56-Dihydrouridine (BioDeep_00000603864)

Main id: BioDeep_00000027590

 

PANOMIX_OTCML-2023


代谢物信息卡片


1-b-D-Ribofuranosylhydrouracil, Dihydrouridine , dihydro-1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione

化学式: C9H14N2O6 (246.0852)
中文名称: 5,6-二氢尿苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)O
InChI: InChI=1S/C9H14N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4,6-8,12,14-15H,1-3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1

描述信息

5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.
5,6-Dihydrouridine is a modified base found in conserved positions in the D-loop of tRNA in Bacteria, Eukaryota, and some Archaea.

同义名列表

4 个代谢物同义名

5,6-Dihydrouridine; 56-Dihydrouridine; 1-b-D-Ribofuranosylhydrouracil, Dihydrouridine , dihydro-1-b-D-Ribofuranosyl-2,4(1H,3H)-pyrimidinedione; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinane-2,4-dione



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Michelle R Denburg, Yunwen Xu, Alison G Abraham, Josef Coresh, Jingsha Chen, Morgan E Grams, Harold I Feldman, Paul L Kimmel, Casey M Rebholz, Eugene P Rhee, Ramachandran S Vasan, Bradley A Warady, Susan L Furth. Metabolite Biomarkers of CKD Progression in Children. Clinical journal of the American Society of Nephrology : CJASN. 2021 08; 16(8):1178-1189. doi: 10.2215/cjn.00220121. [PMID: 34362785]
  • Zhiger Akishev, Sabira Taipakova, Botagoz Joldybayeva, Caroline Zutterling, Izat Smekenov, Alexander A Ishchenko, Dmitry O Zharkov, Amangeldy K Bissenbaev, Murat Saparbaev. The major Arabidopsis thaliana apurinic/apyrimidinic endonuclease, ARP is involved in the plant nucleotide incision repair pathway. DNA repair. 2016 12; 48(?):30-42. doi: 10.1016/j.dnarep.2016.10.009. [PMID: 27836324]
  • Dana Ferraris, Bridget Duvall, Greg Delahanty, Bipin Mistry, Jesse Alt, Camilo Rojas, Christopher Rowbottom, Kristen Sanders, Edgar Schuck, Kuan-Chun Huang, Sanjeev Redkar, Barbara B Slusher, Takashi Tsukamoto. Design, synthesis, and pharmacological evaluation of fluorinated tetrahydrouridine derivatives as inhibitors of cytidine deaminase. Journal of medicinal chemistry. 2014 Mar; 57(6):2582-8. doi: 10.1021/jm401856k. [PMID: 24520856]
  • Wiktoria Struck, Małgorzata Waszczuk-Jankowska, Roman Kaliszan, Michał J Markuszewski. The state-of-the-art determination of urinary nucleosides using chromatographic techniques 'hyphenated' with advanced bioinformatic methods. Analytical and bioanalytical chemistry. 2011 Oct; 401(7):2039-50. doi: 10.1007/s00216-011-4789-6. [PMID: 21359827]
  • Wan-Jun Chen, Yun Bu, Antonio Carapelli, Romano Dallai, Sheng Li, Wen-Ying Yin, Yun-Xia Luan. The mitochondrial genome of Sinentomon erythranum (Arthropoda: Hexapoda: Protura): an example of highly divergent evolution. BMC evolutionary biology. 2011 Aug; 11(?):246. doi: 10.1186/1471-2148-11-246. [PMID: 21871115]
  • Jiao Yin, Gui-Yun Hong, Ai-Min Wang, Ya-Zhong Cao, Zhao-Jun Wei. Mitochondrial genome of the cotton bollworm Helicoverpa armigera (Lepidoptera: Noctuidae) and comparison with other Lepidopterans. Mitochondrial DNA. 2010 Oct; 21(5):160-9. doi: 10.3109/19401736.2010.503242. [PMID: 20958224]
  • Peng Chen, Gunilla Jäger, Bo Zheng. Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana. BMC plant biology. 2010 Sep; 10(?):201. doi: 10.1186/1471-2229-10-201. [PMID: 20836892]
  • Carsten Henneges, Dino Bullinger, Richard Fux, Natascha Friese, Harald Seeger, Hans Neubauer, Stefan Laufer, Christoph H Gleiter, Matthias Schwab, Andreas Zell, Bernd Kammerer. Prediction of breast cancer by profiling of urinary RNA metabolites using Support Vector Machine-based feature selection. BMC cancer. 2009 Apr; 9(?):104. doi: 10.1186/1471-2407-9-104. [PMID: 19344524]
  • André B P van Kuilenburg, Henk van Lenthe, Arno van Cruchten, Willem Kulik. Quantification of 5,6-dihydrouracil by HPLC-electrospray tandem mass spectrometry. Clinical chemistry. 2004 Jan; 50(1):236-8. doi: 10.1373/clinchem.2003.026229. [PMID: 14709662]
  • J Vogel, W R Hess. Complete 5' and 3' end maturation of group II intron-containing tRNA precursors. RNA (New York, N.Y.). 2001 Feb; 7(2):285-92. doi: 10.1017/s1355838201001960. [PMID: 11233985]
  • H Topp, R Duden, G Schöch. 5,6-Dihydrouridine: a marker ribonucleoside for determining whole body degradation rates of transfer RNA in man and rats. Clinica chimica acta; international journal of clinical chemistry. 1993 Sep; 218(1):73-82. doi: 10.1016/0009-8981(93)90223-q. [PMID: 8299222]
  • K Nakano, T Yasaka, K H Schram, M L Reimer, T D McClure, T Nakao, H Yamamoto. Isolation and identification of urinary nucleosides. Applications of high-performance liquid chromatographic methods to the synthesis of 5'-deoxyxanthosine and the simultaneous determination of 5,6-dihydrouridine and pseudouridine. Journal of chromatography. 1990 Aug; 515(?):537-46. doi: 10.1016/s0021-9673(01)89352-3. [PMID: 2283377]
  • M L Reimer, K H Schram, K Nakano, T Yasaka. The identification of 5,6-dihydrouridine in normal human urine by combined gas chromatography/mass spectrometry. Analytical biochemistry. 1989 Sep; 181(2):302-8. doi: 10.1016/0003-2697(89)90247-9. [PMID: 2817393]