Acipimox (BioDeep_00000610782)
代谢物信息卡片
Acipimox
化学式: C6H6N2O3 (154.03784059999998)
中文名称: 阿西莫司
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CN=C(C=[N+]1[O-])C(=O)O
InChI: InChI=1S/C6H6N2O3/c1-4-2-7-5(6(9)10)3-8(4)11/h2-3H,1H3,(H,9,10)
描述信息
C - Cardiovascular system > C10 - Lipid modifying agents > C10A - Lipid modifying agents, plain > C10AD - Nicotinic acid and derivatives
C78276 - Agent Affecting Digestive System or Metabolism > C29703 - Antilipidemic Agent > C98151 - Niacin-based Antilipidemic Agent
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents
D009676 - Noxae > D000963 - Antimetabolites
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94688
- KEGGdrug: D07190
- PubChem: 5310993
- Metlin: METLIN787
- DrugBank: DB09055
- ChEMBL: CHEMBL345714
- CAS: 51037-30-0
- RefMet: Acipimox
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Claire McDonald, Craig Alderson, Matthew G Birkbeck, Laura Brown, Silvia Del Din, Grainne G Gorman, Kieren Hollingsworth, Clare Massarella, Rana Rehman, Lynn Rochester, Avan Ap Sayer, Huizhong Su, Helen Tuppen, Charlotte Warren, Miles D Witham. A study protocol to investigate if acipimox improves muscle function and sarcopenia: an open-label, uncontrolled, before-and-after experimental medicine feasibility study in community-dwelling older adults.
BMJ open.
2024 Feb; 14(2):e076518. doi:
10.1136/bmjopen-2023-076518. [PMID: 38417968] - Marlou L Dirks, Tom S O Jameson, Rob C Andrews, Mandy V Dunlop, Doaa R Abdelrahman, Andrew J Murton, Benjamin T Wall, Francis B Stephens. The impact of forearm immobilization and acipimox administration on muscle amino acid metabolism and insulin sensitivity in healthy, young volunteers.
American journal of physiology. Endocrinology and metabolism.
2024 Jan; ?(?):. doi:
10.1152/ajpendo.00345.2023. [PMID: 38231001] - Lin Wu, Weiyi Huang, Xiaoxiao Liu, Baochun Yang. Investigation of the clinical effects of acipimox in patients with vulnerable carotid atherosclerosis.
Vascular.
2023 Dec; 31(6):1201-1208. doi:
10.1177/17085381221112551. [PMID: 35857037] - Xin Shen, Gaofu Li, Libin Wang, Huijin Yu, Lei Zhou, Huifang Deng, Ningning Wang, Chengcai Lai, Wei Zhou, Yue Gao. Quantification of Acipimox in Plasma and Tissues by LC-MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia.
Molecules (Basel, Switzerland).
2022 Sep; 27(19):. doi:
10.3390/molecules27196413. [PMID: 36234950] - Astrid J Hjelholt, Evelina Charidemou, Julian L Griffin, Steen B Pedersen, Anders Gudiksen, Henriette Pilegaard, Niels Jessen, Niels Møller, Jens O L Jørgensen. Insulin resistance induced by growth hormone is linked to lipolysis and associated with suppressed pyruvate dehydrogenase activity in skeletal muscle: a 2 × 2 factorial, randomised, crossover study in human individuals.
Diabetologia.
2020 12; 63(12):2641-2653. doi:
10.1007/s00125-020-05262-w. [PMID: 32945898] - William D Watson, Kerstin N Timm, Andrew J Lewis, Jack J J Miller, Yaso Emmanuel, Kieran Clarke, Stefan Neubauer, Damian J Tyler, Oliver J Rider. Nicotinic acid receptor agonists impair myocardial contractility by energy starvation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 11; 34(11):14878-14891. doi:
10.1096/fj.202000084rr. [PMID: 32954525] - Astrid Johannesson Hjelholt, Esben Søndergaard, Steen Bønløkke Pedersen, Niels Møller, Niels Jessen, Jens Otto L Jørgensen. Growth hormone upregulates ANGPTL4 mRNA and suppresses lipoprotein lipase via fatty acids: Randomized experiments in human individuals.
Metabolism: clinical and experimental.
2020 04; 105(?):154188. doi:
10.1016/j.metabol.2020.154188. [PMID: 32084431] - Aaron W Aday, Allison B Goldfine, Justin M Gregory, Joshua A Beckman. Impact of Acipimox Therapy on Free Fatty Acid Efflux and Endothelial Function in the Metabolic Syndrome: A Randomized Trial.
Obesity (Silver Spring, Md.).
2019 11; 27(11):1812-1819. doi:
10.1002/oby.22602. [PMID: 31571412] - Henrik H Thomsen, Nikolaj Rittig, Mogens Johannsen, Andreas B Møller, Jens Otto Jørgensen, Niels Jessen, Niels Møller. Effects of 3-hydroxybutyrate and free fatty acids on muscle protein kinetics and signaling during LPS-induced inflammation in humans: anticatabolic impact of ketone bodies.
The American journal of clinical nutrition.
2018 10; 108(4):857-867. doi:
10.1093/ajcn/nqy170. [PMID: 30239561] - Dominique Hansen, Kenneth Verboven, Jan-Willem van Dijk, Antoine Zorenc, Lennert Minten, Kevin Smeets, Lex B Verdijk, Luc J C van Loon. Adipose tissue lipolytic inhibition enhances the glucoregulatory properties of exercise in type 2 diabetes patients.
European journal of sport science.
2018 Oct; 18(9):1245-1254. doi:
10.1080/17461391.2018.1483428. [PMID: 29938604] - C Salvador, A Entenmann, R Salvador, A Niederwanger, R Crazzolara, G Kropshofer. Combination therapy of omega-3 fatty acids and acipimox for children with hypertriglyceridemia and acute lymphoblastic leukemia.
Journal of clinical lipidology.
2018 Sep; 12(5):1260-1266. doi:
10.1016/j.jacl.2018.05.021. [PMID: 30055974] - Brenno Astiarraga, Valéria B Chueire, Aglécio L Souza, Ricardo Pereira-Moreira, Sarah Monte Alegre, Andrea Natali, Andrea Tura, Andrea Mari, Ele Ferrannini, Elza Muscelli. Effects of acute NEFA manipulation on incretin-induced insulin secretion in participants with and without type 2 diabetes.
Diabetologia.
2018 08; 61(8):1829-1837. doi:
10.1007/s00125-018-4633-z. [PMID: 29732475] - Esben Thyssen Vestergaard, Simon Lebech Cichosz, Niels Møller, Jens Otto Lunde Jørgensen, Jesper Fleischer. Short-term acipimox treatment is associated with decreased cardiac parasympathetic modulation.
British journal of clinical pharmacology.
2017 12; 83(12):2671-2677. doi:
10.1111/bcp.13384. [PMID: 28736944] - Seongjoon Park, Toshimitsu Komatsu, Sang Eun Kim, Katsuya Tanaka, Hiroko Hayashi, Ryoichi Mori, Isao Shimokawa. Neuropeptide Y resists excess loss of fat by lipolysis in calorie-restricted mice: a trait potential for the life-extending effect of calorie restriction.
Aging cell.
2017 04; 16(2):339-348. doi:
10.1111/acel.12558. [PMID: 28101970] - P Wolf, Y Winhofer, M Krssak, S Smajis, J Harreiter, L Kosi-Trebotic, C Fürnsinn, C-H Anderwald, S Baumgartner-Parzer, S Trattnig, A Luger, M Krebs. Suppression of plasma free fatty acids reduces myocardial lipid content and systolic function in type 2 diabetes.
Nutrition, metabolism, and cardiovascular diseases : NMCD.
2016 05; 26(5):387-92. doi:
10.1016/j.numecd.2016.03.012. [PMID: 27118107] - Hideo Makimura, Takara L Stanley, Caroline Suresh, Ana Luisa De Sousa-Coelho, Walter R Frontera, Stephanie Syu, Laurie R Braun, Sara E Looby, Meghan N Feldpausch, Martin Torriani, Hang Lee, Mary-Elizabeth Patti, Steven K Grinspoon. Metabolic Effects of Long-Term Reduction in Free Fatty Acids With Acipimox in Obesity: A Randomized Trial.
The Journal of clinical endocrinology and metabolism.
2016 Mar; 101(3):1123-33. doi:
10.1210/jc.2015-3696. [PMID: 26691888] - Aurora Merovci, Muhammad Abdul-Ghani, Andrea Mari, Carolina Solis-Herrera, Juan Xiong, Giuseppe Daniele, Devjit Tripathy, Ralph A DeFronzo. Effect of Dapagliflozin With and Without Acipimox on Insulin Sensitivity and Insulin Secretion in T2DM Males.
The Journal of clinical endocrinology and metabolism.
2016 Mar; 101(3):1249-56. doi:
10.1210/jc.2015-2597. [PMID: 26765576] - A Salerno, G Fragasso, A Esposito, T Canu, G Lattuada, G Manzoni, A Del Maschio, A Margonato, F De Cobelli, G Perseghin. Effects of short-term manipulation of serum FFA concentrations on left ventricular energy metabolism and function in patients with heart failure: no association with circulating bio-markers of inflammation.
Acta diabetologica.
2015 Aug; 52(4):753-61. doi:
10.1007/s00592-014-0695-7. [PMID: 25559351] - Tineke van de Weijer, Esther Phielix, Lena Bilet, Evan G Williams, Eduardo R Ropelle, Alessandra Bierwagen, Roshan Livingstone, Peter Nowotny, Lauren M Sparks, Sabina Paglialunga, Julia Szendroedi, Bas Havekes, Norman Moullan, Eija Pirinen, Jong-Hee Hwang, Vera B Schrauwen-Hinderling, Matthijs K C Hesselink, Johan Auwerx, Michael Roden, Patrick Schrauwen. Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.
Diabetes.
2015 Apr; 64(4):1193-201. doi:
10.2337/db14-0667. [PMID: 25352640] - Giuseppe Daniele, Roy Eldor, Aurora Merovci, Geoffrey D Clarke, Juan Xiong, Devjit Tripathy, Anna Taranova, Muhammad Abdul-Ghani, Ralph A DeFronzo. Chronic reduction of plasma free fatty acid improves mitochondrial function and whole-body insulin sensitivity in obese and type 2 diabetic individuals.
Diabetes.
2014 Aug; 63(8):2812-20. doi:
10.2337/db13-1130. [PMID: 24353180] - Birgitte Nellemann, Esben Søndergaard, Jørgen Jensen, Steen Bønløkke Pedersen, Niels Jessen, Jens Otto Lunde Jørgensen, Søren Nielsen. Kinetics and utilization of lipid sources during acute exercise and acipimox.
American journal of physiology. Endocrinology and metabolism.
2014 Jul; 307(2):E199-208. doi:
10.1152/ajpendo.00043.2014. [PMID: 24895285] - Indrani Sinha-Hikim, Theodore C Friedman, Chang-Sung Shin, Desean Lee, Rasheed Ivey, Amiya P Sinha-Hikim. Nicotine in combination with a high-fat diet causes intramyocellular mitochondrial abnormalities in male mice.
Endocrinology.
2014 Mar; 155(3):865-72. doi:
10.1210/en.2013-1795. [PMID: 24424058] - Fatiha Maskali, Sylvain Poussier, Huguette Louis, Henri Boutley, Mickael Lhuillier, Simon N Thornton, Gilles Karcher, Patrick Lacolley, Pierre Y Marie. Assessment of the early stage of cardiac remodeling of spontaneously hypertensive heart failure rats using the quantitative 3-dimensional analysis provided by acipimox-enhanced FDG-PET.
The international journal of cardiovascular imaging.
2014 Feb; 30(2):449-56. doi:
10.1007/s10554-013-0350-3. [PMID: 24384858] - B Lindegaard, S Ditlevsen, P Plomgaard, B Mittendorfer, B K Pedersen. Acute reduction of lipolysis reduces adiponectin and IL-18: evidence from an intervention study with acipimox and insulin.
Diabetologia.
2013 Sep; 56(9):2034-43. doi:
10.1007/s00125-013-2964-3. [PMID: 23811808] - Hanyu Liang, Puntip Tantiwong, Apiradee Sriwijitkamol, Karthigayan Shanmugasundaram, Sumathy Mohan, Sara Espinoza, Ralph A Defronzo, John J Dubé, Nicolas Musi. Effect of a sustained reduction in plasma free fatty acid concentration on insulin signalling and inflammation in skeletal muscle from human subjects.
The Journal of physiology.
2013 Jun; 591(11):2897-909. doi:
10.1113/jphysiol.2012.247510. [PMID: 23529132] - Hermann Zbinden-Foncea, Luc J C van Loon, Jean-Marc Raymackers, Marc Francaux, Louise Deldicque. Contribution of nonesterified fatty acids to mitogen-activated protein kinase activation in human skeletal muscle during endurance exercise.
International journal of sport nutrition and exercise metabolism.
2013 Jun; 23(3):201-9. doi:
10.1123/ijsnem.23.3.201. [PMID: 23114833] - Kvido Smitka, Hana Papezova, Karel Vondra, Martin Hill, Vojtech Hainer, Jara Nedvidkova. Short-term exercise combined with Acipimox administration induces an increase in plasma ACTH and its subsequent fall in the recovery phase in bulimic women.
Regulatory peptides.
2013 Mar; 182(?):45-52. doi:
10.1016/j.regpep.2012.12.010. [PMID: 23318497] - J Huang, R Chen, C Wei, R Li, G Yuan, X Liu, B Wang, R Guo. Pharmacokinetics and bioequivalence evaluation of two acipimox tablets: a single-dose, randomized-sequence, two-way crossover study in healthy Chinese male volunteers.
Drug research.
2013 Feb; 63(2):79-83. doi:
10.1055/s-0032-1333228. [PMID: 23447078] - Feipeng Jin, Sihua Jiang, Dachun Yang, Xingmei Zhang, Yun Yang, Yan Zhang, Kun Li, Yongjian Yang, Shuangtao Ma. Acipimox attenuates atherosclerosis and enhances plaque stability in ApoE-deficient mice fed a palmitate-rich diet.
Biochemical and biophysical research communications.
2012 Nov; 428(1):86-92. doi:
10.1016/j.bbrc.2012.10.011. [PMID: 23058919] - Ferdinand Roelfsema, Hanno Pijl, Daniel M Keenan, Johannes D Veldhuis. Diminished adrenal sensitivity and ACTH efficacy in obese premenopausal women.
European journal of endocrinology.
2012 Nov; 167(5):633-42. doi:
10.1530/eje-12-0592. [PMID: 22909443] - Hanna-Riikka Lehto, Jussi Pärkkä, Ronald Borra, Helena Tuunanen, Virva Lepomaki, Riitta Parkkola, Juhani Knuuti, Pirjo Nuutila, Patricia Iozzo. Effects of acute and one-week fatty acid lowering on cardiac function and insulin sensitivity in relation with myocardial and muscle fat and adiponectin levels.
The Journal of clinical endocrinology and metabolism.
2012 Sep; 97(9):3277-84. doi:
10.1210/jc.2012-1219. [PMID: 22761459] - Paramita M Ghosh, Zhen-Ju Shu, Bing Zhu, Zhongding Lu, Yuji Ikeno, Jeffrey L Barnes, Chih-Ko Yeh, Bin-Xian Zhang, Michael S Katz, Amrita Kamat. Role of β-adrenergic receptors in regulation of hepatic fat accumulation during aging.
The Journal of endocrinology.
2012 Jun; 213(3):251-61. doi:
10.1530/joe-11-0406. [PMID: 22457517] - Sergey Lupachyk, Pierre Watcho, Nailia Hasanova, Ulrich Julius, Irina G Obrosova. Triglyceride, nonesterified fatty acids, and prediabetic neuropathy: role for oxidative-nitrosative stress.
Free radical biology & medicine.
2012 Apr; 52(8):1255-63. doi:
10.1016/j.freeradbiomed.2012.01.029. [PMID: 22366714] - Janet E Digby, Fernando Martinez, Andrew Jefferson, Neil Ruparelia, Joshua Chai, Malgorzata Wamil, David R Greaves, Robin P Choudhury. Anti-inflammatory effects of nicotinic acid in human monocytes are mediated by GPR109A dependent mechanisms.
Arteriosclerosis, thrombosis, and vascular biology.
2012 Mar; 32(3):669-76. doi:
10.1161/atvbaha.111.241836. [PMID: 22267479] - Clare Stradling, Yen-Fu Chen, Tracy Russell, Martin Connock, G Neil Thomas, Shahrad Taheri. The effects of dietary intervention on HIV dyslipidaemia: a systematic review and meta-analysis.
PloS one.
2012; 7(6):e38121. doi:
10.1371/journal.pone.0038121. [PMID: 22701607] - Kvido Smitka, Hana Papezova, Karel Vondra, Martin Hill, Vojtech Hainer, Jara Nedvidkova. A higher response of plasma neuropeptide Y, growth hormone, leptin levels and extracellular glycerol levels in subcutaneous abdominal adipose tissue to Acipimox during exercise in patients with bulimia nervosa: single-blind, randomized, microdialysis study.
Nutrition & metabolism.
2011 Nov; 8(1):81. doi:
10.1186/1743-7075-8-81. [PMID: 22093818] - Neerja Puri. A study of pathogenesis of acanthosis nigricans and its clinical implications.
Indian journal of dermatology.
2011 Nov; 56(6):678-83. doi:
10.4103/0019-5154.91828. [PMID: 22345770] - Ee L Lim, Kieren G Hollingsworth, Fiona E Smith, Peter E Thelwall, Roy Taylor. Inhibition of lipolysis in Type 2 diabetes normalizes glucose disposal without change in muscle glycogen synthesis rates.
Clinical science (London, England : 1979).
2011 Aug; 121(4):169-77. doi:
10.1042/cs20100611. [PMID: 21388348] - Shuangtao Ma, Dachun Yang, De Li, Bing Tang, Yongjian Yang. Oleic acid induces smooth muscle foam cell formation and enhances atherosclerotic lesion development via CD36.
Lipids in health and disease.
2011 Apr; 10(?):53. doi:
10.1186/1476-511x-10-53. [PMID: 21486455] - Fabrizio Montecucco, Maria Bertolotto, Nicolas Vuilleumier, Ulisse Franciosi, Alessandra Puddu, Silvia Minetti, Andrea Delrio, Alessandra Quercioli, Ettore Bergamini, Luciano Ottonello, Aldo Pende, Sébastien Lenglet, Graziano Pelli, François Mach, Franco Dallegri, Giorgio Luciano Viviani. Acipimox reduces circulating levels of insulin and associated neutrophilic inflammation in metabolic syndrome.
American journal of physiology. Endocrinology and metabolism.
2011 Apr; 300(4):E681-90. doi:
10.1152/ajpendo.00527.2010. [PMID: 21266669] - Pascal P H Hommelberg, Jogchum Plat, Lauren M Sparks, Annemie M W J Schols, Anon L M van Essen, Marco C J M Kelders, Denis van Beurden, Ronald P Mensink, Ramon C J Langen. Palmitate-induced skeletal muscle insulin resistance does not require NF-κB activation.
Cellular and molecular life sciences : CMLS.
2011 Apr; 68(7):1215-25. doi:
10.1007/s00018-010-0515-3. [PMID: 20820848] - Marlieke Visser, Mariska Davids, Hein J Verberne, Wouter E M Kok, Hans W M Niessen, Lenny M W van Venrooij, Riccardo Cocchieri, Willem Wisselink, Bas A J M de Mol, Paul A M van Leeuwen. Rationale and design of a proof-of-concept trial investigating the effect of uninterrupted perioperative (par)enteral nutrition on amino acid profile, cardiomyocytes structure, and cardiac perfusion and metabolism of patients undergoing coronary artery bypass grafting.
Journal of cardiothoracic surgery.
2011 Mar; 6(?):36. doi:
10.1186/1749-8090-6-36. [PMID: 21439030] - Changting Xiao, Adria Giacca, Gary F Lewis. Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans.
Diabetes.
2011 Mar; 60(3):918-24. doi:
10.2337/db10-1433. [PMID: 21270237] - Jara Nedvidkova, Kvido Smitka, Hana Papezova, Karel Vondra, Martin Hill, Vojtech Hainer. Acipimox during exercise points to an inhibitory feedback of GH on ghrelin secretion in bulimic and healthy women.
Regulatory peptides.
2011 Feb; 167(1):134-9. doi:
10.1016/j.regpep.2010.12.012. [PMID: 21237212] - Changting Xiao, Mirjana Pavlic, Linda Szeto, Bruce W Patterson, Gary F Lewis. Effects of acute hyperglucagonemia on hepatic and intestinal lipoprotein production and clearance in healthy humans.
Diabetes.
2011 Feb; 60(2):383-90. doi:
10.2337/db10-0763. [PMID: 20980459] - Christine Ahlström, Lambertus A Peletier, Rasmus Jansson-Löfmark, Johan Gabrielsson. Feedback modeling of non-esterified fatty acids in rats after nicotinic acid infusions.
Journal of pharmacokinetics and pharmacodynamics.
2011 Feb; 38(1):1-24. doi:
10.1007/s10928-010-9172-2. [PMID: 21046209] - Helen Vosper. Extended release niacin-laropiprant in patients with hypercholesterolemia or mixed dyslipidemias improves clinical parameters.
Clinical Medicine Insights. Cardiology.
2011; 5(?):85-101. doi:
10.4137/cmc.s7601. [PMID: 22084607] - Christian Herder, Wouter Peeters, Thomas Illig, Jens Baumert, Dominique P V de Kleijn, Frans L Moll, Ulrike Poschen, Norman Klopp, Martina Müller-Nurasyid, Michael Roden, Michael Preuss, Mahir Karakas, Christa Meisinger, Barbara Thorand, Gerard Pasterkamp, Wolfgang Koenig, Themistocles L Assimes, Panos Deloukas, Jeanette Erdmann, Hilma Holm, Sekar Kathiresan, Inke R König, Ruth McPherson, Muredach P Reilly, Robert Roberts, Nilesh J Samani, Heribert Schunkert, Alexandre F R Stewart. RANTES/CCL5 and risk for coronary events: results from the MONICA/KORA Augsburg case-cohort, Athero-Express and CARDIoGRAM studies.
PloS one.
2011; 6(12):e25734. doi:
10.1371/journal.pone.0025734. [PMID: 22162987] - Thomas Galbo, Grith Skytte Olsen, Bjørn Quistorff, Erica Nishimura. Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism.
PloS one.
2011; 6(11):e27424. doi:
10.1371/journal.pone.0027424. [PMID: 22087313] - Archana Vijayakumar, Shoshana Yakar, Derek Leroith. The intricate role of growth hormone in metabolism.
Frontiers in endocrinology.
2011; 2(?):32. doi:
10.3389/fendo.2011.00032. [PMID: 22654802] - Mei Jun Chen, Ana Jovanovic, Roy Taylor. Utilizing the second-meal effect in type 2 diabetes: practical use of a soya-yogurt snack.
Diabetes care.
2010 Dec; 33(12):2552-4. doi:
10.2337/dc10-0552. [PMID: 21115766] - Mads Halbirk, Helene Nørrelund, Niels Møller, Ole Schmitz, Liv Gøtzsche, Roni Nielsen, Jens Erik Nielsen-Kudsk, Søren Steen Nielsen, Torsten Toftegaard Nielsen, Hans Eiskjær, Hans Erik Bøtker, Henrik Wiggers. Suppression of circulating free fatty acids with acipimox in chronic heart failure patients changes whole body metabolism but does not affect cardiac function.
American journal of physiology. Heart and circulatory physiology.
2010 Oct; 299(4):H1220-5. doi:
10.1152/ajpheart.00475.2010. [PMID: 20709866] - Rajagopal V Sekhar, Ashok Balasubramanyam. Treatment of dyslipidemia in HIV-infected patients.
Expert opinion on pharmacotherapy.
2010 Aug; 11(11):1845-54. doi:
10.1517/14656566.2010.487484. [PMID: 20486828] - R A DeFronzo. Insulin resistance, lipotoxicity, type 2 diabetes and atherosclerosis: the missing links. The Claude Bernard Lecture 2009.
Diabetologia.
2010 Jul; 53(7):1270-87. doi:
10.1007/s00125-010-1684-1. [PMID: 20361178] - Paola Lucidi, Paolo Rossetti, Francesca Porcellati, Simone Pampanelli, Paola Candeloro, Anna Marinelli Andreoli, Gabriele Perriello, Geremia B Bolli, Carmine G Fanelli. Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis.
Diabetes.
2010 Jun; 59(6):1349-57. doi:
10.2337/db09-0745. [PMID: 20299466] - Stella M Daniele, Silvana M Montenegro, María C Tarres, Juan C Picena, Stella M Martinez. The eSS rat, a nonobese model of disordered glucose and lipid metabolism and fatty liver.
Diabetology & metabolic syndrome.
2010 Mar; 2(?):15. doi:
10.1186/1758-5996-2-15. [PMID: 20236525] - Mirjana Pavlic, Changting Xiao, Linda Szeto, Bruce W Patterson, Gary F Lewis. Insulin acutely inhibits intestinal lipoprotein secretion in humans in part by suppressing plasma free fatty acids.
Diabetes.
2010 Mar; 59(3):580-7. doi:
10.2337/db09-1297. [PMID: 20028946] - C Stefanutti, G D'Alessandri, G Russi, G De Silvestro, M G Zenti, P Marson, D Belotherkovsky, A Vivenzio, S Di Giacomo. Treatment of symptomatic HyperLp(a)lipoproteinemia with LDL-apheresis: a multicentre study.
Atherosclerosis. Supplements.
2009 Dec; 10(5):89-94. doi:
10.1016/s1567-5688(09)71819-7. [PMID: 20129383] - Wen Guo, Siu Wong, Jeffrey Pudney, Ravi Jasuja, Ning Hua, Lan Jiang, Andrew Miller, Paul W Hruz, James A Hamilton, Shalender Bhasin. Acipimox, an inhibitor of lipolysis, attenuates atherogenesis in LDLR-null mice treated with HIV protease inhibitor ritonavir.
Arteriosclerosis, thrombosis, and vascular biology.
2009 Dec; 29(12):2028-32. doi:
10.1161/atvbaha.109.191304. [PMID: 19762785] - Ana Jovanovic, Jean Gerrard, Roy Taylor. The second-meal phenomenon in type 2 diabetes.
Diabetes care.
2009 Jul; 32(7):1199-201. doi:
10.2337/dc08-2196. [PMID: 19366973] - Ralph A Defronzo. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitus.
Diabetes.
2009 Apr; 58(4):773-95. doi:
10.2337/db09-9028. [PMID: 19336687] - John A Babraj, Niels B J Vollaard, Cameron Keast, Fergus M Guppy, Greg Cottrell, James A Timmons. Extremely short duration high intensity interval training substantially improves insulin action in young healthy males.
BMC endocrine disorders.
2009 Jan; 9(?):3. doi:
10.1186/1472-6823-9-3. [PMID: 19175906] - Andreas L Birkenfeld, Petra Budziarek, Michael Boschmann, Cedric Moro, Frauke Adams, Gabriele Franke, Michel Berlan, Marie A Marques, Fred C G J Sweep, Friedrich C Luft, Max Lafontan, Jens Jordan. Atrial natriuretic peptide induces postprandial lipid oxidation in humans.
Diabetes.
2008 Dec; 57(12):3199-204. doi:
10.2337/db08-0649. [PMID: 18835931] - Sebastiaan Hammer, Rutger W van der Meer, Hildo J Lamb, Hans H de Boer, Jeroen J Bax, Albert de Roos, Johannes A Romijn, Johannes W A Smit. Short-term flexibility of myocardial triglycerides and diastolic function in patients with type 2 diabetes mellitus.
American journal of physiology. Endocrinology and metabolism.
2008 Sep; 295(3):E714-8. doi:
10.1152/ajpendo.90413.2008. [PMID: 18628354] - C J Zuurbier, H B Van Wezel. Glucose-insulin therapy, plasma substrate levels and cardiac recovery after cardiac ischemic events.
Cardiovascular drugs and therapy.
2008 Apr; 22(2):125-31. doi:
10.1007/s10557-008-6087-x. [PMID: 18266096] - L C Gormsen, J Gjedsted, S Gjedde, H Nørrelund, J S Christiansen, O Schmitz, J O L Jørgensen, N Møller. Dose-response effects of free fatty acids on amino acid metabolism and ureagenesis.
Acta physiologica (Oxford, England).
2008 Mar; 192(3):369-79. doi:
10.1111/j.1748-1716.2007.01771.x. [PMID: 17973949] - Klaus Eisendle, Dennis Linder, Gudrun Ratzinger, Bernhard Zelger, Wolfgang Philipp, Hildegunde Piza, Peter Fritsch, Matthias Schmuth. Inflammation and lipid accumulation in xanthoma disseminatum: Therapeutic considerations.
Journal of the American Academy of Dermatology.
2008 Feb; 58(2 Suppl):S47-9. doi:
10.1016/j.jaad.2006.05.032. [PMID: 18191707] - Marcio C Mancini, Alfredo Halpern. Orlistat in the prevention of diabetes in the obese patient.
Vascular health and risk management.
2008; 4(2):325-36. doi:
10.2147/vhrm.s6808. [PMID: 18561508] - Ester Carballo-Jane, Lynn S Gerckens, Silvi Luell, Allison S Parlapiano, Michael Wolff, Steven L Colletti, James R Tata, Andrew K P Taggart, M Gerard Waters, Jeremy G Richman, Margaret E McCann, Michael J Forrest. Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.
Journal of pharmacological and toxicological methods.
2007 Nov; 56(3):308-16. doi:
10.1016/j.vascn.2007.05.007. [PMID: 17643322] - J H N Lindeman, H Pijl, K Toet, P H C Eilers, B van Ramshorst, M M Buijs, J H van Bockel, T Kooistra. Human visceral adipose tissue and the plasminogen activator inhibitor type 1.
International journal of obesity (2005).
2007 Nov; 31(11):1671-9. doi:
10.1038/sj.ijo.0803650. [PMID: 17471294] - Georgios Arsos, Leo Weijs, Marie de Haas, Evelyn de Vrey, John de Klerk. Intense [18F]FDG tongue uptake in a case of acipimox-related angio-oedema during FDG-PET myocardial viability study.
European journal of nuclear medicine and molecular imaging.
2007 Aug; 34(8):1320-1. doi:
10.1007/s00259-007-0468-4. [PMID: 17546455] - Birgitte Lindegaard, Christian Frøsig, Anne Marie W Petersen, Peter Plomgaard, Susanne Ditlevsen, Bettina Mittendorfer, Gerrit Van Hall, Jørgen F P Wojtaszewski, Bente K Pedersen. Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy.
Diabetes.
2007 Aug; 56(8):2070-7. doi:
10.2337/db07-0144. [PMID: 17601993] - Kenneth Cusi, Sangeeta Kashyap, Amalia Gastaldelli, Mandeep Bajaj, Eugenio Cersosimo. Effects on insulin secretion and insulin action of a 48-h reduction of plasma free fatty acids with acipimox in nondiabetic subjects genetically predisposed to type 2 diabetes.
American journal of physiology. Endocrinology and metabolism.
2007 Jun; 292(6):E1775-81. doi:
10.1152/ajpendo.00624.2006. [PMID: 17299078] - L C Gormsen, N Jessen, J Gjedsted, S Gjedde, H Nørrelund, S Lund, J S Christiansen, S Nielsen, O Schmitz, N Møller. Dose-response effects of free fatty acids on glucose and lipid metabolism during somatostatin blockade of growth hormone and insulin in humans.
The Journal of clinical endocrinology and metabolism.
2007 May; 92(5):1834-42. doi:
10.1210/jc.2006-2659. [PMID: 17341555] - M J Serlie, A J Meijer, J E Groener, M Duran, E Endert, E Fliers, J M Aerts, H P Sauerwein. Short-term manipulation of plasma free fatty acids does not change skeletal muscle concentrations of ceramide and glucosylceramide in lean and overweight subjects.
The Journal of clinical endocrinology and metabolism.
2007 Apr; 92(4):1524-9. doi:
10.1210/jc.2006-2347. [PMID: 17264178] - Rebecca J Tunstall, Andrew J McAinch, Mark Hargreaves, Luc J C van Loon, David Cameron-Smith. Reduced plasma free fatty acid availability during exercise: effect on gene expression.
European journal of applied physiology.
2007 Mar; 99(5):485-93. doi:
10.1007/s00421-006-0376-5. [PMID: 17186295] - Mandeep Bajaj, Rafael Medina-Navarro, Swangjit Suraamornkul, Christian Meyer, Ralph A DeFronzo, Lawrence J Mandarino. Paradoxical changes in muscle gene expression in insulin-resistant subjects after sustained reduction in plasma free fatty acid concentration.
Diabetes.
2007 Mar; 56(3):743-52. doi:
10.2337/db06-0840. [PMID: 17327445] - Morten B Krag, Lars C Gormsen, Zengkui Guo, Jens S Christiansen, Michael D Jensen, Søren Nielsen, Jens O L Jørgensen. Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDL-triglyceride kinetics.
American journal of physiology. Endocrinology and metabolism.
2007 Mar; 292(3):E920-7. doi:
10.1152/ajpendo.00374.2006. [PMID: 17132823] - M H Vickers, P L Hofman, P D Gluckman, P E Lobie, W S Cutfield. Combination therapy with acipimox enhances the effect of growth hormone treatment on linear body growth in the normal and small-for-gestational-age rat.
American journal of physiology. Endocrinology and metabolism.
2006 Dec; 291(6):E1212-9. doi:
10.1152/ajpendo.00614.2005. [PMID: 16803850] - Helena Tuunanen, Erik Engblom, Alexandru Naum, Kjell Någren, Birger Hesse, K E Juhani Airaksinen, Pirjo Nuutila, Patricia Iozzo, Heikki Ukkonen, Lionel H Opie, Juhani Knuuti. Free fatty acid depletion acutely decreases cardiac work and efficiency in cardiomyopathic heart failure.
Circulation.
2006 Nov; 114(20):2130-7. doi:
10.1161/circulationaha.106.645184. [PMID: 17088453] - Colleen Hadigan, James Liebau, Martin Torriani, Rebecca Andersen, Steven Grinspoon. Improved triglycerides and insulin sensitivity with 3 months of acipimox in human immunodeficiency virus-infected patients with hypertriglyceridemia.
The Journal of clinical endocrinology and metabolism.
2006 Nov; 91(11):4438-44. doi:
10.1210/jc.2006-1174. [PMID: 16940448] - Karen L Sweazea, John P McMurtry, Eldon J Braun. Inhibition of lipolysis does not affect insulin sensitivity to glucose uptake in the mourning dove.
Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.
2006 Jul; 144(3):387-94. doi:
10.1016/j.cbpb.2006.04.009. [PMID: 16753324] - Lars C Gormsen, Jakob Gjedsted, Signe Gjedde, Esben Thyssen Vestergaard, Jens S Christiansen, Jens Otto Jørgensen, Søren Nielsen, Niels Møller. Free fatty acids decrease circulating ghrelin concentrations in humans.
European journal of endocrinology.
2006 May; 154(5):667-73. doi:
10.1530/eje.1.02146. [PMID: 16645013] - R D Kurbanov, A B Shek, N F Tashkenbaeva. [Effects of atorvastatin and acipimox on the lipid spectrum of blood plasma, endothelial function and a clinical course of unstable angina pectoris].
Terapevticheskii arkhiv.
2006; 78(8):38-41. doi:
NULL. [PMID: 17078215] - Peter E Carey, Jean Gerrard, Gary W Cline, Chiara Dalla Man, Philip T English, Michael J Firbank, Claudio Cobelli, Roy Taylor. Acute inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production.
American journal of physiology. Endocrinology and metabolism.
2005 Dec; 289(6):E941-7. doi:
10.1152/ajpendo.00195.2005. [PMID: 15998660] - Mandeep Bajaj, Swangjit Suraamornkul, Anthony Romanelli, Gary W Cline, Lawrence J Mandarino, Gerald I Shulman, Ralph A DeFronzo. Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients.
Diabetes.
2005 Nov; 54(11):3148-53. doi:
10.2337/diabetes.54.11.3148. [PMID: 16249438] - E T Vestergaard, T K Hansen, S Nielsen, N Moller, J S Christiansen, J O L Jorgensen. Effects of GH replacement therapy in adults on serum levels of leptin and ghrelin: the role of lipolysis.
European journal of endocrinology.
2005 Oct; 153(4):545-9. doi:
10.1530/eje.1.02000. [PMID: 16189176] - L J C van Loon, R J F Manders, R Koopman, B Kaastra, J H C H Stegen, A P Gijsen, W H M Saris, H A Keizer. Inhibition of adipose tissue lipolysis increases intramuscular lipid use in type 2 diabetic patients.
Diabetologia.
2005 Oct; 48(10):2097-107. doi:
10.1007/s00125-005-1889-x. [PMID: 16096823] - Luc J C van Loon, Michaela Thomason-Hughes, Dumitru Constantin-Teodosiu, René Koopman, Paul L Greenhaff, D Grahame Hardie, Hans A Keizer, Wim H M Saris, Anton J M Wagenmakers. Inhibition of adipose tissue lipolysis increases intramuscular lipid and glycogen use in vivo in humans.
American journal of physiology. Endocrinology and metabolism.
2005 Sep; 289(3):E482-93. doi:
10.1152/ajpendo.00092.2005. [PMID: 15886227] - Xing-gang Yang, Shu-fang Nie, Hai-jiao Bai, Guo-jua Zhang, Wei-san Pan. [The pharmacokinetics and bioequivalence of acipimox sustained-release tablets after a single and multiple oral administration in healthy dogs].
Yao xue xue bao = Acta pharmaceutica Sinica.
2005 May; 40(5):457-61. doi:
NULL. [PMID: 16220793] - Chamindie Punyadeera, Antoine H G Zorenc, René Koopman, Andrew J McAinch, Egbert Smit, Ralph Manders, Hans A Keizer, David Cameron-Smith, Luc J C van Loon. The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle.
European journal of endocrinology.
2005 Mar; 152(3):427-36. doi:
10.1530/eje.1.01872. [PMID: 15757860] - R P F Dullaart, S C Riemens, J R Meinardi, B H R Wolffenbuttel, W J Sluiter. Plasma adiponectin is modestly decreased during 24-hour insulin infusion but not after inhibition of lipolysis by Acipimox.
Scandinavian journal of clinical and laboratory investigation.
2005; 65(6):523-31. doi:
10.1080/00365510500209090. [PMID: 16179286] - Petra Kok, Simon W Kok, Madelon M Buijs, Jos J M Westenberg, Ferdinand Roelfsema, Marijke Frölich, Marcel P M Stokkel, A Edo Meinders, Hanno Pijl. Enhanced circadian ACTH release in obese premenopausal women: reversal by short-term acipimox treatment.
American journal of physiology. Endocrinology and metabolism.
2004 Nov; 287(5):E848-56. doi:
10.1152/ajpendo.00254.2004. [PMID: 15280154] - Huynh van Thien, G J Weverling, M T Ackermans, Nguyen canh Hung, E Endert, P A Kager, H P Sauerwein. FFAs are not involved in regulation of gluconeogenesis and glycogenolysis in adults with uncomplicated P. falciparum malaria.
American journal of physiology. Endocrinology and metabolism.
2004 Oct; 287(4):E609-15. doi:
10.1152/ajpendo.00026.2004. [PMID: 15165991] - Mandeep Bajaj, Swangjit Suraamornkul, Sangeeta Kashyap, Kenneth Cusi, Lawrence Mandarino, Ralph A DeFronzo. Sustained reduction in plasma free fatty acid concentration improves insulin action without altering plasma adipocytokine levels in subjects with strong family history of type 2 diabetes.
The Journal of clinical endocrinology and metabolism.
2004 Sep; 89(9):4649-55. doi:
10.1210/jc.2004-0224. [PMID: 15356076] - Joseph D Layden, Dalia Malkova, Myra A Nimmo. Fat oxidation after acipimox-induced reduction in plasma nonesterified fatty acids during exercise at 0 degrees C and 20 degrees C.
Metabolism: clinical and experimental.
2004 Sep; 53(9):1131-5. doi:
10.1016/j.metabol.2004.03.016. [PMID: 15334373] - Alessio Donati, Gabriella Cavallini, Cristiano Carresi, Zina Gori, Ilaria Parentini, Ettore Bergamini. Anti-aging effects of anti-lipolytic drugs.
Experimental gerontology.
2004 Jul; 39(7):1061-7. doi:
10.1016/j.exger.2004.03.025. [PMID: 15236765] - G Allick, F Sprangers, G J Weverling, M T Ackermans, A J Meijer, J A Romijn, E Endert, P H Bisschop, H P Sauerwein. Free fatty acids increase hepatic glycogen content in obese males.
Metabolism: clinical and experimental.
2004 Jul; 53(7):886-93. doi:
10.1016/j.metabol.2004.01.012. [PMID: 15254882] - Elizabeth L Bernstein, Polyxeni Koutkia, Karin Ljungquist, Jeff Breu, Bridget Canavan, Steven Grinspoon. Acute regulation of adiponectin by free fatty acids.
Metabolism: clinical and experimental.
2004 Jun; 53(6):790-3. doi:
10.1016/j.metabol.2003.12.023. [PMID: 15164330]