Acipimox (BioDeep_00000610782)
代谢物信息卡片
化学式: C6H6N2O3 (154.03784059999998)
中文名称: 阿西莫司
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CN=C(C=[N+]1[O-])C(=O)O
InChI: InChI=1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10)
描述信息
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AD - Nicotinic acid and derivatives
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98151 - Niacin-based Antilipidemic Agent
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94688
- KEGGdrug: D07190
- PubChem: 5310993
- Metlin: METLIN787
- DrugBank: DB09055
- ChEMBL: CHEMBL345714
- CAS: 51037-30-0
- RefMet: Acipimox
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Claire McDonald, Craig Alderson, Matthew G Birkbeck, Laura Brown, Silvia Del Din, Grainne G Gorman, Kieren Hollingsworth, Clare Massarella, Rana Rehman, Lynn Rochester, Avan Ap Sayer, Huizhong Su, Helen Tuppen, Charlotte Warren, Miles D Witham. A study protocol to investigate if acipimox improves muscle function and sarcopenia: an open-label, uncontrolled, before-and-after experimental medicine feasibility study in community-dwelling older adults.
BMJ open.
2024 Feb; 14(2):e076518. doi:
10.1136/bmjopen-2023-076518
. [PMID: 38417968] - Marlou L Dirks, Tom S O Jameson, Rob C Andrews, Mandy V Dunlop, Doaa R Abdelrahman, Andrew J Murton, Benjamin T Wall, Francis B Stephens. The impact of forearm immobilization and acipimox administration on muscle amino acid metabolism and insulin sensitivity in healthy, young volunteers.
American journal of physiology. Endocrinology and metabolism.
2024 Jan; ?(?):. doi:
10.1152/ajpendo.00345.2023
. [PMID: 38231001] - Lin Wu, Weiyi Huang, Xiaoxiao Liu, Baochun Yang. Investigation of the clinical effects of acipimox in patients with vulnerable carotid atherosclerosis.
Vascular.
2023 Dec; 31(6):1201-1208. doi:
10.1177/17085381221112551
. [PMID: 35857037] - Xin Shen, Gaofu Li, Libin Wang, Huijin Yu, Lei Zhou, Huifang Deng, Ningning Wang, Chengcai Lai, Wei Zhou, Yue Gao. Quantification of Acipimox in Plasma and Tissues by LC-MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196413
. [PMID: 36234950] - Astrid J Hjelholt, Evelina Charidemou, Julian L Griffin, Steen B Pedersen, Anders Gudiksen, Henriette Pilegaard, Niels Jessen, Niels Møller, Jens O L Jørgensen. Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2 × 2 factorial, randomised, crossover study in human individuals.
Diabetologia.
2020 12; 63(12):2641-2653. doi:
10.1007/s00125-020-05262-w
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2020 11; 34(11):14878-14891. doi:
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Metabolism: clinical and experimental.
2020 04; 105(?):154188. doi:
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. [PMID: 32084431] - Aaron W Aday, Allison B Goldfine, Justin M Gregory, Joshua A Beckman. Impact of Acipimox Therapy on Free Fatty Acid Efflux and Endothelial Function in the Metabolic Syndrome: A Randomized Trial.
Obesity (Silver Spring, Md.).
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The international journal of cardiovascular imaging.
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. [PMID: 24384858] - B Lindegaard, S Ditlevsen, P Plomgaard, B Mittendorfer, B K Pedersen. Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin.
Diabetologia.
2013 Sep; 56(9):2034-43. doi:
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. [PMID: 23114833] - Kvido Smitka, Hana Papezova, Karel Vondra, Martin Hill, Vojtech Hainer, Jara Nedvidkova. Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women.
Regulatory peptides.
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Arteriosclerosis, thrombosis, and vascular biology.
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PloS one.
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Nutrition & metabolism.
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Regulatory peptides.
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