Chidamide (BioDeep_00000605839)

   


代谢物信息卡片


N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide

化学式: C22H19FN4O2 (390.1491966)
中文名称: 几丁胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CC(=CN=C1)C=CC(=O)NCC2=CC=C(C=C2)C(=O)NC3=C(C=CC(=C3)F)N
InChI: InChI=1S/C22H19FN4O2/c23-18-8-9-19(24)20(12-18)27-22(29)17-6-3-16(4-7-17)14-26-21(28)10-5-15-2-1-11-25-13-15/h1-13H,14,24H2,(H,26,28)(H,27,29)/b10-5+

描述信息

同义名列表

2 个代谢物同义名

Chidamide; N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Sizhen Wang, Zhiqiang Ma, Zhang Shi, Ying Huang, Tianheng Chen, Lei Hou, Tao Jiang, Feng Yang. Chidamide stacked in magnetic polypyrrole nano-composites counter thermotolerance and metastasis for visualized cancer photothermal therapy. Drug delivery. 2022 Dec; 29(1):1312-1325. doi: 10.1080/10717544.2022.2068697. [PMID: 35475384]
  • Bei Zhang, Zhixin Pei, Hongxia Wang, Huimin Wu, Junjie Wang, Junjun Bai, Qinglin Song. Chidamide and Decitabine in Combination with a HAG Priming Regimen for Acute Myeloid Leukemia with TP53 Mutation. Acta medica Okayama. 2022 Feb; 76(1):63-70. doi: 10.18926/amo/63213. [PMID: 35237000]
  • Yong Liu, Yun Xu, Yan Xie, Guang-Hua Chen, Wei Liu, Wei-Qin Yao, Shuang Yan, Ling-Zhi Yan, De-Pei Wu, Cheng-Cheng Fu. [The Effects of Chidamide Combined with Anti-myeloma Drugs on the Proliferation and Apoptosis of Myeloma Cells]. Zhongguo shi yan xue ye xue za zhi. 2021 Aug; 29(4):1187-1194. doi: 10.19746/j.cnki.issn.1009-2137.2021.04.026. [PMID: 34362501]
  • J H Li, J Ma, W Kang, C F Wang, F Bai, K Zhao, N Yao, Q Liu, B L Dang, B W Wang, Q Q Wei, W Z Kang, Y T Sun. The histone deacetylase inhibitor chidamide induces intermittent viraemia in HIV-infected patients on suppressive antiretroviral therapy. HIV medicine. 2020 12; 21(11):747-757. doi: 10.1111/hiv.13027. [PMID: 33369029]
  • H Y Zhao, D Q Li, J Wang, Y Hou, L Sun, J Peng, M Hou. [Effect and mechanism of low-dose chidamide on the treatment of primary immune thrombocytopenia]. Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi. 2020 Apr; 41(4):292-296. doi: 10.3760/cma.j.issn.0253-2727.2020.04.006. [PMID: 32447932]
  • Nan Ding, Abin You, Wei Tian, Liankun Gu, Dajun Deng. Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation. International journal of biological sciences. 2020; 16(14):2595-2611. doi: 10.7150/ijbs.45886. [PMID: 32792859]
  • Zefei Jiang, Wei Li, Xichun Hu, Qingyuan Zhang, Tao Sun, Shude Cui, Shusen Wang, Quchang Ouyang, Yongmei Yin, Cuizhi Geng, Zhongsheng Tong, Ying Cheng, Yueyin Pan, Yuping Sun, Hong Wang, Tao Ouyang, Kangsheng Gu, Jifeng Feng, Xiaojia Wang, Shubin Wang, Tianshu Liu, Jinghua Gao, Massimo Cristofanilli, Zhiqiang Ning, Xianping Lu. Tucidinostat plus exemestane for postmenopausal patients with advanced, hormone receptor-positive breast cancer (ACE): a randomised, double-blind, placebo-controlled, phase 3 trial. The Lancet. Oncology. 2019 06; 20(6):806-815. doi: 10.1016/s1470-2045(19)30164-0. [PMID: 31036468]
  • Haiyan Yang, Cong Li, Zhongjian Chen, Hanzhou Mou, Liqiang Gu. Determination of chidamide in rat plasma and cerebrospinal fluid. Regulatory toxicology and pharmacology : RTP. 2018 Oct; 98(?):24-30. doi: 10.1016/j.yrtph.2018.07.001. [PMID: 30008379]
  • Qiyuan Kuai, Xiaofan Lu, Zhixin Qiao, Rui Wang, Yanbing Wang, Sanxian Ye, Min He, Yu Wang, Tong Zhang, Hao Wu, Suping Ren, Qun Yu. Histone deacetylase inhibitor chidamide promotes reactivation of latent human immunodeficiency virus by introducing histone acetylation. Journal of medical virology. 2018 09; 90(9):1478-1485. doi: 10.1002/jmv.25207. [PMID: 29704439]
  • P S Suresh, V C Devaraj, Nuggehally R Srinivas, Ramesh Mullangi. Review of bioanalytical assays for the quantitation of various HDAC inhibitors such as vorinostat, belinostat, panobinostat, romidepsin and chidamine. Biomedical chromatography : BMC. 2017 Jan; 31(1):. doi: 10.1002/bmc.3807. [PMID: 27511598]
  • Ruolan Gu, Taoyun Liu, Xiaoxia Zhu, Hui Gan, Zhuona Wu, Jian Li, Ying Zheng, Guifang Dou, Zhiyun Meng. Development and validation of a sensitive HPLC-MS/MS method for determination of chidamide (epidaza), a new benzamide class of selective histone deacetylase inhibitor, in human plasma and its clinical application. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2015 Sep; 1000(?):181-6. doi: 10.1016/j.jchromb.2015.07.001. [PMID: 26245362]
  • Xianqin Wang, Mengchun Chen, Congcong Wen, Qingwei Zhang, Jianshe Ma. Determination of chidamide in rat plasma by LC-MS and its application to pharmacokinetics study. Biomedical chromatography : BMC. 2013 Dec; 27(12):1801-6. doi: 10.1002/bmc.3001. [PMID: 23857175]