NSC 23766 (BioDeep_00000601011)
代谢物信息卡片
N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-4,6-quinolinediamine, trihydrochloride
化学式: C24H35N7 (421.295379)
中文名称: N6-[2-[[4-(二乙基氨基)-1-甲基丁基]氨基]-6-甲基-4-嘧啶基]-2-甲基-4,6-喹啉二胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCN(CC)CCCC(C)NC1=NC(=CC(=N1)NC2=CC3=C(C=C(N=C3C=C2)C)N)C
InChI: InChI=1S/C24H35N7/c1-6-31(7-2)12-8-9-16(3)27-24-28-18(5)14-23(30-24)29-19-10-11-22-20(15-19)21(25)13-17(4)26-22/h10-11,13-16H,6-9,12H2,1-5H3,(H2,25,26)(H2,27,28,29,30)
描述信息
NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment.
同义名列表
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:144984
- ChEBI: CHEBI:91883
- PubChem: 409805
- Metlin: METLIN45485
- ChEMBL: CHEMBL257119
- CAS: 733767-34-5
- CAS: 1177865-17-6
- medchemexpress: HY-15723
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhihui Fong, Caoimhín S Griffin, Roddy J Large, Mark A Hollywood, Keith D Thornbury, Gerard P Sergeant. Regulation of P2X1 receptors by modulators of the cAMP effectors PKA and EPAC.
Proceedings of the National Academy of Sciences of the United States of America.
2021 09; 118(37):. doi:
10.1073/pnas.2108094118. [PMID: 34508006] - Daigoro Hirohama, Mitsuhiro Nishimoto, Nobuhiro Ayuzawa, Wakako Kawarazaki, Wataru Fujii, Shigeyoshi Oba, Shigeru Shibata, Takeshi Marumo, Toshiro Fujita. Activation of Rac1-Mineralocorticoid Receptor Pathway Contributes to Renal Injury in Salt-Loaded db/db Mice.
Hypertension (Dallas, Tex. : 1979).
2021 07; 78(1):82-93. doi:
10.1161/hypertensionaha.121.17263. [PMID: 34058848] - Natasha P Murphy, Helen R Mott, Darerca Owen. Progress in the therapeutic inhibition of Cdc42 signalling.
Biochemical Society transactions.
2021 06; 49(3):1443-1456. doi:
10.1042/bst20210112. [PMID: 34100887] - Smrruthi Vaidegi Venugopal, Silvia Caggia, DaJhnae Gambrell-Sanders, Shafiq A Khan. Differential roles and activation of mammalian target of rapamycin complexes 1 and 2 during cell migration in prostate cancer cells.
The Prostate.
2020 04; 80(5):412-423. doi:
10.1002/pros.23956. [PMID: 31995655] - Danelia Ramírez-Ramírez, Monica L Salgado-Lucio, Ana L Roa-Espitia, Reyna Fierro, Humberto González-Márquez, Joaquín Cordero-Martínez, Enrique O Hernández-González. Rac1 is necessary for capacitation and acrosome reaction in guinea pig spermatozoa.
Journal of cellular biochemistry.
2020 04; 121(4):2864-2876. doi:
10.1002/jcb.29521. [PMID: 31692044] - Yao-Yu Hsieh, Tsang-Pai Liu, Pei-Ming Yang. In silico repurposing the Rac1 inhibitor NSC23766 for treating PTTG1-high expressing clear cell renal carcinoma.
Pathology, research and practice.
2019 Jun; 215(6):152373. doi:
10.1016/j.prp.2019.03.002. [PMID: 30871916] - Hua Liang, Jian Huang, Qiong Huang, Yong Can Xie, Hong Zhen Liu, Han Bing Wang. Pharmacological inhibition of Rac1 exerts a protective role in ischemia/reperfusion-induced renal fibrosis.
Biochemical and biophysical research communications.
2018 09; 503(4):2517-2523. doi:
10.1016/j.bbrc.2018.07.009. [PMID: 30208520] - Julia Dolinina, Anna Rippe, Peter Bentzer, Carl M Öberg. Glomerular hyperpermeability after acute unilateral ureteral obstruction: effects of Tempol, NOS, RhoA, and Rac-1 inhibition.
American journal of physiology. Renal physiology.
2018 09; 315(3):F445-F453. doi:
10.1152/ajprenal.00610.2017. [PMID: 29465305] - Siwan Park, Hwanseok Jang, Byung Soo Kim, Changmo Hwang, Gi Seok Jeong, Yongdoo Park. Directional migration of mesenchymal stem cells under an SDF-1α gradient on a microfluidic device.
PloS one.
2017; 12(9):e0184595. doi:
10.1371/journal.pone.0184595. [PMID: 28886159] - Yongzhi Wang, Rundk Hwaiz, Lingtao Luo, Oscar Ö Braun, Eva Norström, Henrik Thorlacius. Rac1 regulates bacterial toxin-induced thrombin generation.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2016 May; 65(5):405-13. doi:
10.1007/s00011-016-0924-3. [PMID: 26873877] - S Meng, Z Su, Z Liu, N Wang, Z Wang. Rac1 contributes to cerebral ischemia reperfusion-induced injury in mice by regulation of Notch2.
Neuroscience.
2015 Oct; 306(?):100-14. doi:
10.1016/j.neuroscience.2015.08.014. [PMID: 26299339] - Jing Zeng, Lin Chen, Bing Chen, Kaizhi Lu, Karine Belguise, Xiaobo Wang, Bin Yi. MicroRNA-199a-5p Regulates the Proliferation of Pulmonary Microvascular Endothelial Cells in Hepatopulmonary Syndrome.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 37(4):1289-300. doi:
10.1159/000430252. [PMID: 26430741] - Guilai Liu, Guoxing Liu, Hong Chen, Kousi Alzoubi, Anja T Umbach, Meinrad Gawaz, Christos Stournaras, Florian Lang. Rapid Upregulation of Orai1 Abundance in the Plasma Membrane of Platelets Following Activation with Thrombin and Collagen Related Peptide.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 37(5):1759-66. doi:
10.1159/000438539. [PMID: 26584277] - Shutong Zhou, Dongni Yu, Shangyong Ning, Heli Zhang, Lei Jiang, Lei He, Miao Li, Mingxiao Sun. Augmented Rac1 Expression and Activity are Associated with Oxidative Stress and Decline of β Cell Function in Obesity.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology.
2015; 35(6):2135-48. doi:
10.1159/000374019. [PMID: 25896148] - Liming Shen, Aochu Yang, Pengwei Yao, Xiaohong Sun, Cheng Chen, Cuiping Mo, Lei Shi, Youjiao Chen, Qiong Liu. Gadolinium promoted proliferation in mouse embryo fibroblast NIH3T3 cells through Rac and PI3K/Akt signaling pathways.
Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine.
2014 Aug; 27(4):753-62. doi:
10.1007/s10534-014-9769-9. [PMID: 25037060] - Matthew Quinn, Matthew McMillin, Cheryl Galindo, Gabriel Frampton, Hae Yong Pae, Sharon DeMorrow. Bile acids permeabilize the blood brain barrier after bile duct ligation in rats via Rac1-dependent mechanisms.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.
2014 Jun; 46(6):527-34. doi:
10.1016/j.dld.2014.01.159. [PMID: 24629820] - Hyundoo Hwang, Eung-Kyun Kim, Juhee Park, Pann-Ghill Suh, Yoon-Kyoung Cho. RhoA and Rac1 play independent roles in lysophosphatidic acid-induced ovarian cancer chemotaxis.
Integrative biology : quantitative biosciences from nano to macro.
2014 Mar; 6(3):267-76. doi:
10.1039/c3ib40183a. [PMID: 24469268] - Rüdiger Dierkes, Kathrin Warnking, Swantje Liedmann, Roman Seyer, Stephan Ludwig, Christina Ehrhardt. The Rac1 inhibitor NSC23766 exerts anti-influenza virus properties by affecting the viral polymerase complex activity.
PloS one.
2014; 9(2):e88520. doi:
10.1371/journal.pone.0088520. [PMID: 24523909] - Yasunari Kageyama, Tomoaki Doi, Shigeru Akamatsu, Gen Kuroyanagi, Akira Kondo, Jun Mizutani, Takanobu Otsuka, Haruhiko Tokuda, Osamu Kozawa, Shinji Ogura. Rac regulates collagen-induced HSP27 phosphorylation via p44/p42 MAP kinase in human platelets.
International journal of molecular medicine.
2013 Oct; 32(4):813-8. doi:
10.3892/ijmm.2013.1455. [PMID: 23900529] - Magdolna Levay, Kurt Allen Krobert, Karola Wittig, Niels Voigt, Marcel Bermudez, Gerhard Wolber, Dobromir Dobrev, Finn Olav Levy, Thomas Wieland. NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors.
The Journal of pharmacology and experimental therapeutics.
2013 Oct; 347(1):69-79. doi:
10.1124/jpet.113.207266. [PMID: 23887096] - Rundk Hwaiz, Zirak Hasan, Milladur Rahman, Su Zhang, Karzan Palani, Ingvar Syk, Bengt Jeppsson, Henrik Thorlacius. Rac1 signaling regulates sepsis-induced pathologic inflammation in the lung via attenuation of Mac-1 expression and CXC chemokine formation.
The Journal of surgical research.
2013 Aug; 183(2):798-807. doi:
10.1016/j.jss.2013.02.045. [PMID: 23545410] - Vijayalakshmi Thamilselvan, Mani Menon, Sivagnanam Thamilselvan. Selective Rac1 inhibition protects renal tubular epithelial cells from oxalate-induced NADPH oxidase-mediated oxidative cell injury.
Urological research.
2012 Aug; 40(4):415-23. doi:
10.1007/s00240-011-0405-7. [PMID: 21814770] - Victoria E Tovell, Chi Y Chau, Peng T Khaw, Maryse Bailly. Rac1 inhibition prevents tissue contraction and MMP mediated matrix remodeling in the conjunctiva.
Investigative ophthalmology & visual science.
2012 Jul; 53(8):4682-91. doi:
10.1167/iovs.11-8577. [PMID: 22695959] - Gérard Gacon, Amel Mettouchi, Emmanuel Lemichez. [The tumor suppressor HACE1 targets Rac1 to ubiquitin-mediated proteasomal degradation].
Medecine sciences : M/S.
2012 Jan; 28(1):39-41. doi:
10.1051/medsci/2012281014. [PMID: 22289828] - Steeve Boulant, Comert Kural, Jean-Christophe Zeeh, Florent Ubelmann, Tomas Kirchhausen. Actin dynamics counteract membrane tension during clathrin-mediated endocytosis.
Nature cell biology.
2011 Aug; 13(9):1124-31. doi:
10.1038/ncb2307. [PMID: 21841790] - John A Humphries, Zuzana Vejlupkova, Anding Luo, Robert B Meeley, Anne W Sylvester, John E Fowler, Laurie G Smith. ROP GTPases act with the receptor-like protein PAN1 to polarize asymmetric cell division in maize.
The Plant cell.
2011 Jun; 23(6):2273-84. doi:
10.1105/tpc.111.085597. [PMID: 21653193] - Alexey V Karpushev, Vladislav Levchenko, Daria V Ilatovskaya, Tengis S Pavlov, Alexander Staruschenko. Novel role of Rac1/WAVE signaling mechanism in regulation of the epithelial Na+ channel.
Hypertension (Dallas, Tex. : 1979).
2011 May; 57(5):996-1002. doi:
10.1161/hypertensionaha.110.157784. [PMID: 21464391] - Suman Dwivedi, Dharmendra Pandey, Anna L Khandoga, Richard Brandl, Wolfgang Siess. Rac1-mediated signaling plays a central role in secretion-dependent platelet aggregation in human blood stimulated by atherosclerotic plaque.
Journal of translational medicine.
2010 Dec; 8(?):128. doi:
10.1186/1479-5876-8-128. [PMID: 21134286] - Sung Yong Eum, Ibolya Andras, Bernhard Hennig, Michal Toborek. NADPH oxidase and lipid raft-associated redox signaling are required for PCB153-induced upregulation of cell adhesion molecules in human brain endothelial cells.
Toxicology and applied pharmacology.
2009 Oct; 240(2):299-305. doi:
10.1016/j.taap.2009.07.022. [PMID: 19632255] - Shigeru Shibata, Miki Nagase, Shigetaka Yoshida, Wakako Kawarazaki, Hidetake Kurihara, Hirotoshi Tanaka, Jun Miyoshi, Yoshimi Takai, Toshiro Fujita. Modification of mineralocorticoid receptor function by Rac1 GTPase: implication in proteinuric kidney disease.
Nature medicine.
2008 Dec; 14(12):1370-6. doi:
10.1038/nm.1879. [PMID: 19029984] - Marcelo G Binker, Andres A Binker-Cosen, Herbert Y Gaisano, Laura I Cosen-Binker. Inhibition of Rac1 decreases the severity of pancreatitis and pancreatitis-associated lung injury in mice.
Experimental physiology.
2008 Oct; 93(10):1091-103. doi:
10.1113/expphysiol.2008.043141. [PMID: 18567599] - Klaudia Giehl, Angela Graness, Margarete Goppelt-Struebe. The small GTPase Rac-1 is a regulator of mesangial cell morphology and thrombospondin-1 expression.
American journal of physiology. Renal physiology.
2008 Feb; 294(2):F407-13. doi:
10.1152/ajprenal.00093.2007. [PMID: 18045834] - Nader H Moniri, Yehia Daaka. Agonist-stimulated reactive oxygen species formation regulates beta2-adrenergic receptor signal transduction.
Biochemical pharmacology.
2007 Jun; 74(1):64-73. doi:
10.1016/j.bcp.2007.03.016. [PMID: 17451656] - Adam T Whaley-Connell, E Matthew Morris, Nathan Rehmer, J Cipporah Yaghoubian, Yongzhong Wei, Melvin R Hayden, Javad Habibi, Craig S Stump, James R Sowers. Albumin activation of NAD(P)H oxidase activity is mediated via Rac1 in proximal tubule cells.
American journal of nephrology.
2007; 27(1):15-23. doi:
10.1159/000098432. [PMID: 17204833] - Yuan Gao, J Bradley Dickerson, Fukun Guo, Jie Zheng, Yi Zheng. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.
Proceedings of the National Academy of Sciences of the United States of America.
2004 May; 101(20):7618-23. doi:
10.1073/pnas.0307512101. [PMID: 15128949]