Trichostatin A (BioDeep_00000602161)
PANOMIX_OTCML-2023
代谢物信息卡片
7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide
化学式: C17H22N2O3 (302.16303419999997)
中文名称: 曲古柳菌素A
谱图信息:
最多检出来源 Chinese Herbal Medicine(otcml) 6%
分子结构信息
SMILES: CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C
InChI: InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1
描述信息
D004791 - Enzyme Inhibitors > D056572 - Histone Deacetylase Inhibitors
D004791 - Enzyme Inhibitors > D011500 - Protein Synthesis Inhibitors
C471 - Enzyme Inhibitor > C1946 - Histone Deacetylase Inhibitor
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
Trichostatin A (TSA) is a potent and specific inhibitor of HDAC class I/II, with an IC50 value of 1.8 nM for HDAC[1].
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:46024
- ChEBI: CHEBI:93196
- PubChem: 444732
- Metlin: METLIN46755
- DrugBank: DB04297
- CAS: 58880-19-6
- MetaboLights: MTBLC46024
- medchemexpress: HY-15144
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Katarzyna Nowak, Barbara Wójcikowska, Monika Gajecka, Anna Elżbieciak, Joanna Morończyk, Anna M Wójcik, Przemysław Żemła, Sylvie Citerne, Agnieszka Kiwior-Wesołowska, Justyna Zbieszczyk, Małgorzata D Gaj. The improvement of the in vitro plant regeneration in barley with the epigenetic modifier of histone acetylation, trichostatin A.
Journal of applied genetics.
2024 Feb; 65(1):13-30. doi:
10.1007/s13353-023-00800-9. [PMID: 37962803] - Jing Yan, Yingqun Nian, Bo Zou, Juqing Wu, Guanghong Zhou, Chunbao Li. Acetylation inhibition alleviates energy metabolism in muscles of minipigs varying with the type of muscle fibers.
Meat science.
2022 Feb; 184(?):108699. doi:
10.1016/j.meatsci.2021.108699. [PMID: 34700176] - Xiang Qiu, Lv Zhu, Huan Wang, Yan Tan, Zhuang Yang, Linyu Yang, Li Wan. From natural products to HDAC inhibitors: An overview of drug discovery and design strategy.
Bioorganic & medicinal chemistry.
2021 12; 52(?):116510. doi:
10.1016/j.bmc.2021.116510. [PMID: 34826681] - Seung Hee Choi, Myoung Hui Lee, Da Mon Jin, Su Ji Ju, Woo Seok Ahn, Eun Yee Jie, Ji Min Lee, Jiyoung Lee, Cha Young Kim, Suk Weon Kim. TSA Promotes CRISPR/Cas9 Editing Efficiency and Expression of Cell Division-Related Genes from Plant Protoplasts.
International journal of molecular sciences.
2021 Jul; 22(15):. doi:
10.3390/ijms22157817. [PMID: 34360584] - Xin Lv, Jun Qiu, Tao Hao, Haoran Zhang, Haiping Jiang, Yang Tan. HDAC inhibitor Trichostatin A suppresses adipogenesis in 3T3-L1 preadipocytes.
Aging.
2021 07; 13(13):17489-17498. doi:
10.18632/aging.203238. [PMID: 34232916] - Xiaoli Liao, Yue Li, Zhenzhu Hu, Ying Lin, Bo Zheng, Jihua Ding. Poplar acetylome profiling reveals lysine acetylation dynamics in seasonal bud dormancy release.
Plant, cell & environment.
2021 06; 44(6):1830-1845. doi:
10.1111/pce.14040. [PMID: 33675080] - Omid Karami, Arezoo Rahimi, Patrick Mak, Anneke Horstman, Kim Boutilier, Monique Compier, Bert van der Zaal, Remko Offringa. An Arabidopsis AT-hook motif nuclear protein mediates somatic embryogenesis and coinciding genome duplication.
Nature communications.
2021 05; 12(1):2508. doi:
10.1038/s41467-021-22815-8. [PMID: 33947865] - Arathi Jayaraman, Tong Zhou, Sundararajan Jayaraman. Histone Modifier Differentially Regulates Gene Expression and Unravels Survival Role of MicroRNA-494 in Jurkat Leukemia.
MicroRNA (Shariqah, United Arab Emirates).
2021; 10(1):39-50. doi:
10.2174/2211536610666210412153322. [PMID: 33845753] - Xiao Min Bie, Luhao Dong, Xiao Hui Li, He Wang, Xi-Qi Gao, Xing Guo Li. Trichostatin A and sodium butyrate promotes plant regeneration in common wheat.
Plant signaling & behavior.
2020 12; 15(12):1820681. doi:
10.1080/15592324.2020.1820681. [PMID: 32962515] - Ryohei Yamamoto, Mitsuru Saito, Takuro Saito, Ryuichiro Sagehashi, Atsushi Koizumi, Taketoshi Nara, Sohei Kanda, Kazuyuki Numakura, Shintaro Narita, Takamitsu Inoue, Shigeru Satoh, Tomonori Habuchi. Treg expansion with trichostatin A ameliorates kidney ischemia/reperfusion injury in mice by suppressing the expression of costimulatory molecules.
Transplant immunology.
2020 12; 63(?):101330. doi:
10.1016/j.trim.2020.101330. [PMID: 32896615] - Jianyin Long, Daniel L Galvan, Koki Mise, Yashpal S Kanwar, Li Li, Naravat Poungavrin, Paul A Overbeek, Benny H Chang, Farhad R Danesh. Role for carbohydrate response element-binding protein (ChREBP) in high glucose-mediated repression of long noncoding RNA Tug1.
The Journal of biological chemistry.
2020 11; 295(47):15840-15852. doi:
10.1074/jbc.ra120.013228. [PMID: 32467232] - Qi Gao, Ai Wei, Fang Chen, Xingren Chen, Wenwen Ding, Zhiquan Ding, Zhiwei Wu, Ronghui Du, Wangsen Cao. Enhancing PPARγ by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice.
Pharmacological research.
2020 10; 160(?):105059. doi:
10.1016/j.phrs.2020.105059. [PMID: 32621955] - Kai Yan, Maolin Ran, Shengnan Li, Junli Zhang, Yu Wang, Zhimin Wang, Dayong Wei, Qinglin Tang. The delayed senescence of postharvest buds in salt ions was related to antioxidant activity, HDA9 and CCX1 in broccoli (Brassica oleracea L. var. Italic Planch.).
Food chemistry.
2020 Sep; 324(?):126887. doi:
10.1016/j.foodchem.2020.126887. [PMID: 32339788] - Haidao Zhang, Fu Guo, Peipei Qi, Yizi Huang, Yongyao Xie, Lei Xu, Ning Han, Lin Xu, Hongwu Bian. OsHDA710-Mediated Histone Deacetylation Regulates Callus Formation of Rice Mature Embryo.
Plant & cell physiology.
2020 Sep; 61(9):1646-1660. doi:
10.1093/pcp/pcaa086. [PMID: 32592489] - Blanca L Valle, Sebastian Rodriguez-Torres, Elisabetta Kuhn, Teresa Díaz-Montes, Edgardo Parrilla-Castellar, Fahcina P Lawson, Oluwasina Folawiyo, Carmen Ili-Gangas, Priscilla Brebi-Mieville, James R Eshleman, James Herman, Ie-Ming Shih, David Sidransky, Rafael Guerrero-Preston. HIST1H2BB and MAGI2 Methylation and Somatic Mutations as Precision Medicine Biomarkers for Diagnosis and Prognosis of High-grade Serous Ovarian Cancer.
Cancer prevention research (Philadelphia, Pa.).
2020 09; 13(9):783-794. doi:
10.1158/1940-6207.capr-19-0412. [PMID: 32581010] - Wei-Cheng Tseng, Ming-Tsun Tsai, Nien-Jung Chen, Der-Cherng Tarng. Trichostatin A Alleviates Renal Interstitial Fibrosis Through Modulation of the M2 Macrophage Subpopulation.
International journal of molecular sciences.
2020 Aug; 21(17):. doi:
10.3390/ijms21175966. [PMID: 32825118] - Ying Xie, Sui Ke, Jingshu Chen, Nengtai Ouyang, Yanan Tian. Epigenetic sensitization of pregnane X receptor-regulated gene expression by dimethyl sulfoxide.
Toxicology letters.
2020 Mar; 321(?):131-137. doi:
10.1016/j.toxlet.2019.12.029. [PMID: 31877331] - Ian Henry Lambert, Dorthe Nielsen, Stefan Stürup. Impact of the histone deacetylase inhibitor trichostatin A on active uptake, volume-sensitive release of taurine, and cell fate in human ovarian cancer cells.
American journal of physiology. Cell physiology.
2020 03; 318(3):C581-C597. doi:
10.1152/ajpcell.00460.2019. [PMID: 31913698] - Rayan Awada, Dorothée Verdier, Solène Froger, Eric Brulard, Simone de Faria Maraschin, Hervé Etienne, David Breton. An innovative automated active compound screening system allows high-throughput optimization of somatic embryogenesis in Coffea arabica.
Scientific reports.
2020 01; 10(1):810. doi:
10.1038/s41598-020-57800-6. [PMID: 31965007] - Andrew E Shouksmith, Justyna M Gawel, Nabanita Nawar, Diana Sina, Yasir S Raouf, Shazreh Bukhari, Liying He, Alexandra E Johns, Pimyupa Manaswiyoungkul, Olasunkanmi O Olaoye, Aaron D Cabral, Abootaleb Sedighi, Elvin D de Araujo, Patrick T Gunning. Class I/IIb-Selective HDAC Inhibitor Exhibits Oral Bioavailability and Therapeutic Efficacy in Acute Myeloid Leukemia.
ACS medicinal chemistry letters.
2020 Jan; 11(1):56-64. doi:
10.1021/acsmedchemlett.9b00471. [PMID: 31938464] - Hiromi Sato. [Linkage of Drug Resistance and Metabolome Shift in Renal Cell Carcinoma Cells].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2020; 140(8):963-968. doi:
10.1248/yakushi.20-00012-1. [PMID: 32741869] - Wenjuan Jiang, Xinrong Yuan, Hong Zhu, Changsheng He, Caiqiong Ge, Qing Tang, Chuanting Xu, Bingfeng Hu, Cheng Huang, Taotao Ma. Inhibition of Histone H3K27 Acetylation Orchestrates Interleukin-9-Mediated and Plays an Anti-Inflammatory Role in Cisplatin-Induced Acute Kidney Injury.
Frontiers in immunology.
2020; 11(?):231. doi:
10.3389/fimmu.2020.00231. [PMID: 32194547] - Morag K Mansley, Andrew J Roe, Sarah L Francis, Jason H Gill, Matthew A Bailey, Stuart M Wilson. Trichostatin A blocks aldosterone-induced Na+ transport and control of serum- and glucocorticoid-inducible kinase 1 in cortical collecting duct cells.
British journal of pharmacology.
2019 12; 176(24):4708-4719. doi:
10.1111/bph.14837. [PMID: 31423568] - Shu-Nan Cui, Zhao-Yuan Chen, Xiao-Bo Yang, Lin Chen, Yi-Yi Yang, Shang-Wen Pan, Ya-Xin Wang, Ji-Qian Xu, Ting Zhou, Hai-Rong Xiao, Lu Qin, Shi-Ying Yuan, You Shang. Trichostatin A modulates the macrophage phenotype by enhancing autophagy to reduce inflammation during polymicrobial sepsis.
International immunopharmacology.
2019 Dec; 77(?):105973. doi:
10.1016/j.intimp.2019.105973. [PMID: 31677992] - Gabriela Lochmanová, Ivana Ihnatová, Hana Kuchaříková, Sylva Brabencová, Dagmar Zachová, Jiří Fajkus, Zbyněk Zdráhal, Miloslava Fojtová. Different Modes of Action of Genetic and Chemical Downregulation of Histone Deacetylases with Respect to Plant Development and Histone Modifications.
International journal of molecular sciences.
2019 Oct; 20(20):. doi:
10.3390/ijms20205093. [PMID: 31615119] - Yanan Zhu, Haiyun Chen, Xiaoqi Zhao, Bin Li, Hangyuan He, Hui Cheng, Hui Wang, Ying Ao. Decreased H3K9ac level of KLF4 mediates podocyte developmental toxicity induced by prenatal caffeine exposure in male offspring rats.
Toxicology letters.
2019 Oct; 314(?):63-74. doi:
10.1016/j.toxlet.2019.07.011. [PMID: 31306741] - Xin Li, Qian Yu. PON1 hypermethylation is associated with progression of renal cell carcinoma.
Journal of cellular and molecular medicine.
2019 10; 23(10):6646-6657. doi:
10.1111/jcmm.14537. [PMID: 31400051] - Chao Huang, Xiao-Fen Wu, Xiu-Lian Wang. Trichostatin a inhibits phenotypic transition and induces apoptosis of the TAF-treated normal colonic epithelial cells through regulation of TGF-β pathway.
The international journal of biochemistry & cell biology.
2019 09; 114(?):105565. doi:
10.1016/j.biocel.2019.105565. [PMID: 31278993] - Yu Ran Lee, Hee Kyoung Joo, Eun Ok Lee, Hyun Sil Cho, Sunga Choi, Cuk-Seong Kim, Byeong Hwa Jeon. ATP Binding Cassette Transporter A1 is Involved in Extracellular Secretion of Acetylated APE1/Ref-1.
International journal of molecular sciences.
2019 Jun; 20(13):. doi:
10.3390/ijms20133178. [PMID: 31261750] - Cláudia Braga, Ana R Vaz, M Conceição Oliveira, M Matilde Marques, Rui Moreira, Dora Brites, Maria J Perry. Targeting gliomas with triazene-based hybrids: Structure-activity relationship, mechanistic study and stability.
European journal of medicinal chemistry.
2019 Jun; 172(?):16-25. doi:
10.1016/j.ejmech.2019.03.048. [PMID: 30939350] - Janis Szeremeta, Jessica Karlsson, Mireille Alhouayek, Christopher J Fowler. Low mRNA expression and activity of monoacylglycerol lipase in human SH-SY5Y neuroblastoma cells.
Prostaglandins & other lipid mediators.
2019 06; 142(?):59-67. doi:
10.1016/j.prostaglandins.2019.04.003. [PMID: 30978461] - Ioannis-Dimosthenis S Adamakis, Emmanuel Panteris, Eleftherios P Eleftheriou. Tubulin Acetylation Mediates Bisphenol A Effects on the Microtubule Arrays of Allium cepa and Triticum turgidum.
Biomolecules.
2019 05; 9(5):. doi:
10.3390/biom9050185. [PMID: 31083539] - Ramya T Kolli, Travis C Glenn, Bradley T Brown, Sukhneeraj P Kaur, Lillie M Barnett, Lawrence H Lash, Brian S Cummings. Bromate-induced Changes in p21 DNA Methylation and Histone Acetylation in Renal Cells.
Toxicological sciences : an official journal of the Society of Toxicology.
2019 04; 168(2):460-473. doi:
10.1093/toxsci/kfz016. [PMID: 30649504] - B-H Bin, S-H Lee, J Bhin, T Irié, S Kim, J Seo, K Mishima, T R Lee, D Hwang, T Fukada, E-G Cho. The epithelial zinc transporter ZIP10 epigenetically regulates human epidermal homeostasis by modulating histone acetyltransferase activity.
The British journal of dermatology.
2019 04; 180(4):869-880. doi:
10.1111/bjd.17339. [PMID: 30339739] - Hiromi Sato, Miaki Uzu, Tatsuro Kashiba, Takuya Fujiwara, Hiroto Hatakeyama, Koichi Ueno, Akihiro Hisaka. Trichostatin A modulates cellular metabolism in renal cell carcinoma to enhance sunitinib sensitivity.
European journal of pharmacology.
2019 Mar; 847(?):143-157. doi:
10.1016/j.ejphar.2019.01.040. [PMID: 30689992] - Chih-Cheng Chang, Kuo-How Huang, Sung-Po Hsu, Yuan-Chii G Lee, Yuh-Mou Sue, Shu-Hui Juan. Simvastatin reduces the carcinogenic effect of 3-methylcholanthrene in renal epithelial cells through histone deacetylase 1 inhibition and RhoA reactivation.
Scientific reports.
2019 03; 9(1):4606. doi:
10.1038/s41598-019-40757-6. [PMID: 30872677] - Yanxiang Shao, Zhenhua Liu, Jianbang Liu, Haizhou Wang, Long Huang, Tianhai Lin, Jiyan Liu, Qiang Wei, Hao Zeng, Gu He, Xiang Li. Expression and epigenetic regulatory mechanism of BNIP3 in clear cell renal cell carcinoma.
International journal of oncology.
2019 01; 54(1):348-360. doi:
10.3892/ijo.2018.4603. [PMID: 30365137] - Min Liu, Biao Chen, Linguo Pei, Qi Zhang, Yunfei Zou, Hao Xiao, Jin Zhou, Liaobin Chen, Hui Wang. Decreased H3K9ac level of StAR mediated testicular dysplasia induced by prenatal dexamethasone exposure in male offspring rats.
Toxicology.
2018 09; 408(?):1-10. doi:
10.1016/j.tox.2018.06.005. [PMID: 29902490] - Diego Uribe, Andres Cardona, Davide Degli Esposti, Marie-Pierre Cros, Cyrille Cuenin, Zdenko Herceg, Mauricio Camargo, Fabian M Cortés-Mancera. Antiproliferative Effects of Epigenetic Modifier Drugs Through E-cadherin Up-regulation in Liver Cancer Cell Lines.
Annals of hepatology.
2018 May; 17(3):444-460. doi:
10.5604/01.3001.0011.7389. [PMID: 29735783] - Rika Azuma, Kei Miyamoto, Mami Oikawa, Masayasu Yamada, Masayuki Anzai. Combinational Treatment of Trichostatin A and Vitamin C Improves the Efficiency of Cloning Mice by Somatic Cell Nuclear Transfer.
Journal of visualized experiments : JoVE.
2018 04; ?(134):. doi:
10.3791/57036. [PMID: 29757287] - Mingjie Xing, Xiumin Chen, Xiaoxia Li, Yifeng Yang, Xiaoxu Wang, Xinyan Cao, Hailong Xue, Shiyong Wang, Yunfei Diao, Weigang Zhao, Meng Zhao, Xuezhe Cui, Tong Chang, Baozeng Xu, Haijun Wei. Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose.
Cell biology international.
2018 Mar; 42(3):324-333. doi:
10.1002/cbin.10899. [PMID: 29064603] - Jing Liu, Man J Livingston, Guie Dong, Chengyuan Tang, Yunchao Su, Guangyu Wu, Xiao-Ming Yin, Zheng Dong. Histone deacetylase inhibitors protect against cisplatin-induced acute kidney injury by activating autophagy in proximal tubular cells.
Cell death & disease.
2018 02; 9(3):322. doi:
10.1038/s41419-018-0374-7. [PMID: 29476062] - Mao-Hua Cai, Xiao-Gang Xu, Shi-Li Yan, Ze Sun, Yin Ying, Bai-Kui Wang, Yue-Xing Tu. Depletion of HDAC1, 7 and 8 by Histone Deacetylase Inhibition Confers Elimination of Pancreatic Cancer Stem Cells in Combination with Gemcitabine.
Scientific reports.
2018 01; 8(1):1621. doi:
10.1038/s41598-018-20004-0. [PMID: 29374219] - Luca Palazzese, Marta Czernik, Domenico Iuso, Paola Toschi, Pasqualino Loi. Nuclear quiescence and histone hyper-acetylation jointly improve protamine-mediated nuclear remodeling in sheep fibroblasts.
PloS one.
2018; 13(3):e0193954. doi:
10.1371/journal.pone.0193954. [PMID: 29543876] - Chun-Wu Tung, Yung-Chien Hsu, Chang-Jhih Cai, Ya-Hsueh Shih, Ching-Jen Wang, Pey-Jium Chang, Chun-Liang Lin. Trichostatin A ameliorates renal tubulointerstitial fibrosis through modulation of the JNK-dependent Notch-2 signaling pathway.
Scientific reports.
2017 11; 7(1):14495. doi:
10.1038/s41598-017-15162-6. [PMID: 29101337] - Yuan Song, Lijun Liu, Gaopeng Li, Lizhe An, Lining Tian. Trichostatin A and 5-Aza-2'-Deoxycytidine influence the expression of cold-induced genes in Arabidopsis.
Plant signaling & behavior.
2017 Nov; 12(11):e1389828. doi:
10.1080/15592324.2017.1389828. [PMID: 29027833] - Fengying Jiang, Daria Ryabova, Jeremie Diedhiou, Pierre Hucl, Harpinder Randhawa, Elizabeth-France Marillia, Nora A Foroud, Francois Eudes, Palak Kathiria. Trichostatin A increases embryo and green plant regeneration in wheat.
Plant cell reports.
2017 Nov; 36(11):1701-1706. doi:
10.1007/s00299-017-2183-3. [PMID: 28752355] - Taotao Ma, Cheng Huang, Qingqing Xu, Yang Yang, Yaru Liu, Xiaoming Meng, Jun Li, Min Ye, Hong Liang. Suppression of BMP-7 by histone deacetylase 2 promoted apoptosis of renal tubular epithelial cells in acute kidney injury.
Cell death & disease.
2017 10; 8(10):e3139. doi:
10.1038/cddis.2017.552. [PMID: 29072686] - Markus Hartl, Magdalena Füßl, Paul J Boersema, Jan-Oliver Jost, Katharina Kramer, Ahmet Bakirbas, Julia Sindlinger, Magdalena Plöchinger, Dario Leister, Glen Uhrig, Greg Bg Moorhead, Jürgen Cox, Michael E Salvucci, Dirk Schwarzer, Matthias Mann, Iris Finkemeier. Lysine acetylome profiling uncovers novel histone deacetylase substrate proteins in Arabidopsis.
Molecular systems biology.
2017 10; 13(10):949. doi:
10.15252/msb.20177819. [PMID: 29061669] - Ashley L Green, Le Zhan, Aseel Eid, Helmut Zarbl, Grace L Guo, Jason R Richardson. Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1.
Neuropharmacology.
2017 Oct; 125(?):189-196. doi:
10.1016/j.neuropharm.2017.07.020. [PMID: 28743636] - Wenjun Lin, Qin Zhang, Lin Liu, Shasha Yin, Zhihong Liu, Wangsen Cao. Klotho restoration via acetylation of Peroxisome Proliferation-Activated Receptor γ reduces the progression of chronic kidney disease.
Kidney international.
2017 09; 92(3):669-679. doi:
10.1016/j.kint.2017.02.023. [PMID: 28416226] - Pooja Pandey, Diaa S Daghma, Andreas Houben, Jochen Kumlehn, Michael Melzer, Twan Rutten. Dynamics of post-translationally modified histones during barley pollen embryogenesis in the presence or absence of the epi-drug trichostatin A.
Plant reproduction.
2017 06; 30(2):95-105. doi:
10.1007/s00497-017-0302-5. [PMID: 28526911] - Alexander Mengel, Alexandra Ageeva, Elisabeth Georgii, Jörg Bernhardt, Keqiang Wu, Jörg Durner, Christian Lindermayr. Nitric Oxide Modulates Histone Acetylation at Stress Genes by Inhibition of Histone Deacetylases.
Plant physiology.
2017 02; 173(2):1434-1452. doi:
10.1104/pp.16.01734. [PMID: 27980017] - Felipe Aquea, Tania Timmermann, Ariel Herrera-Vásquez. Chemical inhibition of the histone acetyltransferase activity in Arabidopsis thaliana.
Biochemical and biophysical research communications.
2017 01; 483(1):664-668. doi:
10.1016/j.bbrc.2016.12.086. [PMID: 27993678] - Elizabeth A Mazzio, Karam F A Soliman. HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells.
Cancer genomics & proteomics.
2017 01; 14(1):17-33. doi:
10.21873/cgp.20016. [PMID: 28031235] - Xi-Feng Zhang, Feng-Hua Huang, Guo-Liang Zhang, Ding-Ping Bai, De Felici Massimo, Yi-Fan Huang, Sangiliyandi Gurunathan. Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3).
International journal of nanomedicine.
2017; 12(?):7551-7575. doi:
10.2147/ijn.s144161. [PMID: 29075115] - Yu-Wei Chang, Kamaleshwar P Singh. Long-term exposure to estrogen enhances chemotherapeutic efficacy potentially through epigenetic mechanism in human breast cancer cells.
PloS one.
2017; 12(3):e0174227. doi:
10.1371/journal.pone.0174227. [PMID: 28323900] - Thierry Buchou, Minjia Tan, Sophie Barral, Anne-Laure Vitte, Sophie Rousseaux, Juan Arechaga, Saadi Khochbin. Purification and Analysis of Male Germ Cells from Adult Mouse Testis.
Methods in molecular biology (Clifton, N.J.).
2017; 1510(?):159-168. doi:
10.1007/978-1-4939-6527-4_12. [PMID: 27761820] - Sin Y Choi, Hae J Kee, Thomas Kurz, Finn K Hansen, Yuhee Ryu, Gwi R Kim, Ming Q Lin, Li Jin, Zhe H Piao, Myung H Jeong. Class I HDACs specifically regulate E-cadherin expression in human renal epithelial cells.
Journal of cellular and molecular medicine.
2016 12; 20(12):2289-2298. doi:
10.1111/jcmm.12919. [PMID: 27420561] - N E Scholpa, R T Kolli, M Moore, R D Arnold, T C Glenn, B S Cummings. Nephrotoxicity of epigenetic inhibitors used for the treatment of cancer.
Chemico-biological interactions.
2016 Oct; 258(?):21-9. doi:
10.1016/j.cbi.2016.08.010. [PMID: 27543423] - Kazuma Yagi, Makoto Ishii, Ho Namkoong, Hideki Fujii, Takahiro Asami, Shoji Suzuki, Takanori Asakura, Kosuke Mizoguchi, Tetsuro Kamo, Sadatomo Tasaka, Satoshi Iwata, Steven L Kunkel, Naoki Hasegawa, Tomoko Betsuyaku. Histone Deacetylase Inhibition Protects Mice Against Lethal Postinfluenza Pneumococcal Infection.
Critical care medicine.
2016 10; 44(10):e980-7. doi:
10.1097/ccm.0000000000001821. [PMID: 27352127] - Viviana Vargas-López, Marisol R Lamprea, Alejandro Múnera. Histone deacetylase inhibition abolishes stress-induced spatial memory impairment.
Neurobiology of learning and memory.
2016 10; 134 Pt B(?):328-38. doi:
10.1016/j.nlm.2016.08.009. [PMID: 27544851] - Tetsuo Adachi, Ayame Kano, Saho Nonomura, Tetsuro Kamiya, Hirokazu Hara. Histone deacetylase inhibitors stimulate the susceptibility of A549 cells to a plasma-activated medium treatment.
Archives of biochemistry and biophysics.
2016 09; 606(?):120-7. doi:
10.1016/j.abb.2016.07.019. [PMID: 27470189] - Nian-Hua Zhang, Rui-Qing Peng, Ya Ding, Xiao-Shi Zhang. Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells.
Oncology reports.
2016 Aug; 36(2):715-20. doi:
10.3892/or.2016.4870. [PMID: 27373420] - Hong Ping Zhang, Lei Wang, Juan Juan Fu, Tao Fan, Zeng Li Wang, Gang Wang. Association between histone hyperacetylation status in memory T lymphocytes and allergen-induced eosinophilic airway inflammation.
Respirology (Carlton, Vic.).
2016 07; 21(5):850-7. doi:
10.1111/resp.12774. [PMID: 26991676] - Christopher J Clarke, Achraf A Shamseddine, Joseph J Jacob, Gabrielle Khalife, Tara A Burns, Yusuf A Hannun. ATRA transcriptionally induces nSMase2 through CBP/p300-mediated histone acetylation.
Journal of lipid research.
2016 05; 57(5):868-81. doi:
10.1194/jlr.m067447. [PMID: 27013100] - L L Hong, K Yu, Q X Yan, X Xu, Y F Shi, H P Ge. [Effect of hydroquinone on the histone deacetylase in human bone marrow mononuclear cells].
Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases.
2016 Mar; 34(3):189-93. doi:
10.3760/cma.j.issn.1001-9391.2016.03.007. [PMID: 27220438] - Xujun Ma, Chao Zhang, Bing Zhang, Chuanping Yang, Shujuan Li. Identification of genes regulated by histone acetylation during root development in Populus trichocarpa.
BMC genomics.
2016 Feb; 17(?):96. doi:
10.1186/s12864-016-2407-x. [PMID: 26847576] - Qin Dai, Jian Liu, Yun-lei Du, Xu Hao, Ji Ying, Yun Tan, Li-qun He, Wei-ming Wang, Nan Chen. Histone deacetylase inhibitors attenuate P-aIgA1-induced cell proliferation and extracellular matrix synthesis in human renal mesangial cells in vitro.
Acta pharmacologica Sinica.
2016 Feb; 37(2):228-34. doi:
10.1038/aps.2015.79. [PMID: 26775659] - Kyounghee Lee, Ok-Sun Park, Su-Jin Jung, Pil Joon Seo. Histone deacetylation-mediated cellular dedifferentiation in Arabidopsis.
Journal of plant physiology.
2016 Feb; 191(?):95-100. doi:
10.1016/j.jplph.2015.12.006. [PMID: 26724747] - Punithavathi Ranganathan, Rania Hamad, Riyaz Mohamed, Calpurnia Jayakumar, Thangaraju Muthusamy, Ganesan Ramesh. Histone deacetylase–mediated silencing of AMWAP expression contributes to cisplatin nephrotoxicity.
Kidney international.
2016 Feb; 89(2):317-26. doi:
10.1038/ki.2015.326. [PMID: 26509586] - Ling Li, François Bonneton, Marie Tohme, Laure Bernard, Xiao Yong Chen, Vincent Laudet. In Vivo Screening Using Transgenic Zebrafish Embryos Reveals New Effects of HDAC Inhibitors Trichostatin A and Valproic Acid on Organogenesis.
PloS one.
2016; 11(2):e0149497. doi:
10.1371/journal.pone.0149497. [PMID: 26900852] - Kimberly P Keil, Helene M Altmann, Lisa L Abler, Laura L Hernandez, Chad M Vezina. Histone acetylation regulates prostate ductal morphogenesis through a bone morphogenetic protein-dependent mechanism.
Developmental dynamics : an official publication of the American Association of Anatomists.
2015 Nov; 244(11):1404-14. doi:
10.1002/dvdy.24321. [PMID: 26283270] - Anu Mehta, Ravinder, Suneel Kumar Onteru, Dheer Singh. HDAC inhibitor prevents LPS mediated inhibition of CYP19A1 expression and 17β-estradiol production in granulosa cells.
Molecular and cellular endocrinology.
2015 Oct; 414(?):73-81. doi:
10.1016/j.mce.2015.07.002. [PMID: 26213324] - Duygu Sancak, Sibel Ozden. Global histone modifications in Fumonisin B1 exposure in rat kidney epithelial cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2015 Oct; 29(7):1809-15. doi:
10.1016/j.tiv.2015.07.019. [PMID: 26208285] - Ramaiah Muthyala, Woo Shik Shin, Jiashu Xie, Yuk Yin Sham. Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia.
Bioorganic & medicinal chemistry letters.
2015 Oct; 25(19):4320-4. doi:
10.1016/j.bmcl.2015.07.065. [PMID: 26264503] - Dawei Cai, Shasha Yin, Jun Yang, Qing Jiang, Wangsen Cao. Histone deacetylase inhibition activates Nrf2 and protects against osteoarthritis.
Arthritis research & therapy.
2015 Sep; 17(?):269. doi:
10.1186/s13075-015-0774-3. [PMID: 26408027] - Radha Dutt Singh, Ratnakar Tiwari, Hafizurrahman Khan, Anoop Kumar, Vikas Srivastava. Arsenic exposure causes epigenetic dysregulation of IL-8 expression leading to proneoplastic changes in kidney cells.
Toxicology letters.
2015 Aug; 237(1):1-10. doi:
10.1016/j.toxlet.2015.05.014. [PMID: 26008221] - Wei Zhao, Wangying Hu, Xiaolong Wang, Nan Xia, Qixiang Hu, Hua Zhou. A traditional Chinese medicine, Lujiao prescription, as a potential therapy for hypertrophic cardiomyocytes by acting on histone acetylation.
Journal of the Chinese Medical Association : JCMA.
2015 Aug; 78(8):486-93. doi:
10.1016/j.jcma.2015.03.006. [PMID: 25913212] - Carola Hedberg Oldfors, Diego Garcia Dios, Anna Linder, Kittichate Visuttijai, Emma Samuelson, Sandra Karlsson, Staffan Nilsson, Afrouz Behboudi. Analysis of an independent tumor suppressor locus telomeric to Tp53 suggested Inpp5k and Myo1c as novel tumor suppressor gene candidates in this region.
BMC genetics.
2015 Jul; 16(?):80. doi:
10.1186/s12863-015-0238-4. [PMID: 26170120] - Jin Meng, Feng Zhang, Xu-Tao Zhang, Tao Zhang, Yu-Hua Li, Lei Fan, Yang Sun, He-Long Zhang, Qi-Bing Mei. Ku70 is essential for histone deacetylase inhibitor trichostatin A-induced apoptosis.
Molecular medicine reports.
2015 Jul; 12(1):581-6. doi:
10.3892/mmr.2015.3358. [PMID: 25695595] - Phillip L Butler, Alexander Staruschenko, Peter M Snyder. Acetylation stimulates the epithelial sodium channel by reducing its ubiquitination and degradation.
The Journal of biological chemistry.
2015 May; 290(20):12497-503. doi:
10.1074/jbc.m114.635540. [PMID: 25787079] - Pu Wang, Lin Zhao, Haoli Hou, Hao Zhang, Yan Huang, Yapei Wang, Hui Li, Fei Gao, Shihan Yan, Lijia Li. Epigenetic Changes are Associated with Programmed Cell Death Induced by Heat Stress in Seedling Leaves of Zea mays.
Plant & cell physiology.
2015 May; 56(5):965-76. doi:
10.1093/pcp/pcv023. [PMID: 25670712] - Sorabh Sharma, Rajeev Taliyan, Shruti Ramagiri. Histone deacetylase inhibitor, trichostatin A, improves learning and memory in high-fat diet-induced cognitive deficits in mice.
Journal of molecular neuroscience : MN.
2015 May; 56(1):1-11. doi:
10.1007/s12031-014-0461-x. [PMID: 25391764] - Lei Wu, Xiao-hua Liu, Tian-hui Wang, Rui-feng Duan, Xue-si Zhou, Hong-tao Liu, Zhi-qing Zhang. [Protective effects of histone deacetylase inhibitor on stress-induced myocardial injury in rats].
Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology.
2015 May; 31(3):193-6. doi:
NULL. [PMID: 26387175] - Tomasz Bieluszewski, Lukasz Galganski, Weronika Sura, Anna Bieluszewska, Mateusz Abram, Agnieszka Ludwikow, Piotr Andrzej Ziolkowski, Jan Sadowski. AtEAF1 is a potential platform protein for Arabidopsis NuA4 acetyltransferase complex.
BMC plant biology.
2015 Mar; 15(?):75. doi:
10.1186/s12870-015-0461-1. [PMID: 25849764] - Yaning Cui, Yu Ling, Junhui Zhou, Xiaojuan Li. Interference of the Histone Deacetylase Inhibits Pollen Germination and Pollen Tube Growth in Picea wilsonii Mast.
PloS one.
2015; 10(12):e0145661. doi:
10.1371/journal.pone.0145661. [PMID: 26710276] - Vindhya Koppaka, Neema Lakshman, W Matthew Petroll. Effect of HDAC Inhibitors on Corneal Keratocyte Mechanical Phenotypes in 3-D Collagen Matrices.
Molecular vision.
2015; 21(?):502-14. doi:
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PloS one.
2015; 10(3):e0120118. doi:
10.1371/journal.pone.0120118. [PMID: 25789466] - Qian Zhang, Fan Yang, Xun Li, Lu-wen Wang, Xiao-gang Chu, Hong Zhang, Zuo-jiong Gong. Trichostatin A Protects Against Experimental Acute-on-Chronic Liver Failure in Rats Through Regulating the Acetylation of Nuclear Factor-κB.
Inflammation.
2015; 38(3):1364-73. doi:
10.1007/s10753-014-0108-7. [PMID: 25604312] - Ming-Hua Chen, Ye-Xiang Wu, Yan-Ni Xu, Peng Liu, Li-Yan Yu, Bin Hong, Wei Jiang, Shu-Yi Si. A new trichostatin analog from Streptomyces sp. CPCC 203909.
Journal of Asian natural products research.
2015; 17(6):676-82. doi:
10.1080/10286020.2015.1042372. [PMID: 25977996] - Qian Zhang, Lian Zhang, LiLi Li, Zhaohui Wang, Jianming Ying, Yu Fan, Ben Xu, Lu Wang, Qianling Liu, Guangfu Chen, Qian Tao, Jie Jin. Interferon regulatory factor 8 functions as a tumor suppressor in renal cell carcinoma and its promoter methylation is associated with patient poor prognosis.
Cancer letters.
2014 Nov; 354(2):227-34. doi:
10.1016/j.canlet.2014.07.040. [PMID: 25109451] - Qing Ye, Yanqin Li, Handong Jiang, Jianfei Xiong, Jiabo Xu, Hui Qin, Bin Liu. Prevention of Pulmonary Fibrosis via Trichostatin A (TSA) in Bleomycin Induced Rats.
Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG.
2014 Oct; 31(3):219-26. doi:
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The Journal of steroid biochemistry and molecular biology.
2014 Oct; 144 Pt B(?):253-9. doi:
10.1016/j.jsbmb.2014.07.008. [PMID: 25090636] - N E Scholpa, X Zhang, R T Kolli, B S Cummings. Epigenetic changes in p21 expression in renal cells after exposure to bromate.
Toxicological sciences : an official journal of the Society of Toxicology.
2014 Oct; 141(2):432-40. doi:
10.1093/toxsci/kfu138. [PMID: 25015661] - Leonel Maldonado, Mariana Brait, Christina Michailidi, Enrico Munari, Tina Driscoll, Luciana Schultz, Trinity Bivalacqua, Mark Schoenberg, David Sidransky, George J Netto, Mohammad Obaidul Hoque. An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine.
Oncotarget.
2014 Jul; 5(14):5218-33. doi:
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Life sciences.
2014 Mar; 99(1-2):31-6. doi:
10.1016/j.lfs.2014.01.064. [PMID: 24486299] - Min Xie, Yongli Kong, Wei Tan, Herman May, Pavan K Battiprolu, Zully Pedrozo, Zhao V Wang, Cyndi Morales, Xiang Luo, Geoffrey Cho, Nan Jiang, Michael E Jessen, John J Warner, Sergio Lavandero, Thomas G Gillette, Aslan T Turer, Joseph A Hill. Histone deacetylase inhibition blunts ischemia/reperfusion injury by inducing cardiomyocyte autophagy.
Circulation.
2014 Mar; 129(10):1139-51. doi:
10.1161/circulationaha.113.002416. [PMID: 24396039] - Benjamin B Green, David E Kerr. Epigenetic contribution to individual variation in response to lipopolysaccharide in bovine dermal fibroblasts.
Veterinary immunology and immunopathology.
2014 Jan; 157(1-2):49-58. doi:
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