Chondritinsulfate (BioDeep_00000603890)
代谢物信息卡片
(2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-sulfooxyoxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylicacid
化学式: C13H21NO15S (463.0632)
中文名称:
谱图信息:
最多检出来源 Homo sapiens(blood) 100%
分子结构信息
SMILES:
InChI:
描述信息
同义名列表
13 个代谢物同义名
(2S,3S,4S,5R,6R)-6-[(2R,3R,4R,5R,6R)-3-acetamido-2,5-dihydroxy-6-sulfooxyoxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylicacid; Chondroitin Sodium Sulfate Ex Shark; Chondroitin sulfate from swine; Chondroitinsulfuric acids; Chondroitinsulfuric acid; Chondroitin sulfic acid; Chondroitin polysulfate; Chondroitin 6-sulfate; Chondroitin sulfate C; Chondroitin sulphate; Chondroitinsulfurate; chondroitin sulfate; Chondritinsulfate
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
1 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(1)
- chondroitin sulfate degradation (metazoa):
H2O + a [chondroitin-sulfate] containing 6-O-sulfo-N-acetylgalactosamine ⟶ a [chondroitin] containing N-acetyl-galactosamine + sulfate
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Liya Bai, Hui Liu, Ran You, Xiaoyu Jiang, Tao Zhang, Yunan Li, Tianhe Shan, Zhanyin Qian, Yinsong Wang, Yuanyuan Liu, Chunyu Li. Combination Nano-Delivery Systems Remodel the Immunosuppressive Tumor Microenvironment for Metastatic Triple-Negative Breast Cancer Therapy.
Molecular pharmaceutics.
2024 May; 21(5):2148-2162. doi:
10.1021/acs.molpharmaceut.3c00242. [PMID: 38536949] - Shanshan Liu, Hailong Tian, Hui Ming, Tingting Zhang, Yajie Gao, Ruolan Liu, Lihua Chen, Chen Yang, Edouard C Nice, Canhua Huang, Jinku Bao, Wei Gao, Zheng Shi. Mitochondrial-Targeted CS@KET/P780 Nanoplatform for Site-Specific Delivery and High-Efficiency Cancer Immunotherapy in Hepatocellular Carcinoma.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2024 Apr; 11(14):e2308027. doi:
10.1002/advs.202308027. [PMID: 38308137] - Yining Niu, Tingting Gao, Hongling Ouyang, Yunxiao Zhang, Tao Gong, Zhirong Zhang, Xi Cao, Yao Fu. Chondroitin Sulfate-Derived Micelles for Adipose Tissue-Targeted Delivery of Celastrol and Phenformin to Enhance Obesity Treatment.
ACS applied bio materials.
2024 Feb; ?(?):. doi:
10.1021/acsabm.3c01216. [PMID: 38315869] - Shuaijun Lu, Hailong Tian, Bowen Li, Lei Li, Hao Jiang, Yajie Gao, Lin Zheng, Canhua Huang, Yuping Zhou, Zhongyan Du, Jia Xu. An Ellagic Acid Coordinated Copper-Based Nanoplatform for Efficiently Overcoming Cancer Chemoresistance by Cuproptosis and Synergistic Inhibition of Cancer Cell Stemness.
Small (Weinheim an der Bergstrasse, Germany).
2023 Dec; ?(?):e2309215. doi:
10.1002/smll.202309215. [PMID: 38044295] - Yi Pan, Yunxiao Zhang, Hongling Ouyang, Tao Gong, Zhirong Zhang, Xi Cao, Yao Fu. Targeted Delivery of Celastrol via Chondroitin Sulfate Derived Hybrid Micelles for Alleviating Symptoms in Nonalcoholic Fatty Liver Disease.
ACS applied bio materials.
2023 Oct; ?(?):. doi:
10.1021/acsabm.3c00612. [PMID: 37890075] - Jessica Pihl, Thomas M Clausen, Jiarong Zhou, Nishta Krishnan, Maj S Ørum-Madsen, Tobias Gustavsson, Robert Dagil, Mads Daugaard, Swati Choudhary, Camilla Foged, Jeffrey D Esko, Liangfang Zhang, Ronnie H Fang, Ali Salanti. Malaria Biomimetic for Tumor Targeted Drug Delivery.
ACS nano.
2023 07; 17(14):13500-13509. doi:
10.1021/acsnano.3c01910. [PMID: 37435892] - Yashi Wang, Lin Xiong, Ziyan Dong, Kaixin Ran, Wenjing Bai, Ziyi Mo, Kexin Huang, Yunxia Ye, Yuan Tao, Sheng Yin, Man Li, Qin He. Autophagy-Interfering Nanoboat Drifting along CD44-Golgi-ER Flow as RNAi Therapeutics for Hepatic Fibrosis.
ACS applied materials & interfaces.
2023 Jun; 15(24):28941-28953. doi:
10.1021/acsami.3c03416. [PMID: 37290012] - Zhejie Chen, Yi Chen, Wei Hao, Mingju Shui, Jinming Zhang, Hefeng Zhou, Chen Zhang, Yitao Wang, Shengpeng Wang. Oral Delivery of Transformable Bilirubin Self-assembled System for Targeted Therapy of Colitis.
Advanced healthcare materials.
2023 Jun; ?(?):e2300946. doi:
10.1002/adhm.202300946. [PMID: 37317667] - Ruichang Gao, Zexiu Qi, Jie Lin, Ge Wang, Ge Chen, Li Yuan, Quancai Sun. Chondroitin Sulfate Alleviated Obesity by Modulating Gut Microbiota and Liver Metabolome in High-Fat-Diet-Induced Obese Mice.
Journal of agricultural and food chemistry.
2023 Jun; ?(?):. doi:
10.1021/acs.jafc.3c02642. [PMID: 37294270] - Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
ACS pharmacology & translational science.
2023 May; 6(5):683-701. doi:
10.1021/acsptsci.2c00194. [PMID: 37200814] - Tao Shen, Shangteng Wang, Quntao Liang, Joshua S Sharp, Zheng Wei. Characterization and antioxidant activities of glycosaminoglycans from dried leech.
Glycoconjugate journal.
2023 04; 40(2):169-178. doi:
10.1007/s10719-023-10105-y. [PMID: 36749437] - Shiwei Hu, Hongli Zhu, Sichun Chen, Xiaofeng Wan, Yishu Liu, Zhaocai Ren, Shuang Gao. Structural Characterization and Effects on Insulin Resistance of a Novel Chondroitin Sulfate from Halaelurus burgeri Skin.
Marine drugs.
2023 Mar; 21(4):. doi:
10.3390/md21040221. [PMID: 37103360] - Renfang Zhu, Wenyue Chen, Donghao Gu, Tianyi Wang, Jiayang Li, Hao Pan. Chondroitin sulfate and L-Cysteine conjugate modified cationic nanostructured lipid carriers: Pre-corneal retention, permeability, and related studies for dry eye treatment.
International journal of biological macromolecules.
2023 Feb; 228(?):624-637. doi:
10.1016/j.ijbiomac.2022.12.238. [PMID: 36581034] - Catharina Husteden, Yazmin A Brito Barrera, Sophia Tegtmeyer, João Borges, Julia Giselbrecht, Matthias Menzel, Andreas Langner, João F Mano, Christian E H Schmelzer, Christian Wölk, Thomas Groth. Lipoplex-Functionalized Thin-Film Surface Coating Based on Extracellular Matrix Components as Local Gene Delivery System to Control Osteogenic Stem Cell Differentiation.
Advanced healthcare materials.
2023 02; 12(5):e2201978. doi:
10.1002/adhm.202201978. [PMID: 36377486] - Roger Sandhoff, Konrad Sandhoff. Neuronal Ganglioside and Glycosphingolipid (GSL) Metabolism and Disease : Cascades of Secondary Metabolic Errors Can Generate Complex Pathologies (in LSDs).
Advances in neurobiology.
2023; 29(?):333-390. doi:
10.1007/978-3-031-12390-0_12. [PMID: 36255681] - Heba M K Ebada, Maha M A Nasra, Rasha A Nassra, Ossama Y Abdallah. Chondroitin sulfate-functionalized lipid nanoreservoirs: a novel cartilage-targeting approach for intra-articular delivery of cassic acid for osteoarthritis treatment.
Drug delivery.
2022 Dec; 29(1):652-663. doi:
10.1080/10717544.2022.2041130. [PMID: 35188017] - Sabir Es-Said, Karima Lafhal, Abdelaati Elkhiat, Miloud Hammoud, Noureddine Regbaoui, Aicha Ezoubeiri, Rachida Makbal, Safia Sbyea, Omar Elhiba, Souad Sellami, Hanane Rais, Abdallah Karim, Halima Gamrani, Noureddine Rada, Mohammed Bouskraoui, Naima Fdil. Flaxseed extract reduces tissue accumulation and enhances urinary excretion of chondroitin sulphate in the rat: a possible new path in substrate reduction therapy for mucopolysaccharidosis.
Pharmaceutical biology.
2022 Dec; 60(1):879-888. doi:
10.1080/13880209.2022.2068618. [PMID: 35634909] - Dandan Huang, Jiajia Gui, Xue Chen, Ruilian Yu, Tao Gong, Zhirong Zhang, Yao Fu. Chondroitin Sulfate-Derived Paclitaxel Nanocrystal via π-π Stacking with Enhanced Stability and Tumor Targetability.
ACS applied materials & interfaces.
2022 Nov; 14(46):51776-51789. doi:
10.1021/acsami.2c15881. [PMID: 36350778] - Weili Wang, Hui Mao, Sujuan Li, Longlong Zhang, Lian Yang, Ronghua Yin, Jinhua Zhao. Branched Chondroitin Sulfate Oligosaccharides Derived from the Sea Cucumber Acaudina molpadioides Stimulate Neurite Outgrowth.
Marine drugs.
2022 Oct; 20(10):. doi:
10.3390/md20100653. [PMID: 36286476] - Ronghua Yin, Ying Pan, Ying Cai, Fan Yang, Na Gao, Dilihumaer Ruzemaimaiti, Jinhua Zhao. Re-understanding of structure and anticoagulation: Fucosylated chondroitin sulfate from sea cucumber Ludwigothurea grisea.
Carbohydrate polymers.
2022 Oct; 294(?):119826. doi:
10.1016/j.carbpol.2022.119826. [PMID: 35868774] - Yu-Shun Lu, Yan-Ting Zhang, Zhi-Man Li, Jian-Bo Chen, Xiao-Hui Huo, Di Qu, Yin-Shi Sun. [Detection of chondroitin sulfate in Cervi Cornu Pantotrichum and Cervi Cornu of different specifications and its application in quality evaluation].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Oct; 47(19):5203-5208. doi:
10.19540/j.cnki.cjcmm.20220616.101. [PMID: 36472026] - Jun Yamada, Shoichiro Maeda, Mariko Soya, Hidefumi Nishida, Kyoko M Iinuma, Shozo Jinno. Alleviation of cognitive deficits via upregulation of chondroitin sulfate biosynthesis by lignan sesamin in a mouse model of neuroinflammation.
The Journal of nutritional biochemistry.
2022 10; 108(?):109093. doi:
10.1016/j.jnutbio.2022.109093. [PMID: 35724814] - Yuzhe He, Miao Sun, Jirong Wang, Xiaofu Yang, Changjian Lin, Lujie Ge, Chenting Ying, Kai Xu, An Liu, Lidong Wu. Chondroitin sulfate microspheres anchored with drug-loaded liposomes play a dual antioxidant role in the treatment of osteoarthritis.
Acta biomaterialia.
2022 10; 151(?):512-527. doi:
10.1016/j.actbio.2022.07.052. [PMID: 35964941] - Long Chen, Yansong Gao, Yujuan Zhao, Ge Yang, Chao Wang, Zijian Zhao, Shengyu Li. Chondroitin sulfate stimulates the secretion of H2S by Desulfovibrio to improve insulin sensitivity in NAFLD mice.
International journal of biological macromolecules.
2022 Jul; 213(?):631-638. doi:
10.1016/j.ijbiomac.2022.05.195. [PMID: 35667460] - Haohuan Li, Caifeng Deng, Yulu Tan, Jianxia Dong, Yuanhao Zhao, Xiaorong Wang, Xingyue Yang, Jingwen Luo, Huile Gao, Yuan Huang, Zhi-Rong Zhang, Tao Gong. Chondroitin sulfate-based prodrug nanoparticles enhance photodynamic immunotherapy via Golgi apparatus targeting.
Acta biomaterialia.
2022 07; 146(?):357-369. doi:
10.1016/j.actbio.2022.05.014. [PMID: 35577045] - Valentina Vassallo, Anastasia Tsianaka, Nicola Alessio, Jana Grübel, Marcella Cammarota, Günter E M Tovar, Alexander Southan, Chiara Schiraldi. Evaluation of novel biomaterials for cartilage regeneration based on gelatin methacryloyl interpenetrated with extractive chondroitin sulfate or unsulfated biotechnological chondroitin.
Journal of biomedical materials research. Part A.
2022 06; 110(6):1210-1223. doi:
10.1002/jbm.a.37364. [PMID: 35088923] - Xiao Chen, Yan-Chao Wu, Pi-Xian Gong, Yu-He Zhang, Hui-Jing Li. Chondroitin sulfate deposited on foxtail millet prolamin/caseinate nanoparticles to improve physicochemical properties and enhance cancer therapeutic effects.
Food & function.
2022 May; 13(9):5343-5352. doi:
10.1039/d2fo00572g. [PMID: 35466985] - Jong Chul Kim, Kiyoon Min, Giyoong Tae. The effect of the surface coating of human adipose-derived stem cells by various GAGs on the biodistribution of them upon intravenous administration.
Materials science & engineering. C, Materials for biological applications.
2022 Apr; 135(?):112671. doi:
10.1016/j.msec.2022.112671. [PMID: 35581060] - Ruiyun Wu, Qian Shen, Pinglan Li, Nan Shang. Sturgeon Chondroitin Sulfate Restores the Balance of Gut Microbiota in Colorectal Cancer Bearing Mice.
International journal of molecular sciences.
2022 Mar; 23(7):. doi:
10.3390/ijms23073723. [PMID: 35409083] - Stephanie Möller, Janine Theiß, Thaira I L Deinert, Karoline Golat, Julian Heinze, Daniela Niemeyer, Ralf Wyrwa, Matthias Schnabelrauch, Elke Bogner. High-Sulfated Glycosaminoglycans Prevent Coronavirus Replication.
Viruses.
2022 02; 14(2):. doi:
10.3390/v14020413. [PMID: 35216006] - Bruna G Carvalho, Bianca B M Garcia, Antonio A Malfatti-Gasperini, Sang W Han, Lucimara G de la Torre. Hybrid polymer/lipid vesicle synthesis: Association between cationic liposomes and lipoplexes with chondroitin sulfate.
Colloids and surfaces. B, Biointerfaces.
2022 Feb; 210(?):112233. doi:
10.1016/j.colsurfb.2021.112233. [PMID: 34838413] - Justin Y A Doritchamou, Jonathan P Renn, Bethany Jenkins, Almahamoudou Mahamar, Alassane Dicko, Michal Fried, Patrick E Duffy. A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates.
eLife.
2022 02; 11(?):. doi:
10.7554/elife.76264. [PMID: 35103596] - Haiting Xu, Ruifeng Luo, Lingling Dong, Xiulan Pu, Qiyan Chen, Naijing Ye, Shanshan Qi, Xiaoqin Han, Wenbiao Nie, Chaomei Fu, Yichen Hu, Jinming Zhang, Fei Gao. pH/ROS dual-sensitive and chondroitin sulfate wrapped poly (β-amino ester)-SA-PAPE copolymer nanoparticles for macrophage-targeted oral therapy for ulcerative colitis.
Nanomedicine : nanotechnology, biology, and medicine.
2022 01; 39(?):102461. doi:
10.1016/j.nano.2021.102461. [PMID: 34562656] - Alexandar Tzankov, Sumit Bhattacharyya, Kumar Kotlo, Joanne K Tobacman. Increase in Chondroitin Sulfate and Decline in Arylsulfatase B May Contribute to Pathophysiology of COVID-19 Respiratory Failure.
Pathobiology : journal of immunopathology, molecular and cellular biology.
2022; 89(2):81-91. doi:
10.1159/000519542. [PMID: 34788765] - Huan Deng, Mumba Mulutula Chilufya, Jiaxin Liu, Lichun Qiao, Xiang Xiao, Yan Zhao, Ziwei Guo, Yizhen Lv, Wenyue Wang, Jiaheng Zhang, Jing Han. Effect of Low Nutrition and T-2 Toxin on C28/I2 Chondrocytes Cell Line and Chondroitin Sulfate-Modifying Sulfotransferases.
Cartilage.
2021 12; 13(2_suppl):818S-825S. doi:
10.1177/19476035211023555. [PMID: 34151604] - Mohammad Ali Javadi, Amir Rezaeian Akbarzadeh, Tahereh Chamani, Mozhgan Rezaei Kanavi. Sinasol versus Optisol-GS for cold preservation of human cornea: a prospective ex vivo and clinical study.
Cell and tissue banking.
2021 Dec; 22(4):563-574. doi:
10.1007/s10561-021-09930-y. [PMID: 33937957] - Eleonora Casula, Maria Manconi, José Antonio Vázquez, Tania Belen Lopez-Mendez, José Luis Pedraz, Esteban Calvo, Antonio Lozano, Marco Zaru, Andreia Ascenso, Maria Letizia Manca. Design of a Nasal Spray Based on Cardiospermum halicacabum Extract Loaded in Phospholipid Vesicles Enriched with Gelatin or Chondroitin Sulfate.
Molecules (Basel, Switzerland).
2021 Nov; 26(21):. doi:
10.3390/molecules26216670. [PMID: 34771079] - Rohini Dwivedi, Priyanka Samanta, Poonam Sharma, Fuming Zhang, Sushil K Mishra, Pavel Kucheryavy, Seon Beom Kim, AyoOluwa O Aderibigbe, Robert J Linhardt, Ritesh Tandon, Robert J Doerksen, Vitor H Pomin. Structural and kinetic analyses of holothurian sulfated glycans suggest potential treatment for SARS-CoV-2 infection.
The Journal of biological chemistry.
2021 10; 297(4):101207. doi:
10.1016/j.jbc.2021.101207. [PMID: 34537241] - Qingshan Shen, Chunhui Zhang, Xiaojie Qin, Hongru Zhang, Zhiqiang Zhang, Aurore Richel. Modulation of gut microbiota by chondroitin sulfate calcium complex during alleviation of osteoporosis in ovariectomized rats.
Carbohydrate polymers.
2021 Aug; 266(?):118099. doi:
10.1016/j.carbpol.2021.118099. [PMID: 34044918] - Oleksandr Korotkyi, Alevtina Huet, Kateryna Dvorshchenko, Nazarii Kobyliak, Tetyana Falalyeyeva, Liudmyla Ostapchenko. Probiotic Composition and Chondroitin Sulfate Regulate TLR-2/4-Mediated NF-κB Inflammatory Pathway and Cartilage Metabolism in Experimental Osteoarthritis.
Probiotics and antimicrobial proteins.
2021 08; 13(4):1018-1032. doi:
10.1007/s12602-020-09735-7. [PMID: 33459997] - Kaipei Luo, Feng Xu, Tianyi Yao, Jianping Zhu, Hua Yu, Guangji Wang, Juan Li. TPGS and chondroitin sulfate dual-modified lipid-albumin nanosystem for targeted delivery of chemotherapeutic agent against multidrug-resistant cancer.
International journal of biological macromolecules.
2021 Jul; 183(?):1270-1282. doi:
10.1016/j.ijbiomac.2021.05.070. [PMID: 34004196] - Xiao Wang, Huan Gu, Huan Zhang, Jing Xian, Jingjing Li, Chaomei Fu, Chen Zhang, Jinming Zhang. Oral Core-Shell Nanoparticles Embedded in Hydrogel Microspheres for the Efficient Site-Specific Delivery of Magnolol and Enhanced Antiulcerative Colitis Therapy.
ACS applied materials & interfaces.
2021 Jul; 13(29):33948-33961. doi:
10.1021/acsami.1c09804. [PMID: 34261306] - Gergo Peter Szekeres, Szilvia Krekic, Rebecca L Miller, Mark Mero, Kevin Pagel, Zsuzsanna Heiner. The interaction of chondroitin sulfate with a lipid monolayer observed by using nonlinear vibrational spectroscopy.
Physical chemistry chemical physics : PCCP.
2021 Jun; 23(23):13389-13395. doi:
10.1039/d1cp01975a. [PMID: 34105546] - Martin W Britten, Laura Lümers, Kenji Tominaga, Jürgen Peters, Daniel Dirkmann. Glycocalyx components affect platelet function, whole blood coagulation, and fibrinolysis: an in vitro study suggesting a link to trauma-induced coagulopathy.
BMC anesthesiology.
2021 03; 21(1):83. doi:
10.1186/s12871-021-01300-1. [PMID: 33740916] - Katarzyna Szurkowska, Paulina Kazimierczak, Joanna Kolmas. Mg,Si-Co-Substituted Hydroxyapatite/Alginate Composite Beads Loaded with Raloxifene for Potential Use in Bone Tissue Regeneration.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22062933. [PMID: 33805785] - Haiyue Huang, Jin Mao, Quntao Liang, Jianghui Lin, Lilong Jiang, Shutao Liu, Joshua S Sharp, Zheng Wei. Structural analysis of glycosaminoglycans from Oviductus ranae.
Glycoconjugate journal.
2021 02; 38(1):25-33. doi:
10.1007/s10719-020-09962-8. [PMID: 33411075] - Han Sol Lee, Nae-Won Kang, Hyelim Kim, Dong Hyun Kim, Jung-Woo Chae, Wonhwa Lee, Gyu Yong Song, Cheong-Weon Cho, Dae-Duk Kim, Jae-Young Lee. Chondroitin sulfate-hybridized zein nanoparticles for tumor-targeted delivery of docetaxel.
Carbohydrate polymers.
2021 Feb; 253(?):117187. doi:
10.1016/j.carbpol.2020.117187. [PMID: 33278965] - Julian E A Leakey, A Afshan Ali, Amy R Babb, Heidi L Badgley, Kelly J Davis, Beth E Juliar, Tatiana I Leakey, Sherry M Lewis, Ralph E Patton, John E Seng. Subchronic toxicity evaluation of glucosamine and glucosamine in combination with chondroitin sulfate in obese Zucker rats.
Toxicology and applied pharmacology.
2021 02; 412(?):115371. doi:
10.1016/j.taap.2020.115371. [PMID: 33345901] - Shuxin Jiang, Huanan Yin, Xiaohui Qi, Weiguo Song, Weiwei Shi, Jiaojiao Mou, Jie Yang. Immunomodulatory effects of fucosylated chondroitin sulfate from Stichopus chloronotus on RAW 264.7 cells.
Carbohydrate polymers.
2021 Jan; 251(?):117088. doi:
10.1016/j.carbpol.2020.117088. [PMID: 33142629] - Stephen Schaaf, Wan Huang, Subashan Perera, Yvette Conley, Inna Belfer, Prakash Jayabalan, Katie Tremont, Paulo Coelho, Sara Ernst, Megan Cortazzo, Debra Weiner, Nam Vo, James Kang, Gwendolyn Sowa. Association of Protein and Genetic Biomarkers With Response to Lumbar Epidural Steroid Injections in Subjects With Axial Low Back Pain.
American journal of physical medicine & rehabilitation.
2021 01; 100(1):48-56. doi:
10.1097/phm.0000000000001514. [PMID: 32576742] - Chiara Caterino, Federica Aragosa, Giovanni Della Valle, Dario Costanza, Francesco Lamagna, Alfonso Piscitelli, Annalisa Nieddu, Gerardo Fatone. Clinical efficacy of Curcuvet and Boswellic acid combined with conventional nutraceutical product: An aid to canine osteoarthritis.
PloS one.
2021; 16(5):e0252279. doi:
10.1371/journal.pone.0252279. [PMID: 34048452] - Lufeng Yan, Mengshan Zhu, Danli Wang, Wenyang Tao, Donghong Liu, Fuming Zhang, Robert J Linhardt, Xingqian Ye, Shiguo Chen. Oral Administration of Fucosylated Chondroitin Sulfate Oligomers in Gastro-Resistant Microcapsules Exhibits a Safe Antithrombotic Activity.
Thrombosis and haemostasis.
2021 Jan; 121(1):15-26. doi:
10.1055/s-0040-1714738. [PMID: 32862408] - Mao Hong, Chongjie Cheng, Xiaowei Sun, Yan Yan, Qidong Zhang, Weiguo Wang, Wanshou Guo. Efficacy and Safety of Intra-Articular Platelet-Rich Plasma in Osteoarthritis Knee: A Systematic Review and Meta-Analysis.
BioMed research international.
2021; 2021(?):2191926. doi:
10.1155/2021/2191926. [PMID: 34337002] - Hajer Bougatef, Zohra Ghlissi, Rim Kallel, Ikram Ben Amor, Tahiya Boudawara, Jalel Gargouri, Zouheir Sahnoun, Nicola Volpi, Assaad Sila, Ali Bougatef. Chondroitin/dermatan sulfate purified from corb (Sciaena umbra) skin and bone: In vivo assessment of anticoagulant activity.
International journal of biological macromolecules.
2020 Dec; 164(?):131-139. doi:
10.1016/j.ijbiomac.2020.07.096. [PMID: 32673716] - Na Gao, Ru Chen, Rongrong Mou, Jingying Xiang, Kai Zhou, Zi Li, Jinhua Zhao. Purification, structural characterization and anticoagulant activities of four sulfated polysaccharides from sea cucumber Holothuria fuscopunctata.
International journal of biological macromolecules.
2020 Dec; 164(?):3421-3428. doi:
10.1016/j.ijbiomac.2020.08.150. [PMID: 32835799] - A Derkacz, P Olczyk, A Jura-Poltorak, E Waluga-Kozlowska, K Olczyk, K Komosinska-Vassev. Clinical significance of urinary glycosaminoglycan excretion in inflammatory bowel disease patients.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2020 Dec; 71(6):. doi:
10.26402/jpp.2020.6.03. [PMID: 33727426] - Yoshiyuki Hattori, Kyoko Tamaki, Sho Sakasai, Kei-Ichi Ozaki, Hiraku Onishi. Effects of PEG anchors in PEGylated siRNA lipoplexes on in vitro gene‑silencing effects and siRNA biodistribution in mice.
Molecular medicine reports.
2020 Nov; 22(5):4183-4196. doi:
10.3892/mmr.2020.11525. [PMID: 33000194] - Doowon Huh, Khoa D Tran, Megan M W Straiko, Matthew W McCarthy, Angela S Loo, Thomas J Walsh, Christopher S Sales. Efficacy of Amphotericin B in Corneal Preservation Media After Extended Frozen Storage.
Cornea.
2020 Oct; 39(10):1274-1277. doi:
10.1097/ico.0000000000002381. [PMID: 32482961] - Aman Khanna, Sivadasan Syam Das, Thozhuthum Parambil Smina, Jestin V Thomas, Ajaikumar B Kunnumakkara, Balu Maliakel, Illathu Madhavamenon Krishnakumar, Ratheesh Mohanan. Curcumagalactomannoside/Glucosamine Combination Improved Joint Health Among Osteoarthritic Subjects as Compared to Chondroitin Sulfate/Glucosamine: Double-Blinded, Randomized Controlled Study.
Journal of alternative and complementary medicine (New York, N.Y.).
2020 Oct; 26(10):945-955. doi:
10.1089/acm.2020.0128. [PMID: 32678677] - Hui Mao, Ying Cai, Shanni Li, Huifang Sun, Lisha Lin, Ying Pan, Wenjiao Yang, Zhicheng He, Ru Chen, Lutan Zhou, Weili Wang, Ronghua Yin, Jinhua Zhao. A new fucosylated glycosaminoglycan containing disaccharide branches from Acaudina molpadioides: Unusual structure and anti-intrinsic tenase activity.
Carbohydrate polymers.
2020 Oct; 245(?):116503. doi:
10.1016/j.carbpol.2020.116503. [PMID: 32718614] - Christof Trabszo, Bastian Ramms, Pradeep Chopra, Renate Lüllmann-Rauch, Stijn Stroobants, Jens Sproß, Anke Jeschke, Thorsten Schinke, Geert-Jan Boons, Jeffrey D Esko, Torben Lübke, Thomas Dierks. Arylsulfatase K inactivation causes mucopolysaccharidosis due to deficient glucuronate desulfation of heparan and chondroitin sulfate.
The Biochemical journal.
2020 09; 477(17):3433-3451. doi:
10.1042/bcj20200546. [PMID: 32856704] - Shiyi Zhao, Yingxia Zhou, Lai Wei, Lihua Chen. Low fouling strategy of electrochemical biosensor based on chondroitin sulfate functionalized gold magnetic particle for voltammetric determination of mycoplasma ovipneumonia in whole serum.
Analytica chimica acta.
2020 Aug; 1126(?):91-99. doi:
10.1016/j.aca.2020.06.015. [PMID: 32736729] - Xin Chen, Tailang Yin, Baozhen Zhang, Beini Sun, Jie Chen, Tianxia Xiao, Baobei Wang, Mengxia Li, Jing Yang, Xiujun Fan. Inhibitory effects of brusatol delivered using glycosaminoglycan‑placental chondroitin sulfate A‑modified nanoparticles on the proliferation, migration and invasion of cancer cells.
International journal of molecular medicine.
2020 Aug; 46(2):817-827. doi:
10.3892/ijmm.2020.4627. [PMID: 32626948] - Hong Xing Zheng, De Jing Chen, Yue Xin Zu, En Zhu Wang, Shan Shan Qi. Chondroitin Sulfate Prevents STZ Induced Diabetic Osteoporosis through Decreasing Blood Glucose, AntiOxidative Stress, Anti-Inflammation and OPG/RANKL Expression Regulation.
International journal of molecular sciences.
2020 Jul; 21(15):. doi:
10.3390/ijms21155303. [PMID: 32722636] - Roger Lawrence, Heather Prill, Preejith P Vachali, Evan G Adintori, Greg de Hart, Raymond Y Wang, Barbara K Burton, Marzia Pasquali, Brett E Crawford. Characterization of disease-specific chondroitin sulfate nonreducing end accumulation in mucopolysaccharidosis IVA.
Glycobiology.
2020 07; 30(7):433-445. doi:
10.1093/glycob/cwz109. [PMID: 31897472] - Yulia Liem, Andrew Judge, John Kirwan, Khadija Ourradi, Yunfei Li, Mohammed Sharif. Multivariable logistic and linear regression models for identification of clinically useful biomarkers for osteoarthritis.
Scientific reports.
2020 07; 10(1):11328. doi:
10.1038/s41598-020-68077-0. [PMID: 32647218] - Paulo C F da Câmara, Liszt Y C Madruga, Roberta M Sabino, Jessi Vlcek, Rosangela C Balaban, Ketul C Popat, Alessandro F Martins, Matt J Kipper. Polyelectrolyte multilayers containing a tannin derivative polyphenol improve blood compatibility through interactions with platelets and serum proteins.
Materials science & engineering. C, Materials for biological applications.
2020 Jul; 112(?):110919. doi:
10.1016/j.msec.2020.110919. [PMID: 32409070] - Zihua Zou, Ming Wei, Jie Fang, Wei Dai, Tingting Sun, Qian Liu, Guiping Gong, Yuxia Liu, Shuang Song, Fangli Ma, Langhong Wang, Linjuan Huang, Zhongfu Wang. Preparation of chondroitin sulfates with different molecular weights from bovine nasal cartilage and their antioxidant activities.
International journal of biological macromolecules.
2020 Jun; 152(?):1047-1055. doi:
10.1016/j.ijbiomac.2019.10.192. [PMID: 31751707] - Mojtaba Enayati, Mahmood Karimi Abdolmaleki, Alireza Abbaspourrad. Synthesis of Cross-Linked Spherical Polycationic Adsorbents for Enhanced Heparin Recovery.
ACS biomaterials science & engineering.
2020 05; 6(5):2822-2831. doi:
10.1021/acsbiomaterials.0c00299. [PMID: 33463302] - Charlotte K Lautrup, Keng W Teik, Ai Unzaki, Shuji Mizumoto, Delfien Syx, Heng H Sin, Irene K Nielsen, Sara Markholt, Shuhei Yamada, Fransiska Malfait, Naomichi Matsumoto, Noriko Miyake, Tomoki Kosho. Delineation of musculocontractural Ehlers-Danlos Syndrome caused by dermatan sulfate epimerase deficiency.
Molecular genetics & genomic medicine.
2020 05; 8(5):e1197. doi:
10.1002/mgg3.1197. [PMID: 32130795] - Chun-Liang Chen, S Saif Hasan, Thomas Klose, Yingyuan Sun, Geeta Buda, Chengqun Sun, William B Klimstra, Michael G Rossmann. Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues.
Proceedings of the National Academy of Sciences of the United States of America.
2020 04; 117(16):8890-8899. doi:
10.1073/pnas.1910670117. [PMID: 32245806] - Haiyue Huang, Su Liu, Jiayan Du, Jianghui Lin, Quntao Liang, Shutao Liu, Zheng Wei. Structural analysis of glycosaminoglycans from Colla corii asini by liquid chromatography-electrospray ion trap mass spectrometry.
Glycoconjugate journal.
2020 04; 37(2):201-207. doi:
10.1007/s10719-019-09904-z. [PMID: 31900724] - Abdur Rauf Khan, Xiaoye Yang, Xiyou Du, Haotong Yang, Yuanxiu Liu, Abdul Qayyum Khan, Guangxi Zhai. Chondroitin sulfate derived theranostic and therapeutic nanocarriers for tumor-targeted drug delivery.
Carbohydrate polymers.
2020 Apr; 233(?):115837. doi:
10.1016/j.carbpol.2020.115837. [PMID: 32059890] - Liyun Wang, Jiafeng Yin, Bo Yang, Chengjuan Qu, Jian Lei, Jing Han, Xiong Guo. Serious Selenium Deficiency in the Serum of Patients with Kashin-Beck Disease and the Effect of Nano-Selenium on Their Chondrocytes.
Biological trace element research.
2020 Mar; 194(1):96-104. doi:
10.1007/s12011-019-01759-7. [PMID: 31175635] - Marta Villalba, María José Linares-Sicilia, Miguel González-Andrades, Marcelina Eisman, Javier Giménez-Almenara, Manuel Arias, Rafael Villalba. In vitro susceptibility of microorganisms isolated from cold stored corneas: increased gentamicin-resistance in cornea banking.
Cell and tissue banking.
2020 Mar; 21(1):159-165. doi:
10.1007/s10561-020-09811-w. [PMID: 31980981] - Jae-Young Lee, Han Sol Lee, Nae-Won Kang, Song Yi Lee, Dong Hyun Kim, Sungyun Kim, In-Soo Yoon, Hyun-Jong Cho, Dae-Duk Kim. Blood component ridable and CD44 receptor targetable nanoparticles based on a maleimide-functionalized chondroitin sulfate derivative.
Carbohydrate polymers.
2020 Feb; 230(?):115568. doi:
10.1016/j.carbpol.2019.115568. [PMID: 31887874] - Mark W Grzanna, Rebecca Y Au, Angela Y Au, Ann M Rashmir, Carmelita G Frondoza. Avocado/Soybean Unsaponifiables, Glucosamine and Chondroitin Sulfate Combination Inhibits Proinflammatory COX-2 Expression and Prostaglandin E2 Production in Tendon-Derived Cells.
Journal of medicinal food.
2020 Feb; 23(2):139-146. doi:
10.1089/jmf.2019.0022. [PMID: 31486703] - Jiaojiao Mou, Qiang Li, Weiwei Shi, Xiaohui Qi, Weiguo Song, Jie Yang. Chain conformation, physicochemical properties of fucosylated chondroitin sulfate from sea cucumber Stichopus chloronotus and its in vitro fermentation by human gut microbiota.
Carbohydrate polymers.
2020 Jan; 228(?):115359. doi:
10.1016/j.carbpol.2019.115359. [PMID: 31635738] - Juzuo Zhang, Beini Sun, Kang Zhang, Zhilong Chen, Wenhan Yang, Guodong Wu, Li Tian, Zhonglin Xiao, Baozhen Zhang, Shiling Chen, Aiwen Le, Youhui Qian, Shaowu Ye, Rihong Zhai, Xiujun Fan. Screening and surveillance of multiple solid tumours using plasma placental-like chondroitin sulfate A (pl-CSA).
International journal of medical sciences.
2020; 17(2):161-169. doi:
10.7150/ijms.39444. [PMID: 32038099] - Daisuke Minakata, Shin-Ichiro Fujiwara, Jin Hayakawa, Hideki Nakasone, Takashi Ikeda, Shin-Ichiro Kawaguchi, Yumiko Toda, Shoko Ito, Shin-Ichi Ochi, Takashi Nagayama, Kiyomi Mashima, Kento Umino, Hirofumi Nakano, Ryoko Yamasaki, Kaoru Morita, Yasufumi Kawasaki, Miyuki Sugimoto, Yuko Ishihara, Chihiro Yamamoto, Masahiro Ashizawa, Kaoru Hatano, Kazuya Sato, Iekuni Oh, Ken Ohmine, Kazuo Muroi, Tsukasa Ohmori, Yoshinobu Kanda. Comparison of Danaparoid Sodium and Synthetic Protease Inhibitors for the Treatment of Disseminated Intravascular Coagulation Associated with Hematological Malignancies: A Retrospective Analysis.
Acta haematologica.
2020; 143(3):250-259. doi:
10.1159/000501818. [PMID: 31461700] - I A Zolotovskaya, I L Davydkin. [Antiresorptive-cytokine effects of the chondroprotective therapy in patients with lower back pain].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2020; 120(4):65-71. doi:
10.17116/jnevro202012004165. [PMID: 32490621] - Eugeni Entchev, Ingrid Jantzen, Philippe Masson, Stephanie Bocart, Bruno Bournique, Jean-Michel Luccarini, Andre Bouchot, Olivier Lacombe, Jean-Louis Junien, Pierre Broqua, Mireille Tallandier. Odiparcil, a potential glycosaminoglycans clearance therapy in mucopolysaccharidosis VI-Evidence from in vitro and in vivo models.
PloS one.
2020; 15(5):e0233032. doi:
10.1371/journal.pone.0233032. [PMID: 32413051] - Uiyoung Han, Jun-Ha Hwang, Jong-Min Lee, Hyeoni Kim, Han-Sung Jung, Jeong-Ho Hong, Jinkee Hong. Transmission and regulation of biochemical stimulus via a nanoshell directly adsorbed on the cell membrane to enhance chondrogenic differentiation of mesenchymal stem cell.
Biotechnology and bioengineering.
2020 01; 117(1):184-193. doi:
10.1002/bit.27183. [PMID: 31560128] - Takehiro Hayashi, Hajime Takatori, Rika Horii, Kouki Nio, Takeshi Terashima, Noriho Iida, Masaaki Kitahara, Tetsuro Shimakami, Kuniaki Arai, Kazuya Kitamura, Kazunori Kawaguchi, Taro Yamashita, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Honda, Tadashi Toyama, Kenichiro Okumura, Kazuto Kozaka, Shuichi Kaneko. Danaparoid sodium-based anticoagulation therapy for portal vein thrombosis in cirrhosis patients.
BMC gastroenterology.
2019 Dec; 19(1):217. doi:
10.1186/s12876-019-1140-8. [PMID: 31842768] - Guoxin Tan, Jinyu Li, Yiming Song, Yibin Yu, Dandan Liu, Weisan Pan. Phenylboronic acid-tethered chondroitin sulfate-based mucoadhesive nanostructured lipid carriers for the treatment of dry eye syndrome.
Acta biomaterialia.
2019 11; 99(?):350-362. doi:
10.1016/j.actbio.2019.08.035. [PMID: 31449929] - Antonietta Stellavato, Odile Francesca Restaino, Valentina Vassallo, Rosario Finamore, Carlo Ruosi, Elisabetta Cassese, Mario De Rosa, Chiara Schiraldi. Comparative Analyses of Pharmaceuticals or Food Supplements Containing Chondroitin Sulfate: Are Their Bioactivities Equivalent?.
Advances in therapy.
2019 11; 36(11):3221-3237. doi:
10.1007/s12325-019-01064-8. [PMID: 31494830] - Benjamin Mordmüller, Mihály Sulyok, Diane Egger-Adam, Mafalda Resende, Willem A de Jongh, Mette H Jensen, Helle Holm Smedegaard, Sisse B Ditlev, Max Soegaard, Lars Poulsen, Charlotte Dyring, Carlos Lamsfus Calle, Annette Knoblich, Javier Ibáñez, Meral Esen, Philippe Deloron, Nicaise Ndam, Saadou Issifou, Sophie Houard, Randall F Howard, Steven G Reed, Odile Leroy, Adrian J F Luty, Thor G Theander, Peter G Kremsner, Ali Salanti, Morten A Nielsen. First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2019 10; 69(9):1509-1516. doi:
10.1093/cid/ciy1140. [PMID: 30629148] - Catherine J Mitran, Angie Mena, Sedami Gnidehou, Shanna Banman, Eliana Arango, Barbara A S Lima, Hazel Lugo, Aravindhan Ganesan, Ali Salanti, Anthony K Mbonye, Francis Ntumngia, Khaled Barakat, John H Adams, Flora S Kano, Luzia H Carvalho, Amanda E Maestre, Michael F Good, Stephanie K Yanow. Antibodies to Cryptic Epitopes in Distant Homologues Underpin a Mechanism of Heterologous Immunity between Plasmodium vivax PvDBP and Plasmodium falciparum VAR2CSA.
mBio.
2019 10; 10(5):. doi:
10.1128/mbio.02343-19. [PMID: 31594821] - Yogapriya Sundaresan, Ganesh Govardhan Gaikwad, Kishan Anilkumar Prajapati, N Venkatesh Prajna, Gowri Priya Chidambaranathan. Comparison of structural integrity and functional status of corneal endothelium stored in Cornisol and Optisol-GS.
Indian journal of ophthalmology.
2019 10; 67(10):1579-1584. doi:
10.4103/ijo.ijo_2026_18. [PMID: 31546484] - Kyoung Sub Kim, Yu Seok Youn, You Han Bae. Immune-triggered cancer treatment by intestinal lymphatic delivery of docetaxel-loaded nanoparticle.
Journal of controlled release : official journal of the Controlled Release Society.
2019 10; 311-312(?):85-95. doi:
10.1016/j.jconrel.2019.08.027. [PMID: 31461664] - Marziyeh Meghdadi, Mohamad Pezeshki-Modaress, Shiva Irani, Seyed Mohammad Atyabi, Mojgan Zandi. Chondroitin sulfate immobilized PCL nanofibers enhance chondrogenic differentiation of mesenchymal stem cells.
International journal of biological macromolecules.
2019 Sep; 136(?):616-624. doi:
10.1016/j.ijbiomac.2019.06.061. [PMID: 31207331] - Susi Anheuser, Bernadette Breiden, Konrad Sandhoff. Ganglioside GM2 catabolism is inhibited by storage compounds of mucopolysaccharidoses and by cationic amphiphilic drugs.
Molecular genetics and metabolism.
2019 Sep; 128(1-2):75-83. doi:
10.1016/j.ymgme.2019.04.007. [PMID: 31097363] - Haohuan Li, Pei Zhang, Jingwen Luo, Danrong Hu, Yuan Huang, Zhi-Rong Zhang, Yao Fu, Tao Gong. Chondroitin Sulfate-Linked Prodrug Nanoparticles Target the Golgi Apparatus for Cancer Metastasis Treatment.
ACS nano.
2019 08; 13(8):9386-9396. doi:
10.1021/acsnano.9b04166. [PMID: 31375027] - Mariam Zewail, Noha Nafee, Maged W Helmy, Nabila Boraie. Coated nanostructured lipid carriers targeting the joints - An effective and safe approach for the oral management of rheumatoid arthritis.
International journal of pharmaceutics.
2019 Aug; 567(?):118447. doi:
10.1016/j.ijpharm.2019.118447. [PMID: 31226475] - Thanaporn Liangsupree, Evgen Multia, Jari Metso, Matti Jauhiainen, Patrik Forssén, Torgny Fornstedt, Katariina Öörni, Aleš Podgornik, Marja-Liisa Riekkola. Rapid affinity chromatographic isolation method for LDL in human plasma by immobilized chondroitin-6-sulfate and anti-apoB-100 antibody monolithic disks in tandem.
Scientific reports.
2019 08; 9(1):11235. doi:
10.1038/s41598-019-47750-z. [PMID: 31375727] - Pinelopi Kastana, Effrosyni Choleva, Evangelia Poimenidi, Nikos Karamanos, Kazuyuki Sugahara, Evangelia Papadimitriou. Insight into the role of chondroitin sulfate E in angiogenesis.
The FEBS journal.
2019 08; 286(15):2921-2936. doi:
10.1111/febs.14830. [PMID: 30932321] - Michael W Wood, Gregory A Barrett-Wilt. Effect of twice-daily oral administration of a chondroitin sulfate-containing supplement on urine chondroitin sulfate concentrations in dogs.
American journal of veterinary research.
2019 Aug; 80(8):799-805. doi:
10.2460/ajvr.80.8.799. [PMID: 31339761] - Makwese Maepa, Cornelius Cano Ssemakalu, Keolebogile Shirley Motaung. The Potential Chondrogenic Effect of Eucomis autumnalis Aqueous Extracts on Porcine Adipose-Derived Mesenchymal Stem Cells.
Tissue engineering. Part A.
2019 08; 25(15-16):1137-1145. doi:
10.1089/ten.tea.2018.0247. [PMID: 30511903] - Michele Carlo Schiavi, Maria Grazia Porpora, Flaminia Vena, Giovanni Prata, Valentina Sciuga, Ottavia D'Oria, Chiara Di Tucci, Delia Savone, Natalia Aleksa, Andrea Giannini, Maria Paola Nusiner, Marzio Angelo Zullo, Ludovico Muzii, Pierluigi Benedetti Panici. Orally Administered Combination of Hyaluronic Acid, Chondroitin Sulfate, Curcumin, and Quercetin in the Prevention of Postcoital Recurrent Urinary Tract Infections: Analysis of 98 Women in Reproductive Age After 6 Months of Treatment.
Female pelvic medicine & reconstructive surgery.
2019 Jul; 25(4):309-312. doi:
10.1097/spv.0000000000000560. [PMID: 29389678]
