adriamycinone (BioDeep_00000606452)
代谢物信息卡片
adriamycinone
化学式: C21H18O9 (414.0950778)
中文名称: 阿霉酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: COC1=CC=CC2=C1C(=O)C3=C(C4=C(CC(CC4O)(C(=O)CO)O)C(=C3C2=O)O)O
InChI: InChI=1S/C21H18O9/c1-30-11-4-2-3-8-14(11)20(28)16-15(17(8)25)18(26)9-5-21(29,12(24)7-22)6-10(23)13(9)19(16)27/h2-4,10,22-23,26-27,29H,5-7H2,1H3/t10-,21-/m0/s1
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:165223
- PubChem: 72401
- Metlin: METLIN657
- ChEMBL: CHEMBL3544660
- CAS: 24385-10-2
- RefMet: Adriamycinone
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(1)
- Doxorubicin Metabolism Pathway:
Adenosine triphosphate + Doxorubicin + Water ⟶ Adenosine diphosphate + Doxorubicin + Phosphate
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lara Zorić, Nikša Drinković, Vedran Micek, Leo Frkanec, Akif Emre Türeli, Nazende Günday-Türeli, Ivana Vinković Vrček, Ruža Frkanec. High-Throughput Method for the Simultaneous Determination of Doxorubicin Metabolites in Rat Urine after Treatment with Different Drug Nanoformulations.
Molecules (Basel, Switzerland).
2022 Feb; 27(4):. doi:
10.3390/molecules27041177. [PMID: 35208967] - Won-Gu Choi, Dong Kyun Kim, Yongho Shin, Ria Park, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Hye Suk Lee. Liquid Chromatography-Tandem Mass Spectrometry for the Simultaneous Determination of Doxorubicin and its Metabolites Doxorubicinol, Doxorubicinone, Doxorubicinolone, and 7-Deoxydoxorubicinone in Mouse Plasma.
Molecules (Basel, Switzerland).
2020 Mar; 25(5):. doi:
10.3390/molecules25051254. [PMID: 32164308] - Kieko Saito, Takuya Fujieda, Hisashi Yoshioka. Feasibility of simple chitosan sheet as drug delivery carrier.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2006 Oct; 64(2):161-6. doi:
10.1016/j.ejpb.2006.04.008. [PMID: 16884897] - I K Barker, S M Crawford, A F Fell. Determination of plasma concentrations of epirubicin and its metabolites by high-performance liquid chromatography during a 96-h infusion in cancer chemotherapy.
Journal of chromatography. B, Biomedical applications.
1996 Jun; 681(2):323-9. doi:
10.1016/0378-4347(96)00030-8. [PMID: 8811443] - D Fraier, E Frigerio, E Pianezzola, M Strolin Benedetti, J Cassidy, P Vasey. A sensitive procedure for the quantitation of free and N-(2-hydroxypropyl) methacrylamide polymer-bound doxorubicin (PK1) and some of its metabolites, 13-dihydrodoxorubicin, 13-dihydrodoxorubicinone and doxorubicinone, in human plasma and urine by reversed-phase HPLC with fluorimetric detection.
Journal of pharmaceutical and biomedical analysis.
1995 Apr; 13(4-5):625-33. doi:
10.1016/0731-7085(95)01301-z. [PMID: 9696578] - S M Golabi, D Nematollahi. Polarographic determination of doxorubicin and daunorubicin in pharmaceutical preparations and biological media.
Journal of pharmaceutical and biomedical analysis.
1992 Oct; 10(10-12):1053-7. doi:
10.1016/0731-7085(91)80118-s. [PMID: 1298361] - M H Bronchud, J M Margison, A Howell, M Lind, S B Lucas, P M Wilkinson. Comparative pharmacokinetics of escalating doses of doxorubicin in patients with metastatic breast cancer.
Cancer chemotherapy and pharmacology.
1990; 25(6):435-9. doi:
10.1007/bf00686055. [PMID: 2311172] - A Sqalli, C Labat, J Oustrin, G Houin, Y Coulais, R Bugat, P Carton. Rapid quantitative determination of doxorubicin and its metabolites in biological samples.
Annales de biologie clinique.
1989; 47(2):63-6. doi:
NULL. [PMID: 2735565] - P M Sokolove, R G Shinaberry. Na+-independent release of Ca2+ from rat heart mitochondria. Induction by adriamycin aglycone.
Biochemical pharmacology.
1988 Mar; 37(5):803-12. doi:
10.1016/0006-2952(88)90165-7. [PMID: 3345198] - R Mahdadi, M Lhermitte, J J Lafitte. Determination of adriamycin and its fluorescent metabolites in human plasma by HPLC.
Biomedical chromatography : BMC.
1987 Feb; 2(1):38-40. doi:
10.1002/bmc.1130020111. [PMID: 3508093] - J Cummings, D J Kerr, S B Kaye. Occurrence of circulating 7-deoxyaglycone metabolites of 4'-deoxydoxorubicin in man.
Cancer chemotherapy and pharmacology.
1987; 20(3):263-4. doi:
10.1007/bf00570499. [PMID: 3677300] - M A Van Lancker, L A Bellemans, A P De Leenheer. Quantitative determination of low concentrations of adriamycin in plasma and cell cultures, using a volatile extraction buffer.
Journal of chromatography.
1986 Jan; 374(2):415-20. doi:
10.1016/s0378-4347(00)83302-2. [PMID: 3457018] - J Cummings. Method for the determination of 4'-deoxydoxorubicin, 4'-deoxydoxorubicinol and their 7-deoxyaglycones in human serum by high-performance liquid chromatography.
Journal of chromatography.
1985 Jun; 341(2):401-9. doi:
10.1016/s0378-4347(00)84053-0. [PMID: 4030989] - J S Lazo, P E Schwartz. Rapid distribution of adriamycin in the ascitic and pleural fluid of women with ovarian carcinomas.
Gynecologic oncology.
1985 May; 21(1):65-72. doi:
10.1016/0090-8258(85)90233-1. [PMID: 3988127] - J Cummings, J F Stuart, K C Calman. Determination of adriamycin, adriamycinol and their 7-deoxyaglycones in human serum by high-performance liquid chromatography.
Journal of chromatography.
1984 Nov; 311(1):125-33. doi:
10.1016/s0378-4347(00)84698-8. [PMID: 6520153] - R Bailey-Wood, C M Dallimore, J A Whittaker. Effect of adriamycin on CFUGM at plasma concentrations found following therapeutic infusions.
British journal of cancer.
1984 Sep; 50(3):351-5. doi:
10.1038/bjc.1984.182. [PMID: 6466545] - R F Ozols, J K Willson, M D Weltz, K R Grotzinger, C E Myers, R C Young. Inhibition of human ovarian cancer colony formation by adriamycin and its major metabolites.
Cancer research.
1980 Nov; 40(11):4109-12. doi:
NULL. [PMID: 7471054] - G Ehninger, H J Stocker, B Proksch, K Wilms. [The pharmacokinetics of adriamycin and adriamycin-metabolites (author's transl)].
Klinische Wochenschrift.
1980 Sep; 58(18):927-34. doi:
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