Sulprostone (BioDeep_00000601089)
代谢物信息卡片
化学式: C23H31NO7S (465.1821)
中文名称: 硫前列酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CS(=O)(=O)NC(=O)CCCC=CCC1C(C(CC1=O)O)C=CC(COC2=CC=CC=C2)O
InChI: InChI=1S/C23H31NO7S/c1-32(29,30)24-23(28)12-8-3-2-7-11-19-20(22(27)15-21(19)26)14-13-17(25)16-31-18-9-5-4-6-10-18/h2,4-7,9-10,13-14,17,19-20,22,25,27H,3,8,11-12,15-16H2,1H3,(H,24,28)/b7-2+,14-13+
描述信息
G - Genito urinary system and sex hormones > G02 - Other gynecologicals > G02A - Uterotonics > G02AD - Prostaglandins
D012102 - Reproductive Control Agents > D008600 - Menstruation-Inducing Agents
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
D012102 - Reproductive Control Agents > D000019 - Abortifacient Agents
C78568 - Prostaglandin Analogue
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:135755
- KEGGdrug: D02725
- PubChem: 5312153
- PubChem: 13532635
- Metlin: METLIN45609
- DrugBank: DB12708
- ChEMBL: CHEMBL1472830
- CAS: 60325-46-4
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
亚细胞结构定位 | 关联基因列表 |
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文献列表
- Yifan Shi, Matthew M Rankin, Lisa D Norquay, Naidong Weng, Shefali Patel. Bioanalysis of sulprostone, a prostaglandin E2 analogue and selective EP3 agonist, in monkey plasma by liquid chromatography-tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2018 Aug; 1092(?):51-57. doi:
10.1016/j.jchromb.2018.05.034
. [PMID: 29883889] - Tingting Fang, Jiayun Hou, Mingyan He, Lingyan Wang, Minghuan Zheng, Xiangdong Wang, Jinglin Xia. Actinidia chinensis Planch root extract (acRoots) inhibits hepatocellular carcinoma progression by inhibiting EP3 expression.
Cell biology and toxicology.
2016 12; 32(6):499-511. doi:
10.1007/s10565-016-9351-z
. [PMID: 27475644] - Rania Nasrallah, Ramzi Hassouneh, Joseph Zimpelmann, Andrew J Karam, Jean-Francois Thibodeau, Dylan Burger, Kevin D Burns, Chris Rj Kennedy, Richard L Hébert. Prostaglandin E2 increases proximal tubule fluid reabsorption, and modulates cultured proximal tubule cell responses via EP1 and EP4 receptors.
Laboratory investigation; a journal of technical methods and pathology.
2015 Sep; 95(9):1044-55. doi:
10.1038/labinvest.2015.79
. [PMID: 26121313] - Kamal M Kassem, Margarette H Clevenger, David L Szandzik, Edward Peterson, Pamela Harding. PGE2 reduces MMP-14 and increases plasminogen activator inhibitor-1 in cardiac fibroblasts.
Prostaglandins & other lipid mediators.
2014 Oct; 113-115(?):62-8. doi:
10.1016/j.prostaglandins.2014.09.002
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Neuropharmacology.
2014 Jul; 82(?):19-27. doi:
10.1016/j.neuropharm.2014.03.005
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Anesthesia and analgesia.
2013 Jan; 116(1):155-61. doi:
10.1213/ane.0b013e31826f084d
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American journal of physiology. Renal physiology.
2012 Aug; 303(3):F449-57. doi:
10.1152/ajprenal.00634.2011
. [PMID: 22622465] - Zhi-Hua Zhang, Yang Yu, Shun-Guang Wei, Yoshiko Nakamura, Kazuhiro Nakamura, Robert B Felder. EP₃ receptors mediate PGE₂-induced hypothalamic paraventricular nucleus excitation and sympathetic activation.
American journal of physiology. Heart and circulatory physiology.
2011 Oct; 301(4):H1559-69. doi:
10.1152/ajpheart.00262.2011
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Molecular pharmacology.
2010 Jun; 77(6):1025-36. doi:
10.1124/mol.110.063933
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Biochemical and biophysical research communications.
2009 Nov; 389(2):372-7. doi:
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Platelets.
2008 Dec; 19(8):605-13. doi:
10.1080/09537100802351073
. [PMID: 19012178] - Natalia Dovlatova, Yanushi D Wijeyeratne, Susan C Fox, Panagiotis Manolopoulos, Andrew J Johnson, Ann E White, M Liaque Latif, Vera Ralevic, Stanley Heptinstall. Detection of P2Y(14) protein in platelets and investigation of the role of P2Y(14) in platelet function in comparison with the EP(3) receptor.
Thrombosis and haemostasis.
2008 Aug; 100(2):261-70. doi:
10.1160/th07-10-0601
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Prostaglandins & other lipid mediators.
2008 Jun; 86(1-4):26-34. doi:
10.1016/j.prostaglandins.2008.02.002
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American journal of physiology. Renal physiology.
2007 Mar; 292(3):F1094-101. doi:
10.1152/ajprenal.00351.2005
. [PMID: 17148783] - Cang-hai Li, Jun Zhou, Hai-ru Huo, Xu-liang Kang, Ting-liang Jiang. [Effect of guizhi tang and its active components on the fever induced by EP3 agonist].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2003 Nov; 28(11):1056-60. doi:
"
. [PMID: 15615417] - Grazia Tamma, Burkhard Wiesner, Jens Furkert, Daniel Hahm, Alexander Oksche, Michael Schaefer, Giovanna Valenti, Walter Rosenthal, Enno Klussmann. The prostaglandin E2 analogue sulprostone antagonizes vasopressin-induced antidiuresis through activation of Rho.
Journal of cell science.
2003 Aug; 116(Pt 16):3285-94. doi:
10.1242/jcs.00640
. [PMID: 12829746] - John D Imig, Matthew D Breyer, Richard M Breyer. Contribution of prostaglandin EP(2) receptors to renal microvascular reactivity in mice.
American journal of physiology. Renal physiology.
2002 Sep; 283(3):F415-22. doi:
10.1152/ajprenal.00351.2001
. [PMID: 12167591] - Najam A Sharif, Terry L Davis. Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques.
The Journal of pharmacy and pharmacology.
2002 Apr; 54(4):539-47. doi:
10.1211/0022357021778655
. [PMID: 11999132] - M Kimura, S Osumi, M Ogihara. Prostaglandin E(2) (EP(1)) receptor agonist-induced DNA synthesis and proliferation in primary cultures of adult rat hepatocytes: the involvement of TGF-alpha.
Endocrinology.
2001 Oct; 142(10):4428-40. doi:
10.1210/endo.142.10.8450
. [PMID: 11564707] - T Suganami, I Tanaka, M Mukoyama, M Kotani, S Muro, K Mori, M Goto, R Ishibashi, M Kasahara, K Yahata, H Makino, A Sugawara, K Nakao. Altered growth response to prostaglandin E2 and its receptor signaling in mesangial cells from stroke-prone spontaneously hypertensive rats.
Journal of hypertension.
2001 Jun; 19(6):1095-103. doi:
10.1097/00004872-200106000-00015
. [PMID: 11403359] - H Hasegawa, H Katoh, Y Yamaguchi, K Nakamura, S Futakawa, M Negishi. Different membrane targeting of prostaglandin EP3 receptor isoforms dependent on their carboxy-terminal tail structures.
FEBS letters.
2000 May; 473(1):76-80. doi:
10.1016/s0014-5793(00)01508-8
. [PMID: 10802063] - M Abramovitz, M Adam, Y Boie, M Carrière, D Denis, C Godbout, S Lamontagne, C Rochette, N Sawyer, N M Tremblay, M Belley, M Gallant, C Dufresne, Y Gareau, R Ruel, H Juteau, M Labelle, N Ouimet, K M Metters. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.
Biochimica et biophysica acta.
2000 Jan; 1483(2):285-93. doi:
10.1016/s1388-1981(99)00164-x
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Kidney international.
1999 Aug; 56(2):589-600. doi:
10.1046/j.1523-1755.1999.00566.x
. [PMID: 10432398] - M K Mater, A P Thelen, D B Jump. Arachidonic acid and PGE2 regulation of hepatic lipogenic gene expression.
Journal of lipid research.
1999 Jun; 40(6):1045-52. doi:
10.1016/s0022-2275(20)33508-2
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European journal of pharmacology.
1997 Dec; 340(2-3):227-41. doi:
10.1016/s0014-2999(97)01383-6
. [PMID: 9537820] - J van Baal, M D de Jong, F J Zijlstra, P H Willems, R J Bindels. Endogenously produced prostanoids stimulate calcium reabsorption in the rabbit cortical collecting system.
The Journal of physiology.
1996 Nov; 497 ( Pt 1)(?):229-39. doi:
10.1113/jphysiol.1996.sp021763
. [PMID: 8951725] - J Datté, A M Offoumou, O M Manda. Uterotonic effects of hydromethanolic extract of Parquetina nigrescens (Periplocaceae) on spontaneous contractile activity in the isolated myometrium of pregnant rats.
Journal of ethnopharmacology.
1996 Jul; 53(1):15-20. doi:
10.1016/0378-8741(96)01420-1
. [PMID: 8807472] - C Anandakumar, M A Choolani, P G Adaikan, Y C Wong, M Gopal, B Marshall, S S Ratnam. Combined chemotherapy in the medical management of tubal pregnancy.
The Australian & New Zealand journal of obstetrics & gynaecology.
1995 Nov; 35(4):437-40. doi:
10.1111/j.1479-828x.1995.tb02162.x
. [PMID: 8717574] - Y Sakairi, H R Jacobson, T D Noland, M D Breyer. Luminal prostaglandin E receptors regulate salt and water transport in rabbit cortical collecting duct.
The American journal of physiology.
1995 Aug; 269(2 Pt 2):F257-65. doi:
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British journal of pharmacology.
1995 Jun; 115(4):672-6. doi:
10.1111/j.1476-5381.1995.tb14985.x
. [PMID: 7582489] - R L Hébert. [Interaction of PGE2 and a specific analog: sulprostone with intracellular second messengers in the kidney].
Nephrologie.
1995; 16(2):209-14. doi:
NULL
. [PMID: 7753305] - R L Hébert. Cellular signalling of PGE2 and its selective receptor analogue sulprostone in rabbit cortical collecting duct.
Prostaglandins, leukotrienes, and essential fatty acids.
1994 Sep; 51(3):147-55. doi:
10.1016/0952-3278(94)90127-9
. [PMID: 7824528] - P Thonneau, B Fougeyrollas, A Spira. Analysis of 369 abortions conducted by mifepristone (RU486) associated with sulprostone in a French family planning center.
Fertility and sterility.
1994 Apr; 61(4):627-31. doi:
10.1016/s0015-0282(16)56637-0
. [PMID: 7512053] - A Ahluwalia, M Perretti. Anti-inflammatory effect of prostanoids in mouse and rat skin: evidence for a role of EP3-receptors.
The Journal of pharmacology and experimental therapeutics.
1994 Mar; 268(3):1526-31. doi:
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The American journal of physiology.
1993 Nov; 265(5 Pt 2):F643-50. doi:
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British journal of pharmacology.
1993 Feb; 108(2):363-9. doi:
10.1111/j.1476-5381.1993.tb12810.x
. [PMID: 8448586] - R N Prasad, S S Ratnam. Uterine rupture after induction of labour for intrauterine death using the prostaglandin E2 analogue sulprostone.
The Australian & New Zealand journal of obstetrics & gynaecology.
1992 Aug; 32(3):282-3. doi:
10.1111/j.1479-828x.1992.tb01968.x
. [PMID: 1445147] - W Kuhnz, G A Hoyer, S Backhus, U Jakobs. Identification of the major metabolites of the prostaglandin E2-analogue sulprostone in human plasma, and isolation from urine (in vivo) and liver perfusate (in vitro) of female guinea-pigs.
Drug metabolism and disposition: the biological fate of chemicals.
1991 Sep; 19(5):920-5. doi:
NULL
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Geburtshilfe und Frauenheilkunde.
1991 Aug; 51(8):649-52. doi:
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Geburtshilfe und Frauenheilkunde.
1990 Jul; 50(7):533-7. doi:
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The Journal of biological chemistry.
1990 May; 265(15):8479-83. doi:
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Gynecologic and obstetric investigation.
1990; 29(4):269-72. doi:
10.1159/000293332
. [PMID: 2361635] - B Larsson, A Jonasson, K Carlström. Sulprostone, a synthetic PGE2 analogue in first trimester abortion. Clinical efficacy and influence on serum progesterone of different single doses.
Gynecologic and obstetric investigation.
1990; 29(1):10-2. doi:
10.1159/000293290
. [PMID: 2351329] - A Nakao, M L Allen, W K Sonnenburg, W L Smith. Regulation of cAMP metabolism by PGE2 in cortical and medullary thick ascending limb of Henle's loop.
The American journal of physiology.
1989 Mar; 256(3 Pt 1):C652-7. doi:
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Geburtshilfe und Frauenheilkunde.
1989 Feb; 49 Suppl 1(?):15-20. doi:
NULL
. [PMID: 2539308] - W Rath, L Pitzel, R Hilgers, W Kuhn. [Dose-dependent effect of locally administered sulprostone gel on serum luteal and placental hormones in cervix priming in the 1st trimester].
Zentralblatt fur Gynakologie.
1989; 111(10):634-44. doi:
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Gynakologische Rundschau.
1989; 29 Suppl 3(?):28-34. doi:
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Acta obstetricia et gynecologica Scandinavica. Supplement.
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The Journal of biological chemistry.
1988 May; 263(13):6155-60. doi:
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Zentralblatt fur Gynakologie.
1988; 110(13):827-31. doi:
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. [PMID: 3176736] - S Saarikoski, J Saastamoinen, I Penttilä, O Castrén. Plasma renin activity and cAMP in termination of pregnancy induced by sulprostone.
British journal of obstetrics and gynaecology.
1987 Apr; 94(4):328-32. doi:
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Gynecologic and obstetric investigation.
1987; 24(1):23-7. doi:
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. [PMID: 2957288] - S Prasad, G Kinra, V Hingorani. Evaluation of intramuscular sulprostone and vacuum aspiration for termination of early pregnancy.
Contraception.
1985 Nov; 32(5):429-35. doi:
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Acta physiologica Hungarica.
1985; 65(4):415-32. doi:
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. [PMID: 3859989] - J Spona, K Baumgarten, J Schmidt, W Gruber, H D Gödicke, W Grünberger. 13,14-Dihydro-15-keto-PGF2 alpha (PGFM) and sulprostone serum levels after application of sulprostone to postpartum women.
European journal of obstetrics, gynecology, and reproductive biology.
1983 Nov; 16(3):173-9. doi:
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Prostaglandins, leukotrienes, and medicine.
1982 Nov; 9(5):483-9. doi:
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Prostaglandins.
1982 Nov; 24(5):691-700. doi:
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Annals of the Academy of Medicine, Singapore.
1982 Oct; 11(4):493-502. doi:
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Prostaglandins.
1982 Sep; 24(3):341-50. doi:
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Prostaglandins, leukotrienes, and medicine.
1982 Aug; 9(2):193-203. doi:
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Prostaglandins, leukotrienes, and medicine.
1982 Aug; 9(2):183-91. doi:
10.1016/0262-1746(82)90007-5
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Contraception.
1982 Feb; 25(2):175-84. doi:
10.1016/0010-7824(82)90028-2
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Prostaglandins and medicine.
1981 Jan; 6(1):1-8. doi:
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Gynecologic and obstetric investigation.
1981; 12(4):203-10. doi:
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Prostaglandins.
1980 Sep; 20(3):487-92. doi:
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