LY83583 (BioDeep_00000605559)
代谢物信息卡片
6-(Phenylamino)-5,8-quinolinedione
化学式: C15H10N2O2 (250.07422400000002)
中文名称: 4-苯胺-1-羟基苯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)NC2=CC(=O)C3=C(C2=O)C=CC=N3
InChI: InChI=1S/C15H10N2O2/c18-13-9-12(17-10-5-2-1-3-6-10)15(19)11-7-4-8-16-14(11)13/h1-9,17H
描述信息
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:78677
- PubChem: 3976
- Metlin: METLIN63044
- ChEMBL: CHEMBL312487
- CAS: 91300-60-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Caifeng Jiao, Pei Wang, Runqiang Yang, Lu Tian, Zhenxin Gu. IP3 Mediates Nitric Oxide-Guanosine 3',5'-Cyclic Monophosphate (NO-cGMP)-Induced Isoflavone Accumulation in Soybean Sprouts under UV-B Radiation.
Journal of agricultural and food chemistry.
2016 Nov; 64(44):8282-8288. doi:
10.1021/acs.jafc.6b02633. [PMID: 27768311] - M A Hossain, W Ye, S Munemasa, Y Nakamura, I C Mori, Y Murata. Cyclic adenosine 5'-diphosphoribose (cADPR) cyclic guanosine 3',5'-monophosphate positively function in Ca(2+) elevation in methyl jasmonate-induced stomatal closure, cADPR is required for methyl jasmonate-induced ROS accumulation NO production in guard cells.
Plant biology (Stuttgart, Germany).
2014 Nov; 16(6):1140-4. doi:
10.1111/plb.12175. [PMID: 24802616] - Jisheng Li, Honglei Jia. cGMP modulates Arabidopsis lateral root formation through regulation of polar auxin transport.
Plant physiology and biochemistry : PPB.
2013 May; 66(?):105-17. doi:
10.1016/j.plaphy.2013.02.014. [PMID: 23500713] - Mingzhu Wu, Fangquan Wang, Chen Zhang, Yanjie Xie, Bin Han, Jingjing Huang, Wenbiao Shen. Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.
Plant molecular biology.
2013 Jan; 81(1-2):27-40. doi:
10.1007/s11103-012-9979-x. [PMID: 23090695] - Yilin Ren, Martin A D'Ambrosio, Hong Wang, John R Falck, Edward L Peterson, Jeffrey L Garvin, Oscar A Carretero. Mechanisms of carbon monoxide attenuation of tubuloglomerular feedback.
Hypertension (Dallas, Tex. : 1979).
2012 Jun; 59(6):1139-44. doi:
10.1161/hypertensionaha.112.192120. [PMID: 22508834] - Tongrong He, Zvonimir S Katusic. Brain-derived neurotrophic factor increases expression of MnSOD in human circulating angiogenic cells.
Microvascular research.
2012 May; 83(3):366-71. doi:
10.1016/j.mvr.2012.01.001. [PMID: 22261313] - Hong Wang, Jeffrey L Garvin, Martin A D'Ambrosio, John R Falck, Pablo Leung, Ruisheng Liu, YiLin Ren, Oscar A Carretero. Heme oxygenase metabolites inhibit tubuloglomerular feedback in vivo.
American journal of physiology. Heart and circulatory physiology.
2011 Apr; 300(4):H1320-6. doi:
10.1152/ajpheart.01118.2010. [PMID: 21239629] - Yao Teng, Wenzhong Xu, Mi Ma. cGMP is required for seed germination in Arabidopsis thaliana.
Journal of plant physiology.
2010 Jul; 167(11):885-9. doi:
10.1016/j.jplph.2010.01.015. [PMID: 20170981] - Amaury de Montaigu, Emanuel Sanz-Luque, Aurora Galván, Emilio Fernández. A soluble guanylate cyclase mediates negative signaling by ammonium on expression of nitrate reductase in Chlamydomonas.
The Plant cell.
2010 May; 22(5):1532-48. doi:
10.1105/tpc.108.062380. [PMID: 20442374] - Michael J Coffey, Susan M Phare, Ming Luo, Marc Peters-Golden. Guanylyl cyclase and protein kinase G mediate nitric oxide suppression of 5-lipoxygenase metabolism in rat alveolar macrophages.
Biochimica et biophysica acta.
2008 Jun; 1781(6-7):299-305. doi:
10.1016/j.bbalip.2008.04.005. [PMID: 18474265] - Chao-Sheng Lo, Zhao-Hong Chen, Tusty-Jiuan Hsieh, Shyi-Jang Shin. Atrial natriuretic peptide attenuates high glucose-activated transforming growth factor-beta, Smad and collagen synthesis in renal proximal tubular cells.
Journal of cellular biochemistry.
2008 Apr; 103(6):1999-2009. doi:
10.1002/jcb.21590. [PMID: 17960594] - Mari L Salmi, Kacey E Morris, Stanley J Roux, D Marshall Porterfield. Nitric oxide and cGMP signaling in calcium-dependent development of cell polarity in Ceratopteris richardii.
Plant physiology.
2007 May; 144(1):94-104. doi:
10.1104/pp.107.096131. [PMID: 17351052] - Sebastian Brauchi, Christian Cea, Jorge G Farias, Juan Bacigalupo, Juan G Reyes. Apoptosis induced by prolonged exposure to odorants in cultured cells from rat olfactory epithelium.
Brain research.
2006 Aug; 1103(1):114-22. doi:
10.1016/j.brainres.2006.05.072. [PMID: 16814749] - Monica Ambrose, Aideen Ryan, Gerald C O'Sullivan, Colum Dunne, Orla P Barry. Induction of apoptosis in renal cell carcinoma by reactive oxygen species: involvement of extracellular signal-regulated kinase 1/2, p38delta/gamma, cyclooxygenase-2 down-regulation, and translocation of apoptosis-inducing factor.
Molecular pharmacology.
2006 Jun; 69(6):1879-90. doi:
10.1124/mol.105.020875. [PMID: 16543392] - Jun Suzuki, Zheng-Gen Jin, David F Meoli, Tetsuya Matoba, Bradford C Berk. Cyclophilin A is secreted by a vesicular pathway in vascular smooth muscle cells.
Circulation research.
2006 Mar; 98(6):811-7. doi:
10.1161/01.res.0000216405.85080.a6. [PMID: 16527992] - María Luciana Lanteri, Gabriela Carolina Pagnussat, Lorenzo Lamattina. Calcium and calcium-dependent protein kinases are involved in nitric oxide- and auxin-induced adventitious root formation in cucumber.
Journal of experimental botany.
2006; 57(6):1341-51. doi:
10.1093/jxb/erj109. [PMID: 16531462] - Tongrong He, Timothy E Peterson, Ekhson L Holmuhamedov, Andre Terzic, Noel M Caplice, Larry W Oberley, Zvonimir S Katusic. Human endothelial progenitor cells tolerate oxidative stress due to intrinsically high expression of manganese superoxide dismutase.
Arteriosclerosis, thrombosis, and vascular biology.
2004 Nov; 24(11):2021-7. doi:
10.1161/01.atv.0000142810.27849.8f. [PMID: 15319267] - Afaf Absood, Akira Furutani, Tsutomu Kawamura, Linda M Graham. A comparison of oxidized LDL-induced collagen secretion by graft and aortic SMCs: role of PDGF.
American journal of physiology. Heart and circulatory physiology.
2004 Sep; 287(3):H1200-6. doi:
10.1152/ajpheart.00228.2004. [PMID: 15142849] - El-Sayed Akool, Hartmut Kleinert, Farid M A Hamada, Mohamed H Abdelwahab, Ulrich Förstermann, Josef Pfeilschifter, Wolfgang Eberhardt. Nitric oxide increases the decay of matrix metalloproteinase 9 mRNA by inhibiting the expression of mRNA-stabilizing factor HuR.
Molecular and cellular biology.
2003 Jul; 23(14):4901-16. doi:
10.1128/mcb.23.14.4901-4916.2003. [PMID: 12832476] - Bing Shen, Chun-Ling Ye, Kai-He Ye, Jian-Jun Liu. Mechanism underlying enhanced endothelium-dependent vasodilatation in thoracic aorta of early stage streptozotocin-induced diabetic mice.
Acta pharmacologica Sinica.
2003 May; 24(5):422-8. doi:
NULL. [PMID: 12740177] - Lionel Valenti, Jacques Mathieu, Yves Chancerelle, Maryse Levacher, Brigitte Chanaud, Martine De Sousa, Suzanne Strzalko, Anh Tuan Dinh-Xuan, Jean-Paul Giroud, Irène Florentin. Nitric oxide inhibits spleen cell proliferative response after burn injury by inducing cytostasis, apoptosis, and necrosis of activated T lymphocytes: role of the guanylate cyclase.
Cellular immunology.
2003 Jan; 221(1):50-63. doi:
10.1016/s0008-8749(03)00064-9. [PMID: 12742382] - P A Ortiz, J L Garvin. NO Inhibits NaCl absorption by rat thick ascending limb through activation of cGMP-stimulated phosphodiesterase.
Hypertension (Dallas, Tex. : 1979).
2001 Feb; 37(2 Pt 2):467-71. doi:
10.1161/01.hyp.37.2.467. [PMID: 11230320] - B Tantini, F Flamigni, C Pignatti, C Stefanelli, M Fattori, A Facchini, E Giordano, C Clô, C M Caldarera. Polyamines, NO and cGMP mediate stimulation of DNA synthesis by tumor necrosis factor and lipopolysaccharide in chick embryo cardiomyocytes.
Cardiovascular research.
2001 Feb; 49(2):408-16. doi:
10.1016/s0008-6363(00)00255-8. [PMID: 11164851] - S Lakshminarayanan, D A Antonetti, T W Gardner, J M Tarbell. Effect of VEGF on retinal microvascular endothelial hydraulic conductivity: the role of NO.
Investigative ophthalmology & visual science.
2000 Dec; 41(13):4256-61. doi:
NULL. [PMID: 11095623] - C D Collard, A Agah, W Reenstra, J Buras, G L Stahl. Endothelial nuclear factor-kappaB translocation and vascular cell adhesion molecule-1 induction by complement: inhibition with anti-human C5 therapy or cGMP analogues.
Arteriosclerosis, thrombosis, and vascular biology.
1999 Nov; 19(11):2623-9. doi:
10.1161/01.atv.19.11.2623. [PMID: 10559004] - M Akahori, S Yamada, N Takeyama, T Tanaka. Nitric oxide ameliorates actinomycin D/endotoxin-induced apoptotic liver failure in mice.
The Journal of surgical research.
1999 Aug; 85(2):286-93. doi:
10.1006/jsre.1999.5621. [PMID: 10423331] - T Y Ahn, D Gómez-Coronado, V Martínez, P Cuevas, I Goldstein, I Sáenz de Tejada. Enhanced contractility of rabbit corpus cavernosum smooth muscle by oxidized low density lipoproteins.
International journal of impotence research.
1999 Feb; 11(1):9-14. doi:
10.1038/sj.ijir.3900378. [PMID: 10098947] - T H Murphy, A P So, S R Vincent. Histochemical detection of quinone reductase activity in situ using LY 83583 reduction and oxidation.
Journal of neurochemistry.
1998 May; 70(5):2156-64. doi:
10.1046/j.1471-4159.1998.70052156.x. [PMID: 9572303] - J D Sadoff, P M Scholz, J Tse, H R Weiss. Reduced myocardial cyclic GMP increases myocardial O2 consumption in control but not renal hypertension-induced cardiac hypertrophy.
Cardiovascular research.
1997 Dec; 36(3):453-9. doi:
10.1016/s0008-6363(97)00204-6. [PMID: 9534866] - T Syrovets, B Tippler, M Rieks, T Simmet. Plasmin is a potent and specific chemoattractant for human peripheral monocytes acting via a cyclic guanosine monophosphate-dependent pathway.
Blood.
1997 Jun; 89(12):4574-83. doi:
10.1182/blood.v89.12.4574. [PMID: 9192782] - G Bischof, T F Serwold, T E Machen. Does nitric oxide regulate capacitative Ca influx in HEK 293 cells?.
Cell calcium.
1997 Feb; 21(2):135-42. doi:
10.1016/s0143-4160(97)90037-3. [PMID: 9132296] - A S Baas, B C Berk. Differential activation of mitogen-activated protein kinases by H2O2 and O2- in vascular smooth muscle cells.
Circulation research.
1995 Jul; 77(1):29-36. doi:
10.1161/01.res.77.1.29. [PMID: 7540516] - G Bischof, J Brenman, D S Bredt, T E Machen. Possible regulation of capacitative Ca2+ entry into colonic epithelial cells by NO and cGMP.
Cell calcium.
1995 Apr; 17(4):250-62. doi:
10.1016/0143-4160(95)90071-3. [PMID: 7545090] - A R Noble, R A Abu-Kishk, M A D'Aloia, B C Williams, D J Lush. Cyclic GMP-linked pathway for renin secretion.
Kidney international.
1994 Dec; 46(6):1588-90. doi:
10.1038/ki.1994.454. [PMID: 7700014] - K J Miller, B J Hoffman. Adenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP.
The Journal of biological chemistry.
1994 Nov; 269(44):27351-6. doi:
10.1016/s0021-9258(18)46992-x. [PMID: 7525554] - X Xu, R A Star, G Tortorici, S Muallem. Depletion of intracellular Ca2+ stores activates nitric-oxide synthase to generate cGMP and regulate Ca2+ influx.
The Journal of biological chemistry.
1994 Apr; 269(17):12645-53. doi:
NULL. [PMID: 7513692] - B A Prins, R M Hu, B Nazario, A Pedram, H J Frank, M A Weber, E R Levin. Prostaglandin E2 and prostacyclin inhibit the production and secretion of endothelin from cultured endothelial cells.
The Journal of biological chemistry.
1994 Apr; 269(16):11938-44. doi:
10.1016/s0021-9258(17)32663-7. [PMID: 8163494] - M A Brandt, K P Conrad. In vivo and in vitro studies of a putative inhibitor of cyclic guanosine 3',5'-monophosphate production.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1991 Jan; 196(1):30-5. doi:
10.3181/00379727-196-43159. [PMID: 1845779] - S J Pandol, M S Schoeffield-Payne. Cyclic GMP mediates the agonist-stimulated increase in plasma membrane calcium entry in the pancreatic acinar cell.
The Journal of biological chemistry.
1990 Aug; 265(22):12846-53. doi:
10.1016/s0021-9258(19)38236-5. [PMID: 2165487] - S J Pandol, M S Schoeffield-Payne. Cyclic GMP regulates free cytosolic calcium in the pancreatic acinar cell.
Cell calcium.
1990 Aug; 11(7):477-86. doi:
10.1016/0143-4160(90)90080-e. [PMID: 1980234] - A A von Ruecker, M Wild, G S Rao, F Bidlingmaier. Atrial natriuretic peptide protects hepatocytes against damage induced by hypoxia and reactive oxygen. Possible role of intracellular free ionized calcium.
Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie.
1989 Sep; 27(9):531-7. doi:
10.1515/cclm.1989.27.9.531. [PMID: 2558149] - D B Light, E M Schwiebert, K H Karlson, B A Stanton. Atrial natriuretic peptide inhibits a cation channel in renal inner medullary collecting duct cells.
Science (New York, N.Y.).
1989 Jan; 243(4889):383-5. doi:
10.1126/science.2463673. [PMID: 2463673] - M Nozaki. [Combined use of bucolome and pyrazolone derivatives (1). Pharmacological activities and blood concentration].
Nihon yakurigaku zasshi. Folia pharmacologica Japonica.
1975 Sep; 71(6):609-29. doi:
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