Tiron (BioDeep_00000606562)
代谢物信息卡片
1,2-Dihydroxybenzene-3,5-disulfonic acid disodium salt
化学式: C6H4Na2O8S2 (313.9143024)
中文名称: 植酸霉
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(C=C(C(=C1O)O)S(=O)(=O)[O-])S(=O)(=O)[O-].[Na+].[Na+]
InChI: /q
描述信息
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents
同义名列表
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:9607
- PubChem: 9001
- Metlin: METLIN68882
- ChEMBL: CHEMBL110526
- MeSH: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt
- CAS: 9001-89-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(4)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shrook A Mohamed, Dalia H El-Kashef, Manar A Nader. Tiron alleviates MPTP-induced Parkinsonism in mice via activation of Keap-1/Nrf2 pathway.
Journal of biochemical and molecular toxicology.
2021 Mar; 35(3):e22685. doi:
10.1002/jbt.22685. [PMID: 33368846] - Shimaa Khaled, Mirhan N Makled, Manar A Nader. Tiron protects against nicotine-induced lung and liver injury through antioxidant and anti-inflammatory actions in rats in vivo.
Life sciences.
2020 Nov; 260(?):118426. doi:
10.1016/j.lfs.2020.118426. [PMID: 32937159] - Francesca De Faveri, Michael Chvanov, Svetlana Voronina, Danielle Moore, Liam Pollock, Lee Haynes, Muhammad Awais, Alison J Beckett, Ulrike Mayer, Robert Sutton, David N Criddle, Ian A Prior, Tom Wileman, Alexei V Tepikin. LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells.
Autophagy.
2020 07; 16(7):1314-1331. doi:
10.1080/15548627.2019.1679514. [PMID: 31651224] - Ashraf Morgan, Marwa A Ibrahim, Mona K Galal, Hanan A Ogaly, Reham M Abd-Elsalam. Innovative perception on using Tiron to modulate the hepatotoxicity induced by titanium dioxide nanoparticles in male rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jul; 103(?):553-561. doi:
10.1016/j.biopha.2018.04.064. [PMID: 29677542] - Ashraf Morgan, Mona K Galal, Hanan A Ogaly, Marwa A Ibrahim, Reham M Abd-Elsalam, Peter Noshy. Tiron ameliorates oxidative stress and inflammation in titanium dioxide nanoparticles induced nephrotoxicity of male rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Sep; 93(?):779-787. doi:
10.1016/j.biopha.2017.07.006. [PMID: 28709131] - Yoshitaka Yasuda, Guo-Gang Feng, Jiazheng Li, Emi Nakamura, Hisaki Hayashi, Motohiko Sato, Yoshihiro Fujiwara, Hiroyuki Kinoshita. High oxygen modifies vasodilator effect of cysteine via enhanced oxidative stress and thromboxane production in the rat mesenteric artery.
Pflugers Archiv : European journal of physiology.
2016 09; 468(9):1555-64. doi:
10.1007/s00424-016-1857-y. [PMID: 27389323] - Hayam Ateyya, Heba M Wagih, Nagla A El-Sherbeeny. Effect of tiron on remote organ injury in rats with severe acute pancreatitis induced by L-arginine.
Naunyn-Schmiedeberg's archives of pharmacology.
2016 Aug; 389(8):873-85. doi:
10.1007/s00210-016-1250-6. [PMID: 27118662] - Jaqueline J Muniz, Letícia N Leite, Bruno S De Martinis, Fernando S Carneiro, Carlos R Tirapelli. Chronic ethanol consumption induces erectile dysfunction: Role of oxidative stress.
Life sciences.
2015 Nov; 141(?):44-53. doi:
10.1016/j.lfs.2015.09.017. [PMID: 26407475] - Massimo Malerba, Raffaella Cerana. Reactive oxygen and nitrogen species in defense/stress responses activated by chitosan in sycamore cultured cells.
International journal of molecular sciences.
2015 Jan; 16(2):3019-34. doi:
10.3390/ijms16023019. [PMID: 25642757] - Ana P P Carda, Katia C Marchi, Elen Rizzi, André S Mecawi, José Antunes-Rodrigues, Claudia M Padovan, Carlos R Tirapelli. Acute restraint stress induces endothelial dysfunction: role of vasoconstrictor prostanoids and oxidative stress.
Stress (Amsterdam, Netherlands).
2015; 18(2):233-43. doi:
10.3109/10253890.2015.1014790. [PMID: 25689973] - Binata Joddar, Michael S Firstenberg, Rashmeet K Reen, Saradhadevi Varadharaj, Mahmood Khan, Rachel C Childers, Jay L Zweier, Keith J Gooch. Arterial levels of oxygen stimulate intimal hyperplasia in human saphenous veins via a ROS-dependent mechanism.
PloS one.
2015; 10(3):e0120301. doi:
10.1371/journal.pone.0120301. [PMID: 25799140] - M F Cheng, L J Chen, M C Wang, C T Hsu, J T Cheng. Decrease of FGF receptor (FGFR) and interstitial fibrosis in the kidney of streptozotocin-induced diabetic rats.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2014 Jan; 46(1):1-7. doi:
10.1055/s-0033-1349090. [PMID: 23828126] - Jixiang Ni, Zheng Dong, Weihong Han, Dmitry Kondrikov, Yunchao Su. The role of RhoA and cytoskeleton in myofibroblast transformation in hyperoxic lung fibrosis.
Free radical biology & medicine.
2013 Aug; 61(?):26-39. doi:
10.1016/j.freeradbiomed.2013.03.012. [PMID: 23517783] - Shinkyu Choi, Ji Aee Kim, Hye-Young Na, Ji-Eun Kim, Seonghee Park, Ki-Hwan Han, Young Ju Kim, Suk Hyo Suh. NADPH oxidase 2-derived superoxide downregulates endothelial KCa3.1 in preeclampsia.
Free radical biology & medicine.
2013 Apr; 57(?):10-21. doi:
10.1016/j.freeradbiomed.2012.12.009. [PMID: 23261940] - Gianluca Gortan Cappellari, Pasquale Losurdo, Sara Mazzucco, Emiliano Panizon, Mitja Jevnicar, Loredana Macaluso, Bruno Fabris, Rocco Barazzoni, Gianni Biolo, Renzo Carretta, Michela Zanetti. Treatment with n-3 polyunsaturated fatty acids reverses endothelial dysfunction and oxidative stress in experimental menopause.
The Journal of nutritional biochemistry.
2013 Jan; 24(1):371-9. doi:
10.1016/j.jnutbio.2012.07.012. [PMID: 23159066] - Satoshi Koba, Ryosuke Watanabe, Naoko Kano, Tatsuo Watanabe. Oxidative stress exaggerates skeletal muscle contraction-evoked reflex sympathoexcitation in rats with hypertension induced by angiotensin II.
American journal of physiology. Heart and circulatory physiology.
2013 Jan; 304(1):H142-53. doi:
10.1152/ajpheart.00423.2012. [PMID: 23086992] - Tusty-Jiuan Hsieh, Pei-Chen Hsieh, Yi-Hong Tsai, Chia-Fang Wu, Chia-Chu Liu, Ming-Yen Lin, Ming-Tsang Wu. Melamine induces human renal proximal tubular cell injury via transforming growth factor-β and oxidative stress.
Toxicological sciences : an official journal of the Society of Toxicology.
2012 Nov; 130(1):17-32. doi:
10.1093/toxsci/kfs231. [PMID: 22915474] - D D Guimarães, C C Carvalho, V A Braga. Scavenging of NADPH oxidase-derived superoxide anions improves depressed baroreflex sensitivity in spontaneously hypertensive rats.
Clinical and experimental pharmacology & physiology.
2012 Apr; 39(4):373-8. doi:
10.1111/j.1440-1681.2012.05679.x. [PMID: 22283703] - Luciana Grazziotin Rossato, Vera Marisa Costa, Paula Guedes de Pinho, Félix Carvalho, Maria de Lourdes Bastos, Fernando Remião. Structural isomerization of synephrine influences its uptake and ensuing glutathione depletion in rat-isolated cardiomyocytes.
Archives of toxicology.
2011 Aug; 85(8):929-39. doi:
10.1007/s00204-010-0630-9. [PMID: 21140131] - Yusuke Takizawa, Takuya Kitazato, Hisanao Kishimoto, Mikio Tomita, Masahiro Hayashi. Effects of antioxidants on drug absorption in in vivo intestinal ischemia/reperfusion.
European journal of drug metabolism and pharmacokinetics.
2011 Jan; 35(3-4):89-95. doi:
10.1007/s13318-010-0020-y. [PMID: 21302034] - Alvar Grönberg, Louise Zettergren, Kerstin Bergh, Mona Ståhle, Johan Heilborn, Kristian Angeby, Pamela L Small, Hannah Akuffo, Sven Britton. Antioxidants protect keratinocytes against M. ulcerans mycolactone cytotoxicity.
PloS one.
2010 Nov; 5(11):e13839. doi:
10.1371/journal.pone.0013839. [PMID: 21079804] - F Guntzer, C Keller, J D Meunier. Determination of the silicon concentration in plant material using Tiron extraction.
The New phytologist.
2010 Nov; 188(3):902-6. doi:
10.1111/j.1469-8137.2010.03416.x. [PMID: 20723075] - Ioannis Papapostolou, Christos D Georgiou. Superoxide radical induces sclerotial differentiation in filamentous phytopathogenic fungi: a superoxide dismutase mimetics study.
Microbiology (Reading, England).
2010 Mar; 156(Pt 3):960-966. doi:
10.1099/mic.0.034579-0. [PMID: 20007647] - V Mohan Murali Achary, Brahma B Panda. Aluminium-induced DNA damage and adaptive response to genotoxic stress in plant cells are mediated through reactive oxygen intermediates.
Mutagenesis.
2010 Mar; 25(2):201-9. doi:
10.1093/mutage/gep063. [PMID: 19955331] - Meng-Fu Cheng, Li-Jen Chen, Juei-Tang Cheng. Decrease of Klotho in the kidney of streptozotocin-induced diabetic rats.
Journal of biomedicine & biotechnology.
2010; 2010(?):513853. doi:
10.1155/2010/513853. [PMID: 20625492] - Satendra Kumar Nirala, Monika Bhadauria, Anil Kumar Upadhyay, Ramesh Mathur, Asha Mathur. Reversal of effects of intra peritoneally administered beryllium nitrate by tiron and CaNa3DTPA alone or in combination with alpha-tocopherol.
Indian journal of experimental biology.
2009 Dec; 47(12):955-63. doi:
. [PMID: 20329698] - Gu-Choul Shin, Changyoun Kim, Jong-Min Lee, Wang-Sik Cho, Sang-Gyu Lee, Mini Jeong, Jaewook Cho, Kyungho Lee. Apigenin-induced apoptosis is mediated by reactive oxygen species and activation of ERK1/2 in rheumatoid fibroblast-like synoviocytes.
Chemico-biological interactions.
2009 Nov; 182(1):29-36. doi:
10.1016/j.cbi.2009.07.016. [PMID: 19647729] - Gillian Groeger, Ashley M Mackey, Christopher A Pettigrew, Lavinia Bhatt, Thomas G Cotter. Stress-induced activation of Nox contributes to cell survival signalling via production of hydrogen peroxide.
Journal of neurochemistry.
2009 Jun; 109(5):1544-54. doi:
10.1111/j.1471-4159.2009.06081.x. [PMID: 19344371] - Vera Marisa Costa, Renata Silva, Rita Ferreira, Francisco Amado, Félix Carvalho, Maria de Lourdes Bastos, Rui Albuquerque Carvalho, Márcia Carvalho, Fernando Remião. Adrenaline in pro-oxidant conditions elicits intracellular survival pathways in isolated rat cardiomyocytes.
Toxicology.
2009 Mar; 257(1-2):70-9. doi:
10.1016/j.tox.2008.12.010. [PMID: 19135123] - Yu Cao, Ling Tao, Yuexing Yuan, Xiangying Jiao, Wayne Bond Lau, Yajing Wang, Theodore Christopher, Bernard Lopez, Lawrence Chan, Barry Goldstein, Xin L Ma. Endothelial dysfunction in adiponectin deficiency and its mechanisms involved.
Journal of molecular and cellular cardiology.
2009 Mar; 46(3):413-9. doi:
10.1016/j.yjmcc.2008.10.014. [PMID: 19027750] - V Dyachenko, U Rueckschloss, G Isenberg. Modulation of cardiac mechanosensitive ion channels involves superoxide, nitric oxide and peroxynitrite.
Cell calcium.
2009 Jan; 45(1):55-64. doi:
10.1016/j.ceca.2008.06.002. [PMID: 18639930] - Ting-Shuan Wu, Yi-Chun Liao, Feng-Yih Yu, Chia-Hao Chang, Biing-Hui Liu. Mechanism of patulin-induced apoptosis in human leukemia cells (HL-60).
Toxicology letters.
2008 Dec; 183(1-3):105-11. doi:
10.1016/j.toxlet.2008.09.018. [PMID: 18992795] - Fatiha Tabet, Ernesto L Schiffrin, Glaucia E Callera, Ying He, Guoying Yao, Arne Ostman, Kai Kappert, Nicholas K Tonks, Rhian M Touyz. Redox-sensitive signaling by angiotensin II involves oxidative inactivation and blunted phosphorylation of protein tyrosine phosphatase SHP-2 in vascular smooth muscle cells from SHR.
Circulation research.
2008 Jul; 103(2):149-58. doi:
10.1161/circresaha.108.178608. [PMID: 18566342] - Satendra Kumar Nirala, Monika Bhadauria, Ramesh Mathur, Asha Mathur. Influence of alpha-tocopherol, propolis and piperine on therapeutic potential of tiferron against beryllium induced toxic manifestations.
Journal of applied toxicology : JAT.
2008 Jan; 28(1):44-54. doi:
10.1002/jat.1250. [PMID: 17429802] - Yongqiang Chen, Eileen McMillan-Ward, Jiming Kong, Sara J Israels, Spencer B Gibson. Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species.
Journal of cell science.
2007 Dec; 120(Pt 23):4155-66. doi:
10.1242/jcs.011163. [PMID: 18032788] - Sadhana Shrivastava, Anjana Jadon, Sangeeta Shukla, Ramesh Mathur. Chelation therapy and vanadium: effect on reproductive organs in rats.
Indian journal of experimental biology.
2007 Jun; 45(6):515-23. doi:
NULL. [PMID: 17585685] - Sadhana Shrivastava, Anjana Jadon, Sangeeta Shukla. Effect of tiron and its combination with nutritional supplements against vanadium intoxication in female albino rats.
The Journal of toxicological sciences.
2007 May; 32(2):185-92. doi:
10.2131/jts.32.185. [PMID: 17538242] - Akira Sasaki, Yasuo Oshima, Akio Fujimura. An approach to elucidate potential mechanism of renal toxicity of arsenic trioxide.
Experimental hematology.
2007 Feb; 35(2):252-62. doi:
10.1016/j.exphem.2006.10.004. [PMID: 17258074] - Biing-Hui Liu, Ting-Shuan Wu, Feng-Yih Yu, Ching-Chyuan Su. Induction of oxidative stress response by the mycotoxin patulin in mammalian cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2007 Feb; 95(2):340-7. doi:
10.1093/toxsci/kfl156. [PMID: 17090621] - Pragya Sharma, Zahoor Ahmad Shah, Amit Kumar, Fakhrul Islam, K P Mishra. Role of combined administration of Tiron and glutathione against aluminum-induced oxidative stress in rat brain.
Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS).
2007; 21(1):63-70. doi:
10.1016/j.jtemb.2006.12.001. [PMID: 17317527] - Xue-Fei Lv, Yi-Bing Zhao, Qun-Fang Zhou, Gui-Bin Jiang, Mao-Yong Song. Determination of alkali-labile phosphoprotein phosphorus from fish plasma using the Tb(3+)-tiron complex as a fluorescence probe.
Journal of environmental sciences (China).
2007; 19(5):616-21. doi:
10.1016/s1001-0742(07)60102-8. [PMID: 17915693] - Patrick Bättig, Lucy J Hathaway, Sandra Hofer, Kathrin Mühlemann. Serotype-specific invasiveness and colonization prevalence in Streptococcus pneumoniae correlate with the lag phase during in vitro growth.
Microbes and infection.
2006 Sep; 8(11):2612-7. doi:
10.1016/j.micinf.2006.07.013. [PMID: 16938479] - Mayuko Nagira, Mikio Tomita, Satoshi Mizuno, Miyuki Kumata, Toshiyuki Ayabe, Masahiro Hayashi. Ischemia/reperfusion injury in the monolayers of human intestinal epithelial cell line caco-2 and its recovery by antioxidants.
Drug metabolism and pharmacokinetics.
2006 Jun; 21(3):230-7. doi:
10.2133/dmpk.21.230. [PMID: 16858127] - Mi Ran Yun, Dong Sun Im, Jong-Soo Lee, Seok Man Son, Sang-Min Sung, Sun Sik Bae, Chi Dae Kim. NAD(P)H oxidase-stimulating activity of serum from type 2 diabetic patients with retinopathy mediates enhanced endothelial expression of E-selectin.
Life sciences.
2006 Apr; 78(22):2608-14. doi:
10.1016/j.lfs.2005.10.044. [PMID: 16343554] - Pragya Sharma, Kaushala Prasad Mishra. Aluminum-induced maternal and developmental toxicity and oxidative stress in rat brain: response to combined administration of Tiron and glutathione.
Reproductive toxicology (Elmsford, N.Y.).
2006 Apr; 21(3):313-21. doi:
10.1016/j.reprotox.2005.06.004. [PMID: 16040227] - Ryouhei Nakano, Hiroyuki Ishida, Amane Makino, Tadahiko Mae. In vivo fragmentation of the large subunit of ribulose-1,5-bisphosphate carboxylase by reactive oxygen species in an intact leaf of cucumber under chilling-light conditions.
Plant & cell physiology.
2006 Feb; 47(2):270-6. doi:
10.1093/pcp/pci245. [PMID: 16373381] - Molly E Beckers-Trapp, Louise Lanoue, Carl L Keen, Robert B Rucker, Janet Y Uriu-Adams. Abnormal development and increased 3-nitrotyrosine in copper-deficient mouse embryos.
Free radical biology & medicine.
2006 Jan; 40(1):35-44. doi:
10.1016/j.freeradbiomed.2005.08.020. [PMID: 16337877] - Timm H Westhoff, Stefanie Scheid, Markus Tölle, Bogac Kaynak, Sven Schmidt, Walter Zidek, Silke Sperling, Markus van der Giet. A physiogenomic approach to study the regulation of blood pressure.
Physiological genomics.
2005 Sep; 23(1):46-53. doi:
10.1152/physiolgenomics.00077.2005. [PMID: 15942020] - Tusty-Jiuan Hsieh, Pierre Fustier, Chih-Chang Wei, Shao-Ling Zhang, Janos G Filep, Shiow-Shiu Tang, Julie R Ingelfinger, I George Fantus, Pavel Hamet, John S D Chan. Reactive oxygen species blockade and action of insulin on expression of angiotensinogen gene in proximal tubular cells.
The Journal of endocrinology.
2004 Dec; 183(3):535-50. doi:
10.1677/joe.1.05871. [PMID: 15590980] - Takeshi Yamaguchi, Shigeru Tanabe, Eiichi Minami, Naoto Shibuya. Activation of phospholipase D induced by hydrogen peroxide in suspension-cultured rice cells.
Plant & cell physiology.
2004 Sep; 45(9):1261-70. doi:
10.1093/pcp/pch150. [PMID: 15509849] - Bea Pauw, Bert van Duijn, Jan W Kijne, Johan Memelink. Activation of the oxidative burst by yeast elicitor in Catharanthus roseus cells occurs independently of the activation of genes involved in alkaloid biosynthesis.
Plant molecular biology.
2004 Aug; 55(6):797-805. doi:
10.1007/s11103-004-1968-2. [PMID: 15604717] - Sanjana Dayal, Erland Arning, Teodoro Bottiglieri, Rainer H Böger, Curt D Sigmund, Frank M Faraci, Steven R Lentz. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice.
Stroke.
2004 Aug; 35(8):1957-62. doi:
10.1161/01.str.0000131749.81508.18. [PMID: 15178827] - R Mathur, Satendra Kumar Nirala, Asha Mathur. Comparative effectiveness of CaNa3DTPA and tiron along with alpha-tocopherol against beryllium-induced biochemical alterations in rats.
Indian journal of experimental biology.
2004 Jun; 42(6):570-4. doi:
. [PMID: 15260107] - Takuya Kishi, Yoshitaka Hirooka, Yoshikuni Kimura, Koji Ito, Hiroaki Shimokawa, Akira Takeshita. Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats.
Circulation.
2004 May; 109(19):2357-62. doi:
10.1161/01.cir.0000128695.49900.12. [PMID: 15117836] - Wei Li, Thomas Jue, John Edwards, Xipping Wang, Thomas H Hintze. Changes in NO bioavailability regulate cardiac O2 consumption: control by intramitochondrial SOD2 and intracellular myoglobin.
American journal of physiology. Heart and circulatory physiology.
2004 Jan; 286(1):H47-54. doi:
10.1152/ajpheart.00730.2003. [PMID: 12919935] - Shinji Susa, Ichiro Wakabayashi. Extracellular alkalosis activates ERK mitogen-activated protein kinase of vascular smooth muscle cells through NADPH-mediated formation of reactive oxygen species.
FEBS letters.
2003 Nov; 554(3):399-402. doi:
10.1016/s0014-5793(03)01198-0. [PMID: 14623101] - Saeid Navabpour, Karl Morris, Rebecca Allen, Elizabeth Harrison, Soheila A-H-Mackerness, Vicky Buchanan-Wollaston. Expression of senescence-enhanced genes in response to oxidative stress.
Journal of experimental botany.
2003 Oct; 54(391):2285-92. doi:
10.1093/jxb/erg267. [PMID: 12947053] - Shingo Matsumoto, Ichiro Koshiishi, Toyoshi Inoguchi, Hajime Nawata, Hideo Utsumi. Confirmation of superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice.
Free radical research.
2003 Jul; 37(7):767-72. doi:
10.1080/1071576031000107344. [PMID: 12911273] - Michael Vetter, Zi-Jiang Chen, Geen-Dong Chang, Danian Che, Shiguo Liu, Chung-Ho Chang. Cyclosporin A disrupts bradykinin signaling through superoxide.
Hypertension (Dallas, Tex. : 1979).
2003 May; 41(5):1136-42. doi:
10.1161/01.hyp.0000068201.48340.3b. [PMID: 12695417] - Kuo-Jang Ho, Tsung-Kwei Liu, Tien-Shang Huang, Fung-Jou Lu. Humic acid mediates iron release from ferritin and promotes lipid peroxidation in vitro: a possible mechanism for humic acid-induced cytotoxicity.
Archives of toxicology.
2003 Feb; 77(2):100-9. doi:
10.1007/s00204-002-0378-y. [PMID: 12590362] - Hui Xu, Gregory D Fink, James J Galligan. Nitric oxide-independent effects of tempol on sympathetic nerve activity and blood pressure in DOCA-salt rats.
American journal of physiology. Heart and circulatory physiology.
2002 Sep; 283(3):H885-92. doi:
10.1152/ajpheart.00134.2002. [PMID: 12181115] - Tusty-Jiuan Hsieh, Shao-Ling Zhang, Janos G Filep, Shiow-Shih Tang, Julie R Ingelfinger, John S D Chan. High glucose stimulates angiotensinogen gene expression via reactive oxygen species generation in rat kidney proximal tubular cells.
Endocrinology.
2002 Aug; 143(8):2975-85. doi:
10.1210/endo.143.8.8931. [PMID: 12130563] - Pragya Sharma, Ahmad Shah, Sangeeta Shukla. Protective effect of Tiron (4,5-dihydroxybenzene-1,3-disulfonic acid disodium salt) against beryllium-induced maternal and fetal toxicity in rats.
Archives of toxicology.
2002 Aug; 76(8):442-8. doi:
10.1007/s00204-002-0356-4. [PMID: 12185411] - I C Mori, R Pinontoan, T Kawano, S Muto. Involvement of superoxide generation in salicylic acid-induced stomatal closure in Vicia faba.
Plant & cell physiology.
2001 Dec; 42(12):1383-8. doi:
10.1093/pcp/pce176. [PMID: 11773531] - R Nakamura, K Egashira, K Arimura, Y Machida, T Ide, H Tsutsui, H Shimokawa, A Takeshita. Increased inactivation of nitric oxide is involved in impaired coronary flow reserve in heart failure.
American journal of physiology. Heart and circulatory physiology.
2001 Dec; 281(6):H2619-25. doi:
10.1152/ajpheart.2001.281.6.h2619. [PMID: 11709431] - E J Hunt, C E Lester, E A Lester, R L Tackett. Effect of St. John's wort on free radical production.
Life sciences.
2001 Jun; 69(2):181-90. doi:
10.1016/s0024-3205(01)01102-x. [PMID: 11441908] - G Wolf, T Hannken, R Schroeder, G Zahner, F N Ziyadeh, R A Stahl. Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells.
FEBS letters.
2001 Jan; 488(3):154-9. doi:
10.1016/s0014-5793(00)02403-0. [PMID: 11163763] - K Arimura, K Egashira, R Nakamura, T Ide, H Tsutsui, H Shimokawa, A Takeshita. Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure.
American journal of physiology. Heart and circulatory physiology.
2001 Jan; 280(1):H68-75. doi:
10.1152/ajpheart.2001.280.1.h68. [PMID: 11123219] - C Swain, G B Chainy. In vitro stimulation of chick brain lipid peroxidation by aluminium, and effects of tiron, EDTA and some antioxidants.
Indian journal of experimental biology.
2000 Dec; 38(12):1231-5. doi:
". [PMID: 11411045] - M S Penn, M Z Cui, A L Winokur, J Bethea, T A Hamilton, P E DiCorleto, G M Chisolm. Smooth muscle cell surface tissue factor pathway activation by oxidized low-density lipoprotein requires cellular lipid peroxidation.
Blood.
2000 Nov; 96(9):3056-63. doi:
". [PMID: 11049984] - P Sharma, S Johri, S Shukla. Beryllium-induced toxicity and its prevention by treatment with chelating agents.
Journal of applied toxicology : JAT.
2000 Jul; 20(4):313-8. doi:
10.1002/1099-1263(200007/08)20:4<313::aid-jat660>3.0.co;2-j. [PMID: 10942906] - Q Y He, A B Mason, B M Tam, R T MacGillivray, R C Woodworth. [13C]Methionine NMR and metal-binding studies of recombinant human transferrin N-lobe and five methionine mutants: conformational changes and increased sensitivity to chloride.
The Biochemical journal.
1999 Dec; 344 Pt 3(?):881-7. doi:
. [PMID: 10585877] - S L Lee, W W Wang, G A Finlay, B L Fanburg. Serotonin stimulates mitogen-activated protein kinase activity through the formation of superoxide anion.
The American journal of physiology.
1999 08; 277(2):L282-91. doi:
10.1152/ajplung.1999.277.2.l282. [PMID: 10444522] - K Kugiyama, S Sugiyama, N Ogata, H Oka, H Doi, Y Ota, H Yasue. Burst production of superoxide anion in human endothelial cells by lysophosphatidylcholine.
Atherosclerosis.
1999 Mar; 143(1):201-4. doi:
10.1016/s0021-9150(98)00288-3. [PMID: 10208496] - S Shukla, P Sharma, S Johri, R Mathur. Influence of chelating agents on the toxicity and distribution of beryllium in rats.
Journal of applied toxicology : JAT.
1998 Sep; 18(5):331-5. doi:
10.1002/(sici)1099-1263(1998090)18:5<331::aid-jat517>3.0.co;2-0. [PMID: 9804433] - N Sakata, K Miyamoto, J Meng, Y Tachikawa, Y Imanaga, S Takebayashi, T Furukawa. Oxidative damage of vascular smooth muscle cells by the glycated protein-cupric ion system.
Atherosclerosis.
1998 Feb; 136(2):263-74. doi:
10.1016/s0021-9150(97)00219-0. [PMID: 9543097] - E J Beatty, M C Cox, T A Frenkiel, Q Y He, A B Mason, P J Sadler, A Tucker, R C Woodworth. Trp128Tyr mutation in the N-lobe of recombinant human serum transferrin: 1H- and 15N-NMR and metal binding studies.
Protein engineering.
1997 May; 10(5):583-91. doi:
10.1093/protein/10.5.583. [PMID: 9215577] - J L Domingo, A de la Torre, M Bellés, E Mayayo, J M Llobet, J Corbella. Comparative effects of the chelators sodium 4,5-dihydroxybenzene-1,3-disulfonate (Tiron) and diethylenetriaminepentaacetic acid (DTPA) on acute uranium nephrotoxicity in rats.
Toxicology.
1997 Mar; 118(1):49-59. doi:
10.1016/s0300-483x(96)03589-5. [PMID: 9074653] - F J Alcaín, H Löw, F L Crane. Inhibition of DNA synthesis in CCL 39 cells by impermeable iron chelators.
Biochemistry and molecular biology international.
1997 Feb; 41(2):303-10. doi:
10.1080/15216549700201311. [PMID: 9063570] - J A Davies, S G Dutremez, C M Hockensmith, R Keck, N Richardson, S Selman, D A Smith, C W Ulmer, L S Wheatley, J Zeiss. Iron-based second-sphere contrast agents for magnetic resonance imaging: development of a model system and evaluation of iron (III) tris (tironate) complex in rats.
Academic radiology.
1996 Nov; 3(11):936-45. doi:
10.1016/s1076-6332(96)80305-9. [PMID: 8959184] - J T Daley, M T Watkins, M L Brown, V Martinez, P Cuevas, I Saenz de Tejada. Prostanoid production in rabbit corpus cavernosum. II. Inhibition by oxidative stress.
The Journal of urology.
1996 Sep; 156(3):1169-73. doi:
". [PMID: 8709340] - A S Baas, B C Berk. Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells.
Circulation research.
1995 Jul; 77(1):29-36. doi:
10.1161/01.res.77.1.29. [PMID: 7540516] - J L Domingo, M Gomez, D J Sanchez, J M Llobet, C L Keen. Tiron administration minimizes the toxicity of vanadate but not its insulin mimetic properties in diabetic rats.
Life sciences.
1992; 50(18):1311-7. doi:
10.1016/0024-3205(92)90281-s. [PMID: 1532846] - A Ortega, D J Sánchez, J L Domingo, J M Llobet, J Corbella. Developmental toxicity evaluation of tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) in mice.
Research communications in chemical pathology and pharmacology.
1991 Jul; 73(1):97-106. doi:
NULL. [PMID: 1882131] - M Gómez, J L Domingo, J M Llobet, J Corbella. Effectiveness of some chelating agents on distribution and excretion of vanadium in rats after prolonged oral administration.
Journal of applied toxicology : JAT.
1991 Jun; 11(3):195-98. doi:
10.1002/jat.2550110307. [PMID: 1918793] - G N Stradling, S A Gray, J C Moody, M Ellender. Efficacy of tiron for enhancing the excretion of uranium from the rat.
Human & experimental toxicology.
1991 May; 10(3):195-8. doi:
10.1177/096032719101000308. [PMID: 1678949] - R K Zalups. An evaluation of Tiron (sodium 4,5-dihydroxybenzene-1,3-disulfonate) as a rescue agent for the nephropathy induced by uranyl fluoride (UO2F2) in rats.
Research communications in chemical pathology and pharmacology.
1991 Apr; 72(1):125-8. doi:
NULL. [PMID: 2052745] - J L Domingo, A Ortega, J M Llobet, J Corbella. Effectiveness of chelation therapy with time after acute uranium intoxication.
Fundamental and applied toxicology : official journal of the Society of Toxicology.
1990 Jan; 14(1):88-95. doi:
10.1016/0272-0590(90)90234-b. [PMID: 2307325] - L S Yoshida, T Miyazawa, K Fujimoto, T Kaneda. Spontaneous and luminol-dependent chemiluminescences from tissue preparations of benzo[a]pyrene-injected mice.
Journal of nutritional science and vitaminology.
1989 Dec; 35(6):569-78. doi:
10.3177/jnsv.35.569. [PMID: 2634738] - M Gómez, J L Domingo, J M Llobet, J L Paternain. Effectiveness of chelation therapy with time after acute vanadium intoxication.
Journal of applied toxicology : JAT.
1988 Dec; 8(6):439-44. doi:
10.1002/jat.2550080609. [PMID: 3230256] - M Takagi, H Onodera, I Miyamoto, N Morita. Effects of active oxygen scavengers on the peroxidation of linoleic acid catalyzed by dehydro-L-ascorbic acid or its degradation products.
Journal of nutritional science and vitaminology.
1988 Feb; 34(1):141-9. doi:
10.3177/jnsv.34.141. [PMID: 3392604] - K Ueda, S Kobayashi, J Morita, T Komano. Site-specific DNA damage caused by lipid peroxidation products.
Biochimica et biophysica acta.
1985 Apr; 824(4):341-8. doi:
10.1016/0167-4781(85)90041-7. [PMID: 3157404]