HU-308 (BioDeep_00000605910)

   


代谢物信息卡片


4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-2-ene-2-methanol

化学式: C27H42O3 (414.3133782)
中文名称: (1R,4R,5R)-REL-(+)-4-[4-(1,1-二甲基庚基)-2,6-二甲氧基苯基]-6,6-二甲基双环[3.1.1]庚-2-烯-2-甲醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCCCCCC(C)(C)C1=CC(=C(C(=C1)OC)C2C=C(C3CC2C3(C)C)CO)OC
InChI: InChI=1S/C27H42O3/c1-8-9-10-11-12-26(2,3)19-14-23(29-6)25(24(15-19)30-7)20-13-18(17-28)21-16-22(20)27(21,4)5/h13-15,20-22,28H,8-12,16-17H2,1-7H3/t20-,21+,22-/m0/s1

描述信息

D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D063385 - Cannabinoid Receptor Modulators
D018377 - Neurotransmitter Agents > D063385 - Cannabinoid Receptor Modulators > D063386 - Cannabinoid Receptor Agonists
C78272 - Agent Affecting Nervous System > C241 - Analgesic Agent

同义名列表

3 个代谢物同义名

Onternabez; HU-308; 4-[4-(1,1-dimethylheptyl)-2,6-dimethoxyphenyl]-6,6-dimethyl-bicyclo[3.1.1]hept-2-ene-2-methanol



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • D Scuteri, L Rombolà, K Hamamura, T Sakurada, C Watanabe, S Sakurada, F Guida, S Boccella, S Maione, G Gallo Afflitto, C Nucci, P Tonin, G Bagetta, M T Corasaniti. Is there a rational basis for cannabinoids research and development in ocular pain therapy? A systematic review of preclinical evidence. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Feb; 146(?):112505. doi: 10.1016/j.biopha.2021.112505. [PMID: 34891121]
  • J T Toguri, E Leishman, A M Szczesniak, R B Laprairie, O Oehler, A J Straiker, M E M Kelly, H B Bradshaw. Inflammation and CB2 signaling drive novel changes in the ocular lipidome and regulate immune cell activity in the eye. Prostaglandins & other lipid mediators. 2018 11; 139(?):54-62. doi: 10.1016/j.prostaglandins.2018.09.004. [PMID: 30232034]
  • Anna-Maria Szczesniak, Richard F Porter, James T Toguri, Joanna Borowska-Fielding, Simon Gebremeskel, Anuja Siwakoti, Brent Johnston, Christian Lehmann, Melanie E M Kelly. Cannabinoid 2 receptor is a novel anti-inflammatory target in experimental proliferative vitreoretinopathy. Neuropharmacology. 2017 Feb; 113(Pt B):627-638. doi: 10.1016/j.neuropharm.2016.08.030. [PMID: 27569993]
  • Sharon Anavi-Goffer, Andrew J Irving, Ruth A Ross. Modulation of l-α-lysophosphatidylinositol/GPR55 MAP kinase signalling by CB2 receptor agonists: identifying novel GPR55 inhibitors. Journal of basic and clinical physiology and pharmacology. 2016 May; 27(3):303-10. doi: 10.1515/jbcpp-2015-0142. [PMID: 27089417]
  • Reem Smoum, Saja Baraghithy, Mukesh Chourasia, Aviva Breuer, Naama Mussai, Malka Attar-Namdar, Natalya M Kogan, Bitya Raphael, Daniele Bolognini, Maria G Cascio, Pietro Marini, Roger G Pertwee, Avital Shurki, Raphael Mechoulam, Itai Bab. CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency. Proceedings of the National Academy of Sciences of the United States of America. 2015 Jul; 112(28):8774-9. doi: 10.1073/pnas.1503395112. [PMID: 26124120]
  • Huan Gui, Xia Liu, Li-Rong Liu, Ding-Feng Su, Sheng-Ming Dai. Activation of cannabinoid receptor 2 attenuates synovitis and joint distruction in collagen-induced arthritis. Immunobiology. 2015 Jun; 220(6):817-22. doi: 10.1016/j.imbio.2014.12.012. [PMID: 25601571]
  • Rentian Feng, Christine A Milcarek, Xiang-Qun Xie. Antagonism of cannabinoid receptor 2 pathway suppresses IL-6-induced immunoglobulin IgM secretion. BMC pharmacology & toxicology. 2014 Jun; 15(?):30. doi: 10.1186/2050-6511-15-30. [PMID: 24913620]
  • Partha Mukhopadhyay, Mohanraj Rajesh, Hao Pan, Vivek Patel, Bani Mukhopadhyay, Sándor Bátkai, Bin Gao, György Haskó, Pál Pacher. Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy. Free radical biology & medicine. 2010 Feb; 48(3):457-67. doi: 10.1016/j.freeradbiomed.2009.11.022. [PMID: 19969072]
  • Mohanraj Rajesh, Hao Pan, Partha Mukhopadhyay, Sándor Bátkai, Douglas Osei-Hyiaman, György Haskó, Lucas Liaudet, Bin Gao, Pál Pacher. Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis. Journal of leukocyte biology. 2007 Dec; 82(6):1382-9. doi: 10.1189/jlb.0307180. [PMID: 17652447]
  • Moisés García-Arencibia, Sara González, Eva de Lago, José A Ramos, Raphael Mechoulam, Javier Fernández-Ruiz. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain research. 2007 Feb; 1134(1):162-70. doi: 10.1016/j.brainres.2006.11.063. [PMID: 17196181]