Lactacystin (BioDeep_00000605856)
代谢物信息卡片
3S-hydroxy-2R-(1-hydroxy-2-methylpropyl)-4R-methyl-5-oxo-2-pyrrolidinecarboxylate-N-acetyl-L-cysteine
化学式: C15H24N2O7S (376.1304154)
中文名称: 乳胞素
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)[C@@H]([C@@]1([C@H]([C@@H](C)C(=O)N1)O)C(=O)SC[C@@H](C(=O)O)NC(=O)C)O
InChI: InChI=1S/C15H24N2O7S/c1-6(2)10(19)15(11(20)7(3)12(21)17-15)14(24)25-5-9(13(22)23)16-8(4)18/h6-7,9-11,19-20H,5H2,1-4H3,(H,16,18)(H,17,21)(H,22,23)/t7-,9+,10+,11+,15-/m1/s1
描述信息
L-Cysteine substituted at nitrogen by an acetyl group and at sulfur by a substituted-lactam carbonyl group.
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:52722
- PubChem: 6610292
- Metlin: METLIN64856
- ChEMBL: CHEMBL374308
- CAS: 133343-34-7
- MetaboLights: MTBLC52722
- RefMet: Lactacystin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Inci Barut, Xiulan He, Erol Sener, Sanna Sämfors, Andrew G Ewing, John S Fletcher. Correlative Cellular Mass Spectrometry Imaging and Amperometry Show Dose Dependent Changes in Lipid Composition and Exocytosis.
Angewandte Chemie (International ed. in English).
2023 04; 62(15):e202217993. doi:
10.1002/anie.202217993. [PMID: 36749546] - Bin Li, Jiaxin Li, Yanwei Hao, Peijun Xie, Shengnan Yue, Shaofeng Wang, Jing Zhang, Yi Zhang. Yuanzhi Powder inhibits tau pathology in SAMP8 mice: Mechanism research of a traditional Chinese formula against Alzheimer's disease.
Journal of ethnopharmacology.
2023 Mar; ?(?):116393. doi:
10.1016/j.jep.2023.116393. [PMID: 37001766] - Stina Leskelä, Nadine Huber, Hannah Rostalski, Teemu Natunen, Anne M Remes, Mari Takalo, Mikko Hiltunen, Annakaisa Haapasalo. C9orf72 Proteins Regulate Autophagy and Undergo Autophagosomal or Proteasomal Degradation in a Cell Type-Dependent Manner.
Cells.
2019 10; 8(10):. doi:
10.3390/cells8101233. [PMID: 31658762] - Jinhua Zhang, Daqiang Zhao, Ning Na, Heng Li, Bin Miao, Liangqing Hong, Zhengyu Huang. Renoprotective effect of erythropoietin via modulation of the STAT6/MAPK/NF-κB pathway in ischemia/reperfusion injury after renal transplantation.
International journal of molecular medicine.
2018 Jan; 41(1):25-32. doi:
10.3892/ijmm.2017.3204. [PMID: 29115389] - Fedor Simko, Olga Pechanova, Kristina Repova, Silvia Aziriova, Kristina Krajcirovicova, Peter Celec, Lubomira Tothova, Stanislava Vrankova, Lucia Balazova, Stefan Zorad, Michaela Adamcova. Lactacystin-Induced Model of Hypertension in Rats: Effects of Melatonin and Captopril.
International journal of molecular sciences.
2017 Jul; 18(8):. doi:
10.3390/ijms18081612. [PMID: 28757582] - Denise Zwanziger, Mathias Schmidt, Jana Fischer, Gunnar Kleinau, Doreen Braun, Ulrich Schweizer, Lars Christian Moeller, Heike Biebermann, Dagmar Fuehrer. The long N-terminus of the human monocarboxylate transporter 8 is a target of ubiquitin-dependent proteasomal degradation which regulates protein expression and oligomerization capacity.
Molecular and cellular endocrinology.
2016 10; 434(?):278-87. doi:
10.1016/j.mce.2016.05.017. [PMID: 27222294] - Catherine Cott, Roland Thuenauer, Alessia Landi, Katja Kühn, Samuel Juillot, Anne Imberty, Josef Madl, Thorsten Eierhoff, Winfried Römer. Pseudomonas aeruginosa lectin LecB inhibits tissue repair processes by triggering β-catenin degradation.
Biochimica et biophysica acta.
2016 Jun; 1863(6 Pt A):1106-18. doi:
10.1016/j.bbamcr.2016.02.004. [PMID: 26862060] - Anmol Kumar, Jaakko Kopra, Kärt Varendi, Lauriina L Porokuokka, Anne Panhelainen, Satu Kuure, Pepin Marshall, Nina Karalija, Mari-Anne Härma, Carolina Vilenius, Kersti Lilleväli, Triin Tekko, Jelena Mijatovic, Nita Pulkkinen, Madis Jakobson, Maili Jakobson, Roxana Ola, Erik Palm, Maria Lindahl, Ingrid Strömberg, Vootele Võikar, T Petteri Piepponen, Mart Saarma, Jaan-Olle Andressoo. GDNF Overexpression from the Native Locus Reveals its Role in the Nigrostriatal Dopaminergic System Function.
PLoS genetics.
2015 Dec; 11(12):e1005710. doi:
10.1371/journal.pgen.1005710. [PMID: 26681446] - Yue Cai, Yuhong Wang, Jia Xu, Xu Zuo, Yanfang Xu. Down-regulation of ether-a-go-go-related gene potassium channel protein through sustained stimulation of AT1 receptor by angiotensin II.
Biochemical and biophysical research communications.
2014 Sep; 452(3):852-7. doi:
10.1016/j.bbrc.2014.09.014. [PMID: 25218469] - Karina Reyes-Gordillo, Ruchi Shah, Jaime Arellanes-Robledo, Zamira Hernández-Nazara, Ana Rosa Rincón-Sánchez, Yutaka Inagaki, Marcos Rojkind, M Raj Lakshman. Mechanisms of action of acetaldehyde in the up-regulation of the human α2(I) collagen gene in hepatic stellate cells: key roles of Ski, SMAD3, SMAD4, and SMAD7.
The American journal of pathology.
2014 May; 184(5):1458-67. doi:
10.1016/j.ajpath.2014.01.020. [PMID: 24641900] - Paresh P Chothe, Peter W Swaan. Resveratrol promotes degradation of the human bile acid transporter ASBT (SLC10A2).
The Biochemical journal.
2014 Apr; 459(2):301-12. doi:
10.1042/bj20131428. [PMID: 24498857] - Tao Chen, Elizabeth M Laurenzana, Denise M Coslo, Fengming Chen, Curtis J Omiecinski. Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptor.
The Biochemical journal.
2014 Feb; 458(1):95-107. doi:
10.1042/bj20130685. [PMID: 24224465] - D Jantas, A Roman, J Kuśmierczyk, E Lorenc-Koci, J Konieczny, T Lenda, W Lasoń. The extent of neurodegeneration and neuroprotection in two chemical in vitro models related to Parkinson's disease is critically dependent on cell culture conditions.
Neurotoxicity research.
2013 Jul; 24(1):41-54. doi:
10.1007/s12640-012-9374-z. [PMID: 23307753] - Hua Su, Conner B Carter, Oskar Laur, Jeff M Sands, Guangping Chen. Forskolin stimulation promotes urea transporter UT-A1 ubiquitination, endocytosis, and degradation in MDCK cells.
American journal of physiology. Renal physiology.
2012 Nov; 303(9):F1325-32. doi:
10.1152/ajprenal.00248.2012. [PMID: 22914781] - Zhen Zhang, Xuping Li, Wen-jie Xie, Houzhen Tuo, Samuel Hintermann, Joseph Jankovic, Weidong Le. Anti-parkinsonian effects of Nurr1 activator in ubiquitin-proteasome system impairment induced animal model of Parkinson's disease.
CNS & neurological disorders drug targets.
2012 Sep; 11(6):768-73. doi:
10.2174/187152712803581155. [PMID: 22483304] - Kayoko Kita, Toshihide Suzuki, Takafumi Ochi. Diphenylarsinic acid promotes degradation of glutaminase C by mitochondrial Lon protease.
The Journal of biological chemistry.
2012 May; 287(22):18163-72. doi:
10.1074/jbc.m112.362699. [PMID: 22493432] - Dong-Hoon Hyun, Jiyeong Kim, Chanil Moon, Chang-Jin Lim, Rafael de Cabo, Mark P Mattson. The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress.
Age (Dordrecht, Netherlands).
2012 Apr; 34(2):359-70. doi:
10.1007/s11357-011-9245-1. [PMID: 21487704] - Bilal A Azakir, Sabrina Di Fulvio, Jochen Kinter, Michael Sinnreich. Proteasomal inhibition restores biological function of mis-sense mutated dysferlin in patient-derived muscle cells.
The Journal of biological chemistry.
2012 Mar; 287(13):10344-10354. doi:
10.1074/jbc.m111.329078. [PMID: 22318734] - Marc de la Roche, Trevor J Rutherford, Deepti Gupta, Dmitry B Veprintsev, Barbara Saxty, Stefan M Freund, Mariann Bienz. An intrinsically labile α-helix abutting the BCL9-binding site of β-catenin is required for its inhibition by carnosic acid.
Nature communications.
2012 Feb; 3(?):680. doi:
10.1038/ncomms1680. [PMID: 22353711] - Angela Martín, José V Pérez-Girón, Raquel Hernanz, Roberto Palacios, Ana M Briones, Ana Fortuño, Guillermo Zalba, Mercedes Salaices, María J Alonso. Peroxisome proliferator-activated receptor-γ activation reduces cyclooxygenase-2 expression in vascular smooth muscle cells from hypertensive rats by interfering with oxidative stress.
Journal of hypertension.
2012 Feb; 30(2):315-26. doi:
10.1097/hjh.0b013e32834f043b. [PMID: 22179086] - Joséphine Beck, Yves Guminski, Christophe Long, Laurence Marcourt, Fadila Derguini, Fabien Plisson, Antonio Grondin, Isabelle Vandenberghe, Stéphane Vispé, Viviane Brel, Yannick Aussagues, Frédéric Ausseil, Paola B Arimondo, Georges Massiot, François Sautel, Frédéric Cantagrel. Semisynthetic neoboutomellerone derivatives as ubiquitin-proteasome pathway inhibitors.
Bioorganic & medicinal chemistry.
2012 Jan; 20(2):819-31. doi:
10.1016/j.bmc.2011.11.066. [PMID: 22206869] - Ivetta Danylesko, Katia Beider, Avichai Shimoni, Arnon Nagler. Novel strategies for immunotherapy in multiple myeloma: previous experience and future directions.
Clinical & developmental immunology.
2012; 2012(?):753407. doi:
10.1155/2012/753407. [PMID: 22649466] - Prodyot K Chatterjee, Michael M Yeboah, Oonagh Dowling, Xiangying Xue, Saul R Powell, Yousef Al-Abed, Christine N Metz. Nicotinic acetylcholine receptor agonists attenuate septic acute kidney injury in mice by suppressing inflammation and proteasome activity.
PloS one.
2012; 7(5):e35361. doi:
10.1371/journal.pone.0035361. [PMID: 22586448] - Pierre Mazot, Alex Cazes, Florent Dingli, Joffrey Degoutin, Théano Irinopoulou, Marie-Claude Boutterin, Bérangère Lombard, Damarys Loew, Bengt Hallberg, Ruth Helen Palmer, Olivier Delattre, Isabelle Janoueix-Lerosey, Marc Vigny. Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment.
PloS one.
2012; 7(3):e33581. doi:
10.1371/journal.pone.0033581. [PMID: 22479414] - Hai-feng Wang, Wu-jiang Liu, Jie Jin, Li-qun Zhou, Li-li Liang, Ying Wang, Ying-lu Guo. [Expression and regulation of androgen receptor in the androgen-independent conversion of prostate cancer cells].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2011 Aug; 43(4):490-5. doi:
NULL. [PMID: 21844951] - Hao Yin, Yulan Jiang, Haijie Li, Jingjing Li, Yu Gui, Xi-Long Zheng. Proteasomal degradation of myocardin is required for its transcriptional activity in vascular smooth muscle cells.
Journal of cellular physiology.
2011 Jul; 226(7):1897-906. doi:
10.1002/jcp.22519. [PMID: 21506120] - Mei-fen Dai, Dan Hu, Dan Zhao. [Effect of epigallocatechin gallate on lactacystin-induced PC12 cell injury].
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine.
2011 May; 31(5):672-5. doi:
". [PMID: 21812272] - Anton Mihic, Vijay S Chauhan, Xiaodong Gao, Gavin Y Oudit, Robert G Tsushima. Trafficking defect and proteasomal degradation contribute to the phenotype of a novel KCNH2 long QT syndrome mutation.
PloS one.
2011 Mar; 6(3):e18273. doi:
10.1371/journal.pone.0018273. [PMID: 21483829] - Nayoung Bae, Taekwon Ahn, Sungkwon Chung, Myung Sook Oh, Hyeonseok Ko, Hyungun Oh, Gunhyuk Park, Hyun Ok Yang. The neuroprotective effect of modified Yeoldahanso-tang via autophagy enhancement in models of Parkinson's disease.
Journal of ethnopharmacology.
2011 Mar; 134(2):313-22. doi:
10.1016/j.jep.2010.12.016. [PMID: 21172413] - Elizabeth A Mazzio, Fran Close, Karam F A Soliman. The biochemical and cellular basis for nutraceutical strategies to attenuate neurodegeneration in Parkinson's disease.
International journal of molecular sciences.
2011 Jan; 12(1):506-69. doi:
10.3390/ijms12010506. [PMID: 21340000] - Mina-Olga Aletrari, Craig McKibbin, Helen Williams, Vidya Pawar, Paola Pietroni, J Michael Lord, Sabine L Flitsch, Roger Whitehead, Eileithyia Swanton, Stephen High, Robert A Spooner. Eeyarestatin 1 interferes with both retrograde and anterograde intracellular trafficking pathways.
PloS one.
2011; 6(7):e22713. doi:
10.1371/journal.pone.0022713. [PMID: 21799938] - J Jose Corbalan, Carlos Medina, Adam Jacoby, Tadeusz Malinski, Marek W Radomski. Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects.
International journal of nanomedicine.
2011; 6(?):2821-35. doi:
10.2147/ijn.s25071. [PMID: 22131828] - Toru Sakairi, Keiju Hiromura, Satoshi Takahashi, Hiroko Hamatani, Shigeru Takeuchi, Mai Tomioka, Akito Maeshima, Takashi Kuroiwa, Yoshihisa Nojima. Effects of proteasome inhibitors on rat renal fibrosis in vitro and in vivo.
Nephrology (Carlton, Vic.).
2011 Jan; 16(1):76-86. doi:
10.1111/j.1440-1797.2010.01367.x. [PMID: 21175982] - Subhash Thalappilly, Xiaolan Feng, Svitlana Pastyryeva, Keiko Suzuki, Daniel Muruve, Daniel Larocque, Stephane Richard, Matthias Truss, Andreas von Deimling, Karl Riabowol, Gesche Tallen. The p53 tumor suppressor is stabilized by inhibitor of growth 1 (ING1) by blocking polyubiquitination.
PloS one.
2011; 6(6):e21065. doi:
10.1371/journal.pone.0021065. [PMID: 21731648] - Yang Wang, Petek Ballar, Yongwang Zhong, Xuebao Zhang, Chao Liu, Ying-Jiu Zhang, Mervyn J Monteiro, Jun Li, Shengyun Fang. SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.
PloS one.
2011; 6(8):e24478. doi:
10.1371/journal.pone.0024478. [PMID: 21909394] - Asaf A Qureshi, Julia C Reis, Christopher J Papasian, David C Morrison, Nilofer Qureshi. Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.
Lipids in health and disease.
2010 Dec; 9(?):143. doi:
10.1186/1476-511x-9-143. [PMID: 21162750] - Abhinav Grover, Ashutosh Shandilya, Virendra S Bisaria, Durai Sundar. Probing the anticancer mechanism of prospective herbal drug Withaferin A on mammals: a case study on human and bovine proteasomes.
BMC genomics.
2010 Dec; 11 Suppl 4(?):S15. doi:
10.1186/1471-2164-11-s4-s15. [PMID: 21143798] - C L Gentile, D Wang, K T Pfaffenbach, R Cox, Y Wei, Michael J Pagliassotti. Fatty acids regulate CREBh via transcriptional mechanisms that are dependent on proteasome activity and insulin.
Molecular and cellular biochemistry.
2010 Nov; 344(1-2):99-107. doi:
10.1007/s11010-010-0533-3. [PMID: 20607591] - Stephen K Ball, Mark C Field, John R Tippins. Regulation of thromboxane receptor signaling at multiple levels by oxidative stress-induced stabilization, relocation and enhanced responsiveness.
PloS one.
2010 Sep; 5(9):e12798. doi:
10.1371/journal.pone.0012798. [PMID: 20856817] - Shota Takumi, Masaharu Komatsu, Tatsuhiko Furukawa, Ryuji Ikeda, Tomoyuki Sumizawa, Hitomi Akenaga, Yuta Maeda, Kohji Aoyama, Koji Arizono, Seiichi Ando, Toru Takeuchi. p53 Plays an important role in cell fate determination after exposure to microcystin-LR.
Environmental health perspectives.
2010 Sep; 118(9):1292-8. doi:
10.1289/ehp.1001899. [PMID: 20421190] - Hirokazu Adachi, Takao Kurooka, Wataru Otsu, Mutsumi Inaba. The forced aggresome formation of a bovine anion exchanger 1 (AE1) mutant through association with δF508-cystic fibrosis transmembrane conductance regulator upon proteasome inhibition in HEK293 cells.
The Japanese journal of veterinary research.
2010 Aug; 58(2):101-10. doi:
NULL. [PMID: 20715420] - Valentí Gómez, Marta Sesé, Anna Santamaría, Juan D Martínez, Elisabet Castellanos, Marta Soler, Timothy M Thomson, Rosanna Paciucci. Regulation of aurora B kinase by the lipid raft protein flotillin-1.
The Journal of biological chemistry.
2010 Jul; 285(27):20683-90. doi:
10.1074/jbc.m110.130591. [PMID: 20430883] - Nazira Ozgen, David H Lau, Iryna N Shlapakova, Warren Sherman, Steven J Feinmark, Peter Danilo, Michael R Rosen. Determinants of CREB degradation and KChIP2 gene transcription in cardiac memory.
Heart rhythm.
2010 Jul; 7(7):964-70. doi:
10.1016/j.hrthm.2010.03.024. [PMID: 20346417] - Fenglian Xu, Juliane Proft, Sarah Gibbs, Bob Winkfein, Jadah N Johnson, Naweed Syed, Janice E A Braun. Quercetin targets cysteine string protein (CSPalpha) and impairs synaptic transmission.
PloS one.
2010 Jun; 5(6):e11045. doi:
10.1371/journal.pone.0011045. [PMID: 20548785] - Ashenafi Y Tilahun, Jayne E Theuer, Robin Patel, Chella S David, Govindarajan Rajagopalan. Detrimental effect of the proteasome inhibitor, bortezomib in bacterial superantigen- and lipopolysaccharide-induced systemic inflammation.
Molecular therapy : the journal of the American Society of Gene Therapy.
2010 Jun; 18(6):1143-54. doi:
10.1038/mt.2010.53. [PMID: 20372109] - Prabir K Chakraborty, Wing-Kee Lee, Malte Molitor, Natascha A Wolff, Frank Thévenod. Cadmium induces Wnt signaling to upregulate proliferation and survival genes in sub-confluent kidney proximal tubule cells.
Molecular cancer.
2010 May; 9(?):102. doi:
10.1186/1476-4598-9-102. [PMID: 20459685] - Jordan T F Young, John J Heikkila. Proteasome inhibition induces hsp30 and hsp70 gene expression as well as the acquisition of thermotolerance in Xenopus laevis A6 cells.
Cell stress & chaperones.
2010 May; 15(3):323-34. doi:
10.1007/s12192-009-0147-4. [PMID: 19838833] - Ana B Sanz, Maria D Sanchez-Niño, Maria C Izquierdo, Aniela Jakubowski, Pilar Justo, Luis M Blanco-Colio, Marta Ruiz-Ortega, Rafael Selgas, Jesús Egido, Alberto Ortiz. TWEAK activates the non-canonical NFkappaB pathway in murine renal tubular cells: modulation of CCL21.
PloS one.
2010 Jan; 5(1):e8955. doi:
10.1371/journal.pone.0008955. [PMID: 20126461] - Hwan-Ching Tai, Henrike Besche, Alfred L Goldberg, Erin M Schuman. Characterization of the Brain 26S Proteasome and its Interacting Proteins.
Frontiers in molecular neuroscience.
2010; 3(?):. doi:
10.3389/fnmol.2010.00012. [PMID: 20717473] - Dolores Pérez-Sala, Patricia Boya, Irene Ramos, Mónica Herrera, Konstantinos Stamatakis. The C-terminal sequence of RhoB directs protein degradation through an endo-lysosomal pathway.
PloS one.
2009 Dec; 4(12):e8117. doi:
10.1371/journal.pone.0008117. [PMID: 19956591] - Mariko Nobukuni, Hideki Mochizuki, Satoshi Okada, Nobuhisa Kameyama, Anna Tanaka, Hikaru Yamamoto, Taku Amano, Takahiro Seki, Norio Sakai. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation.
Journal of pharmacological sciences.
2009 Dec; 111(4):392-404. doi:
10.1254/jphs.09195fp. [PMID: 19946177] - Ronald L Mellgren, Katsuya Miyake, Irina Kramerova, Melissa J Spencer, Nathalie Bourg, Marc Bartoli, Isabelle Richard, Peter A Greer, Paul L McNeil. Calcium-dependent plasma membrane repair requires m- or mu-calpain, but not calpain-3, the proteasome, or caspases.
Biochimica et biophysica acta.
2009 Dec; 1793(12):1886-93. doi:
10.1016/j.bbamcr.2009.09.013. [PMID: 19781581] - Peter D Donnellan, B Therese Kinsella. Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively.
Journal of molecular signaling.
2009 Sep; 4(?):7. doi:
10.1186/1750-2187-4-7. [PMID: 19781057] - Irina V Majoul, Daria Onichtchouk, Eugenia Butkevich, Dirk Wenzel, Levon M Chailakhyan, Rainer Duden. Limiting transport steps and novel interactions of Connexin-43 along the secretory pathway.
Histochemistry and cell biology.
2009 Sep; 132(3):263-80. doi:
10.1007/s00418-009-0617-x. [PMID: 19626334] - Wei Qiu, Qiaozhu Su, Angela C Rutledge, Jing Zhang, Khosrow Adeli. Glucosamine-induced endoplasmic reticulum stress attenuates apolipoprotein B100 synthesis via PERK signaling.
Journal of lipid research.
2009 Sep; 50(9):1814-23. doi:
10.1194/jlr.m800343-jlr200. [PMID: 19383982] - Borbala Daroczi, Gabor Kari, Qing Ren, Adam P Dicker, Ulrich Rodeck. Nuclear factor kappaB inhibitors alleviate and the proteasome inhibitor PS-341 exacerbates radiation toxicity in zebrafish embryos.
Molecular cancer therapeutics.
2009 Sep; 8(9):2625-34. doi:
10.1158/1535-7163.mct-09-0198. [PMID: 19723885] - June Chunqiu Hou, Dumaine Williams, Jérôme Vicogne, Jeffrey E Pessin. The glucose transporter 2 undergoes plasma membrane endocytosis and lysosomal degradation in a secretagogue-dependent manner.
Endocrinology.
2009 Sep; 150(9):4056-64. doi:
10.1210/en.2008-1685. [PMID: 19477941] - Mohamed Mohamed Soliman, Yakut Abdel-Fattah El-Senosi, Maysara Mahmoud Salem, Omniya Mahmoud Abdel Hamid, Kimura Kazuhiro. Role of protease inhibitors and acylation stimulating protein in the adipogenesis in 3T3-L1 cells.
Journal of veterinary science.
2009 Sep; 10(3):197-201. doi:
10.4142/jvs.2009.10.3.197. [PMID: 19687619] - Jyh-Ming Chow, Hui-Yi Lin, Shing-Chuan Shen, Ming-Shun Wu, Cheng-Wei Lin, Wen-Ta Chiu, Chien-Huang Lin, Yen-Chou Chen. Zinc protoporphyrin inhibition of lipopolysaccharide-, lipoteichoic acid-, and peptidoglycan-induced nitric oxide production through stimulating iNOS protein ubiquitination.
Toxicology and applied pharmacology.
2009 Jun; 237(3):357-65. doi:
10.1016/j.taap.2009.04.009. [PMID: 19376148] - Irina Tcherepanova, Aijing Starr, Brad Lackford, Melissa D Adams, Jean-Pierre Routy, Mohamed Rachid Boulassel, David Calderhead, Don Healey, Charles Nicolette. The immunosuppressive properties of the HIV Vpr protein are linked to a single highly conserved residue, R90.
PloS one.
2009 Jun; 4(6):e5853. doi:
10.1371/journal.pone.0005853. [PMID: 19516896] - Tsutomu Wada, Satoshi Ohshima, Eriko Fujisawa, Daisuke Koya, Hiroshi Tsuneki, Toshiyasu Sasaoka. Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3T3-L1 adipocytes.
Endocrinology.
2009 Apr; 150(4):1662-9. doi:
10.1210/en.2008-1018. [PMID: 19095745] - Seiji Torii, Naoya Saito, Ayumi Kawano, Ni Hou, Kohjiro Ueki, Rohit N Kulkarni, Toshiyuki Takeuchi. Gene silencing of phogrin unveils its essential role in glucose-responsive pancreatic beta-cell growth.
Diabetes.
2009 Mar; 58(3):682-92. doi:
10.2337/db08-0970. [PMID: 19073770] - Lívia O Santos, Fernanda A Marinho, Ellen F Altoé, Bianca S Vitório, Carlos R Alves, Constança Britto, Maria Cristina M Motta, Marta H Branquinha, André L S Santos, Claudia M d'Avila-Levy. HIV aspartyl peptidase inhibitors interfere with cellular proliferation, ultrastructure and macrophage infection of Leishmania amazonensis.
PloS one.
2009; 4(3):e4918. doi:
10.1371/journal.pone.0004918. [PMID: 19325703] - Kristina Wiberg, Kristina Carlson, Anna Aleskog, Rolf Larsson, Peter Nygren, Elin Lindhagen. In vitro activity of bortezomib in cultures of patient tumour cells--potential utility in haematological malignancies.
Medical oncology (Northwood, London, England).
2009; 26(2):193-201. doi:
10.1007/s12032-008-9107-6. [PMID: 19016012] - Jeremiah S Hinson, Matt D Medlin, Joan M Taylor, Christopher P Mack. Regulation of myocardin factor protein stability by the LIM-only protein FHL2.
American journal of physiology. Heart and circulatory physiology.
2008 Sep; 295(3):H1067-H1075. doi:
10.1152/ajpheart.91421.2007. [PMID: 18586895] - Arowu R Tanaka, Fumi Kano, Akitsugu Yamamoto, Kazumitsu Ueda, Masayuki Murata. Formation of cholesterol-enriched structures by aberrant intracellular accumulation of ATP-binding cassette transporter A1.
Genes to cells : devoted to molecular & cellular mechanisms.
2008 Aug; 13(8):889-904. doi:
10.1111/j.1365-2443.2008.01213.x. [PMID: 18782226] - Yuanli Li, Rong Cong, Daniel Biemesderfer. The COOH terminus of megalin regulates gene expression in opossum kidney proximal tubule cells.
American journal of physiology. Cell physiology.
2008 Aug; 295(2):C529-37. doi:
10.1152/ajpcell.00037.2008. [PMID: 18495814] - In-Hwan Lee, Hui-Young Kim, Myunghye Kim, Ji-Sook Hahn, Seung R Paik. Dequalinium-induced cell death of yeast expressing alpha-synuclein-GFP fusion protein.
Neurochemical research.
2008 Jul; 33(7):1393-400. doi:
10.1007/s11064-008-9598-8. [PMID: 18322792] - Bradford G Hill, Petra Haberzettl, Yonis Ahmed, Sanjay Srivastava, Aruni Bhatnagar. Unsaturated lipid peroxidation-derived aldehydes activate autophagy in vascular smooth-muscle cells.
The Biochemical journal.
2008 Mar; 410(3):525-34. doi:
10.1042/bj20071063. [PMID: 18052926] - F-Y Liu, X-Z Li, Y-M Peng, H Liu, Y-H Liu. Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition.
Kidney international.
2008 Mar; 73(5):588-94. doi:
10.1038/sj.ki.5002713. [PMID: 18059455] - Guillermo L Lehmann, Flavia I Carreras, Leandro R Soria, Sergio A Gradilone, Raúl A Marinelli. LPS induces the TNF-alpha-mediated downregulation of rat liver aquaporin-8: role in sepsis-associated cholestasis.
American journal of physiology. Gastrointestinal and liver physiology.
2008 Feb; 294(2):G567-75. doi:
10.1152/ajpgi.00232.2007. [PMID: 18174273] - Yoshiki Narimatsu, Yuzuru Ikehara, Hiroko Iwasaki, Chizu Nonomura, Takashi Sato, Hayao Nakanishi, Hisashi Narimatsu. Immunocytochemical analysis for intracellular dynamics of C1GalT associated with molecular chaperone, Cosmc.
Biochemical and biophysical research communications.
2008 Feb; 366(1):199-205. doi:
10.1016/j.bbrc.2007.11.121. [PMID: 18061573] - Yu Nakamura, Daisuke Matsubara, Akiteru Goto, Satoshi Ota, Oguni Sachiko, Shumpei Ishikawa, Hiroyuki Aburatani, Keiji Miyazawa, Masashi Fukayama, Toshiro Niki. Constitutive activation of c-Met is correlated with c-Met overexpression and dependent on cell-matrix adhesion in lung adenocarcinoma cell lines.
Cancer science.
2008 Jan; 99(1):14-22. doi:
10.1111/j.1349-7006.2007.00640.x. [PMID: 17953713] - Ji-Hong Yao, Ying-Hua Li, Zhen-Zhen Wang, Xue-Song Zhang, Yu-Zhu Wang, Jin-Chan Yuan, Qin Zhou, Ke-Xin Liu, Xiao-Feng Tian. Proteasome inhibitor lactacystin ablates liver injury induced by intestinal ischaemia-reperfusion.
Clinical and experimental pharmacology & physiology.
2007 Nov; 34(11):1102-8. doi:
10.1111/j.1440-1681.2007.04674.x. [PMID: 17880361] - Jennifer Whitsett, Matthew J Picklo, Jeannette Vasquez-Vivar. 4-Hydroxy-2-nonenal increases superoxide anion radical in endothelial cells via stimulated GTP cyclohydrolase proteasomal degradation.
Arteriosclerosis, thrombosis, and vascular biology.
2007 Nov; 27(11):2340-7. doi:
10.1161/atvbaha.107.153742. [PMID: 17872449] - Patricia J Tam, Clifford A Lingwood. Membrane cytosolic translocation of verotoxin A1 subunit in target cells.
Microbiology (Reading, England).
2007 Aug; 153(Pt 8):2700-2710. doi:
10.1099/mic.0.2007/006858-0. [PMID: 17660434] - Emanuela Cazzaniga, Alessandra Bulbarelli, Arianna Cassetti, Elena Lonati, Francesca Re, Paola Palestini, Tatsuro Mutoh, Massimo Masserini. Beta-amyloid (25-35) enhances lipid metabolism and protein ubiquitination in cultured neurons.
Journal of neuroscience research.
2007 Aug; 85(10):2253-61. doi:
10.1002/jnr.21354. [PMID: 17510978] - Qunyan Jin, Wei Ding, Kathleen M Mulder. Requirement for the dynein light chain km23-1 in a Smad2-dependent transforming growth factor-beta signaling pathway.
The Journal of biological chemistry.
2007 Jun; 282(26):19122-32. doi:
10.1074/jbc.m609915200. [PMID: 17420258] - Xiaoyue Pan, Farah N Hussain, Jahangir Iqbal, Miriam H Feuerman, M Mahmood Hussain. Inhibiting proteasomal degradation of microsomal triglyceride transfer protein prevents CCl4-induced steatosis.
The Journal of biological chemistry.
2007 Jun; 282(23):17078-89. doi:
10.1074/jbc.m701742200. [PMID: 17405876] - Masako Sasaki, Jun Sukegawa, Katsutoshi Miyosawa, Teruyuki Yanagisawa, Satoko Ohkubo, Norimichi Nakahata. Low expression of cell-surface thromboxane A2 receptor beta-isoform through the negative regulation of its membrane traffic by proteasomes.
Prostaglandins & other lipid mediators.
2007 Jun; 83(4):237-49. doi:
10.1016/j.prostaglandins.2006.12.001. [PMID: 17499743] - Y Sun, A Ottosson, S Pervaiz, B Fadeel. Smac-mediated sensitization of human B-lymphoma cells to staurosporine- and lactacystin-triggered apoptosis is apoptosome-dependent.
Leukemia.
2007 May; 21(5):1035-43. doi:
10.1038/sj.leu.2404660. [PMID: 17377587] - Pei-Yin Lin, Susan P Fosmire, See-Hyoung Park, Jin-Young Park, Shairaz Baksh, Jaime F Modiano, Robert H Weiss. Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance.
Molecular cancer.
2007 Feb; 6(?):16. doi:
10.1186/1476-4598-6-16. [PMID: 17300726] - Alison K Holzer, Stephen B Howell. The internalization and degradation of human copper transporter 1 following cisplatin exposure.
Cancer research.
2006 Nov; 66(22):10944-52. doi:
10.1158/0008-5472.can-06-1710. [PMID: 17108132] - Xiao-Feng Tian, Xue-Song Zhang, Ying-Hua Li, Zheng-Zheng Wang, Feng Zhang, Li-Ming Wang, Ji-Hong Yao. Proteasome inhibition attenuates lung injury induced by intestinal ischemia reperfusion in rats.
Life sciences.
2006 Oct; 79(22):2069-76. doi:
10.1016/j.lfs.2006.06.027. [PMID: 16875703] - Steeve Kwan Tat, Marc Padrines, Sandrine Theoleyre, Severine Couillaud-Battaglia, Dominique Heymann, Françoise Redini, Yannick Fortun. OPG/membranous--RANKL complex is internalized via the clathrin pathway before a lysosomal and a proteasomal degradation.
Bone.
2006 Oct; 39(4):706-15. doi:
10.1016/j.bone.2006.03.016. [PMID: 16750945] - Meng Shyan Choy, Boon Huat Bay, Heung-Chin Cheng, Nam Sang Cheung. PTEN is recruited to specific microdomains of the plasma membrane during lactacystin-induced neuronal apoptosis.
Neuroscience letters.
2006 Sep; 405(1-2):120-5. doi:
10.1016/j.neulet.2006.06.037. [PMID: 16857313] - Wen Shen, Nikia S Brown, Patrick F Finn, J Fred Dice, Harold A Franch. Akt and Mammalian target of rapamycin regulate separate systems of proteolysis in renal tubular cells.
Journal of the American Society of Nephrology : JASN.
2006 Sep; 17(9):2414-23. doi:
10.1681/asn.2005111157. [PMID: 16885413] - Stephana Carelli, Anna Maria Di Giulio, Simona Paratore, Silvano Bosari, Alfredo Gorio. Degradation of insulin-like growth factor-I receptor occurs via ubiquitin-proteasome pathway in human lung cancer cells.
Journal of cellular physiology.
2006 Aug; 208(2):354-62. doi:
10.1002/jcp.20670. [PMID: 16619240] - Yingjun Luan, Helen R Griffiths. Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages.
Archives of biochemistry and biophysics.
2006 Jun; 450(1):89-99. doi:
10.1016/j.abb.2006.03.016. [PMID: 16620763] - E Minet, J-P Cosse, C Demazy, M Raes, C Michiels. Accumulation of the pro-apoptotic factor Bak is controlled by antagonist factor Mcl-1 availability.
Apoptosis : an international journal on programmed cell death.
2006 Jun; 11(6):1039-47. doi:
10.1007/s10495-006-6650-5. [PMID: 16547591] - Pirjo M Apaja, Jussi T Tuusa, E Maritta Pietilä, Hannu J Rajaniemi, Ulla E Petäjä-Repo. Luteinizing hormone receptor ectodomain splice variant misroutes the full-length receptor into a subcompartment of the endoplasmic reticulum.
Molecular biology of the cell.
2006 May; 17(5):2243-55. doi:
10.1091/mbc.e05-09-0875. [PMID: 16495341] - Yun-Sik Lee, Jie Wan, Bong-Jo Kim, Myung-Ae Bae, Byoung J Song. Ubiquitin-dependent degradation of p53 protein despite phosphorylation at its N terminus by acetaminophen.
The Journal of pharmacology and experimental therapeutics.
2006 Apr; 317(1):202-8. doi:
10.1124/jpet.105.096719. [PMID: 16330492] - Lawrence Levine. Cyclooxygenase expression is not required for release of arachidonic acid from cells by some nonsteroidal anti-inflammatory drugs and cancer preventive agents.
BMC pharmacology.
2006 Mar; 6(?):7. doi:
10.1186/1471-2210-6-7. [PMID: 16571133] - Christelle Carteron, Antonio Ferrer-Montiel, Hugo Cabedo. Characterization of a neural-specific splicing form of the human neuregulin 3 gene involved in oligodendrocyte survival.
Journal of cell science.
2006 Mar; 119(Pt 5):898-909. doi:
10.1242/jcs.02799. [PMID: 16478787] - Vivian Gama, Tomoyuki Yoshida, Jose A Gomez, David P Basile, Lindsey D Mayo, Arthur L Haas, Shigemi Matsuyama. Involvement of the ubiquitin pathway in decreasing Ku70 levels in response to drug-induced apoptosis.
Experimental cell research.
2006 Feb; 312(4):488-99. doi:
10.1016/j.yexcr.2005.11.016. [PMID: 16368436] - Udo Hasler, Søren Nielsen, Eric Féraille, Pierre-Yves Martin. Posttranscriptional control of aquaporin-2 abundance by vasopressin in renal collecting duct principal cells.
American journal of physiology. Renal physiology.
2006 Jan; 290(1):F177-87. doi:
10.1152/ajprenal.00056.2005. [PMID: 15985652] - Mads Lerdrup, Anette M Hommelgaard, Michael Grandal, Bo van Deurs. Geldanamycin stimulates internalization of ErbB2 in a proteasome-dependent way.
Journal of cell science.
2006 Jan; 119(Pt 1):85-95. doi:
10.1242/jcs.02707. [PMID: 16352662] - Zahra Faghiri, Nicolas G Bazan. Selective relocalization and proteasomal downregulation of PKCalpha induced by platelet-activating factor in retinal pigment epithelium.
Investigative ophthalmology & visual science.
2006 Jan; 47(1):397-404. doi:
10.1167/iovs.05-0290. [PMID: 16384990] - P Pisu, D Bellovino, S Gaetani. Copper regulated synthesis, secretion and degradation of ceruloplasmin in a mouse immortalized hepatocytic cell line.
Cellular and molecular biology (Noisy-le-Grand, France).
2005 Dec; Suppl 51(?):OL859-67. doi:
NULL. [PMID: 16405854]