Aceglutamide (BioDeep_00000604292)

Main id: BioDeep_00000017822

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2S)-2-Acetamido-5-amino-5-oxopentanoic acid

化学式: C7H12N2O4 (188.0797)
中文名称: N-乙酰-L-谷氨酰胺
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)NC(CCC(=O)N)C(=O)O
InChI: InChI=1S/C7H12N2O4/c1-4(10)9-5(7(12)13)2-3-6(8)11/h5H,2-3H2,1H3,(H2,8,11)(H,9,10)(H,12,13)/t5-/m0/s1

描述信息

C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
Aceglutamide (α-N-Acetyl-L-glutamine) is a psychostimulant and nootropic, used to improve memory and concentration[1].

同义名列表

6 个代谢物同义名

Aceglutamide; (2S)-2-Acetamido-5-amino-5-oxopentanoic acid; Nα-Acetyl-L-glutamine; N-Acetyl-L-glutamine; α-N-Acetyl-L-glutamine; N2-Acetylglutamine



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Jingjing Zhang, Rui Zhou, Changpei Xiang, Fangfang Fan, Jinhuan Gao, Yi Zhang, Shihuan Tang, Haiyu Xu, Hongjun Yang. Enhanced thioredoxin, glutathione and Nrf2 antioxidant systems by safflower extract and aceglutamide attenuate cerebral ischaemia/reperfusion injury. Journal of cellular and molecular medicine. 2020 05; 24(9):4967-4980. doi: 10.1111/jcmm.15099. [PMID: 32266795]
  • Lei Gao, Yunwen Xue, Zunjian Zhang, Yuan Tian. Enantioseparation of N-acetyl-glutamine enantiomers by LC-MS/MS and its application to a plasma protein binding study. Biomedical chromatography : BMC. 2019 Sep; 33(9):e4559. doi: 10.1002/bmc.4559. [PMID: 31016738]
  • D P K Ng, A Salim, Y Liu, L Zou, F G Xu, S Huang, H Leong, C N Ong. A metabolomic study of low estimated GFR in non-proteinuric type 2 diabetes mellitus. Diabetologia. 2012 Feb; 55(2):499-508. doi: 10.1007/s00125-011-2339-6. [PMID: 22038517]
  • Joana Carrola, Cláudia M Rocha, António S Barros, Ana M Gil, Brian J Goodfellow, Isabel M Carreira, João Bernardo, Ana Gomes, Vitor Sousa, Lina Carvalho, Iola F Duarte. Metabolic signatures of lung cancer in biofluids: NMR-based metabonomics of urine. Journal of proteome research. 2011 Jan; 10(1):221-30. doi: 10.1021/pr100899x. [PMID: 21058631]
  • Blair U Bradford, Thomas M O'Connell, Jun Han, Oksana Kosyk, Svitlana Shymonyak, Pamela K Ross, Jason Winnike, Hiroshi Kono, Ivan Rusyn. Metabolomic profiling of a modified alcohol liquid diet model for liver injury in the mouse uncovers new markers of disease. Toxicology and applied pharmacology. 2008 Oct; 232(2):236-43. doi: 10.1016/j.taap.2008.06.022. [PMID: 18674555]
  • R N Van Coster, E A Gerlo, T G Giardina, U F Engelke, J E Smet, C M De Praeter, V A Meersschaut, L J De Meirleir, S H Seneca, B Devreese, J G Leroy, S Herga, J P Perrier, R A Wevers, W Lissens. Aminoacylase I deficiency: a novel inborn error of metabolism. Biochemical and biophysical research communications. 2005 Dec; 338(3):1322-6. doi: 10.1016/j.bbrc.2005.10.126. [PMID: 16274666]
  • S X Racine, P Le Toumelin, F Adnet, Y Cohen, M Cupa, E Hantz, L Le Moyec. N-acetyl functions and acetate detected by nuclear magnetic resonance spectroscopy of urine to detect renal dysfunction following aminoglycoside and/or glycopeptide antibiotic therapy. Nephron. Physiology. 2004; 97(4):p53-7. doi: 10.1159/000079179. [PMID: 15331932]
  • K Sugahara, J Zhang, H Kodama. Liquid chromatographic-mass spectrometric analysis of N-acetylamino acids in human urine. Journal of chromatography. B, Biomedical applications. 1994 Jul; 657(1):15-21. doi: 10.1016/0378-4347(94)80064-2. [PMID: 7952062]
  • M C Gouttebel, C Astre, D Briand, B Saint-Aubert, P M Girardot, H Joyeux. Influence of N-acetylglutamine or glutamine infusion on plasma amino acid concentrations during the early phase of small-bowel adaptation in the dog. JPEN. Journal of parenteral and enteral nutrition. 1992 Mar; 16(2):117-21. doi: 10.1177/0148607192016002117. [PMID: 1556804]
  • Y Chen. Clinical research on treating senile dementia by combining acupuncture with acupoint-injection. Acupuncture & electro-therapeutics research. 1992; 17(2):61-73. doi: 10.3727/036012992816357800. [PMID: 1353652]
  • I Magnusson, R Kihlberg, A Alvestrand, J Wernerman, L Ekman, J Wahren. Utilization of intravenously administered N-acetyl-L-glutamine in humans. Metabolism: clinical and experimental. 1989 Aug; 38(8 Suppl 1):82-8. doi: 10.1016/0026-0495(89)90148-0. [PMID: 2569664]