L-NIL (BioDeep_00000605508)

   


代谢物信息卡片


2-Amino-6-(1-aminoethylideneamino)hexanoic acid

化学式: C8H17N3O2 (187.1321)
中文名称: L-NIL, N6-（1-亚氨基乙基）-1-赖氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=NCCCCC(C(=O)O)N)N
InChI: InChI=1S/C8H17N3O2/c1-6(9)11-5-3-2-4-7(10)8(12)13/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13)

描述信息

An L-lysine derivative that is L-lysine in which one of the hydrogens attached to N(6) is substituted by an acetimidoyl group
D004791 - Enzyme Inhibitors

同义名列表

5 个代谢物同义名

N(6)-acetimidoyl-L-lysine; L-NIL; 2-Amino-6-(1-aminoethylideneamino)hexanoic acid; N6-(1-iminoethyl)-L-lysine, dihydrochloride; N6-(1-Iminoethyl)-L-lysine



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Ahmed Elkamhawy, Nam Youn Kim, Ahmed H E Hassan, Jung-Eun Park, Sora Paik, Jeong-Eun Yang, Kwang-Seok Oh, Byung Ho Lee, Mi Young Lee, Kye Jung Shin, Ae Nim Pae, Kyung-Tae Lee, Eun Joo Roh. Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents. European journal of medicinal chemistry. 2020 Feb; 188(?):111955. doi: 10.1016/j.ejmech.2019.111955. [PMID: 31893550]
  • Sharon Angela Tanuseputero, Ming-Tsan Lin, Sung-Ling Yeh, Chiu-Li Yeh. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators of inflammation. 2020; 2020(?):3201635. doi: 10.1155/2020/3201635. [PMID: 32454788]
  • Xiao-Yan Liu, You-Bo Zhang, Xiu-Wei Yang, Yan-Fang Yang, Wei Xu, Wei Zhao, Kai-Feng Peng, Yun Gong, Ni-Fu Liu, Peng Zhang. Anti-Inflammatory Activity of Some Characteristic Constituents from the Vine Stems of Spatholobus suberectus. Molecules (Basel, Switzerland). 2019 Oct; 24(20):. doi: 10.3390/molecules24203750. [PMID: 31627460]
  • Consuelo Pasten, Cristóbal Alvarado, Jocelyn Rocco, Luis Contreras, Paula Aracena, Jéssica Liberona, Cristian Suazo, Luis Michea, Carlos E Irarrázabal. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. American journal of physiology. Renal physiology. 2019 04; 316(4):F624-F634. doi: 10.1152/ajprenal.00398.2018. [PMID: 30516425]
  • Young Hye Seo, Ju-Hyun Jeon, Miran Jeong, Seung Mok Ryu, Won Kyung Jeon, Dae Sik Jang, Sang Hee Shim, Dongho Lee, Jung-Hye Choi, Jun Lee. Chemical Constituents of Apios americana Tubers and Their Inhibitory Activities on Nitric Oxide Production in Lipopolysaccharide-Stimulated RAW 264.7 Macrophages. Journal of natural products. 2018 07; 81(7):1598-1603. doi: 10.1021/acs.jnatprod.8b00182. [PMID: 29932657]
  • Da Hye Lee, Ji-Sun Shin, Shin-Young Kang, Seung-Bin Lee, Jin Su Lee, Seung Mok Ryu, Kyung Tae Lee, Dongho Lee, Dae Sik Jang. Iridoids from the Roots of Patrinia scabra and Their Inhibitory Potential on LPS-Induced Nitric Oxide Production. Journal of natural products. 2018 06; 81(6):1468-1473. doi: 10.1021/acs.jnatprod.8b00229. [PMID: 29799195]
  • Samia S Messeha, Najla O Zarmouh, Patricia Mendonca, Malak G Kolta, Karam F A Soliman. The attenuating effects of plumbagin on pro-inflammatory cytokine expression in LPS-activated BV-2 microglial cells. Journal of neuroimmunology. 2017 12; 313(?):129-137. doi: 10.1016/j.jneuroim.2017.09.007. [PMID: 28950995]
  • Wei Wei, Xiu-Wen Wu, Gai-Gai Deng, Xiu-Wei Yang. Anti-inflammatory coumarins with short- and long-chain hydrophobic groups from roots of Angelica dahurica cv. Hangbaizhi. Phytochemistry. 2016 Mar; 123(?):58-68. doi: 10.1016/j.phytochem.2016.01.006. [PMID: 26775737]
  • Hye Mi Kim, Su Jung Kim, Ha-Yeong Kim, Byeol Ryu, Hokwang Kwak, Jonghyun Hur, Jung-Hye Choi, Dae Sik Jang. Constituents of the stem barks of Ailanthus altissima and their potential to inhibit LPS-induced nitric oxide production. Bioorganic & medicinal chemistry letters. 2015 Mar; 25(5):1017-20. doi: 10.1016/j.bmcl.2015.01.034. [PMID: 25666824]
  • Birandra K Sinha, Ashutosh Kumar, Suchandra Bhattacharjee, Michael G Espey, Ronald P Mason. Effect of nitric oxide on the anticancer activity of the topoisomerase-active drugs etoposide and adriamycin in human melanoma cells. The Journal of pharmacology and experimental therapeutics. 2013 Dec; 347(3):607-14. doi: 10.1124/jpet.113.207928. [PMID: 24049059]
  • Melissa B Aldrich, Eva M Sevick-Muraca. Cytokines are systemic effectors of lymphatic function in acute inflammation. Cytokine. 2013 Oct; 64(1):362-9. doi: 10.1016/j.cyto.2013.05.015. [PMID: 23764549]
  • Asli Korkmaz, Dürdane Kolankaya. Inhibiting inducible nitric oxide synthase with rutin reduces renal ischemia/reperfusion injury. Canadian journal of surgery. Journal canadien de chirurgie. 2013 Feb; 56(1):6-14. doi: 10.1503/cjs.004811. [PMID: 23187035]
  • Tsun-Yung Kuo, Chuen-Lin Huang, Jung-Mou Yang, Wei-Jung Huang, Nai-Kuei Huang, Yue-Wen Chen, Ren-Jye Lin, Ying-Chen Yang. The role of ribosylated-BSA in regulating PC12 cell viability. Cell biology and toxicology. 2012 Aug; 28(4):255-67. doi: 10.1007/s10565-012-9220-3. [PMID: 22543687]
  • Mireille Bentz, Charlotte Zaouter, Qin Shi, Hassan Fahmi, Florina Moldovan, Julio C Fernandes, Mohamed Benderdour. Inhibition of inducible nitric oxide synthase prevents lipid peroxidation in osteoarthritic chondrocytes. Journal of cellular biochemistry. 2012 Jul; 113(7):2256-67. doi: 10.1002/jcb.24096. [PMID: 22573548]
  • Tae-Jin Ju, Jin-Myoung Dan, Young-Je Cho, So-Young Park. Inhibition of Inducible Nitric Oxide Synthase Attenuates Monosodium Urate-induced Inflammation in Mice. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology. 2011 Dec; 15(6):363-9. doi: 10.4196/kjpp.2011.15.6.363. [PMID: 22359474]
  • R Schneider, M Meusel, B Betz, M Kersten, K Möller-Ehrlich, C Wanner, H Koepsell, C Sauvant. Nitric oxide-induced regulation of renal organic cation transport after renal ischemia-reperfusion injury. American journal of physiology. Renal physiology. 2011 Nov; 301(5):F997-F1004. doi: 10.1152/ajprenal.00264.2011. [PMID: 21835768]
  • Elina Pathak, Philip R Mayeux. In vitro model of sepsis-induced renal epithelial reactive nitrogen species generation. Toxicological sciences : an official journal of the Society of Toxicology. 2010 Jun; 115(2):475-81. doi: 10.1093/toxsci/kfq058. [PMID: 20176626]
  • M Kadkhodaee, M Zahmatkesh, H R Sadeghipour, A Eslamifar, J Taeb, A Shams, M Mahdavi-Mazdeh. Proteinuria is reduced by inhibition of inducible nitric oxide synthase in rat renal ischemia-reperfusion injury. Transplantation proceedings. 2009 Sep; 41(7):2907-9. doi: 10.1016/j.transproceed.2009.07.014. [PMID: 19765470]
  • W Sosroseno, P S Bird, G J Seymour. Effect of exogenous nitric oxide on murine immune response induced by Aggregatibacter actinomycetemcomitans lipopolysaccharide. Journal of periodontal research. 2009 Aug; 44(4):529-36. doi: 10.1111/j.1600-0765.2008.01157.x. [PMID: 18973550]
  • Emma T B Olesen, Sophie de Seigneux, Guixian Wang, Sophie C Lütken, Jørgen Frøkiaer, Tae-Hwan Kwon, Søren Nielsen. Rapid and segmental specific dysregulation of AQP2, S256-pAQP2 and renal sodium transporters in rats with LPS-induced endotoxaemia. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2009 Aug; 24(8):2338-49. doi: 10.1093/ndt/gfp011. [PMID: 19193739]
  • Manh Hung Tran, Hai Dang Nguyen, Jin Cheol Kim, Jae Sue Choi, Hyeong Kyu Lee, Byung-Sun Min. Phenolic glycosides from Alangium salviifolium leaves with inhibitory activity on LPS-induced NO, PGE(2), and TNF-alpha production. Bioorganic & medicinal chemistry letters. 2009 Aug; 19(15):4389-93. doi: 10.1016/j.bmcl.2009.05.070. [PMID: 19500975]
  • Matthieu Legrand, Emre Almac, Egbert G Mik, Tanja Johannes, Asli Kandil, Rick Bezemer, Didier Payen, Can Ince. L-NIL prevents renal microvascular hypoxia and increase of renal oxygen consumption after ischemia-reperfusion in rats. American journal of physiology. Renal physiology. 2009 May; 296(5):F1109-17. doi: 10.1152/ajprenal.90371.2008. [PMID: 19225052]
  • Chinedu Njoku, Sally E Self, Philip Ruiz, Ann F Hofbauer, Gary S Gilkeson, Jim C Oates. Inducible nitric oxide synthase inhibitor SD-3651 reduces proteinuria in MRL/lpr mice deficient in the NOS2 gene. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2008 Oct; 56(7):911-9. doi: 10.2310/jim.0b013e3181889e13. [PMID: 18797415]
  • Muralidhar Kondapaneni, John R McGregor, Daniela Salvemini, Victor E Laubach, Wolfram E Samlowski. Inducible nitric oxide synthase (iNOS) is not required for IL-2-induced hypotension and vascular leak syndrome in mice. Journal of immunotherapy (Hagerstown, Md. : 1997). 2008 May; 31(4):325-33. doi: 10.1097/cji.0b013e31816112e8. [PMID: 18391763]
  • Hsing I Chen, Diana Yuwung Yeh, Shang Jyh Kao. The detrimental role of inducible nitric oxide synthase in the pulmonary edema caused by hypercalcemia in conscious rats and isolated lungs. Journal of biomedical science. 2008 Mar; 15(2):227-38. doi: 10.1007/s11373-007-9211-1. [PMID: 17906944]
  • Su-Mei Lin, Chien-Wei Liao, Yun-Ho Lin, Chin-Cheng Lee, Ting-Chang Kao, Chia-Kwung Fan. Inducible nitric oxide synthase inhibition influenced granuloma formation with suppressed collagen expression in myositis caused by Toxocara canis in mice. Parasitology research. 2008 Mar; 102(4):577-85. doi: 10.1007/s00436-007-0791-5. [PMID: 18034265]
  • Tae Bong Kang, Yung Choon Yoo, Kwan Hee Lee, Ho Sup Yoon, Erk Her, Jong Bae Kim, Seong Kyu Song. Korean mistletoe lectin (KML-IIU) and its subchains induce nitric oxide (NO) production in murine macrophage cells. Journal of biomedical science. 2008 Mar; 15(2):197-204. doi: 10.1007/s11373-007-9210-2. [PMID: 17940853]
  • Yung Hsiang Hsu, Bang Gee Hsu, Hsing I Chen. Malignant alterations following early blockade of nitric oxide synthase in hypertensive rats. The Chinese journal of physiology. 2007 Dec; 50(6):283-93. doi: NULL. [PMID: 18442011]
  • Nesina Avdagić, Emina Nakas-Ićindić, Senija Rasić, Almira Hadzović-Dzuvo, Asija Zaciragić, Amina Valjevac. The effects of inducible nitric oxide synthase inhibitor L-N6-(1-iminoethyl) lysine in gentamicin-induced acute tubular necrosis in rats. Bosnian journal of basic medical sciences. 2007 Nov; 7(4):345-51. doi: 10.17305/bjbms.2007.3025. [PMID: 18039194]
  • Yuji Kadoi, Fumio Goto. Effects of selective iNOS inhibition on systemic hemodynamics and mortality rate on endotoxic shock in streptozotocin-induced diabetic rats. Shock (Augusta, Ga.). 2007 Nov; 28(5):602-9. doi: 10.1097/shk.0b013e31804d452d. [PMID: 17607161]
  • Liping Wu, Neriman Gokden, Philip R Mayeux. Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injury. Journal of the American Society of Nephrology : JASN. 2007 Jun; 18(6):1807-15. doi: 10.1681/asn.2006121402. [PMID: 17494883]
  • R Ghaznavi, M Kadkhodaee. Comparative effects of selective and non-selective nitric oxide synthase inhibition in gentamicin-induced rat nephrotoxicity. Archives of toxicology. 2007 Jun; 81(6):453-7. doi: 10.1007/s00204-006-0157-2. [PMID: 17039356]
  • Chain Fa Su, Fwu Lin Yang, Hsing I Chen. Inhibition of inducible nitric oxide synthase attenuates acute endotoxin-induced lung injury in rats. Clinical and experimental pharmacology & physiology. 2007 Apr; 34(4):339-46. doi: 10.1111/j.1440-1681.2007.04553.x. [PMID: 17324147]
  • W Sosroseno, M Musa, M Ravichandran, M Fikri Ibrahim, P S Bird, G J Seymour. Effect of L-N6-(1-iminoethyl)-lysine, an inducible nitric oxide synthase inhibitor, on murine immune response induced by Actinobacillus actinomycetemcomitans lipopolysaccharide. Journal of periodontal research. 2007 Apr; 42(2):124-30. doi: 10.1111/j.1600-0765.2006.00925.x. [PMID: 17305870]
  • Liping Wu, Philip R Mayeux. Effects of the inducible nitric-oxide synthase inhibitor L-N(6)-(1-iminoethyl)-lysine on microcirculation and reactive nitrogen species generation in the kidney following lipopolysaccharide administration in mice. The Journal of pharmacology and experimental therapeutics. 2007 Mar; 320(3):1061-7. doi: 10.1124/jpet.106.117184. [PMID: 17202403]
  • Martin Matejovic, Ales Krouzecky, Jaroslav Radej, Richard Rokyta, Hana Kralova, Peter Radermacher, Ivan Novak. Coagulation and endothelial dysfunction during longterm hyperdynamic porcine bacteremia--effects of selective inducible nitric oxide synthase inhibition. Thrombosis and haemostasis. 2007 Feb; 97(2):304-9. doi: 10.1160/th06-09-0498. [PMID: 17264961]
  • Tiina Kipari, Jean-Francois Cailhier, David Ferenbach, Simon Watson, Kris Houlberg, David Walbaum, Spike Clay, John Savill, Jeremy Hughes. Nitric oxide is an important mediator of renal tubular epithelial cell death in vitro and in murine experimental hydronephrosis. The American journal of pathology. 2006 Aug; 169(2):388-99. doi: 10.2353/ajpath.2006.050964. [PMID: 16877341]
  • Wei Li, Hua He, Tetsuya Kawakita, Edgar M Espana, Scheffer C G Tseng. Amniotic membrane induces apoptosis of interferon-gamma activated macrophages in vitro. Experimental eye research. 2006 Feb; 82(2):282-92. doi: 10.1016/j.exer.2005.06.022. [PMID: 16109408]
  • Cathy J Walsh, Jason D Toranto, C Taylor Gilliland, David R Noyes, Ashby B Bodine, Carl A Luer. Nitric oxide production by nurse shark (Ginglymostoma cirratum) and clearnose skate (Raja eglanteria) peripheral blood leucocytes. Fish & shellfish immunology. 2006 Jan; 20(1):40-6. doi: 10.1016/j.fsi.2005.03.011. [PMID: 15927484]
  • Prasun K Datta, Shawn Dhupar, Elias A Lianos. Regulatory effects of inducible nitric oxide synthase on cyclooxygenase-2 and heme oxygenase-1 expression in experimental glomerulonephritis. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 2006 Jan; 21(1):51-7. doi: 10.1093/ndt/gfi135. [PMID: 16204297]
  • M Zahmatkesh, M Kadkhodaee, H A Arab, S Shams. Effects of co-administration of an iNOS inhibitor with a broad-spectrum reactive species scavenger in rat renal ischemia/reperfusion injury. Nephron. Experimental nephrology. 2006; 103(3):e119-25. doi: 10.1159/000092197. [PMID: 16554662]
  • Manish M Tiwari, Robert W Brock, Judit K Megyesi, Gur P Kaushal, Philip R Mayeux. Disruption of renal peritubular blood flow in lipopolysaccharide-induced renal failure: role of nitric oxide and caspases. American journal of physiology. Renal physiology. 2005 Dec; 289(6):F1324-32. doi: 10.1152/ajprenal.00124.2005. [PMID: 15998845]
  • Chinedu J Njoku, Kennerly S Patrick, Philip Ruiz, Jim C Oates. Inducible nitric oxide synthase inhibitors reduce urinary markers of systemic oxidant stress in murine proliferative lupus nephritis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2005 Nov; 53(7):347-52. doi: 10.2310/6650.2005.53705. [PMID: 16297360]
  • Chin-Cheng Lee, Yi-Yang Lee, Cheng-Kuei Chang, Mao-Tsun Lin. Selective inhibition of inducible nitric oxide synthase attenuates renal ischemia and damage in experimental heatstroke. Journal of pharmacological sciences. 2005 Sep; 99(1):68-76. doi: 10.1254/jphs.fp0050300. [PMID: 16127242]
  • S Chlopicki, M Walski, J B Bartus. Ultrastructure of immediate microvascular lung injury induced by bacterial endotoxin in the isolated, no-deficient lung perfused with full blood. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. 2005 Sep; 56 Suppl 4(?):47-64. doi: ". [PMID: 16204776]
  • Chia-Chi Lee, Nien-Tseng Lin, Yung Hsing Hsu, Hsing I Chen. Inducible nitric oxide synthase inhibition potentiates multiple organ dysfunction induced by endotoxin in conscious rats. Journal of cardiovascular pharmacology. 2005 May; 45(5):396-403. doi: 10.1097/01.fjc.0000157438.72483.ae. [PMID: 15821434]
  • H Asakura, R Asamura, Y Ontachi, T Hayashi, M Yamazaki, E Morishita, K-I Miyamoto, S Nakao. Selective inducible nitric oxide synthase inhibition attenuates organ dysfunction and elevated endothelin levels in LPS-induced DIC model rats. Journal of thrombosis and haemostasis : JTH. 2005 May; 3(5):1050-5. doi: 10.1111/j.1538-7836.2005.01248.x. [PMID: 15869603]
  • Jürgen Theuer, Erdenechimeg Shagdarsuren, Dominik N Muller, Eva Kaergel, Horst Honeck, Joon-Keun Park, Anette Fiebeler, Ralf Dechend, Hermann Haller, Friedrich C Luft, Wolf-Hagen Schunck. Inducible NOS inhibition, eicosapentaenoic acid supplementation, and angiotensin II-induced renal damage. Kidney international. 2005 Jan; 67(1):248-58. doi: 10.1111/j.1523-1755.2005.00075.x. [PMID: 15610248]
  • Per Sandstrom, Mark E Brooke-Smith, Anthony C Thomas, Marlene B Grivell, Gino T P Saccone, James Toouli, Joar Svanvik. Highly selective inhibition of inducible nitric oxide synthase ameliorates experimental acute pancreatitis. Pancreas. 2005 Jan; 30(1):e10-5. doi: NULL. [PMID: 15632690]
  • M Kadkhodaee, A Qasemi. Inhibition of inducible nitric oxide synthase reduces lipopolysaccharide-induced renal injury in the rat. Clinical and experimental pharmacology & physiology. 2004 Dec; 31(12):842-6. doi: 10.1111/j.1440-1681.2004.04096.x. [PMID: 15659046]
  • Yuji Kadoi, Fumio Goto. Selective inducible nitric oxide inhibition can restore hemodynamics, but does not improve neurological dysfunction in experimentally-induced septic shock in rats. Anesthesia and analgesia. 2004 Jul; 99(1):212-220. doi: 10.1213/01.ane.0000118111.94913.22. [PMID: 15281532]
  • Martin Matejovic, Ales Krouzecky, Vendula Martinkova, Richard Rokyta, Hana Kralova, Vladislav Treska, Peter Radermacher, Ivan Novak. Selective inducible nitric oxide synthase inhibition during long-term hyperdynamic porcine bacteremia. Shock (Augusta, Ga.). 2004 May; 21(5):458-65. doi: 10.1097/00024382-200405000-00010. [PMID: 15087823]
  • Takako Yokozawa, Dong Young Rhyu, Eun Ju Cho. (-)-Epicatechin 3-O-gallate ameliorates the damages related to peroxynitrite production by mechanisms distinct from those of other free radical inhibitors. The Journal of pharmacy and pharmacology. 2004 Feb; 56(2):231-9. doi: 10.1211/0022357022601. [PMID: 15005882]
  • Galen M Pieper, Vani Nilakantan, Gail Hilton, Xianghua Zhou, Ashwani K Khanna, Nadine L N Halligan, Christopher C Felix, Bal Kampalath, Owen W Griffith, Mike A Hayward, Allan M Roza, Mark B Adams. Variable efficacy of N6-(1-iminoethyl)-L-lysine in acute cardiac transplant rejection. American journal of physiology. Heart and circulatory physiology. 2004 Feb; 286(2):H525-34. doi: 10.1152/ajpheart.00356.2003. [PMID: 14715498]
  • Barbara Tribl, Ryon M Bateman, Stephanie Milkovich, William J Sibbald, Christopher G Ellis. Effect of nitric oxide on capillary hemodynamics and cell injury in the pancreas during Pseudomonas pneumonia-induced sepsis. American journal of physiology. Heart and circulatory physiology. 2004 Jan; 286(1):H340-5. doi: 10.1152/ajpheart.00234.2003. [PMID: 12969889]
  • Jin Wen Ding, Kewei Wang, John J Brems, Richard L Gamelli. Protection against concanavalin A-induced hepatocyte apoptosis by molsidomine is time-dependent. Journal of the American College of Surgeons. 2004 Jan; 198(1):67-77. doi: 10.1016/j.jamcollsurg.2003.08.014. [PMID: 14698313]
  • Frederick A Gage, Yoram Vodovotz. Normalization of nitric oxide flux improves physiological parameters of porcine kidneys maintained on pulsatile perfusion. Nitric oxide : biology and chemistry. 2003 Nov; 9(3):141-7. doi: 10.1016/j.niox.2003.10.001. [PMID: 14732337]
  • Prabal K Chatterjee, Espen O Kvale, Nimesh S A Patel, Christoph Thiemermann. GW274150 inhibits nitric oxide production by primary cultures of rat proximal tubular cells. Medical science monitor : international medical journal of experimental and clinical research. 2003 Oct; 9(10):BR357-62. doi: NULL. [PMID: 14523323]
  • Leon A Tapondjou, David Lontsi, Beibam L Sondengam, Fazarna Shaheen, Mohammad I Choudhary, Atta-ur-Rahman, Fanie R van Heerden, Hee-Juhn Park, Kyung-Tae Lee. Saponins from Cussonia bancoensis and their inhibitory effects on nitric oxide production. Journal of natural products. 2003 Sep; 66(9):1266-9. doi: 10.1021/np020412g. [PMID: 14510614]
  • Galen M Pieper, Nadine L N Halligan, Gail Hilton, Eugene A Konorev, Christopher C Felix, Allan M Roza, Mark B Adams, Owen W Griffith. Non-heme iron protein: a potential target of nitric oxide in acute cardiac allograft rejection. Proceedings of the National Academy of Sciences of the United States of America. 2003 Mar; 100(6):3125-30. doi: 10.1073/pnas.0636938100. [PMID: 12624190]
  • Roman P Korolkiewicz, Marek Ujda, Jarosław Dabkowski, Jarosław Ruczyński, Piotr Rekowski, Jacek Petrusewicz. Differential salutary effects of nonselective and selective COX-2 inhibitors in postoperative ileus in rats. The Journal of surgical research. 2003 Feb; 109(2):161-9. doi: 10.1016/s0022-4804(02)00095-1. [PMID: 12643859]
  • A Veihelmann, A Hofbauer, F Krombach, M Dorger, M Maier, H-J Refior, K Messmer. Differential function of nitric oxide in murine antigen-induced arthritis. Rheumatology (Oxford, England). 2002 May; 41(5):509-17. doi: 10.1093/rheumatology/41.5.509. [PMID: 12011373]
  • Prabal K Chatterjee, Nimesh S A Patel, Espen O Kvale, Salvatore Cuzzocrea, Paul A J Brown, Keith N Stewart, Helder Mota-Filipe, Christoph Thiemermann. Inhibition of inducible nitric oxide synthase reduces renal ischemia/reperfusion injury. Kidney international. 2002 Mar; 61(3):862-71. doi: 10.1046/j.1523-1755.2002.00234.x. [PMID: 11849439]
  • Francis B Gabbai, Terry C Hammond, Scott C Thomson, Ser Khang, Carolyn J Kelly. Effect of acute iNOS inhibition on glomerular function in tubulointerstitial nephritis. Kidney international. 2002 Mar; 61(3):851-4. doi: 10.1046/j.1523-1755.2002.00232.x. [PMID: 11849437]
  • Christopher M Reilly, Libby W Farrelly, Dana Viti, Shakisha T Redmond, Florence Hutchison, Phil Ruiz, Pam Manning, Jane Connor, Gary S Gilkeson. Modulation of renal disease in MRL/lpr mice by pharmacologic inhibition of inducible nitric oxide synthase. Kidney international. 2002 Mar; 61(3):839-46. doi: 10.1046/j.1523-1755.2002.00230.x. [PMID: 11849435]
  • Ralf Westenfeld, Alexander Gawlik, Emile de Heer, Masashi Kitahara, Faikah Abou-Rebyeh, Juergen Floege, Markus Ketteler. Selective inhibition of inducible nitric oxide synthase enhances intraglomerular coagulation in chronic anti-Thy 1 nephritis. Kidney international. 2002 Mar; 61(3):834-8. doi: 10.1046/j.1523-1755.2002.00229.x. [PMID: 11849434]
  • Prasun K Datta, Eugene J Gross, Elias A Lianos. Interactions between inducible nitric oxide synthase and heme oxygenase-1 in glomerulonephritis. Kidney international. 2002 Mar; 61(3):847-50. doi: 10.1046/j.1523-1755.2002.00231.x. [PMID: 11849436]
  • Jack A Hinson, Thomas J Bucci, Lisa K Irwin, Sherryll L Michael, Philip R Mayeux. Effect of inhibitors of nitric oxide synthase on acetaminophen-induced hepatotoxicity in mice. Nitric oxide : biology and chemistry. 2002 Mar; 6(2):160-7. doi: 10.1006/niox.2001.0404. [PMID: 11890740]
  • John M Menezes, Chris Hierholzer, Simon C Watkins, Timothy R Billiar, Andrew B Peitzman, Brian G Harbrecht. The modulation of hepatic injury and heat shock expression by inhibition of inducible nitric oxide synthase after hemorrhagic shock. Shock (Augusta, Ga.). 2002 Jan; 17(1):13-8. doi: 10.1097/00024382-200201000-00003. [PMID: 11795663]
  • E Noiri, A Nakao, K Uchida, H Tsukahara, M Ohno, T Fujita, S Brodsky, M S Goligorsky. Oxidative and nitrosative stress in acute renal ischemia. American journal of physiology. Renal physiology. 2001 Nov; 281(5):F948-57. doi: 10.1152/ajprenal.2001.281.5.f948. [PMID: 11592952]
  • M Porst, A Hartner, H Krause, K F Hilgers, R Veelken. Inducible nitric oxide synthase and glomerular hemodynamics in rats with liver cirrhosis. American journal of physiology. Renal physiology. 2001 Aug; 281(2):F293-9. doi: 10.1152/ajprenal.2001.281.2.f293. [PMID: 11457721]
  • D A Geller, S H Chia, Y Takahashi, G P Yagnik, G Tsoulfas, N Murase. Protective role of the L-arginine-nitric oxide synthase pathway on preservation injury after rat liver transplantation. JPEN. Journal of parenteral and enteral nutrition. 2001 May; 25(3):142-7. doi: 10.1177/0148607101025003142. [PMID: 11334063]
  • S Walpen, K F Beck, L Schaefer, I Raslik, W Eberhardt, R M Schaefer, J Pfeilschifter. Nitric oxide induces MIP-2 transcription in rat renal mesangial cells and in a rat model of glomerulonephritis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2001 Mar; 15(3):571-3. doi: 10.1096/fj.00-0518fje. [PMID: 11259370]
  • G Sass, K Koerber, R Bang, H Guehring, G Tiegs. Inducible nitric oxide synthase is critical for immune-mediated liver injury in mice. The Journal of clinical investigation. 2001 Feb; 107(4):439-47. doi: 10.1172/jci10613. [PMID: 11181643]
  • U Werner, K Brune, B Layh, H Guehring. Determination of L-iminoethyl-L-lysine in serum by liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications. 2000 Nov; 749(1):35-40. doi: 10.1016/s0378-4347(00)00375-3. [PMID: 11129076]
  • L M Walker, P D Walker, S Z Imam, S F Ali, P R Mayeux. Evidence for peroxynitrite formation in renal ischemia-reperfusion injury: studies with the inducible nitric oxide synthase inhibitor L-N(6)-(1-Iminoethyl)lysine. The Journal of pharmacology and experimental therapeutics. 2000 Oct; 295(1):417-22. doi: NULL. [PMID: 10992009]
  • M J Lortie, S Ishizuka, D Schwartz, R C Blantz. Bioactive products of arginine in sepsis: tissue and plasma composition after LPS and iNOS blockade. American journal of physiology. Cell physiology. 2000 Jun; 278(6):C1191-9. doi: 10.1152/ajpcell.2000.278.6.c1191. [PMID: 10837347]
  • K Tsukada, T Hasegawa, S Tsutsumi, H Katoh, H Kuwano, T Miyazaki, Y Yamamoto. Effect of uric acid on liver injury during hemorrhagic shock. Surgery. 2000 Apr; 127(4):439-46. doi: 10.1067/msy.2000.104486. [PMID: 10776436]
  • I H Vos, J A Joles, M Schurink, G Weckbecker, T Stojanovic, T J Rabelink, H J Gröne. Inhibition of inducible nitric oxide synthase improves graft function and reduces tubulointerstitial injury in renal allograft rejection. European journal of pharmacology. 2000 Mar; 391(1-2):31-8. doi: 10.1016/s0014-2999(00)00021-2. [PMID: 10720632]
  • D Behr-Roussel, A Rupin, S Simonet, J Fabiani, T J Verbeuren. Urinary nitrate excretion in cholesterol-fed rabbits: effect of a chronic treatment by N-iminoethyl-L-lysine, a selective inhibitor of inducible nitric oxide synthase. European journal of pharmacology. 2000 Feb; 388(3):275-9. doi: 10.1016/s0014-2999(99)00836-5. [PMID: 10675737]
  • C Zhang, L M Walker, P R Mayeux. Role of nitric oxide in lipopolysaccharide-induced oxidant stress in the rat kidney. Biochemical pharmacology. 2000 Jan; 59(2):203-9. doi: 10.1016/s0006-2952(99)00324-x. [PMID: 10810455]
  • S N Waddington, K Mosley, V Cattell. Induced nitric oxide (NO) synthesis in heterologous nephrotoxic nephritis; effects of selective inhibition in neutrophil-dependent glomerulonephritis. Clinical and experimental immunology. 1999 Nov; 118(2):309-14. doi: 10.1046/j.1365-2249.1999.01049.x. [PMID: 10540196]
  • D M McKay, J Lu, S Jedrzkiewicz, W Ho, K A Sharkey. Nitric oxide participates in the recovery of normal jejunal epithelial ion transport following exposure to the superantigen, Staphylococcus aureus enterotoxin B. Journal of immunology (Baltimore, Md. : 1950). 1999 Oct; 163(8):4519-26. doi: NULL. [PMID: 10510395]
  • C R Hung, P C Hung. Protective effects of several amino acid-nutrients on gastric hemorrhagic erosions in acid-irrigated stomachs of septic rats. The Chinese journal of physiology. 1999 Sep; 42(3):161-9. doi: ". [PMID: 10707890]
  • S M Sladek, A Westerhausen-Larson, J M Roberts. Endogenous nitric oxide suppresses rat myometrial connexin 43 gap junction protein expression during pregnancy. Biology of reproduction. 1999 Jul; 61(1):8-13. doi: 10.1095/biolreprod61.1.8. [PMID: 10377025]
  • J Satriano, S Ishizuka, D C Archer, R C Blantz, C J Kelly. Regulation of intracellular polyamine biosynthesis and transport by NO and cytokines TNF-alpha and IFN-gamma. The American journal of physiology. 1999 04; 276(4):C892-9. doi: 10.1152/ajpcell.1999.276.4.c892. [PMID: 10199820]
  • S S Greenberg, X Zhao, L Hua, J F Wang, S Nelson, J Ouyang. Ethanol inhibits lung clearance of Pseudomonas aeruginosa by a neutrophil and nitric oxide-dependent mechanism, in vivo. Alcoholism, clinical and experimental research. 1999 Apr; 23(4):735-44. doi: NULL. [PMID: 10235311]
  • K Sato, D M Rodman, I F McMurtry. Hypoxia inhibits increased ETB receptor-mediated NO synthesis in hypertensive rat lungs. The American journal of physiology. 1999 04; 276(4):L571-81. doi: 10.1152/ajplung.1999.276.4.l571. [PMID: 10198355]
  • A Jablonka-Shariff, R Basuray, L M Olson. Inhibitors of nitric oxide synthase influence oocyte maturation in rats. Journal of the Society for Gynecologic Investigation. 1999 Mar; 6(2):95-101. doi: 10.1016/s1071-5576(98)00053-7. [PMID: 10205780]
  • G M Wray, C G Millar, C J Hinds, C Thiemermann. Selective inhibition of the activity of inducible nitric oxide synthase prevents the circulatory failure, but not the organ injury/dysfunction, caused by endotoxin. Shock (Augusta, Ga.). 1998 May; 9(5):329-35. doi: 10.1097/00024382-199805000-00003. [PMID: 9617881]
  • E A Lianos, K Guglielmi, M Sharma. Regulatory interactions between inducible nitric oxide synthase and eicosanoids in glomerular immune injury. Kidney international. 1998 Mar; 53(3):645-53. doi: 10.1046/j.1523-1755.1998.00791.x. [PMID: 9507210]
  • D S Fletcher, W R Widmer, S Luell, A Christen, C Orevillo, S Shah, D Visco. Therapeutic administration of a selective inhibitor of nitric oxide synthase does not ameliorate the chronic inflammation and tissue damage associated with adjuvant-induced arthritis in rats. The Journal of pharmacology and experimental therapeutics. 1998 Feb; 284(2):714-21. doi: NULL. [PMID: 9454819]
  • F B Gabbai, C Boggiano, T Peter, S Khang, C Archer, D P Gold, C J Kelly. Inhibition of inducible nitric oxide synthase intensifies injury and functional deterioration in autoimmune interstitial nephritis. Journal of immunology (Baltimore, Md. : 1950). 1997 Dec; 159(12):6266-75. doi: NULL. [PMID: 9550431]
  • V C Ridger, E R Pettipher, C E Bryant, S D Brain. Effect of the inducible nitric oxide synthase inhibitors aminoguanidine and L-N6-(1-iminoethyl)lysine on zymosan-induced plasma extravasation in rat skin. Journal of immunology (Baltimore, Md. : 1950). 1997 Jul; 159(1):383-90. doi: NULL. [PMID: 9200477]
  • K A Ribbons, M G Currie, J R Connor, P T Manning, P C Allen, P Didier, M S Ratterree, D A Clark, M J Miller. The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey. The Journal of pharmacology and experimental therapeutics. 1997 Feb; 280(2):1008-15. doi: NULL. [PMID: 9023318]
  • W M Moore, R K Webber, K F Fok, G M Jerome, J R Connor, P T Manning, P S Wyatt, T P Misko, F S Tjoeng, M G Currie. 2-Iminopiperidine and other 2-iminoazaheterocycles as potent inhibitors of human nitric oxide synthase isoforms. Journal of medicinal chemistry. 1996 Feb; 39(3):669-72. doi: 10.1021/jm950766n. [PMID: 8576908]
  • J R Connor, P T Manning, S L Settle, W M Moore, G M Jerome, R K Webber, F S Tjoeng, M G Currie. Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase. European journal of pharmacology. 1995 Jan; 273(1-2):15-24. doi: 10.1016/0014-2999(94)00672-t. [PMID: 7537678]