Ascorbyl palmitate (BioDeep_00000606755)
代谢物信息卡片
L-Ascorbyl 6-palmitate
化学式: C22H38O7 (414.2617)
中文名称: L-抗坏血酸棕榈酸酯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCC(=O)OCC(C1C(=C(C(=O)O1)O)O)O
InChI: InChI=1S/C22H38O7/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(24)28-16-17(23)21-19(25)20(26)22(27)29-21/h17,21,23,25-26H,2-16H2,1H3/t17-,21+/m0/s1
描述信息
D020011 - Protective Agents > D016587 - Antimutagenic Agents
D020011 - Protective Agents > D000975 - Antioxidants
C26170 - Protective Agent > C275 - Antioxidant
D000970 - Antineoplastic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:140768
- KEGGdrug: D88276
- KEGGdrug: D02412
- PubChem: 54680660
- Metlin: METLIN73561
- ChEMBL: CHEMBL220190
- CAS: 137-66-6
- RefMet: Ascorbyl palmitate
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Svetlana Momchilova, Adriana Kazakova, Sabina Taneva, Katerina Aleksieva, Ralitsa Mladenova, Yordanka Karakirova, Zhanina Petkova, Mariana Kamenova-Nacheva, Desislava Teneva, Petko Denev. Effect of Gamma Irradiation on Fat Content, Fatty Acids, Antioxidants and Oxidative Stability of Almonds, and Electron Paramagnetic Resonance (EPR) Study of Treated Nuts.
Molecules (Basel, Switzerland).
2023 Feb; 28(3):. doi:
10.3390/molecules28031439. [PMID: 36771103] - Hong-Sik Hwang, Jill K Winkler-Moser. Bicarbonates and carbonates as antioxidants in vegetable oils at frying temperatures.
Journal of food science.
2023 Feb; 88(2):717-731. doi:
10.1111/1750-3841.16442. [PMID: 36576154] - Atefeh Amiri-Rigi, Sreejarani Kesavan Pillai, Mohammad Naushad Emmambux. Development of hemp seed oil nanoemulsions loaded with ascorbyl palmitate: Effect of operational parameters, emulsifiers, and wall materials.
Food chemistry.
2023 Jan; 400(?):134052. doi:
10.1016/j.foodchem.2022.134052. [PMID: 36067691] - Martin Doert, Sandra Grebenteuch, Lothar W Kroh, Sascha Rohn. A ternary system of α-tocopherol with phosphatidylethanolamine and l-ascorbyl palmitate in bulk oils provides antioxidant synergy through stabilization and regeneration of α-tocopherol.
Food chemistry.
2022 Oct; 391(?):133084. doi:
10.1016/j.foodchem.2022.133084. [PMID: 35605536] - Lin Li, Hongliang Wang, Jun Ye, Yankun Chen, Renyun Wang, Dujia Jin, Yuling Liu. Mechanism Study on Nanoparticle Negative Surface Charge Modification by Ascorbyl Palmitate and Its Improvement of Tumor Targeting Ability.
Molecules (Basel, Switzerland).
2022 Jul; 27(14):. doi:
10.3390/molecules27144408. [PMID: 35889281] - Ranran Shi, Yueqin Li, Lianliang Liu. Synergistic anti-oxidative and antimicrobial effects of oat phenolic compounds and ascorbate palmitoyl on fish balls during cold storage.
Journal of food science.
2021 Oct; 86(10):4628-4636. doi:
10.1111/1750-3841.15922. [PMID: 34549438] - Manat Chaijan, Kesinee Srirattanachot, Mudtorlep Nisoa, Ling-Zhi Cheong, Worawan Panpipat. Role of antioxidants on physicochemical properties and in vitro bioaccessibility of β-carotene loaded nanoemulsion under thermal and cold plasma discharge accelerated tests.
Food chemistry.
2021 Mar; 339(?):128157. doi:
10.1016/j.foodchem.2020.128157. [PMID: 33152897] - Yan Shen, Ting Lu, Xiao-Yang Liu, Man-Tong Zhao, Fa-Wen Yin, Kanyasiri Rakariyatham, Da-Yong Zhou. Improving the oxidative stability and lengthening the shelf life of DHA algae oil with composite antioxidants.
Food chemistry.
2020 May; 313(?):126139. doi:
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Food chemistry.
2020 Mar; 309(?):125688. doi:
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Journal of food science.
2019 Jun; 84(6):1390-1399. doi:
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International journal of molecular sciences.
2019 Feb; 20(3):. doi:
10.3390/ijms20030669. [PMID: 30720739] - Sarah A Willett, Casimir C Akoh. Physicochemical characterization of organogels prepared from menhaden oil or structured lipid with phytosterol blend or sucrose stearate/ascorbyl palmitate blend.
Food & function.
2019 Jan; 10(1):180-190. doi:
10.1039/c8fo01725e. [PMID: 30516201] - Farzaneh Fathi, Hossein Mohammadzadeh-Aghdash, Yousef Sohrabi, Parvin Dehghan, Jafar Ezzati Nazhad Dolatabadi. Kinetic and thermodynamic studies of bovine serum albumin interaction with ascorbyl palmitate and ascorbyl stearate food additives using surface plasmon resonance.
Food chemistry.
2018 Apr; 246(?):228-232. doi:
10.1016/j.foodchem.2017.11.023. [PMID: 29291843] - Min Zhou, Xin Li, Yuanyuan Li, Qiu'e Yao, Yue Ming, Ziwei Li, Laichun Lu, Sanjun Shi. Ascorbyl palmitate-incorporated paclitaxel-loaded composite nanoparticles for synergistic anti-tumoral therapy.
Drug delivery.
2017 Nov; 24(1):1230-1242. doi:
10.1080/10717544.2017.1370619. [PMID: 28856937] - O P Bamidele, K G Duodu, M N Emmambux. Encapsulation and antioxidant activity of ascorbyl palmitate with maize starch during pasting.
Carbohydrate polymers.
2017 Jun; 166(?):202-208. doi:
10.1016/j.carbpol.2017.02.095. [PMID: 28385224] - Shashank Gaur, Elizabeth M Sloffer, Ankur Ojha, Falguni Patra, Dharmendra Shukla, Nicki J Engeseth, Pramthesh R Patel, Juan E Andrade. Omega-3-Fortified Lipid-Based Nutrient Supplement: Development, Characterization, and Consumer Acceptability.
Food and nutrition bulletin.
2017 06; 38(2):158-171. doi:
10.1177/0379572117701234. [PMID: 28359208] - D M Dries, L Knaepen, B Goderis, J A Delcour. Encapsulation of the antioxidant ascorbyl palmitate in V-type granular cold-water swelling starch affects the properties of both.
Carbohydrate polymers.
2017 Jun; 165(?):402-409. doi:
10.1016/j.carbpol.2017.02.057. [PMID: 28363566] - Rohit Upadhyay, Sneha Sehwag, Hari Niwas Mishra. Chemometric approach to develop frying stable sunflower oil blends stabilized with oleoresin rosemary and ascorbyl palmitate.
Food chemistry.
2017 Mar; 218(?):496-504. doi:
10.1016/j.foodchem.2016.09.105. [PMID: 27719941] - Li Xiao, Nobuhiko Miwa. The Lipophilic Vitamin C Derivative, 6-O-Palmitoylascorbate Protects Human Keratinocytes and 3D-Human Skin Equivalents Against X-Ray-Induced Oxidative Stress and Apoptosis More Markedly Than L-Ascorbic Acid.
Journal of cellular biochemistry.
2017 02; 118(2):318-329. doi:
10.1002/jcb.25639. [PMID: 27350661] - Molly J Sproston, Casimir C Akoh. Antioxidative Effects of a Glucose-Cysteine Maillard Reaction Product on the Oxidative Stability of a Structured Lipid in a Complex Food Emulsion.
Journal of food science.
2016 Dec; 81(12):C2923-C2931. doi:
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Food chemistry.
2016 Apr; 196(?):567-76. doi:
10.1016/j.foodchem.2015.09.031. [PMID: 26593529] - Li Xiao, Takeki Tsutsui, Nobuhiko Miwa. The lipophilic vitamin C derivative, 6-o-palmitoylascorbate, protects human lymphocytes, preferentially over ascorbate, against X-ray-induced DNA damage, lipid peroxidation, and protein carbonylation.
Molecular and cellular biochemistry.
2014 Sep; 394(1-2):247-59. doi:
10.1007/s11010-014-2101-8. [PMID: 24898782] - Vessela Kancheva, Adriana Slavova-Kazakova, Davide Fabbri, Maria Antonietta Dettori, Giovanna Delogu, Michał Janiak, Ryszard Amarowicz. Protective effects of equimolar mixtures of monomer and dimer of dehydrozingerone with α-tocopherol and/or ascorbyl palmitate during bulk lipid autoxidation.
Food chemistry.
2014 Aug; 157(?):263-74. doi:
10.1016/j.foodchem.2014.02.036. [PMID: 24679780] - Riyaz Mohamed, Shaista Tarannum, Manjunath Yariswamy, Hamse K Vivek, Jalahalli M Siddesha, Nataraju Angaswamy, Bannikuppe S Vishwanath. Ascorbic acid 6-palmitate: a potent inhibitor of human and soybean lipoxygenase-dependent lipid peroxidation.
The Journal of pharmacy and pharmacology.
2014 Jun; 66(6):769-78. doi:
10.1111/jphp.12200. [PMID: 24359271] - Luciano Benedini, Silvia Antollini, Maria Laura Fanani, Santiago Palma, Paula Messina, Pablo Schulz. Study of the influence of ascorbyl palmitate and amiodarone in the stability of unilamellar liposomes.
Molecular membrane biology.
2014 Mar; 31(2-3):85-94. doi:
10.3109/09687688.2014.896956. [PMID: 24650150] - Milagro Mottola, Natalia Wilke, Luciano Benedini, Rafael Gustavo Oliveira, Maria Laura Fanani. Ascorbyl palmitate interaction with phospholipid monolayers: electrostatic and rheological preponderancy.
Biochimica et biophysica acta.
2013 Nov; 1828(11):2496-505. doi:
10.1016/j.bbamem.2013.06.016. [PMID: 23806650] - Temelkan Bakır, Inci Sönmezoğlu, Filiz Imer, Reşat Apak. Polar paradox revisited: analogous pairs of hydrophilic and lipophilic antioxidants in linoleic acid emulsion containing Cu(II).
Journal of the science of food and agriculture.
2013 Aug; 93(10):2478-85. doi:
10.1002/jsfa.6063. [PMID: 23520052] - Bente M Jensen, John Sørensen, Grith Mortensen, Martin B Sørensen, Trine K Dalsgaard. Effect of antioxidants on oxidation during the production of whey fat concentrate.
Journal of agricultural and food chemistry.
2011 Dec; 59(24):13012-7. doi:
10.1021/jf203295p. [PMID: 22070410] - DeMarquis O Loyd, Sean M Lynch. Lipid-soluble vitamin C palmitate and protection of human high-density lipoprotein from hypochlorite-mediated oxidation.
International journal of cardiology.
2011 Oct; 152(2):256-7. doi:
10.1016/j.ijcard.2011.07.094. [PMID: 21872949] - José Batista, Georg Schlechtingen, Tim Friedrichson, Tobias Braxmeier, Jürgen Bajorath. Lipid-like sulfoxides and amine oxides as inhibitors of mast cell activation.
European journal of medicinal chemistry.
2011 Jun; 46(6):2147-51. doi:
10.1016/j.ejmech.2011.02.068. [PMID: 21421276] - F Pop. Chemical stabilization of oils rich in long-chain polyunsaturated fatty acids during storage.
Food science and technology international = Ciencia y tecnologia de los alimentos internacional.
2011 Apr; 17(2):111-7. doi:
10.1177/1082013210368738. [PMID: 21447601] - Raju Jukanti, Gopinath Devraj, Apte S Shashank, Rambhau Devraj. Biodistribution of ascorbyl palmitate loaded doxorubicin pegylated liposomes in solid tumor bearing mice.
Journal of microencapsulation.
2011; 28(2):142-9. doi:
10.3109/02652048.2010.542496. [PMID: 21265713] - P O Nnamani, A A Attama, E C Ibezim, M U Adikwu. SRMS142-based solid lipid microparticles: application in oral delivery of glibenclamide to diabetic rats.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2010 Sep; 76(1):68-74. doi:
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Annals of the New York Academy of Sciences.
2010 Mar; 1190(?):141-50. doi:
10.1111/j.1749-6632.2009.05263.x. [PMID: 20388145] - Kyung Mi Lee, Jung Yeon Kwon, Ki Won Lee, Hyong Joo Lee. Ascorbic acid 6-palmitate suppresses gap-junctional intercellular communication through phosphorylation of connexin 43 via activation of the MEK-ERK pathway.
Mutation research.
2009 Jan; 660(1-2):51-6. doi:
10.1016/j.mrfmmm.2008.10.012. [PMID: 19026667] - Yohko Kuge, Ayato Kanda, Setsuko Hara. Pursuit of oxidation behavior for conjugated polyenoyl glycerols and establishment of their novel oxidation prevention method.
Journal of oleo science.
2009; 58(6):295-301. doi:
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Analytical biochemistry.
2008 Nov; 382(1):1-8. doi:
10.1016/j.ab.2008.07.021. [PMID: 18694720] - J H Han, H-M Hwang, S Min, J M Krochta. Coating of peanuts with edible whey protein film containing alpha-tocopherol and ascorbyl palmitate.
Journal of food science.
2008 Oct; 73(8):E349-55. doi:
10.1111/j.1750-3841.2008.00910.x. [PMID: 19019105] - Veerawat Teeranachaideekul, Eliana B Souto, Rainer H Müller, Varaporn B Junyaprasert. Physicochemical characterization and in vitro release studies of ascorbyl palmitate-loaded semi-solid nanostructured lipid carriers (NLC gels).
Journal of microencapsulation.
2008 Mar; 25(2):111-20. doi:
10.1080/02652040701817762. [PMID: 18246489] - Veerawat Teeranachaideekul, Rainer Helmut Müller, Varaporn Buraphacheep Junyaprasert. Encapsulation of ascorbyl palmitate in nanostructured lipid carriers (NLC)--effects of formulation parameters on physicochemical stability.
International journal of pharmaceutics.
2007 Aug; 340(1-2):198-206. doi:
10.1016/j.ijpharm.2007.03.022. [PMID: 17482778] - J H Han, J M Krochta. Physical properties of whey protein coating solutions and films containing antioxidants.
Journal of food science.
2007 Jun; 72(5):E308-14. doi:
10.1111/j.1750-3841.2007.00358.x. [PMID: 17995731] - Mette B Let, Charlotte Jacobsen, Anne S Meyer. Ascorbyl palmitate, gamma-tocopherol, and EDTA affect lipid oxidation in fish oil enriched salad dressing differently.
Journal of agricultural and food chemistry.
2007 Mar; 55(6):2369-75. doi:
10.1021/jf062675c. [PMID: 17319681] - M Uner, S A Wissing, G Yener, R H Müller. Skin moisturizing effect and skin penetration of ascorbyl palmitate entrapped in solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) incorporated into hydrogel.
Die Pharmazie.
2005 Oct; 60(10):751-5. doi:
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Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2005 Sep; 56 Suppl 4(?):197-201. doi:
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Die Pharmazie.
2005 Aug; 60(8):577-82. doi:
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Journal of agricultural and food chemistry.
2005 Jun; 53(13):5429-37. doi:
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Journal of microencapsulation.
2004 Nov; 21(7):761-74. doi:
10.1080/02652040400015403. [PMID: 15799226] - Mieczysław Pokorski, Ahlam Ramadan, Magdalena Marczak. Ascorbyl palmitate augments hypoxic respiratory response in the cat.
Journal of biomedical science.
2004 Jul; 11(4):465-71. doi:
10.1007/bf02256095. [PMID: 15153781] - D Gopinath, D Ravi, B R Rao, S S Apte, D Renuka, D Rambhau. Ascorbyl palmitate vesicles (Aspasomes): formation, characterization and applications.
International journal of pharmaceutics.
2004 Mar; 271(1-2):95-113. doi:
10.1016/j.ijpharm.2003.10.032. [PMID: 15129977] - M Pokorski, B Gonet. Capacity of ascorbyl palmitate to produce the ascorbyl radical in vitro: an electron spin resonance investigation.
Physiological research.
2004; 53(3):311-6. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2003 Jul; 19(4):181-9. doi:
10.1016/s0928-0987(03)00104-0. [PMID: 12885382] - Mieczysław Pokorski, Magdalena Marczak, Aneta Dymecka, Piotr Suchocki. Ascorbyl palmitate as a carrier of ascorbate into neural tissues.
Journal of biomedical science.
2003 Mar; 10(2):193-8. doi:
10.1007/bf02256054. [PMID: 12595755] - Karl-Heinz Wagner, Patrick Feigl, Ibrahim Elmadfa. Ascorbyl palmitate and its synergism to tocopherols.
Forum of nutrition.
2003; 56(?):347-8. doi:
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The Journal of investigative dermatology.
2002 Nov; 119(5):1103-8. doi:
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Archives of medical research.
2002 Nov; 33(6):515-9. doi:
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Clinical pharmacology and therapeutics.
2002 Sep; 72(3):247-55. doi:
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The Journal of dermatological treatment.
2002 Sep; 13(3):133-41. doi:
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Journal of medicinal chemistry.
2002 Jan; 45(2):462-8. doi:
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Journal of cellular biochemistry.
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Journal of agricultural and food chemistry.
2001 Mar; 49(3):1224-7. doi:
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Free radical biology & medicine.
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Free radical biology & medicine.
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