Formestane (BioDeep_00000603882)
代谢物信息卡片
Formestane
化学式: C19H26O3 (302.1881846)
中文名称: 4-雄烯-4-醇-3,17-二酮, 福美司坦
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC(=O)C(=C1CCC3C2CCC4(C3CCC4=O)C)O
InChI: InChI=1S/C19H26O3/c1-18-10-8-15(20)17(22)14(18)4-3-11-12-5-6-16(21)19(12,2)9-7-13(11)18/h11-13,22H,3-10H2,1-2H3/t11-,12-,13-,18+,19-/m0/s1
描述信息
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02B - Hormone antagonists and related agents > L02BG - Aromatase inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
C274 - Antineoplastic Agent > C2189 - Signal Transduction Inhibitor > C129824 - Antineoplastic Protein Inhibitor
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D047072 - Aromatase Inhibitors
C274 - Antineoplastic Agent > C129818 - Antineoplastic Hormonal/Endocrine Agent > C481 - Antiestrogen
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C1740 - Aromatase Inhibitor
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
C471 - Enzyme Inhibitor > C129825 - Antineoplastic Enzyme Inhibitor
C147908 - Hormone Therapy Agent > C547 - Hormone Antagonist
D000970 - Antineoplastic Agents
同义名列表
1 个代谢物同义名
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shiyao Huang, Ziming Wu, Youyou Chen, Han Li, Linglin Zou, Alexander T Teichmann, Yao Luo, Lifeng Zhang, Lanyang Gao. Dermal repeated dose toxicity study of the anti-breast cancer drug Formestane cream in Bama minipig.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2023 Aug; 178(?):113927. doi:
10.1016/j.fct.2023.113927. [PMID: 37406756] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Nor Amira Khurshid Ahmed, Shern Kwok Lim, Ganesh N Pandian, Hiroshi Sugiyama, Chong Yew Lee, Boon Yin Khoo, Kit Lam Chan. Differentially expressed genes on the growth of mouse Leydig cells treated with standardised Eurycoma longifolia extract.
Molecular medicine reports.
2020 Nov; 22(5):3645-3658. doi:
10.3892/mmr.2020.11485. [PMID: 32901880] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Amina Cheboub, Nadia Regouat, Reda Djidjik, Assia Slimani, Fatima Hadj-Bekkouche. Short-term aromatase inhibition induces prostatic alterations in adult wistar rat: A biochemical, histopathological and immunohistochemical study.
Acta histochemica.
2019 Nov; 121(8):151441. doi:
10.1016/j.acthis.2019.151441. [PMID: 31522738] - X de la Torre, D Martinez Brito, C Colamonici, M K Parr, F Botrè. Metabolism of formestane in humans: Identification of urinary biomarkers for antidoping analysis.
Steroids.
2019 06; 146(?):34-42. doi:
10.1016/j.steroids.2019.03.005. [PMID: 30904502] - Annekathrin Martina Keiler, Oliver Zierau, Sylvi Wolf, Patrick Diel, Wilhelm Schänzer, Günter Vollmer, David Machalz, Gerhard Wolber, Maria Kristina Parr. Androgen- and estrogen-receptor mediated activities of 4-hydroxytestosterone, 4-hydroxyandrostenedione and their human metabolites in yeast based assays.
Toxicology letters.
2018 Aug; 292(?):39-45. doi:
10.1016/j.toxlet.2018.04.026. [PMID: 29702199] - Thijs Meijer, Martien L Essers, George Kaklamanos, Saskia S Sterk, Leendert A van Ginkel. Determination and confirmation of selective estrogen receptor modulators (SERMs), anti-estrogens and aromatase inhibitors in bovine and porcine urine using UHPLC-MS/MS.
Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.
2017 Apr; 34(4):641-651. doi:
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British journal of sports medicine.
2015 May; 49(9):614-22. doi:
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2015; 21(23):3395-401. doi:
10.2174/13816128113199990413. [PMID: 23782143] - Xavier de la Torre, Cristiana Colamonici, Davide Curcio, Daniel Jardines, Francesco Molaioni, Maria Kristina Parr, Francesco Botrè. Detection of formestane abuse by mass spectrometric techniques.
Drug testing and analysis.
2014 Nov; 6(11-12):1133-40. doi:
10.1002/dta.1759. [PMID: 25516450] - Myeong Hyeon Park, In Sook Kim, Sun-A Kim, Chun-Soo Na, Cheol Yi Hong, Mi-Sook Dong, Hye Hyun Yoo. Inhibitory effect of Rhus verniciflua Stokes extract on human aromatase activity; butin is its major bioactive component.
Bioorganic & medicinal chemistry letters.
2014 Apr; 24(7):1730-3. doi:
10.1016/j.bmcl.2014.02.039. [PMID: 24630560] - Michael Polet, Pieter Van Renterghem, Wim Van Gansbeke, Peter Van Eenoo. Profiling of urinary formestane and confirmation by isotope ratio mass spectrometry.
Steroids.
2013 Nov; 78(11):1103-9. doi:
10.1016/j.steroids.2013.07.011. [PMID: 23933120] - Gary N W Leung, W H Kwok, Terence S M Wan, Kenneth K H Lam, Peter J Schiff. Metabolic studies of formestane in horses.
Drug testing and analysis.
2013 Jun; 5(6):412-9. doi:
10.1002/dta.1444. [PMID: 23339113] - Thomas Piper, Gregor Fusshöller, Caroline Emery, Wilhelm Schänzer, Martial Saugy. Investigations on carbon isotope ratios and concentrations of urinary formestane.
Drug testing and analysis.
2012 Dec; 4(12):942-50. doi:
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Pharmacology, biochemistry, and behavior.
2009 Oct; 93(4):406-12. doi:
10.1016/j.pbb.2009.06.002. [PMID: 19520107] - Adam T Cawley, Graham J Trout, Rymantas Kazlauskas, Adrian V George. The detection of androstenedione abuse in sport: a mass spectrometry strategy to identify the 4-hydroxyandrostenedione metabolite.
Rapid communications in mass spectrometry : RCM.
2008 Dec; 22(24):4147-57. doi:
10.1002/rcm.3826. [PMID: 19025884] - Simone C B Gnoatto, Alexandra Dassonville-Klimpt, Sophie Da Nascimento, Philippe Galéra, Karim Boumediene, Grace Gosmann, Pascal Sonnet, Safa Moslemi. Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition.
European journal of medicinal chemistry.
2008 Sep; 43(9):1865-77. doi:
10.1016/j.ejmech.2007.11.021. [PMID: 18192087] - Lucía Martínez-Mota, José Juan Cruz-Martínez, Sergio Márquez-Baltazar, Alonso Fernández-Guasti. Estrogens participate in the antidepressant-like effect of desipramine and fluoxetine in male rats.
Pharmacology, biochemistry, and behavior.
2008 Jan; 88(3):332-40. doi:
10.1016/j.pbb.2007.09.003. [PMID: 17915301] - Shih-Min Hsia, Chih-Lan Yeh, Yueh-Hsiung Kuo, Paulus S Wang, Wenchang Chiang. Effects of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on the secretion of progesterone and estradiol in vivo and in vitro.
Experimental biology and medicine (Maywood, N.J.).
2007 Oct; 232(9):1181-94. doi:
10.3181/0612-rm-306. [PMID: 17895526] - Thomas Nisslein, Johannes Freudenstein. Coadministration of the aromatase inhibitor formestane and an isopropanolic extract of black cohosh in a rat model of chemically induced mammary carcinoma.
Planta medica.
2007 Apr; 73(4):318-22. doi:
10.1055/s-2007-967130. [PMID: 17354167] - Maxie Kohler, Maria K Parr, Georg Opfermann, Mario Thevis, Nils Schlörer, Franz-Josef Marner, Wilhelm Schänzer. Metabolism of 4-hydroxyandrostenedione and 4-hydroxytestosterone: Mass spectrometric identification of urinary metabolites.
Steroids.
2007 Mar; 72(3):278-86. doi:
10.1016/j.steroids.2006.11.018. [PMID: 17207827] - Jenifer R Prosperi, Fredika M Robertson. Cyclooxygenase-2 directly regulates gene expression of P450 Cyp19 aromatase promoter regions pII, pI.3 and pI.7 and estradiol production in human breast tumor cells.
Prostaglandins & other lipid mediators.
2006 Oct; 81(1-2):55-70. doi:
10.1016/j.prostaglandins.2006.07.003. [PMID: 16997132] - Jean-Philippe Spano, David Khayat, Thierry Delozier. [Aromatase inhibitors in adjuvant setting in breast cancer].
Bulletin du cancer.
2004 Dec; 91 Suppl 4(?):S239-43. doi:
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Pediatric endocrinology reviews : PER.
2004 Sep; 2(1):2-7. doi:
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Marine environmental research.
2004 Aug; 58(2-5):337-42. doi:
10.1016/j.marenvres.2004.03.078. [PMID: 15178051] - Nicoletta Zilembo, Emilio Bajetta, Ettore Bichisao, Antonia Martinetti, Ignazia La Torre, Paolo Bidoli, Raffaella Longarini, Tindara Portale, Ettore Seregni, Emilio Bombardieri. The estrogen suppression after sequential treatment with formestane in advanced breast cancer patients.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2004 May; 58(4):255-9. doi:
10.1016/j.biopha.2003.12.009. [PMID: 15183852] - Christian P Schneider, Martin G Schwacha, T S Anantha Samy, Kirby I Bland, Irshad H Chaudry. Androgen-mediated modulation of macrophage function after trauma-hemorrhage: central role of 5alpha-dihydrotestosterone.
Journal of applied physiology (Bethesda, Md. : 1985).
2003 Jul; 95(1):104-12. doi:
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The Journal of steroid biochemistry and molecular biology.
2003 Mar; 84(4):469-78. doi:
10.1016/s0960-0760(03)00068-2. [PMID: 12732292] - S Gupta, N Alfaidy, A C Holloway, W L Whittle, S J Lye, W Gibb, J R G Challis. Effects of cortisol and oestradiol on hepatic 11beta-hydroxysteroid dehydrogenase type 1 and glucocorticoid receptor proteins in late-gestation sheep fetus.
The Journal of endocrinology.
2003 Feb; 176(2):175-84. doi:
10.1677/joe.0.1760175. [PMID: 12553866] - T Y Tong, V H Goh. Effects of 4-hydroxyandrostenedione and hyperstimulation with pregnant mare serum gonadotrophin on early embryonic development in rats.
Canadian journal of physiology and pharmacology.
2001 Sep; 79(9):744-53. doi:
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The Journal of steroid biochemistry and molecular biology.
2001 Apr; 77(1):39-47. doi:
10.1016/s0960-0760(01)00029-2. [PMID: 11358673] - P Chavassieux, P Garnero, F Duboeuf, P Vergnaud, F Brunner-Ferber, P D Delmas, P J Meunier. Effects of a new selective estrogen receptor modulator (MDL 103,323) on cancellous and cortical bone in ovariectomized ewes: a biochemical, histomorphometric, and densitometric study.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
2001 Jan; 16(1):89-96. doi:
10.1359/jbmr.2001.16.1.89. [PMID: 11149494] - A Martinetti, L Ferrari, L Celio, L Mariani, R Miceli, N Zilembo, M Di Bartolomeo, L Toffolatti, P Pozzi, E Seregni, E Bombardieri, E Bajetta. The luteinising hormone-releasing hormone analogue triptorelin with or without the aromatase inhibitor formestane in premenopausal breast cancer: effects on bone metabolism markers.
The Journal of steroid biochemistry and molecular biology.
2000 Dec; 75(1):65-73. doi:
10.1016/s0960-0760(00)00138-2. [PMID: 11179910] - A M Brodie, V C Njar. Aromatase inhibitors and their application in breast cancer treatment*.
Steroids.
2000 Apr; 65(4):171-9. doi:
10.1016/s0039-128x(99)00104-x. [PMID: 10713305] - G Fiorelli, L Picariello, V Martineti, F Tonelli, M L Brandi. Estrogen synthesis in human colon cancer epithelial cells.
The Journal of steroid biochemistry and molecular biology.
1999 Dec; 71(5-6):223-30. doi:
10.1016/s0960-0760(99)00144-2. [PMID: 10704911] - M Dowsett, D Doody, S Miall, A Howes, J English, R C Coombes. Vorozole results in greater oestrogen suppression than formestane in postmenopausal women and when added to goserelin in premenopausal women with advanced breast cancer.
Breast cancer research and treatment.
1999 Jul; 56(1):25-34. doi:
10.1023/a:1006289811540. [PMID: 10517340] - L Celio, A Martinetti, L Ferrari, R Buzzoni, L Mariani, R Miceli, E Seregni, G Procopio, A Cassata, E Bombardieri, E Bajetta. Premenopausal breast cancer patients treated with a gonadotropin-releasing hormone analog alone or in combination with an aromatase inhibitor: a comparative endocrine study.
Anticancer research.
1999 May; 19(3B):2261-8. doi:
NULL. [PMID: 10472341] - G B Anker, H Refsum, P M Ueland, D C Johannessen, E A Lien, P E Lonning. Influence of aromatase inhibitors on plasma total homocysteine in postmenopausal breast cancer patients.
Clinical chemistry.
1999 Feb; 45(2):252-6. doi:
10.1093/clinchem/45.2.252. [PMID: 9931048] - P E Lønning. Pharmacological profiles of exemestane and formestane, steroidal aromatase inhibitors used for treatment of postmenopausal breast cancer.
Breast cancer research and treatment.
1998; 49 Suppl 1(?):S45-52; discussion S73. doi:
10.1023/a:1006048722559. [PMID: 9797017] - E Bajetta, N Zilembo, S Barni, C Noberasco, A Martinetti, L Ferrari, G Schieppati, R Buzzoni, A Jirillo, M Amichetti, M D'Aprile, G Comella, E Bichisao, G F Bolelli, A Attili, E Bombardieri. A multicentre, randomized, pharmacokinetic, endocrine and clinical study to evaluate formestane in breast cancer patients at first relapse: endocrine and clinical results. The Italian Trials in Medical Oncology (I.T.M.O.) group.
Annals of oncology : official journal of the European Society for Medical Oncology.
1997 Jul; 8(7):649-54. doi:
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Molecular endocrinology (Baltimore, Md.).
1997 Jun; 11(7):917-27. doi:
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Oncology.
1997; 54 Suppl 2(?):19-22. doi:
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Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
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Endocrinology.
1996 Dec; 137(12):5589-96. doi:
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Drugs & aging.
1996 Oct; 9(4):292-306. doi:
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The Journal of steroid biochemistry and molecular biology.
1996 Sep; 59(1):55-61. doi:
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The Journal of steroid biochemistry and molecular biology.
1996 Jul; 58(4):439-45. doi:
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The Journal of clinical endocrinology and metabolism.
1996 Jun; 81(6):2216-21. doi:
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European journal of cancer (Oxford, England : 1990).
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Cancer letters.
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The Journal of steroid biochemistry and molecular biology.
1995 Dec; 55(3-4):385-93. doi:
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The Journal of steroid biochemistry and molecular biology.
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Cancer chemotherapy and pharmacology.
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Journal of cancer research and clinical oncology.
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Tumori.
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British journal of cancer.
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British journal of cancer.
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Breast cancer research and treatment.
1994; 30(1):1-6. doi:
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Breast cancer research and treatment.
1994; 30(2):127-32. doi:
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Annals of oncology : official journal of the European Society for Medical Oncology.
1994; 5 Suppl 7(?):S15-7. doi:
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Annals of oncology : official journal of the European Society for Medical Oncology.
1994; 5 Suppl 7(?):S7-10. doi:
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1994; 5 Suppl 7(?):S3-5. doi:
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