Lificiguat (BioDeep_00000605873)
代谢物信息卡片
5-[1-(phenylmethyl)-1H-indazol-3-yl]-2-furanmethanol
化学式: C19H16N2O2 (304.12117159999997)
中文名称: 利非西呱
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=N2)C4=CC=C(O4)CO
InChI: InChI=1S/C19H16N2O2/c22-13-15-10-11-18(23-15)19-16-8-4-5-9-17(16)21(20-19)12-14-6-2-1-3-7-14/h1-11,22H,12-13H2
描述信息
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
D020536 - Enzyme Activators
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:142430
- ChEBI: CHEBI:93060
- PubChem: 5712
- Metlin: METLIN64877
- ChEMBL: CHEMBL333985
- CAS: 170632-47-0
- CAS: 154453-18-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zebo Hu, Qianwen Zhu, Ying Wang, Xue Deng, Hui Yang, Mingjun Zhou, Jiyuan Zhang, Hao Wang, Haosen Wang, Lin Wang, Cui Zhang, Shu Li. Lipid nephrotoxicity mediated by HIF-1α activation accelerates tubular injury in diabetic nephropathy.
Renal failure.
2024 Dec; 46(1):2347446. doi:
10.1080/0886022x.2024.2347446. [PMID: 38695335] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Yu Ah Hong, So Young Jung, Keum Jin Yang, Dai Sig Im, Kyung Hwan Jeong, Cheol Whee Park, Hyeon Seok Hwang. Cilastatin Preconditioning Attenuates Renal Ischemia-Reperfusion Injury via Hypoxia Inducible Factor-1α Activation.
International journal of molecular sciences.
2020 May; 21(10):. doi:
10.3390/ijms21103583. [PMID: 32438631] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Jin-Wen Wang, Chin-Bin Yeh, Shao-Jiun Chou, Kuo-Cheng Lu, Tzu-Hui Chu, Wei-Yu Chen, Jui-Lin Chien, Mao-Hsiung Yen, Tien-Hua Chen, Jia-Fwu Shyu. YC-1 alleviates bone loss in ovariectomized rats by inhibiting bone resorption and inducing extrinsic apoptosis in osteoclasts.
Journal of bone and mineral metabolism.
2018 Sep; 36(5):508-518. doi:
10.1007/s00774-017-0866-z. [PMID: 28983668] - Wenpei Dong, Ping Yu, Tielong Zhang, Chenzhuang Zhu, Jun Qi, Junhao Liang. Adrenomedullin serves a role in the humoral pathway of delayed remote ischemic preconditioning via a hypoxia-inducible factor-1α-associated mechanism.
Molecular medicine reports.
2018 03; 17(3):4547-4553. doi:
10.3892/mmr.2018.8450. [PMID: 29344650] - Jianming Wu, Xiao Ke, Wei Fu, Xiaoping Gao, Hongcheng Zhang, Wei Wang, Na Ma, Manxi Zhao, Xiaofeng Hao, Zhirong Zhang. Inhibition of Hypoxia-Induced Retinal Angiogenesis by Specnuezhenide, an Effective Constituent of Ligustrum lucidum Ait., through Suppression of the HIF-1α/VEGF Signaling Pathway.
Molecules (Basel, Switzerland).
2016 Dec; 21(12):. doi:
10.3390/molecules21121756. [PMID: 28009852] - W D Shen, W Zhang, Q H Xu, P F Liu. [Effect of targeted inhibition of hypoxia-inducible factor-1α by 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole on the progression of non-alcoholic fatty liver disease in rats].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology.
2016 Oct; 24(10):749-754. doi:
10.3760/cma.j.issn.1007-3418.2016.10.007. [PMID: 27938560] - Bijaya K Nayak, Karthigayan Shanmugasundaram, William E Friedrichs, Rita C Cavaglierii, Mandakini Patel, Jeffrey Barnes, Karen Block. HIF-1 Mediates Renal Fibrosis in OVE26 Type 1 Diabetic Mice.
Diabetes.
2016 05; 65(5):1387-97. doi:
10.2337/db15-0519. [PMID: 26908870] - Leo Tsui, Shwu-Fen Chang, Hsiang-Po Huang, Tsorng-Harn Fong, I-Jong Wang. YC-1 induces lipid droplet formation in RAW 264.7 macrophages.
Journal of biomedical science.
2016 Jan; 23(?):2. doi:
10.1186/s12929-016-0218-7. [PMID: 26767504] - Dong Hoon Shin, Haiyue Lin, Haifeng Zheng, Kyung Su Kim, Jin Young Kim, Yang Sook Chun, Jong Wan Park, Joo Hyun Nam, Woo Kyung Kim, Yin Hua Zhang, Sung Joon Kim. HIF-1α-mediated upregulation of TASK-2 K⁺ channels augments Ca²⁺ signaling in mouse B cells under hypoxia.
Journal of immunology (Baltimore, Md. : 1950).
2014 Nov; 193(10):4924-33. doi:
10.4049/jimmunol.1301829. [PMID: 25305321] - C-Y Tsou, C-Y Chen, J-F Zhao, K-H Su, H-T Lee, S-J Lin, S-K Shyue, S-H Hsiao, T-S Lee. Activation of soluble guanylyl cyclase prevents foam cell formation and atherosclerosis.
Acta physiologica (Oxford, England).
2014 Apr; 210(4):799-810. doi:
10.1111/apha.12210. [PMID: 24299003] - Nergiz Hacer Turgut, Tijen Kaya Temiz, Bülent Turgut, Baris Karadas, Mesut Parlak, Ihsan Bagcivan. Investigation of the role of the NO-cGMP pathway on YC-1 and DEA/NO effects on thoracic aorta smooth muscle responses in a rat preeclampsia model.
Canadian journal of physiology and pharmacology.
2013 Oct; 91(10):797-803. doi:
10.1139/cjpp-2013-0086. [PMID: 24144050] - Kwok-Keung Lam, Pao-Yun Cheng, Yen-Mei Lee, Yu-Pei Liu, Cheng Ding, Won-Hsiung Liu, Mao-Hsiung Yen. The role of heat shock protein 70 in the protective effect of YC-1 on heat stroke rats.
European journal of pharmacology.
2013 Jan; 699(1-3):67-73. doi:
10.1016/j.ejphar.2012.11.044. [PMID: 23219797] - Lan Yao, Xiaowei Nie, Shuai Shi, Shasha Song, Xuewei Hao, Shuzhen Li, Daling Zhu. Reciprocal regulation of HIF-1α and 15-LO/15-HETE promotes anti-apoptosis process in pulmonary artery smooth muscle cells during hypoxia.
Prostaglandins & other lipid mediators.
2012 Dec; 99(3-4):96-106. doi:
10.1016/j.prostaglandins.2012.09.001. [PMID: 22982617] - Michal Aharoni-Simon, Sarit Anavi, Uwe Beifuss, Zecharia Madar, Oren Tirosh. Nitric oxide, can it be only good? Increasing the antioxidant properties of nitric oxide in hepatocytes by YC-1 compound.
Nitric oxide : biology and chemistry.
2012 Dec; 27(4):248-56. doi:
10.1016/j.niox.2012.08.076. [PMID: 22955014] - Sophie Doublier, Dimas C Belisario, Manuela Polimeni, Laura Annaratone, Chiara Riganti, Elena Allia, Dario Ghigo, Amalia Bosia, Anna Sapino. HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast.
BMC cancer.
2012 Jan; 12(?):4. doi:
10.1186/1471-2407-12-4. [PMID: 22217342] - Markus Hoenicka, Andreas Keyser, Leopold Rupprecht, Thomas Puehler, Stephan Hirt, Christof Schmid. Endothelium-dependent vasoconstriction in isolated vessel grafts: a novel mechanism of vasospasm?.
The Annals of thoracic surgery.
2011 Oct; 92(4):1299-306. doi:
10.1016/j.athoracsur.2011.05.114. [PMID: 21958775] - Kuniko Kimura, Masayuki Iwano, Debra F Higgins, Yukinari Yamaguchi, Kimihiko Nakatani, Koji Harada, Atsushi Kubo, Yasuhiro Akai, Erinn B Rankin, Eric G Neilson, Volker H Haase, Yoshihiko Saito. Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis.
American journal of physiology. Renal physiology.
2008 Oct; 295(4):F1023-9. doi:
10.1152/ajprenal.90209.2008. [PMID: 18667485] - Rebecca C Stratton, Paul E Squires, Anne K Green. ANP stimulates hepatocyte Ca2+ efflux via plasma membrane recruitment of PKGIalpha.
Biochemical and biophysical research communications.
2008 Apr; 368(4):965-70. doi:
10.1016/j.bbrc.2008.02.030. [PMID: 18280805] - M Slupski, L Szadujkis-Szadurski, G Grześk, R Szadujkis-Szadurski, K Szadujkis-Szadurska, Z Wlodarczyk, M Masztalerz, I Piotrowiak, M Jasiński. Guanylate cyclase activators influence reactivity of human mesenteric superior arteries retrieved and preserved in the same conditions as transplanted kidneys.
Transplantation proceedings.
2007 Jun; 39(5):1350-3. doi:
10.1016/j.transproceed.2007.02.079. [PMID: 17580137] - Paula Ferrer, Miguel Asensi, Sonia Priego, María Benlloch, Salvador Mena, Angel Ortega, Elena Obrador, Juan M Esteve, José M Estrela. Nitric oxide mediates natural polyphenol-induced Bcl-2 down-regulation and activation of cell death in metastatic B16 melanoma.
The Journal of biological chemistry.
2007 Feb; 282(5):2880-90. doi:
10.1074/jbc.m605934200. [PMID: 17135264] - A Elizabeth Linder, Romulo Leite, Kimberly Lauria, Thomas M Mills, R Clinton Webb. Penile erection requires association of soluble guanylyl cyclase with endothelial caveolin-1 in rat corpus cavernosum.
American journal of physiology. Regulatory, integrative and comparative physiology.
2006 May; 290(5):R1302-8. doi:
10.1152/ajpregu.00601.2005. [PMID: 16373436] - A Elizabeth Linder, Lynnette P McCluskey, Kenneth R Cole, Katherine M Lanning, R Clinton Webb. Dynamic association of nitric oxide downstream signaling molecules with endothelial caveolin-1 in rat aorta.
The Journal of pharmacology and experimental therapeutics.
2005 Jul; 314(1):9-15. doi:
10.1124/jpet.105.083634. [PMID: 15778264] - Jih-Pyang Wang, Yu-San Chen, Chi-Ren Tsai, Li-Jiau Huang, Sheng-Chu Kuo. The blockade of cyclopiazonic acid-induced store-operated Ca2+ entry pathway by YC-1 in neutrophils.
Biochemical pharmacology.
2004 Nov; 68(10):2053-64. doi:
10.1016/j.bcp.2004.07.011. [PMID: 15476676] - Florian Mullershausen, Michael Russwurm, Andreas Friebe, Doris Koesling. Inhibition of phosphodiesterase type 5 by the activator of nitric oxide-sensitive guanylyl cyclase BAY 41-2272.
Circulation.
2004 Apr; 109(14):1711-3. doi:
10.1161/01.cir.0000126286.47618.bd. [PMID: 15066950] - Jörg Kempfert, Sönke Behrends. Analysis of nitric oxide-sensitive guanylyl cyclase in human platelets before and after aggregation.
Platelets.
2003 Nov; 14(7-8):429-35. doi:
10.1080/0953710032000141752. [PMID: 14713512] - Eun-Jin Yeo, Yang-Sook Chun, Young-Suk Cho, Jinho Kim, June-Chul Lee, Myung-Suk Kim, Jong-Wan Park. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1.
Journal of the National Cancer Institute.
2003 Apr; 95(7):516-25. doi:
10.1093/jnci/95.7.516. [PMID: 12671019] - Kerry L Homer, Janet C Wanstall. Inhibition of rat platelet aggregation by the diazeniumdiolate nitric oxide donor MAHMA NONOate.
British journal of pharmacology.
2002 Dec; 137(7):1071-81. doi:
10.1038/sj.bjp.0704971. [PMID: 12429580] - Hanna Kotikoski, Päivi Alajuuma, Eeva Moilanen, Pertteli Salmenperä, Olli Oksala, Pekka Laippala, Heikki Vapaatalo. Comparison of nitric oxide donors in lowering intraocular pressure in rabbits: role of cyclic GMP.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
2002 Feb; 18(1):11-23. doi:
10.1089/108076802317233171. [PMID: 11858611] - R Ferrero, M Torres. Prolonged exposure to YC-1 induces apoptosis in adrenomedullary endothelial and chromaffin cells through a cGMP-independent mechanism.
Neuropharmacology.
2001 Dec; 41(7):895-906. doi:
10.1016/s0028-3908(01)00131-9. [PMID: 11684154] - C M Teng, C C Wu, F N Ko, F Y Lee, S C Kuo. YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice.
European journal of pharmacology.
1997 Feb; 320(2-3):161-6. doi:
10.1016/s0014-2999(96)00911-9. [PMID: 9059849] - S M Yu, Z J Cheng, J H Guh, F Y Lee, S C Kuo. Mechanism of anti-proliferation caused by YC-1, an indazole derivative, in cultured rat A10 vascular smooth-muscle cells.
The Biochemical journal.
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