6α-Hydroxy paclitaxel (BioDeep_00000606738)

   


代谢物信息卡片


6α-Hydroxypaclitaxel

化学式: C47H51NO15 (869.3258536)
中文名称: 6α-羟基紫杉醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=C2C(C(=O)C3(C(C(C(C2(C)C)(CC1OC(=O)C(C(C4=CC=CC=C4)NC(=O)C5=CC=CC=C5)O)O)OC(=O)C6=CC=CC=C6)C7(COC7C(C3O)O)OC(=O)C)C)OC(=O)C
InChI: InChI=1S/C47H51NO15/c1-24-30(61-43(57)33(51)32(27-16-10-7-11-17-27)48-41(55)28-18-12-8-13-19-28)22-47(58)40(62-42(56)29-20-14-9-15-21-29)36-45(6,38(54)35(60-25(2)49)31(24)44(47,4)5)37(53)34(52)39-46(36,23-59-39)63-26(3)50/h7-21,30,32-37,39-40,51-53,58H,22-23H2,1-6H3,(H,48,55)/t30-,32-,33+,34-,35+,36-,37-,39+,40-,45-,46+,47+/m0/s1

描述信息

同义名列表

3 个代谢物同义名

6alpha-Hydroxypaclitaxel; 6α-Hydroxy paclitaxel; 6α-Hydroxypaclitaxel



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(5)

BioCyc(0)

PlantCyc(0)

代谢反应

50 个相关的代谢反应过程信息。

Reactome(50)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Haijin Huang, Haolin Huang, Yongbing Sun, Qian Liu. The Quantification of Paclitaxel and Its Two Major Metabolites in Biological Samples by HPLC-MS/MS and Its Application in a Pharmacokinetic and Tumor Distribution Study in Xenograft Nude Mouse. Molecules (Basel, Switzerland). 2023 Jan; 28(3):. doi: 10.3390/molecules28031027. [PMID: 36770692]
  • Mei-Juan Xu, Li-Feng Jiang, Ting Wu, Ji-Hong Chu, Yi-Dan Wei, Ji-Ye Aa, Guang-Ji Wang, Hai-Ping Hao, Wen-Zheng Ju, Ping Li. Inhibitory Effects of Danshen components on CYP2C8 and CYP2J2. Chemico-biological interactions. 2018 Jun; 289(?):15-22. doi: 10.1016/j.cbi.2018.04.011. [PMID: 29689254]
  • Bianca Posocco, Mauro Buzzo, Andrea Follegot, Luciana Giodini, Roberto Sorio, Elena Marangon, Giuseppe Toffoli. A new high-performance liquid chromatography-tandem mass spectrometry method for the determination of paclitaxel and 6α-hydroxy-paclitaxel in human plasma: Development, validation and application in a clinical pharmacokinetic study. PloS one. 2018; 13(2):e0193500. doi: 10.1371/journal.pone.0193500. [PMID: 29474420]
  • Hiroaki Yamaguchi, Asuka Fujikawa, Hajime Ito, Nobuaki Tanaka, Ayako Furugen, Kazuaki Miyamori, Natsuko Takahashi, Jiro Ogura, Masaki Kobayashi, Takehiro Yamada, Nariyasu Mano, Ken Iseki. Quantitative determination of paclitaxel and its metabolites, 6α-hydroxypaclitaxel and p-3'-hydroxypaclitaxel, in human plasma using column-switching liquid chromatography/tandem mass spectrometry. Biomedical chromatography : BMC. 2013 Apr; 27(4):539-44. doi: 10.1002/bmc.2826. [PMID: 23018973]
  • Wei Zhang, Ginger E Dutschman, Xin Li, Yung-Chi Cheng. Quantitation of paclitaxel and its two major metabolites using a liquid chromatography-electrospray ionization tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2011 Jul; 879(22):2018-22. doi: 10.1016/j.jchromb.2011.05.024. [PMID: 21705287]
  • Henrik Gréen, Karin Vretenbrant, Björn Norlander, Curt Peterson. Measurement of paclitaxel and its metabolites in human plasma using liquid chromatography/ion trap mass spectrometry with a sonic spray ionization interface. Rapid communications in mass spectrometry : RCM. 2006; 20(14):2183-9. doi: 10.1002/rcm.2567. [PMID: 16791868]
  • Heleen A Bardelmeijer, Ingrid A M Oomen, Michel J X Hillebrand, Jos H Beijnen, Jan H M Schellens, Olaf van Tellingen. Metabolism of paclitaxel in mice. Anti-cancer drugs. 2003 Mar; 14(3):203-9. doi: 10.1097/00001813-200303000-00003. [PMID: 12634614]
  • M H Kang, W D Figg, Y Ando, M V Blagosklonny, D Liewehr, T Fojo, S E Bates. The P-glycoprotein antagonist PSC 833 increases the plasma concentrations of 6alpha-hydroxypaclitaxel, a major metabolite of paclitaxel. Clinical cancer research : an official journal of the American Association for Cancer Research. 2001 Jun; 7(6):1610-7. doi: NULL. [PMID: 11410497]
  • M T Huizing, A Sparreboom, H Rosing, O van Tellingen, H M Pinedo, J H Beijnen. Quantification of paclitaxel metabolites in human plasma by high-performance liquid chromatography. Journal of chromatography. B, Biomedical applications. 1995 Dec; 674(2):261-8. doi: 10.1016/0378-4347(95)00308-8. [PMID: 8788155]
  • A Sparreboom, M T Huizing, J J Boesen, W J Nooijen, O van Tellingen, J H Beijnen. Isolation, purification, and biological activity of mono- and dihydroxylated paclitaxel metabolites from human feces. Cancer chemotherapy and pharmacology. 1995; 36(4):299-304. doi: 10.1007/bf00689047. [PMID: 7628049]