kawai, Hideki Kawanishi, Shuzo Kobayashi, Junko Kumagai, Kiyoshi Maekawa, Ikuto Masakane, Jun Minakuchi, Koji Mitsuiki, Takashi Mizuguchi, Satoshi Morimoto, Toyoaki Murohara, Tatsuya Nakatani, Shigeo Negi, Shinichi Nishi, Mitsushige Nishikawa, Tetsuya Ogawa, Kazumichi Ohta, Takayasu Ohtake, Mikio Okamura, Senji Okuno, Takashi Shigematsu, Toshitsugu Sugimoto, Masashi Suzuki, Hideki Tahara, Yoshiaki Takemoto, Kenji Tanaka, Yoshihiro Tominaga, Yoshiharu Tsubakihara, Yoshihiro Tsujimoto, Kazuhiko Tsuruya, Shinichiro Ueda, Yuzo Watanabe, Kunihiro Yamagata, Tomoyuki Yamakawa, Shozo Yano, Keitaro Yokoyama, Noriaki Yorioka, Minoru Yoshiyama, Yoshiki Nishizawa. Effect of Oral Alfacalcidol on Clinical Outcomes in Patients Without Secondary Hyperparathyroidism Receiving Maintenance Hemodialysis: The J-DAVID Randomized Clinical Trial.
JAMA.
2018 12; 320(22):2325-2334. doi:
10.1001/jama.2018.17749. [PMID: 30535217] - Eri Ito, Daijo Inaguma, Shigehisa Koide, Kazuo Takahashi, Hiroki Hayashi, Midori Hasegawa, Yukio Yuzawa. Effect of combined vitamin D receptor activator and lanthanum carbonate on serum fibroblast growth factor 23 level in predialysis patients (CVD-LAF study): design and method.
Clinical and experimental nephrology.
2018 Dec; 22(6):1309-1314. doi:
10.1007/s10157-018-1584-0. [PMID: 29748907] - Nan Li, Yan Jiang, Shuli He, Zhen Zhao, Jing Sun, Mei Li, Ou Wang, Xiaoping Xing, Weibo Xia. Efficacy and safety of alfacalcidol in Chinese postmenopausal women aged over 65 with osteoporosis or osteopenia: An open label, non-comparative, post marketing observational study.
Medicine.
2018 Nov; 97(47):e13159. doi:
10.1097/md.0000000000013159. [PMID: 30461612] - Ausra Snipaitiene, Rima Sileikiene, Justina Klimaite, Edita Jasinskiene, Rimantas Uktveris, Lina Jankauskaite. Unusual case of chronic recurrent multifocal osteomyelitis.
Pediatric rheumatology online journal.
2018 Jul; 16(1):49. doi:
10.1186/s12969-018-0267-4. [PMID: 30053822] - Rabab M Ali, Muhammad Y Al-Shorbagy, Maged W Helmy, Hanan S El-Abhar. Role of Wnt4/β-catenin, Ang II/TGFβ, ACE2, NF-κB, and IL-18 in attenuating renal ischemia/reperfusion-induced injury in rats treated with Vit D and pioglitazone.
European journal of pharmacology.
2018 Jul; 831(?):68-76. doi:
10.1016/j.ejphar.2018.04.032. [PMID: 29715453] - Aulia Rizka, Siti Setiati, Kuntjoro Harimurti, M Sadikin, Indra G Mansur. Effect of Alfacalcidol on Inflammatory markers and T Cell Subsets in Elderly with Frailty Syndrome: a Double Blind Randomized Controlled Trial.
Acta medica Indonesiana.
2018 Jul; 50(3):215-221. doi:
NULL. [PMID: 30333271] - Pablo Antonio Ureña-Torres, Mario Cozzolino, Jordi Bover. [Utilization of alfacalcidol and active vitamin D analogs in chronic kidney disease].
Nephrologie & therapeutique.
2018 Jun; 14(4):189-200. doi:
10.1016/j.nephro.2017.03.003. [PMID: 29545131] - A Yajima, K Tsuchiya, L F Bonewald, M Inaba, Y Tominaga, T Tanizawa, A Ito, K Nitta. Case report: Electron microscopic evaluation of bone from a patient treated with cinacalcet hydrochloride, maxacalcitol, and alfacalcidol for hyperparathyroid bone disease with secondary hyperparathyroidism.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2018 05; 29(5):1203-1209. doi:
10.1007/s00198-018-4402-3. [PMID: 29492624] - J C Han, J G Wang, G H Chen, J L Zhang, N Zhang, H X Qu, Y Guo, Y F Yan, X J Yang. 1α-Hydroxycholecalciferol improves the growth performance and up-regulates the mRNA expression of vitamin D receptor in the small intestine and kidney of broiler chickens.
Poultry science.
2018 Apr; 97(4):1263-1270. doi:
10.3382/ps/pex423. [PMID: 29452375] - K Uenishi, M Tokiwa, S Kato, M Shiraki. Stimulation of intestinal calcium absorption by orally administrated vitamin D3 compounds: a prospective open-label randomized trial in osteoporosis.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2018 03; 29(3):723-732. doi:
10.1007/s00198-017-4351-2. [PMID: 29273827] - Yoshihisa Hirota, Kimie Nakagawa, Keigo Isomoto, Toshiyuki Sakaki, Noboru Kubodera, Maya Kamao, Naomi Osakabe, Yoshitomo Suhara, Toshio Okano. Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.
PloS one.
2018; 13(10):e0199856. doi:
10.1371/journal.pone.0199856. [PMID: 30281599] - Ladan Zand, Rajiv Kumar. The Use of Vitamin D Metabolites and Analogues in the Treatment of Chronic Kidney Disease.
Endocrinology and metabolism clinics of North America.
2017 12; 46(4):983-1007. doi:
10.1016/j.ecl.2017.07.008. [PMID: 29080646] - Shunsuke Yamada, Mina Matsuo, Masanori Tokumoto, Hiroaki Ooboshi. Hypercalcaemia-induced acute kidney injury in an older patient with osteoporosis treated with alfacalcidol for denosumab-induced hypocalcaemia.
Nephrology (Carlton, Vic.).
2017 07; 22(7):572-573. doi:
10.1111/nep.12843. [PMID: 28621008] - Vishal Dey, Tariq E Farrah, Jamie P Traynor, Elaine M Spalding, Susan E Robertson, Colin C Geddes. Symptomatic fracture risk in the renal replacement therapy population.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2017 Jul; 32(7):1211-1216. doi:
10.1093/ndt/gfw222. [PMID: 27257273] - Amani M Ali, Samah Selim, Maggie M Abbassi, Nirmeen A Sabry. Effect of alfacalcidol on the pulmonary function of adult asthmatic patients: A randomized trial.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.
2017 05; 118(5):557-563. doi:
10.1016/j.anai.2017.02.014. [PMID: 28377173] - Xiaoyu Yang, Ling Wu, Guoping Li, Qin Ran, Lei Zhang. [Alphacalcidol combined with dexamethasone for reducing pulmonary fibrosis in mice and its mechanism].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology.
2017 Apr; 33(4):488-491. doi:
NULL. [PMID: 28395719] - Jana Figurová, Ingrid Dravecká, Jana Petríková, Martin Javorský, Ivica Lazúrová. The effect of alfacalcidiol and metformin on metabolic disturbances in women with polycystic ovary syndrome.
Hormone molecular biology and clinical investigation.
2017 Mar; 29(3):85-91. doi:
10.1515/hmbci-2016-0039. [PMID: 28157691] - Kousuke Iba, Tomoko Sonoda, Junichi Takada, Takayuki Dohke, Toshihiko Yamashita. Further significant effects of eldecalcitol on bone resorption markers and bone mineral density in postmenopausal osteoporosis patients having undergone long-term bisphosphonate treatment.
Journal of bone and mineral metabolism.
2017 Mar; 35(2):171-176. doi:
10.1007/s00774-016-0738-y. [PMID: 26832388] - Sandrine Rauscher, Jean-Philippe Lafrance, Vincent Pichette, Robert Z Bell, Katherine Desforges, Laurence Lepage, Georges Ouellet, Denis Ouimet, Martine Leblanc, Caroline Lamarche, Sarah Bezzaoucha, Michel Vallee. Conversion of oral alfacalcidol to oral calcitriol in the treatment of secondary hyperparathyroidism in chronic hemodialysis patients.
International urology and nephrology.
2017 Feb; 49(2):325-328. doi:
10.1007/s11255-016-1446-1. [PMID: 27822674] - Lucia Spath, Alessandra Ulivieri, Luca Lavra, Laura Fidanza, Marta Carlesimo, Maria Giubettini, Alessandra Narcisi, Emidio Luciani, Barbara Bucci, Daniela Pisani, Salvatore Sciacchitano, Armando Bartolazzi. Antiproliferative Effects of 1α-OH-vitD3 in Malignant Melanoma: Potential Therapeutic implications.
Scientific reports.
2017 01; 7(?):40370. doi:
10.1038/srep40370. [PMID: 28074906] - Stephanie Rutledge, Michele Harrison, Martin O'Connell, Tadhg O'Dwyer, Maria M Byrne. Acute presentation of a giant intrathyroidal parathyroid adenoma: a case report.
Journal of medical case reports.
2016 Oct; 10(1):286. doi:
10.1186/s13256-016-1078-1. [PMID: 27756436] - Guillaume Jean, Jean-Claude Souberbielle, Eric Zaoui, Christie Lorriaux, Jean-Marc Hurot, Brice Mayor, Patrik Deleaval, Manolie Mehdi, Charles Chazot. Analysis of the kinetics of the parathyroid hormone, and of associated patient outcomes, in a cohort of haemodialysis patients.
BMC nephrology.
2016 10; 17(1):153. doi:
10.1186/s12882-016-0365-9. [PMID: 27756251] - C Capatina, A Caragheorgheopol, M Berteanu, C Poiana. Short-term Administration of Alphacalcidol is Associated with More Significant Improvement of Muscular Performance in Women with Vitamin D Deficiency Compared to Native Vitamin D.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2016 Sep; 124(8):461-465. doi:
10.1055/s-0042-103932. [PMID: 27169685] - Shu-Jun Ren, Guo-Li Xing, Nai-Wu Hu, Wei-Ming Xu, Yong-Qi Wang, Qing-Ping Dong, Yi-Chang Jiang. Bu-Shen-Jian-Pi-Yi-Qi Therapy Prevents Alcohol-Induced Osteoporosis in Rats.
American journal of therapeutics.
2016 Sep; 23(5):e1135-42. doi:
10.1097/mjt.0000000000000298. [PMID: 26291589] - C Varim, S Sipahi, S Yaylaci, T Kaya, A Nalbant. EFFECTS OF VITAMIN D ANALOGS ON ERYTHROPOIESIS-STIMULATING AGENT DASAGE AND SECONDARY ANEMIA IN HEMODIALYSIS PATIENTS.
Georgian medical news.
2016 Mar; ?(252):26-32. doi:
. [PMID: 27119831] - Takeshi Sato, Koji Muroya, Yumi Asakura, Akihiro Yachie, Gen Nishimura, Noriko Aida, Jiro Machida, Yukichi Tanaka, Tomonobu Hasegawa, Masanori Adachi. Polyostotic osteolysis and hypophosphatemic rickets with elevated serum fibroblast growth factor 23: A case report.
American journal of medical genetics. Part A.
2015 Oct; 167A(10):2430-4. doi:
10.1002/ajmg.a.37193. [PMID: 26059403] - Yoshie Omori-Mizuno, Nobuaki Nakayama, Mie Inao, Junji Funyu, Shinichi Asabe, Kengo Tomita, Kou Nishikawa, Yasuo Hosoda, Masahiko Tanaka, Yoshiaki Hashimoto, Koji Yakabi, Yohei Koshima, Satoshi Mochida. Randomized study comparing vitamin D3 and 1α-Hydroxyvitamin D3 in combination with pegylated interferon/ribavirin therapy for chronic hepatitis C.
Journal of gastroenterology and hepatology.
2015 Sep; 30(9):1384-90. doi:
10.1111/jgh.12949. [PMID: 25778685] - Yan-Ping Yang, Bo Shuai, Lin Shen, Xiao-Juan Xu, Chen Ma, Lin Lv. Effect of Qing'e formula on circulating sclerostin levels in patients with postmenopausal osteoporosis.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban.
2015 Aug; 35(4):525-530. doi:
10.1007/s11596-015-1464-8. [PMID: 26223921] - Rikako Hiramatsu, Yoshifumi Ubara, Naoki Sawa, Junichi Hoshino, Eiko Hasegawa, Masahiro Kawada, Aya Imafuku, Keiichi Sumida, Koki Mise, Noriko Hayami, Tatsuya Suwabe, Kenmei Takaichi. Denosumab for low bone mass in hemodialysis patients: a noncontrolled trial.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
2015 Jul; 66(1):175-7. doi:
10.1053/j.ajkd.2015.03.012. [PMID: 25979349] - Ahmed Alayoud, Driss El Kabbaj, Mohammed Benyahia, Mohammed Asseraji, Nadir Zemraoui. Effects of lowering dialysate calcium concentration on mineral metabolism and hemodynamic parameters in hemodialysis patients.
Iranian journal of kidney diseases.
2015 Mar; 9(2):132-7. doi:
NULL. [PMID: 25851292] - Koji Nakamura, Kenjiro Sawada, Michiyo Sugiyama, Seiji Mabuchi, Takeshi Hisamatsu, Yukihiro Nishio, Kimihiko Ito, Tadashi Kimura, Shoji Kamiura, Ken-ichirou Morishige. Efficacy of raloxifene hydrochloride for the prevention of health care problems in patients who undergo surgery for endometrial cancer: a multicenter randomized clinical trial.
International journal of gynecological cancer : official journal of the International Gynecological Cancer Society.
2015 Feb; 25(2):288-95. doi:
10.1097/igc.0000000000000333. [PMID: 25569817] - Nancy Formosa, John Torpiano, Jeremy Allgrove, Mehul T Dattani. Anticonvulsant treatment associated with intractable hypocalcaemia in a female child with hypoparathyroidism.
Hormone research in paediatrics.
2015; 83(1):62-6. doi:
10.1159/000365048. [PMID: 25227206] - Dorota Drożdż, Przemko Kwinta, Krystyna Sztefko, Katarzyna Zachwieja, Monika Miklaszewska, Tomasz Drożdż, Monika Łatka, Jacek A Pietrzyk. [Do we successfully treat anemia and calcium-phosphate disorders in children with chronic kidney disease at the beginning of the twenty-first century?].
Przeglad lekarski.
2015; 72(7):349-53. doi:
. [PMID: 26817347] - Ling-Xiao Chen, Zhi-Rui Zhou, Yu-Lin Li, Guang-Zhi Ning, Tian-Song Zhang, Di Zhang, Shi-Qing Feng. Comparison of Bone Mineral Density in Lumbar Spine and Fracture Rate among Eight Drugs in Treatments of Osteoporosis in Men: A Network Meta-Analysis.
PloS one.
2015; 10(5):e0128032. doi:
10.1371/journal.pone.0128032. [PMID: 26010450] - Daisuke Watanabe, Mari Hotta, Atsuhiro Ichihara. Osteomalacia, severe thoracic deformities and respiratory failure in a young woman with anorexia nervosa.
Internal medicine (Tokyo, Japan).
2015; 54(8):929-34. doi:
10.2169/internalmedicine.54.3673. [PMID: 25876575] - Lola S Abboskhujaeva, Saydiganikhodja I Ismailov, Nodira M Alikhanova. Efficacy of strontium ranelate in combination with a D-hormone analog for the treatment of postmenopausal osteoporosis.
Drugs in R&D.
2014 Dec; 14(4):315-24. doi:
10.1007/s40268-014-0069-1. [PMID: 25480348] - Lise Sofie Bislev, Tanja Sikjaer, Lars Rejnmark. Effects on calcium homeostasis of changing PTH replacement therapy of postoperative hypoparathyroidism from intact PTH to teriparatide: a case series.
Calcified tissue international.
2014 Oct; 95(4):374-81. doi:
10.1007/s00223-014-9898-8. [PMID: 25086672] - Toshiyuki Takano, Satoshi Kondo, Hitoshi Saito, Toshio Matsumoto. Relationship between the effect of eldecalcitol and serum 25(OH)D level.
The Journal of steroid biochemistry and molecular biology.
2014 Oct; 144 Pt A(?):124-7. doi:
10.1016/j.jsbmb.2013.11.005. [PMID: 24240066] - Ayako Shiraishi, Sadaoki Sakai, Hitoshi Saito, Fumiaki Takahashi. Eldecalcitol improves mechanical strength of cortical bones by stimulating the periosteal bone formation in the senescence-accelerated SAM/P6 mice - a comparison with alfacalcidol.
The Journal of steroid biochemistry and molecular biology.
2014 Oct; 144 Pt A(?):119-23. doi:
10.1016/j.jsbmb.2013.10.024. [PMID: 24189542] - Evangelina Charitaki, Andrew Davenport. Aortic pulse wave velocity in haemodialysis patients is associated with the prescription of active vitamin D analogues.
Journal of nephrology.
2014 Aug; 27(4):431-7. doi:
10.1007/s40620-014-0040-9. [PMID: 24473732] - Deepak Kumar Khajuria, Rema Razdan, Debiprosad Roy Mahapatra. Zoledronic acid in combination with alfacalcidol has additive effects on trabecular microarchitecture and mechanical properties in osteopenic ovariectomized rats.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association.
2014 Jul; 19(4):646-56. doi:
10.1007/s00776-014-0557-8. [PMID: 24668309] - Terumasa Ikeda, Kouichi Maruyama, Hiroshi Kaji, Masao Akagi. Effects of alendronate or alfacalcidol on bone metabolic indices and bone mineral density in patients with ophthalmologic disease treated with glucocorticoid.
Modern rheumatology.
2014 Jul; 24(4):671-6. doi:
10.3109/14397595.2013.860886. [PMID: 24313921] - Isabelle Normand, Naoual Elftouh, Louis-Philippe Laurin, Denis Ouimet, Hind Harrak, Jean-Philippe Lafrance. Association between vitamin D receptor activator and the risk of infection-related hospitalizations among incident hemodialysis patients: a nested case-control study.
Pharmacoepidemiology and drug safety.
2014 Mar; 23(3):261-7. doi:
10.1002/pds.3576. [PMID: 24470433] - Marc Vervloet. Clinical uses of 1-alpha-hydroxycholecalciferol.
Current vascular pharmacology.
2014 Mar; 12(2):300-5. doi:
10.2174/15701611113119990132. [PMID: 23713871] - Myriam Lessard, Denis Ouimet, Martine Leblanc, Annie-Claire Nadeau-Fredette, Robert Bell, Jean-Philippe Lafrance, Vincent Pichette, Michel Vallée. Comparison of oral and intravenous alfacalcidol in chronic hemodialysis patients.
BMC nephrology.
2014 Feb; 15(?):27. doi:
10.1186/1471-2369-15-27. [PMID: 24495277] - L Iu Milovanova, I A Dobrosmyslov, Iu S Milovanov. [Experience with active vitamin D metabolites in phosphorus-calcium metabolic disorders in patients with predialysis chronic kidney disease].
Terapevticheskii arkhiv.
2014; 86(6):52-6. doi:
NULL. [PMID: 25095656] - Yan Jiang, Zhen-Lin Zhang, Zhong-Lan Zhang, Han-Min Zhu, Yi-Yong Wu, Qun Cheng, Feng-Li Wu, Xiao-Ping Xing, Jian-Li Liu, Wei Yu, Xun-Wu Meng. Menatetrenone versus alfacalcidol in the treatment of Chinese postmenopausal women with osteoporosis: a multicenter, randomized, double-blinded, double-dummy, positive drug-controlled clinical trial.
Clinical interventions in aging.
2014; 9(?):121-7. doi:
10.2147/cia.s54107. [PMID: 24426779] - A M Puzikov. [Osteoporosis correction in experiment].
Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology.
2014; ?(2):25-31. doi:
. [PMID: 25518471] - Safwat A Ahmed, Mostafa K Mesbah, Diaa T Youssef, Sherief I Khalifa. Microbial production of 1α-hydroxyvitamin D3 from vitamin D3.
Natural product research.
2014; 28(7):444-8. doi:
10.1080/14786419.2013.872104. [PMID: 24456427] - Johnny Sayegh, Jean-François Augusto, Daniel Chappard, Paolo Insalaco, Jean-François Subra. A case of severe osteomalacia secondary to phosphate diabetes in a renal transplant recipient.
International urology and nephrology.
2013 Dec; 45(6):1795-9. doi:
10.1007/s11255-012-0283-0. [PMID: 22990413] - Sara Panizo, Sara Barrio-Vázquez, Manuel Naves-Díaz, Natalia Carrillo-López, Isabel Rodríguez, Amalia Fernández-Vázquez, Jose M Valdivielso, Ravi Thadhani, Jorge B Cannata-Andía. Vitamin D receptor activation, left ventricular hypertrophy and myocardial fibrosis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2013 Nov; 28(11):2735-44. doi:
10.1093/ndt/gft268. [PMID: 24013683] - Edwin C Y Chow, Matthew R Durk, Han-Joo Maeng, K Sandy Pang. Comparative effects of 1α-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 on transporters and enzymes in fxr(+/+) and fxr(-/-) mice.
Biopharmaceutics & drug disposition.
2013 Oct; 34(7):402-16. doi:
10.1002/bdd.1856. [PMID: 23897575] - Steve Y Rhieu, Andrew J Annalora, Guochun Wang, Caroline C Flarakos, Rose M Gathungu, Paul Vouros, Rita Sigüeiro, Antonio Mouriño, Inge Schuster, G Tayhas R Palmore, G Satyanarayana Reddy. Metabolic stability of 3-epi-1α,25-dihydroxyvitamin D3 over 1 α 25-dihydroxyvitamin D3: metabolism and molecular docking studies using rat CYP24A1.
Journal of cellular biochemistry.
2013 Oct; 114(10):2293-305. doi:
10.1002/jcb.24576. [PMID: 23606409] - Shunsuke Yamada, Kazuhiko Tsuruya, Hisako Yoshida, Masatomo Taniguchi, Naoki Haruyama, Shigeru Tanaka, Masahiro Eriguchi, Toshiaki Nakano, Takanari Kitazono. The clinical utility of serum tartrate-resistant acid phosphatase 5b in the assessment of bone resorption in patients on peritoneal dialysis.
Clinical endocrinology.
2013 Jun; 78(6):844-51. doi:
10.1111/cen.12070. [PMID: 23078546] - J D Ringe, P Farahmand, E Schacht. Alfacalcidol in men with osteoporosis: a prospective, observational, 2-year trial on 214 patients.
Rheumatology international.
2013 Mar; 33(3):637-43. doi:
10.1007/s00296-012-2429-x. [PMID: 22527138] - Seigo Hara, Koshi N Kishimoto, Hiroshi Okuno, Masahiko Tanaka, Hideo Saito, Akira Oizumi, Eiji Itoi. Effects of alfacalcidol on back extensor strength gained through back extensor exercise in postmenopausal women with osteoporosis.
American journal of physical medicine & rehabilitation.
2013 Feb; 92(2):101-10. doi:
10.1097/phm.0b013e31826ed991. [PMID: 23044701] - Abdulrazak Alghareeb, Alaa Sabry, Hassan Bawadekji, Khalid Alsaran. Intravenous alfacalcidol once versus twice or thrice weekly in hemodialysis patients.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2013 Feb; 17(1):30-4. doi:
10.1111/j.1744-9987.2012.01131.x. [PMID: 23379490] - Keisuke Nagasaki, Shuichi Tsuchiya, Akihiko Saitoh, Tsutomu Ogata, Maki Fukami. Neuromuscular symptoms in a patient with familial pseudohypoparathyroidism type Ib diagnosed by methylation-specific multiplex ligation-dependent probe amplification.
Endocrine journal.
2013; 60(2):231-6. doi:
10.1507/endocrj.ej12-0257. [PMID: 23095209] - Elizabeth A Bobeck, Katie M Meyer, Christian Helvig, Martin Petkovich, Mark E Cook. Sevelamer hydrochloride binds phosphate released from phytate in chicks fed 1α-hydroxy cholecalciferol.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
2013 Jan; 23(1):21-7. doi:
10.1053/j.jrn.2011.12.005. [PMID: 22406121] - Lydia Foucan, Jacques Ducros, Henri Merault. Vitamin D status in dark-skinned patients undergoing hemodialysis in a continually sunny country.
Journal of nephrology.
2012 Nov; 25(6):983-8. doi:
10.5301/jn.5000079. [PMID: 22252845] - Tetsuya Ogawa, Ai Kyono, Masayo Sato, Himiko Sugimoto, Kuniaki Otsuka, Kosaku Nitta. Vitamin D receptor agonist supplementation and suppression of inflammation may have advantage for all-cause mortality in hemodialysis patients.
Clinical and experimental nephrology.
2012 Oct; 16(5):779-85. doi:
10.1007/s10157-012-0626-2. [PMID: 22457088] - Per Ivarsen, Johan Vestergaard Povlsen, Kent Lodberg Christensen. Effect of alfacalcidol on cardiac function in patients with chronic kidney disease stage 4 and secondary hyperparathyroidism: a pilot study.
Scandinavian journal of urology and nephrology.
2012 Oct; 46(5):381-8. doi:
10.3109/00365599.2012.693131. [PMID: 22724916] - Hanne Skou Jørgensen, Simon Winther, Johan Vestergaard Povlsen, Per Ivarsen. Effect of vitamin-D analogue on albuminuria in patients with non-dialysed chronic kidney disease stage 4-5: a retrospective single center study.
BMC nephrology.
2012 Sep; 13(?):102. doi:
10.1186/1471-2369-13-102. [PMID: 22958603] - Subash Somalanka, Mysore K Phanish. Hyperparathyroidism in a renal transplant patient: an unusual cause of resistance to therapy.
BMJ case reports.
2012 Aug; 2012(?):. doi:
10.1136/bcr-2012-006463. [PMID: 22891023] - Tatsuo Suda, Fumiaki Takahashi, Naoyuki Takahashi. Bone effects of vitamin D - Discrepancies between in vivo and in vitro studies.
Archives of biochemistry and biophysics.
2012 Jul; 523(1):22-9. doi:
10.1016/j.abb.2011.11.011. [PMID: 22107950] - Ditte Hansen, Knud Rasmussen, Susanne M Pedersen, Lars M Rasmussen, Lisbet Brandi. Changes in fibroblast growth factor 23 during treatment of secondary hyperparathyroidism with alfacalcidol or paricalcitol.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Jun; 27(6):2263-9. doi:
10.1093/ndt/gfr668. [PMID: 22140123] - Richard S Fish, John Cunningham. FGF-23 and vitamin D: don't shoot the messenger?.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Jun; 27(6):2137-9. doi:
10.1093/ndt/gfs088. [PMID: 22523113] - Mariko Ogawa, Tetsuya Ogawa, Tomoko Inoue, Kuniaki Otsuka, Kosaku Nitta. Effect of alfacalcidol therapy on the survival of chronic hemodialysis patients.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2012 Jun; 16(3):248-53. doi:
10.1111/j.1744-9987.2012.01061.x. [PMID: 22607568] - Itsuo Gorai, Shin Hattori, Yaku Tanaka, Yasuhisa Iwaoki. Alfacalcidol-supplemented raloxifene therapy has greater bone-sparing effect than raloxifene-alone therapy in postmenopausal Japanese women with osteoporosis or osteopenia.
Journal of bone and mineral metabolism.
2012 May; 30(3):349-58. doi:
10.1007/s00774-011-0325-1. [PMID: 22130786] - Chwan-Li Shen, Christina Samathanam, Suzanne Graham, Raul Y Dagda, Ming-Chien Chyu, Dale M Dunn. Green tea polyphenols and 1-α-OH-vitamin D₃ attenuate chronic inflammation-induced myocardial fibrosis in female rats.
Journal of medicinal food.
2012 Mar; 15(3):269-77. doi:
10.1089/jmf.2011.0163. [PMID: 22181074] - Ditte Hansen. A randomised clinical study of alfacalcidol and paricalcitol.
Danish medical journal.
2012 Feb; 59(2):B4400. doi:
. [PMID: 22293059] - Pornpimol Rianthavorn, Kantima Pisutikul, Tawatchai Deekajorndech, Supatporn Tepmongkol, Kanya Suphapeetiporn. Prevention of bone loss in children receiving long-term glucocorticoids with calcium and alfacalcidol or menatetrenone.
Journal of pediatric endocrinology & metabolism : JPEM.
2012; 25(3-4):307-12. doi:
10.1515/jpem-2011-0441. [PMID: 22768661] - Rikako Hiramatsu, Yoshifumi Ubara, Tatsuya Suwabe, Keiichi Sumida, Noriko Hayami, Masayuki Yamanouchi, Koki Mise, Eiko Hasegawa, Junichi Hoshino, Naoki Sawa, Kenmei Takaichi. Osteomalacia and insufficiency fracture in a hemodialysis patient with autosomal dominant polycystic kidney disease.
Internal medicine (Tokyo, Japan).
2012; 51(23):3277-80. doi:
10.2169/internalmedicine.51.8109. [PMID: 23207124] - E Segal, I Hochberg, Y Weisman, S Ish-Shalom. Severe postpartum osteoporosis with increased PTHrP during lactation in a patient after total thyroidectomy and parathyroidectomy.
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA.
2011 Nov; 22(11):2907-11. doi:
10.1007/s00198-010-1515-8. [PMID: 21243337] - Rajiv Kumar. New clinical trials with vitamin D and analogs in renal disease.
Kidney international.
2011 Oct; 80(8):793-6. doi:
10.1038/ki.2011.260. [PMID: 21832981] - Ditte Hansen, Knud Rasmussen, Henning Danielsen, Helmut Meyer-Hofmann, Egidijus Bacevicius, Thomas G Lauridsen, Jens K Madsen, Birgitte G Tougaard, Peter Marckmann, Peter Thye-Roenn, Jørgen E Nielsen, Svend Kreiner, Lisbet Brandi. No difference between alfacalcidol and paricalcitol in the treatment of secondary hyperparathyroidism in hemodialysis patients: a randomized crossover trial.
Kidney international.
2011 Oct; 80(8):841-50. doi:
10.1038/ki.2011.226. [PMID: 21832979] - Naoyuki Iwamoto, Yutaka Inaba, Naomi Kobayashi, Takashi Ishida, Yohei Yukizawa, Tomoyuki Saito. A comparison of the effects of alendronate and alfacalcidol on bone mineral density around the femoral implant and in the lumbar spine after total hip arthroplasty.
The Journal of bone and joint surgery. American volume.
2011 Jul; 93(13):1203-9. doi:
10.2106/jbjs.i.01714. [PMID: 21776573] - Hajime Orimo, Toshitaka Nakamura, Masao Fukunaga, Hiroaki Ohta, Takayuki Hosoi, Yukari Uemura, Tatsuhiko Kuroda, Nobuaki Miyakawa, Yasuo Ohashi, Masataka Shiraki. Effects of alendronate plus alfacalcidol in osteoporosis patients with a high risk of fracture: the Japanese Osteoporosis Intervention Trial (JOINT) - 02.
Current medical research and opinion.
2011 Jun; 27(6):1273-84. doi:
10.1185/03007995.2011.580341. [PMID: 21554143] - Takayuki Hamano, Naohiko Fujii, Isao Matsui, Chikako Nakano, Kazunori Inoue, Kodo Tomida, Satoshi Mikami, Noriyuki Okada, Yoshiharu Tsubakihara, Hiromi Rakugi, Yoshitaka Isaka. Guideline-practice gap in the management of predialysis chronic kidney disease mineral bone disorder in Japan.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.
2011 Jun; 15 Suppl 1(?):2-8. doi:
10.1111/j.1744-9987.2011.00918.x. [PMID: 21595844] - Kraiwiporn Kiattisunthorn, Kittikarn Wutyam, Artit Indranoi, Somkiat Vasuvattakul. Randomized trial comparing pulse calcitriol and alfacalcidol for the treatment of secondary hyperparathyroidism in haemodialysis patients.
Nephrology (Carlton, Vic.).
2011 Mar; 16(3):277-84. doi:
10.1111/j.1440-1797.2010.01398.x. [PMID: 21342321] - J Testerink, H Degens, J Rittweger, A Shiraishi, R T Jaspers, A de Haan. Effects of alfacalcidol on the contractile properties of the gastrocnemius medialis muscle in adult and old rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2011 Feb; 62(1):111-8. doi:
NULL. [PMID: 21451216] - M Salgueira, A I Martínez, J A Milán. Regression of vascular calcification in a patient treated with cinacalcet: a case report.
Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia.
2011; 31(5):602-6. doi:
10.3265/nefrologia.pre2011.may.10869. [PMID: 21959728] - G Jean, D Lataillade, L Genet, E Legrand, F Kuentz, X Moreau-Gaudry, D Fouque. Impact of hypovitaminosis D and alfacalcidol therapy on survival of hemodialysis patients: results from the French ARNOS study.
Nephron. Clinical practice.
2011; 118(2):c204-10. doi:
10.1159/000321507. [PMID: 21178377] - Junko Okuno, Shigeo Tomura, Takako Fukasaku, Mi-Ji Kim, Tomohiro Okura, Kiyoji Tanaka, Hisako Yanagi. [Examination of effects of alfacalcidol vitamin D supplement and renal function on improvement in the physical fitness of pre-frail elderly persons attending a nursing care prevention class].
Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics.
2011; 48(6):691-8. doi:
10.3143/geriatrics.48.691. [PMID: 22322042] - James Fotheringham, Saba P Balasubramanian, Barney Harrison, Martin Wilkie. Post-parathyroidectomy parathyroid hormone levels: the impact on patient survival - a single-centre study in a stage 5 chronic kidney disease population.
Nephron. Clinical practice.
2011; 119(2):c113-20. doi:
10.1159/000326683. [PMID: 21757948]