LY255283 (BioDeep_00000605577)

   


代谢物信息卡片


1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone

化学式: C19H28N4O3 (360.2161298)
中文名称: 1-[5-乙基-2-羟基-4-[[6-甲基-6-(1H-四唑-5-基)庚基]氧基]苯基]乙酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CCC1=CC(=C(C=C1OCCCCCC(C)(C)C2=NNN=N2)O)C(=O)C
InChI: InChI=1S/C19H28N4O3/c1-5-14-11-15(13(2)24)16(25)12-17(14)26-10-8-6-7-9-19(3,4)18-20-22-23-21-18/h11-12,25H,5-10H2,1-4H3,(H,20,21,22,23)

描述信息

D019141 - Respiratory System Agents > D018927 - Anti-Asthmatic Agents > D020024 - Leukotriene Antagonists
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists

同义名列表

3 个代谢物同义名

1-[5-Ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-YL)heptyl]oxy]phenyl]ethanone; LY255283; 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yui Matsumoto, Yukiko Matsuya, Kano Nagai, Kikuko Amagase, Kazuko Saeki, Kenjiro Matsumoto, Takehiko Yokomizo, Shinichi Kato. Leukotriene B4 Receptor Type 2 Accelerates the Healing of Intestinal Lesions by Promoting Epithelial Cell Proliferation. The Journal of pharmacology and experimental therapeutics. 2020 04; 373(1):1-9. doi: 10.1124/jpet.119.263145. [PMID: 31941716]
  • JaeIn Park, Jae-Hyun Jang, Jae-Hong Kim. Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells. Biochimica et biophysica acta. Molecular cell research. 2019 03; 1866(3):329-336. doi: 10.1016/j.bbamcr.2018.12.006. [PMID: 30553812]
  • Yan Zhang, Rachel M Olson, Charles R Brown. Macrophage LTB4 drives efficient phagocytosis of Borrelia burgdorferi via BLT1 or BLT2. Journal of lipid research. 2017 03; 58(3):494-503. doi: 10.1194/jlr.m068882. [PMID: 28053185]
  • Hyunju Kim, Jung-A Choi, Jae-Hong Kim. Ras promotes transforming growth factor-β (TGF-β)-induced epithelial-mesenchymal transition via a leukotriene B4 receptor-2-linked cascade in mammary epithelial cells. The Journal of biological chemistry. 2014 Aug; 289(32):22151-60. doi: 10.1074/jbc.m114.556126. [PMID: 24990945]
  • Peng Liu, Xing Xu, Lili Chen, Lei Ma, Xu Shen, Lihong Hu. Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists. Bioorganic & medicinal chemistry. 2014 Mar; 22(5):1596-607. doi: 10.1016/j.bmc.2014.01.032. [PMID: 24513188]
  • Young Hee Nam, Arim Min, Seong Hoon Kim, Young Ah Lee, Kyeong Ah Kim, Kyoung-Ju Song, Myeong Heon Shin. Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2012 Feb; 61(2):97-102. doi: 10.1007/s00011-011-0425-3. [PMID: 22215047]
  • Anne-Sofie Johansson, Jesper Z Haeggström, Jan Palmblad. Commonly used leukotriene B4 receptor antagonists possess intrinsic activity as agonists in human endothelial cells: Effects on calcium transients, adhesive events and mediator release. Prostaglandins, leukotrienes, and essential fatty acids. 2011 Mar; 84(3-4):109-12. doi: 10.1016/j.plefa.2010.11.003. [PMID: 21183325]
  • Kyung-Jin Cho, Ji-Min Seo, YoungHyun Shin, Min-Hyuk Yoo, Choon-Sik Park, Shin-Hwa Lee, Yoon-Seok Chang, Sang-Heon Cho, Jae-Hong Kim. Blockade of airway inflammation and hyperresponsiveness by inhibition of BLT2, a low-affinity leukotriene B4 receptor. American journal of respiratory cell and molecular biology. 2010 Mar; 42(3):294-303. doi: 10.1165/rcmb.2008-0445oc. [PMID: 19448154]
  • M M Teixeira, M A Lindsay, M A Giembycz, P G Hellewell. Role of arachidonic acid in leukotriene B(4)-induced guinea-pig eosinophil homotypic aggregation. European journal of pharmacology. 1999 Nov; 384(2-3):183-90. doi: 10.1016/s0014-2999(99)00697-4. [PMID: 10611440]
  • A G Rossi, K E Norman, D Donigi-Gale, T S Shoupe, R Edwards, T J Williams. The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction. British journal of pharmacology. 1992 Sep; 107(1):44-9. doi: 10.1111/j.1476-5381.1992.tb14461.x. [PMID: 1330163]
  • M Rola-Pleszczynski, J Stanková. Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms. Blood. 1992 Aug; 80(4):1004-11. doi: . [PMID: 1323342]
  • A Karasawa, J P Guo, X L Ma, P S Tsao, A M Lefer. Protective actions of a leukotriene B4 antagonist in splanchnic ischemia and reperfusion in rats. The American journal of physiology. 1991 Aug; 261(2 Pt 1):G191-8. doi: 10.1152/ajpgi.1991.261.2.g191. [PMID: 1651656]
  • R A Hahn, B R MacDonald, P J Simpson, B D Potts, C J Parli. Antagonism of leukotriene B4 receptors does not limit canine myocardial infarct size. The Journal of pharmacology and experimental therapeutics. 1990 Apr; 253(1):58-66. doi: NULL. [PMID: 2158553]