2,8-Dihydroxyadenine (BioDeep_00000603628)
Main id: BioDeep_00000025205
代谢物信息卡片
2,8-Dihydroxyadenine
化学式: C5H5N5O2 (167.04432300000002)
中文名称: 2,8-二羟基腺嘌呤
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C12=C(NC(=O)N=C1NC(=O)N2)N
InChI: InChI=1S/C5H5N5O2/c6-2-1-3(9-4(11)7-1)10-5(12)8-2/h(H5,6,7,8,9,10,11,12)
描述信息
A member of the class of 6-aminopurines that is adenine bearing two hydroxy substituents at positions 2 and 8. It is a highly insoluble metabolite of adenine that causes radiolucent urolithiasis. It is produced by individuals who suffer from adenine phosphoribosyltransferase (APRT) deficiency, a rare autosomal recessive error of purine metabolism.
同义名列表
1 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:183641
- ChEBI: CHEBI:179632
- PubChem: 92268
- Metlin: METLIN5390
- CAS: 1022140-21-1
- CAS: 30377-37-8
- MetaboLights: MTBLC183641
- KEGG: C22500
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Julia Moellmann, Katja Krueger, Dickson W L Wong, Barbara M Klinkhammer, Eva M Buhl, Jonas Dehairs, Johan V Swinnen, Heidi Noels, Joachim Jankowski, Corinna Lebherz, Peter Boor, Nikolaus Marx, Michael Lehrke. 2,8-Dihydroxyadenine-induced nephropathy causes hexosylceramide accumulation with increased mTOR signaling, reduced levels of protective SirT3 expression and impaired renal mitochondrial function.
Biochimica et biophysica acta. Molecular basis of disease.
2023 Aug; ?(?):166825. doi:
10.1016/j.bbadis.2023.166825. [PMID: 37536502] - Yamei Cheng, Luying Guo, Meifang Wang, Jianghua Chen, Rending Wang. Recurrence of 2,8-dihydroxyadenine Crystalline Nephropathy in a Kidney Transplant Recipient: A Case Report and Literature Review.
Internal medicine (Tokyo, Japan).
2021 Aug; 60(16):2651-2657. doi:
10.2169/internalmedicine.6640-20. [PMID: 33678741] - Jyotsna Yesodharan, N V Seethalekshmy, Rajesh R Nair. Recurrent DHA nephropathy in renal allograft-revisiting clinicopathological aspects of a rare entity.
Indian journal of pathology & microbiology.
2021 Jul; 64(3):504-508. doi:
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Urolithiasis.
2020 Aug; 48(4):337-344. doi:
10.1007/s00240-020-01187-6. [PMID: 32399606] - Barbara Mara Klinkhammer, Sonja Djudjaj, Uta Kunter, Runolfur Palsson, Vidar Orn Edvardsson, Thorsten Wiech, Margret Thorsteinsdottir, Sverrir Hardarson, Orestes Foresto-Neto, Shrikant R Mulay, Marcus Johannes Moeller, Wilhelm Jahnen-Dechent, Jürgen Floege, Hans-Joachim Anders, Peter Boor. Cellular and Molecular Mechanisms of Kidney Injury in 2,8-Dihydroxyadenine Nephropathy.
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