Isoacitretin (BioDeep_00000605237)
代谢物信息卡片
Isoacitretin
化学式: C21H26O3 (326.1881846)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C/C(=C\C=C\C(=C/C(=O)O)\C)/C=C/c1c(C)cc(c(C)c1C)OC
InChI: InChI=1S/C21H26O3/c1-14(8-7-9-15(2)12-21(22)23)10-11-19-16(3)13-20(24-6)18(5)17(19)4/h7-13H,1-6H3,(H,22,23)/b9-7+,11-10+,14-8+,15-12-
描述信息
D020011 - Protective Agents > D000975 - Antioxidants > D002338 - Carotenoids
D003879 - Dermatologic Agents > D007641 - Keratolytic Agents
同义名列表
1 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:50174
- PubChem: 6437841
- Metlin: METLIN621
- MeSH: Acitretin
- CAS: 69427-46-9
- RefMet: Isoacitretin
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Anna A Lauer, Vu Thu Thuy Nguyen, Daniel Janitschke, Malena Dos Santos Guilherme, Cornel M Bachmann, Heike S Grimm, Tobias Hartmann, Kristina Endres, Marcus O W Grimm. The Influence of Acitretin on Brain Lipidomics in Adolescent Mice-Implications for Pediatric and Adolescent Dermatological Therapy.
International journal of molecular sciences.
2022 Dec; 23(24):. doi:
10.3390/ijms232415535. [PMID: 36555176] - Gabriele Roccuzzo, Tommaso Tibaldi, Francesco Cavallo, Carola Aquino, Teresa Rolle, Pietro Quaglino, Simone Ribero. Retinoid-associated myopia in dermatologic patients: a systematic review.
Cutaneous and ocular toxicology.
2022 Dec; 41(4):318-322. doi:
10.1080/15569527.2022.2137177. [PMID: 36260481] - Lin Yi, L I Xun, Wang Zi, Zheng Xiaoran, Hang Haiyan, L I Lingling. Efficacy and safety of external application of Chinese herbal medicine for psoriasis vulgaris: a systematic review of randomized controlled trials.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2022 08; 42(4):493-504. doi:
10.19852/j.cnki.jtcm.20220617.001. [PMID: 35848965] - Aiai Geng, Tianli Pei, Xueyi Zhao, Bo Jia. A Meta-analysis of Xiaoyin Granules Combined with Acitretin Capsule in the Treatment of Psoriasis Vulgaris.
Computational and mathematical methods in medicine.
2022; 2022(?):7360975. doi:
10.1155/2022/7360975. [PMID: 35936361] - Lin Chen, Jie Li, Ying Yao, Shanlong Wang, Shuangjin Zheng, Xinggang Ju, Bin Zhang. Circulating microRNA profile unveils mechanisms of action of acitretin for psoriasis vulgaris.
Bioengineered.
2021 12; 12(1):1838-1850. doi:
10.1080/21655979.2021.1925205. [PMID: 33975513] - Pelin Esme, Sema Nur Coban, Bilge Ugur, Meltem Aylı, Ercan Caliskan. A case of psoriasis successfully treated by extracorporeal photopheresis during COVID-19 pandemic.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2021 Oct; 60(5):103200. doi:
10.1016/j.transci.2021.103200. [PMID: 34215520] - Anna A Lauer, Daniel Janitschke, Malena Dos Santos Guilherme, Vu Thu Thuy Nguyen, Cornel M Bachmann, Sen Qiao, Bianca Schrul, Ulrich Boehm, Heike S Grimm, Tobias Hartmann, Kristina Endres, Marcus O W Grimm. Shotgun lipidomics of liver and brain tissue of Alzheimer's disease model mice treated with acitretin.
Scientific reports.
2021 07; 11(1):15301. doi:
10.1038/s41598-021-94706-3. [PMID: 34315969] - Zongsong Wu, Fabrice E Graf, Hans H Hirsch. Acitretin and Retinoic Acid Derivatives Inhibit BK Polyomavirus Replication in Primary Human Proximal Renal Tubular Epithelial and Urothelial Cells.
Journal of virology.
2021 07; 95(15):e0012721. doi:
10.1128/jvi.00127-21. [PMID: 34011542] - Omar Badri, Chrysalyne D Schmults, Pritesh S Karia, Emily S Ruiz. Efficacy and Cost Analysis for Acitretin for Basal and Squamous Cell Carcinoma Prophylaxis in Renal Transplant Recipients.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.].
2021 01; 47(1):125-126. doi:
10.1097/dss.0000000000002423. [PMID: 32371782] - Ania Henning, Joshua Weaver, Matthew Reedy. Acquired Epidermodysplasia Verruciformis in the Setting of Renal Transplant.
The American Journal of dermatopathology.
2021 Jan; 43(1):71-74. doi:
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Cell reports. Medicine.
2020 11; 1(8):100129. doi:
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Annales de dermatologie et de venereologie.
2020 Sep; 147(8-9):530-534. doi:
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The Journal of dermatological treatment.
2020 Aug; 31(5):524-530. doi:
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Journal of the European Academy of Dermatology and Venereology : JEADV.
2020 Jun; 34(6):e270-e272. doi:
10.1111/jdv.16244. [PMID: 31991497] - Mao Li, Xia Hu, Ping-Sheng Hao. Research 'recover from illness defense complex' helper T cell immune mechanisms based on the 'Fuxie' theory clearing away heat evil thoroughly nourishing kidney treatment of recurrent blood-heat syndrome Psoriasis.
Medicine.
2020 May; 99(20):e20161. doi:
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International journal of dermatology.
2020 Apr; 59(4):445-450. doi:
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International journal of dermatology.
2020 Feb; 59(2):207-215. doi:
10.1111/ijd.14646. [PMID: 31531981] - Xiao Wang, Chunwei Cao, Yongshun Li, Tang Hai, Qitao Jia, Ying Zhang, Qiantao Zheng, Jing Yao, Guosong Qin, Hongyong Zhang, Ruigao Song, Yanfang Wang, Guanghou Shui, Sin Man Lam, Zhonghua Liu, Hong Wei, Anming Meng, Qi Zhou, Jianguo Zhao. A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment.
Journal of molecular cell biology.
2019 12; 11(12):1029-1041. doi:
10.1093/jmcb/mjz021. [PMID: 30925591] - Yu Chen, Liang Xue, Dong-Jie Guo, Jing-Yi Mao, Min-Feng Wu, Rong Xu, Xin Li, Bin Li, Fu-Lun Li. Combination Therapy of Acitretin Capsule and Chinese Herbs for Patients with Lichen Planus Pigmentosus-Inversus.
Chinese journal of integrative medicine.
2019 Dec; 25(12):922-925. doi:
10.1007/s11655-019-3033-7. [PMID: 31444667] - H-J Shi, H Zhou, A-L Ma, L Wang, Q Gao, N Zhang, H-B Song, K-P Bo, W Ma. Oxymatrine therapy inhibited epidermal cell proliferation and apoptosis in severe plaque psoriasis.
The British journal of dermatology.
2019 11; 181(5):1028-1037. doi:
10.1111/bjd.17852. [PMID: 30822359] - Anna Baran, Paulina Kiluk, Magdalena Świderska, Magdalena Maciaszek, Hanna Myśliwiec, Iwona Flisiak. Adipocyte Fatty Acid-Binding Protein as a Novel Marker of Psoriasis and Clinical Response to Acitretin.
Lipids.
2019 08; 54(8):445-452. doi:
10.1002/lipd.12173. [PMID: 31281982] - Yanjuan Duan, Jialing Zou, Jingyi Mao, Dongjie Guo, Minfeng Wu, Ning Xu, Jie Zhou, Yanbin Zhang, Wanjun Guo, Waishu Jin. Plasma miR-126 expression correlates with risk and severity of psoriasis and its high level at baseline predicts worse response to Tripterygium wilfordii Hook F in combination with acitretin.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Jul; 115(?):108761. doi:
10.1016/j.biopha.2019.108761. [PMID: 31100542] - Leena Chularojanamontri, Narumol Silpa-Archa, Chanisada Wongpraparut, Pichaya Limphoka. Long-term safety and drug survival of acitretin in psoriasis: a retrospective observational study.
International journal of dermatology.
2019 May; 58(5):593-599. doi:
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The Journal of pharmacy and pharmacology.
2018 Jul; 70(7):919-928. doi:
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The Australasian journal of dermatology.
2018 May; 59(2):147-148. doi:
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Clinical nutrition ESPEN.
2018 04; 24(?):54-57. doi:
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Current vascular pharmacology.
2018; 16(5):510-521. doi:
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Anais brasileiros de dermatologia.
2017 May; 92(3):319-322. doi:
10.1590/abd1806-4841.20175536. [PMID: 29186241] - Chen Yu, Xueli Fan, Zhenlu Li, Xiaoming Liu, Gang Wang. Efficacy and safety of total glucosides of paeony combined with acitretin in the treatment of moderate-to-severe plaque psoriasis: a double-blind, randomised, placebo-controlled trial.
European journal of dermatology : EJD.
2017 Apr; 27(2):150-154. doi:
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Southern medical journal.
2017 01; 110(1):65-75. doi:
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Journal of drugs in dermatology : JDD.
2015 Jul; 14(7):747-9. doi:
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Pharmacoepidemiology and drug safety.
2015 May; 24(5):526-33. doi:
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Chinese medical journal.
2015 Feb; 128(4):443-9. doi:
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Dermatology (Basel, Switzerland).
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Annales de dermatologie et de venereologie.
2014 Dec; 141(12):790-8. doi:
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International journal of dermatology.
2014 Nov; 53(11):1305-18. doi:
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The Journal of international medical research.
2014 Oct; 42(5):1118-22. doi:
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Pediatric dermatology.
2014 Sep; 31(5):612-4. doi:
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The Australasian journal of dermatology.
2014 Feb; 55(1):43-8. doi:
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Journal of the American Academy of Dermatology.
2014 Jan; 70(1):168-77. doi:
10.1016/j.jaad.2013.09.020. [PMID: 24184141] - Ming-Lian Yu, Yue Yang, Cong-Min Wang, Meng-Meng Zhang, Miao-Chun Bai, Yue-Ling Guo. Acitretin exhibits inhibitory effects towards UDP-glucuronosyltransferase (UGT)1A9-mediated 4-methylumbelliferone (4-MU) and propofol glucuronidation reaction.
Die Pharmazie.
2013 Jun; 68(6):449-52. doi:
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Dermatology (Basel, Switzerland).
2013; 227(2):103-8. doi:
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The Journal of dermatology.
2012 Nov; 39(11):916-21. doi:
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Vox sanguinis.
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Clinical and experimental dermatology.
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Journal of pharmaceutical and biomedical analysis.
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Biomedical chromatography : BMC.
2011 Jun; 25(6):680-8. doi:
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Menopause (New York, N.Y.).
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Bioorganic & medicinal chemistry.
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International journal of pharmaceutics.
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Klinische Padiatrie.
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European journal of medicinal chemistry.
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Journal of perinatology : official journal of the California Perinatal Association.
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Prescrire international.
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International journal of clinical pharmacology and therapeutics.
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Chinese journal of integrative medicine.
2009 Apr; 15(2):141-4. doi:
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Journal of clinical immunology.
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Transfusion.
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Archives of dermatological research.
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The British journal of dermatology.
2008 Nov; 159(5):1208-9. doi:
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Journal of the American Academy of Dermatology.
2008 Aug; 59(2 Suppl 1):S39-40. doi:
10.1016/j.jaad.2007.08.035. [PMID: 18625379] - Christopher M Hunzeker, William Fangman, Jo-Ann M Latkowski. Folliculotropic mycosis fungoides.
Dermatology online journal.
2007 Jan; 13(1):5. doi:
NULL. [PMID: 17511938] - A Damasiewicz-Bodzek, B Kos-Kudła, B Suwała-Jurczyk. The effect of various methods of psoriasis treatment on somatotrophin axis hormones in serum.
Journal of clinical pharmacy and therapeutics.
2006 Aug; 31(4):343-9. doi:
10.1111/j.1365-2710.2006.00747.x. [PMID: 16882103] - E Campalani, M H Allen, D Fairhurst, H S Young, C O Mendonca, A D Burden, C E M Griffiths, M A Crook, J N W N Barker, C H Smith. Apolipoprotein E gene polymorphisms are associated with psoriasis but do not determine disease response to acitretin.
The British journal of dermatology.
2006 Feb; 154(2):345-52. doi:
10.1111/j.1365-2133.2005.06950.x. [PMID: 16433808] - R P Katugampola, A Y Finlay. Oral retinoid therapy for disorders of keratinization: single-centre retrospective 25 years' experience on 23 patients.
The British journal of dermatology.
2006 Feb; 154(2):267-76. doi:
10.1111/j.1365-2133.2005.06906.x. [PMID: 16433796] - Helen S Young, Angela M Summers, Ian R Read, David A Fairhurst, Darren J Plant, Emanuela Campalani, Catherine H Smith, Jonathan N W N Barker, Michael J Detmar, Paul E C Brenchley, Christopher E M Griffiths. Interaction between genetic control of vascular endothelial growth factor production and retinoid responsiveness in psoriasis.
The Journal of investigative dermatology.
2006 Feb; 126(2):453-9. doi:
10.1038/sj.jid.5700096. [PMID: 16385345] - S Corbetta, R Angioni, A Cattaneo, P Beck-Peccoz, A Spada. Effects of retinoid therapy on insulin sensitivity, lipid profile and circulating adipocytokines.
European journal of endocrinology.
2006 Jan; 154(1):83-6. doi:
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Journal of endocrinological investigation.
2005 Dec; 28(11):961-4. doi:
10.1007/bf03345332. [PMID: 16483172] - Victoria L Brown, Catherine L Atkins, Lucy Ghali, Rino Cerio, Catherine A Harwood, Charlotte M Proby. Safety and efficacy of 5\% imiquimod cream for the treatment of skin dysplasia in high-risk renal transplant recipients: randomized, double-blind, placebo-controlled trial.
Archives of dermatology.
2005 Aug; 141(8):985-93. doi:
10.1001/archderm.141.8.985. [PMID: 16103328] - Renata V Carneiro, Mírian N Sotto, Luiz S Azevedo, Luiz E Ianhez, Evandro A Rivitti. Acitretin and skin cancer in kidney transplanted patients. Clinical and histological evaluation and immunohistochemical analysis of lymphocytes, natural killer cells and Langerhans' cells in sun exposed and sun protected skin.
Clinical transplantation.
2005 Feb; 19(1):115-21. doi:
10.1111/j.1399-0012.2004.00311.x. [PMID: 15659144] - Uwe-Frithjof Haustein, Uwe Paasch. Aggressive undifferentiated squamous cell carcinoma in an immunosuppressed patient after kidney transplantation.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.
2005 Jan; 3(1):44-6. doi:
10.1046/j.1439-0353.2005.04740.x. [PMID: 16353749] - Xin Liu, Hai-Shu Lin, Sui Yung Chan, Paul C Ho. Biopharmaceutics of beta-cyclodextrin derivative-based formulations of acitretin in Sprague-Dawley rats.
Journal of pharmaceutical sciences.
2004 Apr; 93(4):805-15. doi:
10.1002/jps.10578. [PMID: 14999719] - Jürgen V Smit, Ruud G L de Sévaux, Willeke A M Blokx, Peter C M van de Kerkhof, Andries J Hoitsma, Elke M G J de Jong. Acitretin treatment in (pre)malignant skin disorders of renal transplant recipients: Histologic and immunohistochemical effects.
Journal of the American Academy of Dermatology.
2004 Feb; 50(2):189-96. doi:
10.1016/s0190-9622(03)01837-1. [PMID: 14726871] - E Lee, J Koo. Single-center retrospective study of long-term use of low-dose acitretin (Soriatane) for psoriasis.
The Journal of dermatological treatment.
2004 Jan; 15(1):8-13. doi:
10.1080/095466303100184473. [PMID: 14754643] - R G L de Sévaux, J V Smit, E M G J de Jong, P C M van de Kerkhof, A J Hoitsma. Acitretin treatment of premalignant and malignant skin disorders in renal transplant recipients: clinical effects of a randomized trial comparing two doses of acitretin.
Journal of the American Academy of Dermatology.
2003 Sep; 49(3):407-12. doi:
10.1067/s0190-9622(03)01831-0. [PMID: 12963902] - Willeke A M Blokx, Jurgen V Smit, Peter C M de Wilde, Peter C M van de Kerkhof, Dirk J Ruiter, Elke M G J de Jong. Immunohistochemical effects of temporary cessation of long-term acitretin treatment in keratinocytic intraepidermal neoplasia of renal transplant recipients.
Archives of dermatology.
2003 May; 139(5):671-3. doi:
10.1001/archderm.139.5.671. [PMID: 12756113] - P I Spuls, M Rozenblit, M Lebwohl. Retrospective study of the efficacy of narrowband UVB and acitretin.
The Journal of dermatological treatment.
2003; 14 Suppl 2(?):17-20. doi:
10.1080/jdt.14.s2.17.20. [PMID: 14578094] - Iain Robert McNamara, James Muir, Andrew John Galbraith. Acitretin for prophylaxis of cutaneous malignancies after cardiac transplantation.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2002 Nov; 21(11):1201-5. doi:
10.1016/s1053-2498(02)00456-4. [PMID: 12431493] - Renu George, Warren Weightman, Graeme R Russ, Kym M Bannister, Timothy H Mathew. Acitretin for chemoprevention of non-melanoma skin cancers in renal transplant recipients.
The Australasian journal of dermatology.
2002 Nov; 43(4):269-73. doi:
10.1046/j.1440-0960.2002.00613.x. [PMID: 12423433] - Ozlem Yerebakan, Oya Ermis, Ertan Yilmaz, Erdal Basaran. Treatment of arsenical keratosis and Bowen's disease with acitretin.
International journal of dermatology.
2002 Feb; 41(2):84-7. doi:
10.1046/j.1365-4362.2002.01372.x. [PMID: 11982642] - Stacy L McClure, Jayme Valentine, Kenneth B Gordon. Comparative tolerability of systemic treatments for plaque-type psoriasis.
Drug safety.
2002; 25(13):913-27. doi:
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Archives of dermatology.
2002 Jan; 138(1):61-5. doi:
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Acta dermato-venereologica.
2001 Oct; 81(5):353-5. doi:
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The British journal of dermatology.
2000 Dec; 143(6):1164-9. doi:
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Journal of the European Academy of Dermatology and Venereology : JEADV.
2000 Nov; 14(6):473-8. doi:
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Journal of the American Academy of Dermatology.
1999 Sep; 41(3 Pt 2):S7-S12. doi:
10.1016/s0190-9622(99)70359-2. [PMID: 10459140] - D B McKenna, G M Murphy. Skin cancer chemoprophylaxis in renal transplant recipients: 5 years of experience using low-dose acitretin.
The British journal of dermatology.
1999 Apr; 140(4):656-60. doi:
10.1046/j.1365-2133.1999.02765.x. [PMID: 10233316] - O Vanhooteghem, J Andre, J M Pochet, J Demaubeuge, M Song. Occurrence of gouty tophi following acitretin therapy.
Clinical and experimental dermatology.
1998 Nov; 23(6):274-6. doi:
10.1046/j.1365-2230.1998.00362.x. [PMID: 10233625] - A L Kuijpers, J P Van Pelt, M Bergers, P J Boegheim, J E Den Bakker, G Siegenthaler, P C Van de Kerkhof, J Schalkwijk. The effects of oral liarozole on epidermal proliferation and differentiation in severe plaque psoriasis are comparable with those of acitretin.
The British journal of dermatology.
1998 Sep; 139(3):380-9. doi:
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The Medical letter on drugs and therapeutics.
1997 Nov; 39(1013):105-6. doi:
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Acta dermato-venereologica.
1996 Nov; 76(6):442-3. doi:
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Lancet (London, England).
1996 Oct; 348(9034):1107. doi:
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Archives of dermatological research.
1996 Aug; 288(9):543-8. doi:
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Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.
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