ODQ (BioDeep_00000605513)
代谢物信息卡片
1h-[1,2,4]Oxadiazolo[4,3-a]quinoxalin-1-one
化学式: C9H5N3O2 (187.03817500000002)
中文名称: 1H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)N=CC3=NOC(=O)N23
InChI: InChI=1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:91215
- PubChem: 1456
- Metlin: METLIN62975
- ChEMBL: CHEMBL598952
- CAS: 41443-28-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Luis Arias-Durán, Samuel Estrada-Soto, Monserrat Hernández-Morales, César Millán-Pacheco, Gabriel Navarrete-Vázquez, Rafael Villalobos-Molina, Maximiliano Ibarra-Barajas, Julio C Almanza-Pérez. Antihypertensive and vasorelaxant effect of leucodin and achillin isolated from Achillea millefolium through calcium channel blockade and NO production: In vivo, functional ex vivo and in silico studies.
Journal of ethnopharmacology.
2021 Jun; 273(?):113948. doi:
10.1016/j.jep.2021.113948. [PMID: 33610712] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Clara Alba-Betancourt, Amanda Sánchez-Recillas, Angel J Alonso-Castro, David Esquivel-Juárez, Juan R Zapata-Morales, Víctor Yáñez-Pérez, Daniel Álvarez-Camacho, Yessica E Medina-Rivera, Marco M González-Chávez, Deisy Gasca-Martínez, Rolffy Ortiz-Andrade. Antidiarrheal, vasorelaxant, and neuropharmacological actions of the diterpene tilifodiolide.
Drug development research.
2019 11; 80(7):981-991. doi:
10.1002/ddr.21578. [PMID: 31343767] - Hae Jin Kim, Ji Hyun Jang, Yin Hua Zhang, Hae Young Yoo, Sung Joon Kim. Fast relaxation and desensitization of angiotensin II contraction in the pulmonary artery via AT1R and Akt-mediated phosphorylation of muscular eNOS.
Pflugers Archiv : European journal of physiology.
2019 10; 471(10):1317-1330. doi:
10.1007/s00424-019-02305-z. [PMID: 31468138] - Yousuf M Al Suleimani, Ahmed S Al Mahruqi. The endogenous lipid N-arachidonoyl glycine is hypotensive and nitric oxide-cGMP-dependent vasorelaxant.
European journal of pharmacology.
2017 Jan; 794(?):209-215. doi:
10.1016/j.ejphar.2016.11.040. [PMID: 27890711] - Jing Gao, Jingze Zhang, Zhuo Qu, Hong Zhou, Yongling Tong, Dan Liu, Honggai Yang, Wenyuan Gao. Study on the mechanisms of the bronchodilator effects of Folium Eriobotryae and the selected active ingredient on isolated guinea pig tracheal strips.
Pharmaceutical biology.
2016 Nov; 54(11):2742-2752. doi:
10.1080/13880209.2016.1183134. [PMID: 27251608] - Giovane S Galdino, Carlos H Xavier, Renato Almeida, Grazielle Silva, Marcos A Fontes, Gustavo Menezes, Igor D Duarte, Andrea C Perez. The Nitric oxide/CGMP/KATP pathway mediates systemic and central antinociception induced by resistance exercise in rats.
The International journal of neuroscience.
2015; 125(10):765-73. doi:
10.3109/00207454.2014.970256. [PMID: 25271801] - C V Oztekin, S Gur, N A Abdulkadir, M Kartal, M Karabakan, A O Akdemir, C S Gökkaya, M Cetinkaya. Analysis of pomegranate juice components in rat corpora cavernosal relaxation.
International journal of impotence research.
2014 Mar; 26(2):45-50. doi:
10.1038/ijir.2013.33. [PMID: 23903908] - Ting-Lin Yen, Wan-Jung Lu, Li-Ming Lien, Philip Aloysius Thomas, Tzu-Yin Lee, Hou-Chang Chiu, Joen-Rong Sheu, Kuan-Hung Lin. Amarogentin, a secoiridoid glycoside, abrogates platelet activation through PLC γ 2-PKC and MAPK pathways.
BioMed research international.
2014; 2014(?):728019. doi:
10.1155/2014/728019. [PMID: 24868545] - Luis C Matavelli, Jiqian Huang, Helmy M Siragy. In vivo regulation of renal expression of (pro)renin receptor by a low-sodium diet.
American journal of physiology. Renal physiology.
2012 Dec; 303(12):F1652-7. doi:
10.1152/ajprenal.00204.2012. [PMID: 23077099] - A Joshi, O L Woodman. Increased nitric oxide activity compensates for increased oxidative stress to maintain endothelial function in rat aorta in early type 1 diabetes.
Naunyn-Schmiedeberg's archives of pharmacology.
2012 Nov; 385(11):1083-94. doi:
10.1007/s00210-012-0794-3. [PMID: 22965470] - Monika Thumova, Vladimir Pech, Otto Froehlich, Diana Agazatian, Xiaonan Wang, Jill W Verlander, Young Hee Kim, Susan M Wall. Pendrin protein abundance in the kidney is regulated by nitric oxide and cAMP.
American journal of physiology. Renal physiology.
2012 Sep; 303(6):F812-20. doi:
10.1152/ajprenal.00577.2011. [PMID: 22811483] - Ming-Guo Feng, Minolfa C Prieto, L Gabriel Navar. Nebivolol-induced vasodilation of renal afferent arterioles involves β3-adrenergic receptor and nitric oxide synthase activation.
American journal of physiology. Renal physiology.
2012 Sep; 303(5):F775-82. doi:
10.1152/ajprenal.00233.2012. [PMID: 22674024] - I Brivio, C Buccellati, F Fumagalli, J Hodge, C Casagrande, G C Folco, A Sala. The pulmonary pharmacology of [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide] (2NTX-99), an anti-atherotrombotic compound with therapeutic potential in pathological conditions that target lung vasculature.
Prostaglandins & other lipid mediators.
2012 Aug; 98(3-4):116-21. doi:
10.1016/j.prostaglandins.2012.01.007. [PMID: 22342851] - Song Nan Jin, Jin Fu Wen, Ting Ting Wang, Dae Gill Kang, Ho Sub Lee, Kyung Woo Cho. Vasodilatory effects of ethanol extract of Radix Paeoniae Rubra and its mechanism of action in the rat aorta.
Journal of ethnopharmacology.
2012 Jun; 142(1):188-93. doi:
10.1016/j.jep.2012.04.035. [PMID: 22543176] - Francine Nsuadi Manga, Charaf El Khattabi, Jeanine Fontaine, Guy Berkenboom, Pierre Duez, José Lami Nzunzu, Stéphanie Pochet. Vascular effects and antioxidant activity of two Combretum species from Democratic Republic of Congo.
Journal of ethnopharmacology.
2012 Jun; 142(1):194-200. doi:
10.1016/j.jep.2012.04.039. [PMID: 22564815] - Hye Kyung Kim, Bo Ram Choi, Yun Ok Bak, Chen Zhao, Sung Won Lee, Ju-Hong Jeon, Insuk So, Jong Kwan Park. The role of capillarisin from Artemisia capillaris on penile erection.
Phytotherapy research : PTR.
2012 Jun; 26(6):800-5. doi:
10.1002/ptr.3635. [PMID: 22072532] - Jian Yang, Caiyu Chen, Hongmei Ren, Yu Han, Duofen He, Lin Zhou, Ulrich Hopfer, Pedro A Jose, Chunyu Zeng. Angiotensin II AT(2) receptor decreases AT(1) receptor expression and function via nitric oxide/cGMP/Sp1 in renal proximal tubule cells from Wistar-Kyoto rats.
Journal of hypertension.
2012 Jun; 30(6):1176-84. doi:
10.1097/hjh.0b013e3283532099. [PMID: 22504846] - Wen-Fei Chiou, Tian-Shung Wu. 9-hydroxycanthin-6-one induces penile erection and delays ejaculation.
The journal of sexual medicine.
2012 Apr; 9(4):1027-36. doi:
10.1111/j.1743-6109.2011.02296.x. [PMID: 21569213] - Kenjiro Tanaka, Takahiro Shimizu, Lianyi Lu, Kunihiko Yokotani. Possible involvement of S-nitrosylation of brain cyclooxygenase-1 in bombesin-induced central activation of adrenomedullary outflow in rats.
European journal of pharmacology.
2012 Mar; 679(1-3):40-50. doi:
10.1016/j.ejphar.2012.01.005. [PMID: 22293370] - Jiqian Huang, Helmy M Siragy. Sodium depletion enhances renal expression of (pro)renin receptor via cyclic GMP-protein kinase G signaling pathway.
Hypertension (Dallas, Tex. : 1979).
2012 Feb; 59(2):317-23. doi:
10.1161/hypertensionaha.111.186056. [PMID: 22203739] - Shona Harmon, Iwona Inkielewicz-Stepniak, Michael Jones, Mark Ledwidge, Maria Jose Santos-Martinez, Carlos Medina, Marek W Radomski, John F Gilmer. Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets.
The Journal of pharmacy and pharmacology.
2012 Jan; 64(1):77-89. doi:
10.1111/j.2042-7158.2011.01380.x. [PMID: 22150675] - Hong-Jye Hong, Feng-Lin Hsu, Shih-Chang Tsai, Cheng-Hsin Lin, Ju-Chi Liu, Jin-Jer Chen, Tzu-Hurng Cheng, Paul Chan. Tanshinone IIA attenuates cyclic strain-induced endothelin-1 expression in human umbilical vein endothelial cells.
Clinical and experimental pharmacology & physiology.
2012 Jan; 39(1):63-8. doi:
10.1111/j.1440-1681.2011.05637.x. [PMID: 22032308] - Luminita H Pojoga, Jonathan S Williams, Tham M Yao, Abhinav Kumar, Joseph D Raffetto, Graciliano R A do Nascimento, Ossama M Reslan, Gail K Adler, Gordon H Williams, Yujiang Shi, Raouf A Khalil. Histone demethylase LSD1 deficiency during high-salt diet is associated with enhanced vascular contraction, altered NO-cGMP relaxation pathway, and hypertension.
American journal of physiology. Heart and circulatory physiology.
2011 Nov; 301(5):H1862-71. doi:
10.1152/ajpheart.00513.2011. [PMID: 21873498] - Wachirawadee Malakul, Kornkanok Ingkaninan, Pattara Sawasdee, Owen L Woodman. The ethanolic extract of Kaempferia parviflora reduces ischaemic injury in rat isolated hearts.
Journal of ethnopharmacology.
2011 Sep; 137(1):184-91. doi:
10.1016/j.jep.2011.05.004. [PMID: 21600275] - Clara Sciorati, Daniela Miglietta, Roberta Buono, Viviana Pisa, Dario Cattaneo, Emanuele Azzoni, Silvia Brunelli, Emilio Clementi. A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy.
Pharmacological research.
2011 Sep; 64(3):210-7. doi:
10.1016/j.phrs.2011.05.003. [PMID: 21609764] - Jiaming Yang, Paul S P Ip, John H K Yeung, Chun-Tao Che. Inhibitory effect of schisandrin on spontaneous contraction of isolated rat colon.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Aug; 18(11):998-1005. doi:
10.1016/j.phymed.2011.02.014. [PMID: 21514126] - Marcelo R Choi, Marisa R Citarella, Brenda M Lee, Florencia Lucano, Belisario E Fernández. Urodilatin increases renal dopamine uptake: intracellular network involved.
Journal of physiology and biochemistry.
2011 Jun; 67(2):243-7. doi:
10.1007/s13105-010-0069-8. [PMID: 21210317] - Guglielmina Froldi, Riccardo Bertin, Enrico Secchi, Giuseppe Zagotto, Mariano Martínez-Vázquez, Aída García-Argaéz. Vasorelaxation by extracts of Casimiroa spp. in rat resistance vessels and pharmacological study of cellular mechanisms.
Journal of ethnopharmacology.
2011 Apr; 134(3):637-43. doi:
10.1016/j.jep.2011.01.008. [PMID: 21236328] - Agnese Secondo, Pasquale Molinaro, Anna Pannaccione, Alba Esposito, Maria Cantile, Pellegrino Lippiello, Rossana Sirabella, Takahiro Iwamoto, Gianfranco Di Renzo, Lucio Annunziato. Nitric oxide stimulates NCX1 and NCX2 but inhibits NCX3 isoform by three distinct molecular determinants.
Molecular pharmacology.
2011 Mar; 79(3):558-68. doi:
10.1124/mol.110.069658. [PMID: 21159997] - María F Albertoni Borghese, Layne M Bettini, Carlos H Nitta, Sergio de Frutos, Mónica Majowicz, Laura V Gonzalez Bosc. Aquaporin-2 promoter is synergistically regulated by nitric oxide and nuclear factor of activated T cells.
Nephron extra.
2011 Jan; 1(1):124-38. doi:
10.1159/000333066. [PMID: 22470386] - Song Nan Jin, Jin Fu Wen, Hye Yoom Kim, Dae Gill Kang, Ho Sub Lee, Kyung Woo Cho. Vascular relaxation by ethanol extract of Xanthoceras sorbifolia via Akt- and SOCE-eNOS-cGMP pathways.
Journal of ethnopharmacology.
2010 Oct; 132(1):240-5. doi:
10.1016/j.jep.2010.08.007. [PMID: 20713148] - Patcharin Tep-Areenan, Pattara Sawasdee, Michael Randall. Possible mechanisms of vasorelaxation for 5,7-dimethoxyflavone from Kaempferia parviflora in the rat aorta.
Phytotherapy research : PTR.
2010 Oct; 24(10):1520-5. doi:
10.1002/ptr.3164. [PMID: 20878704] - Gabriella Aviello, Caterina Scalisi, Rosaria Fileccia, Raffaele Capasso, Barbara Romano, Angelo A Izzo, Francesca Borrelli. Inhibitory effect of caffeic acid phenethyl ester, a plant-derived polyphenolic compound, on rat intestinal contractility.
European journal of pharmacology.
2010 Aug; 640(1-3):163-7. doi:
10.1016/j.ejphar.2010.04.040. [PMID: 20451513] - Thaís P Ribeiro, Dayanne L Porto, Camilla P Menezes, Alessandra A Antunes, Darízy F Silva, Damião P De Sousa, Lia S Nakao, Valdir A Braga, Isac A Medeiros. Unravelling the cardiovascular effects induced by alpha-terpineol: a role for the nitric oxide-cGMP pathway.
Clinical and experimental pharmacology & physiology.
2010 Aug; 37(8):811-6. doi:
10.1111/j.1440-1681.2010.05383.x. [PMID: 20374260] - Ravi K Deevi, Madhuri Koney-Dash, Adrien Kissenpfennig, James A Johnston, Kai Schuh, Ulrich Walter, Karim Dib. Vasodilator-stimulated phosphoprotein regulates inside-out signaling of beta2 integrins in neutrophils.
Journal of immunology (Baltimore, Md. : 1950).
2010 Jun; 184(12):6575-84. doi:
10.4049/jimmunol.0903910. [PMID: 20483741] - Amaury de Montaigu, Emanuel Sanz-Luque, Aurora Galván, Emilio Fernández. A soluble guanylate cyclase mediates negative signaling by ammonium on expression of nitrate reductase in Chlamydomonas.
The Plant cell.
2010 May; 22(5):1532-48. doi:
10.1105/tpc.108.062380. [PMID: 20442374] - Jung-Ok Lee, Kiyuk Chang, Chul Young Kim, Sang Hoon Jung, Seung-Woo Lee, Min-Ho Oak. Lysimachia clethroides extract promote vascular relaxation via endothelium-dependent mechanism.
Journal of cardiovascular pharmacology.
2010 May; 55(5):481-8. doi:
10.1097/fjc.0b013e3181d7066f. [PMID: 20164788] - Fushun Hao, Shiling Zhao, Huan Dong, Huan Zhang, Lirong Sun, Chen Miao. Nia1 and Nia2 are involved in exogenous salicylic acid-induced nitric oxide generation and stomatal closure in Arabidopsis.
Journal of integrative plant biology.
2010 Mar; 52(3):298-307. doi:
10.1111/j.1744-7909.2010.00920.x. [PMID: 20377690] - Takayuki Matsumoto, Tsuneo Kobayashi, Keiko Ishida, Yusuke Hirasawa, Hiroshi Morita, Toshio Honda, Katsuo Kamata. Vasodilator effect of Cassiarin A, a novel antiplasmodial alkaloid from Cassia siamea, in rat isolated mesenteric artery.
Biological & pharmaceutical bulletin.
2010; 33(5):844-8. doi:
10.1248/bpb.33.844. [PMID: 20460764] - Mounia Skiker, Hassane Mekhfi, Mohamed Aziz, Benyounes Haloui, Saad Lahlou, Abdelkhaleq Legssyer, Mohamed Bnouham, Abderrahim Ziyyat. Artemisia herba-alba Asso relaxes the rat aorta through activation of NO/cGMP pathway and K(ATP) channels.
Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi.
2010; 46(3):165-74. doi:
10.1540/jsmr.46.165. [PMID: 20647693] - Birgit Nimmervoll, Nina Svoboda, Beata Sacha, Hubert H Kerschbaum. Sustained elevation of cyclic guanosine monophosphate induces apoptosis in microglia.
Brain research bulletin.
2009 Dec; 80(6):428-32. doi:
10.1016/j.brainresbull.2009.08.002. [PMID: 19682559] - David C Lieb, Brandon A Kemp, Nancy L Howell, John J Gildea, Robert M Carey. Reinforcing feedback loop of renal cyclic guanosine 3' 5' -monophosphate and interstitial hydrostatic pressure in pressure-natriuresis.
Hypertension (Dallas, Tex. : 1979).
2009 Dec; 54(6):1278-83. doi:
10.1161/hypertensionaha.109.131995. [PMID: 19841292] - W J Wilkinson, H C Gadeberg, A W J Harrison, N D Allen, D Riccardi, P J Kemp. Carbon monoxide is a rapid modulator of recombinant and native P2X(2) ligand-gated ion channels.
British journal of pharmacology.
2009 Oct; 158(3):862-71. doi:
10.1111/j.1476-5381.2009.00354.x. [PMID: 19694727] - Juliana T Clemente-Napimoga, Adriana Pellegrini-da-Silva, Vinícius H A Ferreira, Marcelo H Napimoga, Carlos A Parada, Cláudia H Tambeli. Gonadal hormones decrease temporomandibular joint kappa-mediated antinociception through a down-regulation in the expression of kappa opioid receptors in the trigeminal ganglia.
European journal of pharmacology.
2009 Sep; 617(1-3):41-7. doi:
10.1016/j.ejphar.2009.06.036. [PMID: 19567249] - W Sosroseno, P S Bird, G J Seymour. Effect of exogenous nitric oxide on murine immune response induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide.
Journal of periodontal research.
2009 Aug; 44(4):529-36. doi:
10.1111/j.1600-0765.2008.01157.x. [PMID: 18973550] - Balasubramanian Srilatha, Lingxu Hu, Ganesan P Adaikan, Philip K Moore. Initial characterization of hydrogen sulfide effects in female sexual function.
The journal of sexual medicine.
2009 Jul; 6(7):1875-84. doi:
10.1111/j.1743-6109.2009.01291.x. [PMID: 19453900] - Chee-Wan Lee, Dan Li, Keith M Channon, David J Paterson. L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats.
Journal of molecular and cellular cardiology.
2009 Jul; 47(1):149-55. doi:
10.1016/j.yjmcc.2009.03.023. [PMID: 19362092] - Thejass Punathil, Santosh K Katiyar. Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2.
Molecular carcinogenesis.
2009 Mar; 48(3):232-242. doi:
10.1002/mc.20473. [PMID: 18680102] - Daniel Fernandes, Regina Sordi, Letícia Kramer Pacheco, Geisson Marcos Nardi, Bettina Tomio Heckert, Christina Gaspar Villela, Amanda Revoredo Lobo, Christina Barja-Fidalgo, Jamil Assreuy. Late, but not early, inhibition of soluble guanylate cyclase decreases mortality in a rat sepsis model.
The Journal of pharmacology and experimental therapeutics.
2009 Mar; 328(3):991-9. doi:
10.1124/jpet.108.142034. [PMID: 19073910] - Stuart A Reichler, Jonathan Torres, Amy L Rivera, Viviana A Cintolesi, Greg Clark, Stanley J Roux. Intersection of two signalling pathways: extracellular nucleotides regulate pollen germination and pollen tube growth via nitric oxide.
Journal of experimental botany.
2009; 60(7):2129-38. doi:
10.1093/jxb/erp091. [PMID: 19363208] - Chol-Jun Kwak, Eriko Kubo, Kiwako Fujii, Yuri Nishimura, Shuhei Kobuchi, Mamoru Ohkita, Makiko Yoshimura, Yoshinobu Kiso, Yasuo Matsumura. Antihypertensive effect of French maritime pine bark extract (Flavangenol): possible involvement of endothelial nitric oxide-dependent vasorelaxation.
Journal of hypertension.
2009 Jan; 27(1):92-101. doi:
10.1097/hjh.0b013e3283186994. [PMID: 19145776] - Luciana Pontes Coelho, Magda Fráguas Serra, Ana Lúcia de Aguiar Pires, Renato Sérgio Balão Cordeiro, Patrícia Machado Rodrigues e Silva, Marcelo Henrique dos Santos, Marco Aurélio Martins. 7-Epiclusianone, a tetraprenylated benzophenone, relaxes airway smooth muscle through activation of the nitric oxide-cGMP pathway.
The Journal of pharmacology and experimental therapeutics.
2008 Oct; 327(1):206-14. doi:
10.1124/jpet.108.138032. [PMID: 18591220] - Jun Chen, Ji-Hong Liu, Tao Wang, Heng-Jun Xiao, Chun-Ping Yin, Jun Yang. Effects of plant extract neferine on cyclic adenosine monophosphate and cyclic guanosine monophosphate levels in rabbit corpus cavernosum in vitro.
Asian journal of andrology.
2008 Mar; 10(2):307-12. doi:
10.1111/j.1745-7262.2008.00342.x. [PMID: 18097520] - Koen Van Crombruggen, Luc Van Nassauw, Pieter Demetter, Claude Cuvelier, Jean-Pierre Timmermans, Romain A Lefebvre. Influence of soluble guanylate cyclase inhibition on inflammation and motility disturbances in DSS-induced colitis.
European journal of pharmacology.
2008 Jan; 579(1-3):337-49. doi:
10.1016/j.ejphar.2007.10.021. [PMID: 18022154] - Victoria Seto, Christina Hirota, Simon Hirota, Luke J Janssen. E-Ring Isoprostanes Stimulate a Cl Conductance in Airway Epithelium via Prostaglandin E2-Selective Prostanoid Receptors.
American journal of respiratory cell and molecular biology.
2008 Jan; 38(1):88-94. doi:
10.1165/rcmb.2007-0117oc. [PMID: 17673688] - Andreas Knorr, Claudia Hirth-Dietrich, Cristina Alonso-Alija, Michael Härter, Michael Hahn, Yvonne Keim, Frank Wunder, Johannes-Peter Stasch. Nitric oxide-independent activation of soluble guanylate cyclase by BAY 60-2770 in experimental liver fibrosis.
Arzneimittel-Forschung.
2008; 58(2):71-80. doi:
10.1055/s-0031-1296471. [PMID: 18412020] - K B Balestrasse, C G Zilli, M L Tomaro. Signal transduction pathways and haem oxygenase induction in soybean leaves subjected to salt stress.
Redox report : communications in free radical research.
2008; 13(6):255-62. doi:
10.1179/135100008x308966. [PMID: 19017465] - Yanan Xu, Changhai Cui, Cheuk Pang, Yves Christen, Yuan Luo. Restoration of impaired phosphorylation of cyclic AMP response element-binding protein (CREB) by EGb 761 and its constituents in Abeta-expressing neuroblastoma cells.
The European journal of neuroscience.
2007 Nov; 26(10):2931-9. doi:
10.1111/j.1460-9568.2007.05905.x. [PMID: 18001288] - Carlos Graça, Cristiane Hatsuko Baggio, Cristina Setim Freitas, Yanna Dantas Rattmann, Lauro Mera de Souza, Thales Ricardo Cipriani, Guilherme Lanzi Sassaki, Lia Rieck, Roberto Pontarolo, José Eduardo da Silva-Santos, Maria Consuelo Andrade Marques. In vivo assessment of safety and mechanisms underlying in vitro relaxation induced by Mikania laevigata Schultz Bip. ex Baker in the rat trachea.
Journal of ethnopharmacology.
2007 Jul; 112(3):430-9. doi:
10.1016/j.jep.2007.03.026. [PMID: 17573215] - M Slupski, L Szadujkis-Szadurski, G Grześk, R Szadujkis-Szadurski, K Szadujkis-Szadurska, Z Wlodarczyk, M Masztalerz, I Piotrowiak, M Jasiński. Guanylate cyclase activators influence reactivity of human mesenteric superior arteries retrieved and preserved in the same conditions as transplanted kidneys.
Transplantation proceedings.
2007 Jun; 39(5):1350-3. doi:
10.1016/j.transproceed.2007.02.079. [PMID: 17580137] - Sunny Sun-Kin Chan, Tin-Yan Cheng, Ge Lin. Relaxation effects of ligustilide and senkyunolide A, two main constituents of Ligusticum chuanxiong, in rat isolated aorta.
Journal of ethnopharmacology.
2007 May; 111(3):677-80. doi:
10.1016/j.jep.2006.12.018. [PMID: 17222996] - Madhu Chauhan, Gracious R Ross, Uma Yallampalli, Chandra Yallampalli. Adrenomedullin-2, a novel calcitonin/calcitonin-gene-related peptide family peptide, relaxes rat mesenteric artery: influence of pregnancy.
Endocrinology.
2007 Apr; 148(4):1727-35. doi:
10.1210/en.2006-1105. [PMID: 17218418] - Hai-Bin Xu, Zhao-Quan Huang. Vasorelaxant effects of icariin on isolated canine coronary artery.
Journal of cardiovascular pharmacology.
2007 Apr; 49(4):207-13. doi:
10.1097/fjc.0b013e3180325abe. [PMID: 17438405] - Carlos R Tirapelli, Claudia R de Andrade, Adriano O Cassano, Fernando A De Souza, Sergio R Ambrosio, Fernando B da Costa, Ana M de Oliveira. Antispasmodic and relaxant effects of the hidroalcoholic extract of Pimpinella anisum (Apiaceae) on rat anococcygeus smooth muscle.
Journal of ethnopharmacology.
2007 Mar; 110(1):23-9. doi:
10.1016/j.jep.2006.08.031. [PMID: 17027208] - Jingang Gui, Yan Song, Nian-Lin Reena Han, Fwu-Shan Sheu. Characterization of transcriptional regulation of neurogranin by nitric oxide and the role of neurogranin in SNP-induced cell death: implication of neurogranin in an increased neuronal susceptibility to oxidative stress.
International journal of biological sciences.
2007 Feb; 3(4):212-24. doi:
10.7150/ijbs.3.212. [PMID: 17389928] - Kim E Wever, Rosalinde Masereeuw, David S Miller, Xiao M Hang, Gert Flik. Endothelin and calciotropic hormones share regulatory pathways in multidrug resistance protein 2-mediated transport.
American journal of physiology. Renal physiology.
2007 Jan; 292(1):F38-46. doi:
10.1152/ajprenal.00479.2005. [PMID: 16912062] - Bahjat Al-Ani, Peter W Hewett, Suborna Ahmed, Melissa Cudmore, Takeshi Fujisawa, Shakil Ahmad, Asif Ahmed. The release of nitric oxide from S-nitrosothiols promotes angiogenesis.
PloS one.
2006 Dec; 1(?):e25. doi:
10.1371/journal.pone.0000025. [PMID: 17183652] - Fady T Botros, L Gabriel Navar. Interaction between endogenously produced carbon monoxide and nitric oxide in regulation of renal afferent arterioles.
American journal of physiology. Heart and circulatory physiology.
2006 Dec; 291(6):H2772-8. doi:
10.1152/ajpheart.00528.2006. [PMID: 16844915] - Hyun-Jung An, Oky Maeng, Kyoung-Hee Kang, Jie-Oh Lee, Young-Sang Kim, Sang-Gi Paik, Hayyoung Lee. Activation of Ras up-regulates pro-apoptotic BNIP3 in nitric oxide-induced cell death.
The Journal of biological chemistry.
2006 Nov; 281(45):33939-48. doi:
10.1074/jbc.m605819200. [PMID: 16954213] - Takashi Yoshida, Ryuji Inoue, Takashi Morii, Nobuaki Takahashi, Shinichiro Yamamoto, Yuji Hara, Makoto Tominaga, Shunichi Shimizu, Yoji Sato, Yasuo Mori. Nitric oxide activates TRP channels by cysteine S-nitrosylation.
Nature chemical biology.
2006 Nov; 2(11):596-607. doi:
10.1038/nchembio821. [PMID: 16998480] - Francis Fu Yuen Lam, Sai Wang Seto, Yiu Wa Kwan, John Hok Keung Yeung, Paul Chan. Activation of the iberiotoxin-sensitive BKCa channels by salvianolic acid B of the porcine coronary artery smooth muscle cells.
European journal of pharmacology.
2006 Sep; 546(1-3):28-35. doi:
10.1016/j.ejphar.2006.07.038. [PMID: 16928370] - Francisco Aguirre-Crespo, Jorge Vergara-Galicia, Rafael Villalobos-Molina, Juan Javier López-Guerrero, Gabriel Navarrete-Vázquez, Samuel Estrada-Soto. Ursolic acid mediates the vasorelaxant activity of Lepechinia caulescens via NO release in isolated rat thoracic aorta.
Life sciences.
2006 Aug; 79(11):1062-8. doi:
10.1016/j.lfs.2006.03.006. [PMID: 16630635] - Ruriko Koto, Masatoshi Imamura, Chie Watanabe, Satoshi Obayashi, Mitsuya Shiraishi, Yasuharu Sasaki, Hiroshi Azuma. Linalyl acetate as a major ingredient of lavender essential oil relaxes the rabbit vascular smooth muscle through dephosphorylation of myosin light chain.
Journal of cardiovascular pharmacology.
2006 Jul; 48(1):850-6. doi:
10.1097/01.fjc.0000238589.00365.42. [PMID: 16891914] - Michael J Ryan, Nikki L Jernigan, Heather A Drummond, Gerald R McLemore, John M Rimoldi, Sambasiva R Poreddy, Rama S V Gadepalli, David E Stec. Renal vascular responses to CORM-A1 in the mouse.
Pharmacological research.
2006 Jul; 54(1):24-9. doi:
10.1016/j.phrs.2006.01.012. [PMID: 16524742] - J-H Chiu, K-K Chen, T-M Chien, W-F Chiou, C-C Chen, J-Y Wang, W-Y Lui, C-W Wu. Epimedium brevicornum Maxim extract relaxes rabbit corpus cavernosum through multitargets on nitric oxide/cyclic guanosine monophosphate signaling pathway.
International journal of impotence research.
2006 Jul; 18(4):335-42. doi:
10.1038/sj.ijir.3901437. [PMID: 16395327] - Carola Buccellati, Angelo Sala, Giuseppe Rossoni, Valérie Capra, G Enrico Rovati, Antonio Di Gennaro, Giancarlo Folco, Susanna Colli, Cesare Casagrande. Pharmacological characterization of 2NTX-99 [4-methoxy-N1-(4-trans-nitrooxycyclohexyl)-N3-(3-pyridinylmethyl)-1,3-benzenedicarboxamide], a potential antiatherothrombotic agent with antithromboxane and nitric oxide donor activity in platelet and vascular preparations.
The Journal of pharmacology and experimental therapeutics.
2006 May; 317(2):830-7. doi:
10.1124/jpet.105.097170. [PMID: 16399881] - Keiko Iwasaki-Kurashige, Renzo Y Loyaga-Rendon, Hitoshi Matsumoto, Takahisa Tokunaga, Hiroshi Azuma. Possible mediators involved in decreasing peripheral vascular resistance with blackcurrant concentrate (BC) in hind-limb perfusion model of the rat.
Vascular pharmacology.
2006 Apr; 44(4):215-23. doi:
10.1016/j.vph.2005.12.001. [PMID: 16448858] - Roman E Perri, Daniel A Langer, Suvro Chatterjee, Simon J Gibbons, Jay Gadgil, Sheng Cao, Gianrico Farrugia, Vijay H Shah. Defects in cGMP-PKG pathway contribute to impaired NO-dependent responses in hepatic stellate cells upon activation.
American journal of physiology. Gastrointestinal and liver physiology.
2006 Mar; 290(3):G535-42. doi:
10.1152/ajpgi.00297.2005. [PMID: 16269521] - Cheng-Dean Shih, Jih-Jung Chen, Hsinn-Hsing Lee. Activation of nitric oxide signaling pathway mediates hypotensive effect of Muntingia calabura L. (Tiliaceae) leaf extract.
The American journal of Chinese medicine.
2006; 34(5):857-72. doi:
10.1142/s0192415x0600434x. [PMID: 17080550] - A Sandouka, B J Fuller, B E Mann, C J Green, R Foresti, R Motterlini. Treatment with CO-RMs during cold storage improves renal function at reperfusion.
Kidney international.
2006 Jan; 69(2):239-47. doi:
10.1038/sj.ki.5000016. [PMID: 16408112] - Dae Gill Kang, Mi Kyoung Moon, Deok Ho Choi, Jun Kyoung Lee, Tae Oh Kwon, Ho Sub Lee. Vasodilatory and anti-inflammatory effects of the 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) via a nitric oxide-cGMP pathway.
European journal of pharmacology.
2005 Nov; 524(1-3):111-9. doi:
10.1016/j.ejphar.2005.08.061. [PMID: 16253226] - Andrew C Skinn, Wallace K MacNaughton. Nitric oxide inhibits cAMP-dependent CFTR trafficking in intestinal epithelial cells.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Oct; 289(4):G739-44. doi:
10.1152/ajpgi.00425.2004. [PMID: 15994425] - Paloma Alonso-Magdalena, Ouahiba Laribi, Ana B Ropero, Esther Fuentes, Cristina Ripoll, Bernat Soria, Angel Nadal. Low doses of bisphenol A and diethylstilbestrol impair Ca2+ signals in pancreatic alpha-cells through a nonclassical membrane estrogen receptor within intact islets of Langerhans.
Environmental health perspectives.
2005 Aug; 113(8):969-77. doi:
10.1289/ehp.8002. [PMID: 16079065] - Aliye Uc, Russell F Husted, Radhamma L Giriyappa, Bradley E Britigan, John B Stokes. Hemin induces active chloride secretion in Caco-2 cells.
American journal of physiology. Gastrointestinal and liver physiology.
2005 Aug; 289(2):G202-8. doi:
10.1152/ajpgi.00518.2004. [PMID: 15805100] - Chinnasamy Thirunavukkarasu, Tadahiro Uemura, Lian Fu Wang, Simon C Watkins, Chandrashekhar R Gandhi. Normal rat hepatic stellate cells respond to endotoxin in LBP-independent manner to produce inhibitor(s) of DNA synthesis in hepatocytes.
Journal of cellular physiology.
2005 Aug; 204(2):654-65. doi:
10.1002/jcp.20366. [PMID: 15828022] - Seung-Soo Chung, Duck-Sun Ahn, Hong-Ghi Lee, Young-Ho Lee, Taick-Sang Nam. Inhibition of carbachol-evoked oscillatory currents by the NO donor sodium nitroprusside in guinea-pig ileal myocytes.
Experimental physiology.
2005 Jul; 90(4):577-86. doi:
10.1113/expphysiol.2004.029611. [PMID: 15833757] - Emmanouil Karteris, Manu Vatish, Edward W Hillhouse, Dimitris K Grammatopoulos. Preeclampsia is associated with impaired regulation of the placental nitric oxide-cyclic guanosine monophosphate pathway by corticotropin-releasing hormone (CRH) and CRH-related peptides.
The Journal of clinical endocrinology and metabolism.
2005 Jun; 90(6):3680-7. doi:
10.1210/jc.2004-2210. [PMID: 15784708] - K Sathishkumar, R Gracious Ross, Dnyaneshwar U Bawankule, Kautuk K Sardar, Vellanki Ravi Prakash, Santosh K Mishra. Segmental heterogeneity in the mechanism of sodium nitroprusside-induced relaxation in ovine pulmonary artery.
Journal of cardiovascular pharmacology.
2005 Jun; 45(6):491-8. doi:
10.1097/01.fjc.0000159043.50488.ac. [PMID: 15897774] - Chong-Bin Zhu, Ana M Carneiro, Wolfgang R Dostmann, William A Hewlett, Randy D Blakely. p38 MAPK activation elevates serotonin transport activity via a trafficking-independent, protein phosphatase 2A-dependent process.
The Journal of biological chemistry.
2005 Apr; 280(16):15649-58. doi:
10.1074/jbc.m410858200. [PMID: 15728187] - Shiu-Jen Chen, Kao-Hsiang Chen, Chin-Chen Wu. Nitric oxide-cyclic GMP contributes to abnormal activation of Na+-K+-ATPase in the aorta from rats with endotoxic shock.
Shock (Augusta, Ga.).
2005 Feb; 23(2):179-85. doi:
10.1097/01.shk.0000148071.73975.38. [PMID: 15665735] - Robin E Gandley, Vladimir A Tyurin, Wan Huang, Antonio Arroyo, Ashi Daftary, Gail Harger, Jianfei Jiang, Bruce Pitt, Robert N Taylor, Carl A Hubel, Valerian E Kagan. S-nitrosoalbumin-mediated relaxation is enhanced by ascorbate and copper: effects in pregnancy and preeclampsia plasma.
Hypertension (Dallas, Tex. : 1979).
2005 Jan; 45(1):21-7. doi:
10.1161/01.hyp.0000150158.42620.3e. [PMID: 15569857] - Ana Paula Sendão Oliveira, Lusiane M Bendhack. Relaxation induced by acetylcholine involves endothelium-derived hyperpolarizing factor in 2-kidney 1-clip hypertensive rat carotid arteries.
Pharmacology.
2004 Dec; 72(4):231-9. doi:
10.1159/000080378. [PMID: 15539883] - Lesley J Bryan-Lluka, Marisa H Papacostas, Filip A Paczkowski, Janet C Wanstall. Nitric oxide donors inhibit 5-hydroxytryptamine (5-HT) uptake by the human 5-HT transporter (SERT).
British journal of pharmacology.
2004 Sep; 143(1):63-70. doi:
10.1038/sj.bjp.0705904. [PMID: 15302679] - Kazuyoshi Nakamura, Junko Hirano, Manabu Kubokawa. Regulation of an inwardly rectifying K+ channel by nitric oxide in cultured human proximal tubule cells.
American journal of physiology. Renal physiology.
2004 Sep; 287(3):F411-7. doi:
10.1152/ajprenal.00014.2004. [PMID: 15140759] - Chong-Bin Zhu, William A Hewlett, Igor Feoktistov, Italo Biaggioni, Randy D Blakely. Adenosine receptor, protein kinase G, and p38 mitogen-activated protein kinase-dependent up-regulation of serotonin transporters involves both transporter trafficking and activation.
Molecular pharmacology.
2004 Jun; 65(6):1462-74. doi:
10.1124/mol.65.6.1462. [PMID: 15155839] - Julia M Orshal, Raouf A Khalil. Interleukin-6 impairs endothelium-dependent NO-cGMP-mediated relaxation and enhances contraction in systemic vessels of pregnant rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
2004 Jun; 286(6):R1013-23. doi:
10.1152/ajpregu.00729.2003. [PMID: 15142856] - Carlos R Tirapelli, Sergio R Ambrosio, Fernando B da Costa, Silvia T Coutinho, Dionéia C R de Oliveira, Ana M de Oliveira. Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta.
European journal of pharmacology.
2004 May; 492(2-3):233-41. doi:
10.1016/j.ejphar.2004.04.003. [PMID: 15178370] - Xiao-Hong Jin, Helen E McGrath, John J Gildea, Helmy M Siragy, Robin A Felder, Robert M Carey. Renal interstitial guanosine cyclic 3', 5'-monophosphate mediates pressure-natriuresis via protein kinase G.
Hypertension (Dallas, Tex. : 1979).
2004 May; 43(5):1133-9. doi:
10.1161/01.hyp.0000123574.60586.7d. [PMID: 15007031]