URB597 (BioDeep_00000600934)

   


代谢物信息卡片


(3-(aminocarbonyl)[1,1-biphenyl]-3-yl)-cyclohexylcarbamate

化学式: C20H22N2O3 (338.16303419999997)
中文名称: URB-597
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1CCC(CC1)NC(=O)OC2=CC=CC(=C2)C3=CC(=CC=C3)C(=O)N
InChI: InChI=1S/C20H22N2O3/c21-19(23)16-8-4-6-14(12-16)15-7-5-11-18(13-15)25-20(24)22-17-9-2-1-3-10-17/h4-8,11-13,17H,1-3,9-10H2,(H2,21,23)(H,22,24)

描述信息

URB-597 (KDS-4103) is an orally bioavailable and selective FAAH inhibitor. URB-597 inhibits FAAH activity with an IC50s of approximately 5 nM in rat brain membranes, 0.5 nM in intact rat neurons, 3 nM in human liver microsomes. Antidepressant-like effects. Analgesic activity[1].

同义名列表

4 个代谢物同义名

3-Carbamoyl-[1,1-biphenyl]-3-yl cyclohexylcarbamate; URB597; (3-(aminocarbonyl)[1,1-biphenyl]-3-yl)-cyclohexylcarbamate; KDS-4103



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Daniela Kovacs, Enrica Flori, Emanuela Bastonini, Sarah Mosca, Emilia Migliano, Carlo Cota, Marco Zaccarini, Stefania Briganti, Giorgia Cardinali. Targeting Fatty Acid Amide Hydrolase Counteracts the Epithelial-to-Mesenchymal Transition in Keratinocyte-Derived Tumors. International journal of molecular sciences. 2023 Dec; 24(24):. doi: 10.3390/ijms242417379. [PMID: 38139209]
  • Junfeng Hao, Qiguang Chen, Yongmin Feng, Qiyu Jiang, Huiwei Sun, Botian Deng, Xin Huang, Jibin Guan, Qiuping Chen, Xincheng Liu, Yanjin Wang, Peng Cao, Fan Feng, Xiaoyu Li. Combination treatment with FAAH inhibitors/URB597 and ferroptosis inducers significantly decreases the growth and metastasis of renal cell carcinoma cells via the PI3K-AKT signaling pathway. Cell death & disease. 2023 04; 14(4):247. doi: 10.1038/s41419-023-05779-z. [PMID: 37024452]
  • Sherif S Abdel Mageed, Ramy M Ammar, Noha N Nassar, Helmy Moawad, Ahmed S Kamel. Role of PI3K/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat. Neuropharmacology. 2022 04; 207(?):108935. doi: 10.1016/j.neuropharm.2021.108935. [PMID: 34968475]
  • Harisa Ferizovic, Natasa Spasojevic, Milica Jankovic, Bojana Stefanovic, Sladjana Dronjak. Effects of Fatty Acid Amide Hydroxylase Inhibitor URB597 on the Catecholaminergic Activity of the Adrenal Medulla in Stressed Male and Female Rats. Pharmacology. 2022; 107(1-2):81-89. doi: 10.1159/000519332. [PMID: 34794150]
  • Karla Chavira-Ramos, Mario Orozco-Morales, Çimen Karasu, Alexey A Tinkov, Michael Aschner, Abel Santamaría, Ana Laura Colín-González. URB597 Prevents the Short-Term Excitotoxic Cell Damage in Rat Cortical Slices: Role of Cannabinoid 1 Receptors. Neurotoxicity research. 2021 Apr; 39(2):146-155. doi: 10.1007/s12640-020-00301-1. [PMID: 33141426]
  • Harisa Ferizovic, Natasa Spasojevic, Bojana Stefanovic, Milica Jankovic, Sladjana Dronjak. The fatty acid amide hydrolase inhibitor URB597 modulates splenic catecholamines in chronically stressed female and male rats. International immunopharmacology. 2020 Aug; 85(?):106615. doi: 10.1016/j.intimp.2020.106615. [PMID: 32447219]
  • Michał Biernacki, Marta Baranowska-Kuczko, Gabriella N Niklińska, Elżbieta Skrzydlewska. The FAAH Inhibitor URB597 Modulates Lipid Mediators in the Brain of Rats with Spontaneous Hypertension. Biomolecules. 2020 07; 10(7):. doi: 10.3390/biom10071022. [PMID: 32664225]
  • Izabela Dobrzyńska, Barbara Szachowicz-Petelska, Anna Pędzińska-Betiuk, Zbigniew A Figaszewski, Elżbieta Skrzydlewska. Effects of hypertension and FAAH inhibitor treatment of rats with primary and secondary hypertension considering the physicochemical properties of erythrocytes. Toxicology mechanisms and methods. 2020 May; 30(4):297-305. doi: 10.1080/15376516.2020.1727595. [PMID: 32028814]
  • Alessia Santori, Paola Colucci, Giulia Federica Mancini, Maria Morena, Maura Palmery, Viviana Trezza, Stefano Puglisi-Allegra, Matthew N Hill, Patrizia Campolongo. Anandamide modulation of circadian- and stress-dependent effects on rat short-term memory. Psychoneuroendocrinology. 2019 10; 108(?):155-162. doi: 10.1016/j.psyneuen.2019.06.018. [PMID: 31302498]
  • Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Elżbieta Skrzydlewska. Long-term administration of fatty acid amide hydrolase inhibitor (URB597) to rats with spontaneous hypertension disturbs liver redox balance and phospholipid metabolism. Advances in medical sciences. 2019 Mar; 64(1):15-23. doi: 10.1016/j.advms.2018.06.002. [PMID: 30243113]
  • Izabela Dobrzyńska, Barbara Szachowicz-Petelska, Jolanta Weresa, Zbigniew A Figaszewski, Elżbieta Skrzydlewska. Changes in physicochemical properties of kidney cells membrane as a consequence of hypertension and treatment of hypertensive rats with FAAH inhibitor. Chemico-biological interactions. 2019 Feb; 299(?):52-58. doi: 10.1016/j.cbi.2018.11.024. [PMID: 30502333]
  • Ewa Harasim-Symbor, Agnieszka Polak, Anna Pędzińska-Betiuk, Jolanta Weresa, Barbara Malinowska, Alicja Lewandowska, Irena Kasacka, Adrian Chabowski. Fatty acid amide hydrolase inhibitor (URB597) as a regulator of myocardial lipid metabolism in spontaneously hypertensive rats. Chemistry and physics of lipids. 2019 01; 218(?):141-148. doi: 10.1016/j.chemphyslip.2018.12.007. [PMID: 30578756]
  • Andalib Danandeh, Valentina Vozella, James Lim, Fariba Oveisi, Gina L Ramirez, David Mears, Gary Wynn, Daniele Piomelli. Effects of fatty acid amide hydrolase inhibitor URB597 in a rat model of trauma-induced long-term anxiety. Psychopharmacology. 2018 Nov; 235(11):3211-3221. doi: 10.1007/s00213-018-5020-7. [PMID: 30251159]
  • Michał Biernacki, Wojciech Łuczaj, Iwona Jarocka-Karpowicz, Ewa Ambrożewicz, Marek Toczek, Elżbieta Skrzydlewska. The Effect of Long-Term Administration of Fatty Acid Amide Hydrolase Inhibitor URB597 on Oxidative Metabolism in the Heart of Rats with Primary and Secondary Hypertension. Molecules (Basel, Switzerland). 2018 Sep; 23(9):. doi: 10.3390/molecules23092350. [PMID: 30223427]
  • Michał Biernacki, Barbara Malinowska, Magdalena Timoszuk, Martek Toczek, Anna Jastrząb, Patryk Remiszewski, Elżbieta Skrzydlewska. Hypertension and chronic inhibition of endocannabinoid degradation modify the endocannabinoid system and redox balance in rat heart and plasma. Prostaglandins & other lipid mediators. 2018 09; 138(?):54-63. doi: 10.1016/j.prostaglandins.2018.09.001. [PMID: 30201316]
  • Amir Segev, Nachshon Korem, Tomer Mizrachi Zer-Aviv, Hila Abush, Rachel Lange, Garrett Sauber, Cecilia J Hillard, Irit Akirav. Role of endocannabinoids in the hippocampus and amygdala in emotional memory and plasticity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2018 09; 43(10):2017-2027. doi: 10.1038/s41386-018-0135-4. [PMID: 29977073]
  • Lisa E Flannery, Rebecca J Henry, Daniel M Kerr, David P Finn, Michelle Roche. FAAH, but not MAGL, inhibition modulates acute TLR3-induced neuroimmune signaling in the rat, independent of sex. Journal of neuroscience research. 2018 06; 96(6):989-1001. doi: 10.1002/jnr.24120. [PMID: 28726298]
  • Michał Biernacki, Ewa Ambrożewicz, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewska. Redox system and phospholipid metabolism in the kidney of hypertensive rats after FAAH inhibitor URB597 administration. Redox biology. 2018 05; 15(?):41-50. doi: 10.1016/j.redox.2017.11.022. [PMID: 29197803]
  • Agnieszka Polak, Ewa Harasim-Symbor, Barbara Malinowska, Irena Kasacka, Alicja Lewandowska, Adrian Chabowski. The Endocannabinoid System Affects Myocardial Glucose Metabolism in the DOCA-Salt Model of Hypertension. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2018; 46(2):727-739. doi: 10.1159/000488730. [PMID: 29621749]
  • Elisabetta Esposito, Markus Drechsler, Paolo Mariani, Federica Carducci, Michela Servadio, Francesca Melancia, Patrizia Ratano, Patrizia Campolongo, Viviana Trezza, Rita Cortesi, Claudio Nastruzzi. Lipid nanoparticles for administration of poorly water soluble neuroactive drugs. Biomedical microdevices. 2017 Sep; 19(3):44. doi: 10.1007/s10544-017-0188-x. [PMID: 28526975]
  • Agnieszka Polak, Ewa Harasim-Symbor, Barbara Malinowska, Irena Kasacka, Anna Pędzińska-Betiuk, Jolanta Weresa, Adrian Chabowski. The effects of chronic FAAH inhibition on myocardial lipid metabolism in normotensive and DOCA-salt hypertensive rats. Life sciences. 2017 Aug; 183(?):1-10. doi: 10.1016/j.lfs.2017.06.019. [PMID: 28633967]
  • Angel Escamilla-Ramírez, Esperanza García, Guadalupe Palencia-Hernández, Ana Laura Colín-González, Sonia Galván-Arzate, Isaac Túnez, Julio Sotelo, Abel Santamaría. URB597 and the Cannabinoid WIN55,212-2 Reduce Behavioral and Neurochemical Deficits Induced by MPTP in Mice: Possible Role of Redox Modulation and NMDA Receptors. Neurotoxicity research. 2017 May; 31(4):532-544. doi: 10.1007/s12640-016-9698-1. [PMID: 28092019]
  • Marisol Maya-López, Hipolito A Ruiz-Contreras, María de Jesús Negrete-Ruíz, Julián Elías Martínez-Sánchez, Juan Benítez-Valenzuela, Ana Laura Colín-González, Juana Villeda-Hernández, Laura Sánchez-Chapul, Carmen Parra-Cid, Edgar Rangel-López, Abel Santamaría. URB597 reduces biochemical, behavioral and morphological alterations in two neurotoxic models in rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2017 Apr; 88(?):745-753. doi: 10.1016/j.biopha.2017.01.116. [PMID: 28157650]
  • Helmut Dahlhaus, Walburga Hanekamp, Matthias Lehr. (Indolylalkyl)piperidine carbamates as inhibitors of fatty acid amide hydrolase (FAAH). MedChemComm. 2017 Mar; 8(3):616-620. doi: 10.1039/c6md00683c. [PMID: 30108777]
  • Michał Biernacki, Wojciech Łuczaj, Agnieszka Gęgotek, Marek Toczek, Katarzyna Bielawska, Elżbieta Skrzydlewska. Crosstalk between liver antioxidant and the endocannabinoid systems after chronic administration of the FAAH inhibitor, URB597, to hypertensive rats. Toxicology and applied pharmacology. 2016 06; 301(?):31-41. doi: 10.1016/j.taap.2016.04.006. [PMID: 27086176]
  • Elisabetta Esposito, Markus Drechsler, Rita Cortesi, Claudio Nastruzzi. Encapsulation of cannabinoid drugs in nanostructured lipid carriers. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V. 2016 May; 102(?):87-91. doi: 10.1016/j.ejpb.2016.03.005. [PMID: 26952905]
  • Marek Toczek, Marta Baranowska-Kuczko, Emilia Grzęda, Anna Pędzińska-Betiuk, Jolanta Weresa, Barbara Malinowska. Age-specific influences of chronic administration of the fatty acid amide hydrolase inhibitor URB597 on cardiovascular parameters and organ hypertrophy in DOCA-salt hypertensive rats. Pharmacological reports : PR. 2016 Apr; 68(2):363-9. doi: 10.1016/j.pharep.2015.10.004. [PMID: 26922540]
  • Yoko Shimoda, Masayuki Fujinaga, Akiko Hatori, Joji Yui, Yiding Zhang, Nobuki Nengaki, Yusuke Kurihara, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Hideki Ishii, Ming-Rong Zhang. N-(3,4-Dimethylisoxazol-5-yl)piperazine-4-[4-(2-fluoro-4-[(11)C]methylphenyl)thiazol-2-yl]-1-carboxamide: A promising positron emission tomography ligand for fatty acid amide hydrolase. Bioorganic & medicinal chemistry. 2016 Feb; 24(4):627-34. doi: 10.1016/j.bmc.2015.12.026. [PMID: 26740152]
  • Yvonne Wollank, Robert Ramer, Igor Ivanov, Achim Salamon, Kirsten Peters, Burkhard Hinz. Inhibition of FAAH confers increased stem cell migration via PPARα. Journal of lipid research. 2015 Oct; 56(10):1947-60. doi: 10.1194/jlr.m061473. [PMID: 26263913]
  • J F C Pedrazzi, A C Issy, F V Gomes, F S Guimarães, E A Del-Bel. Cannabidiol effects in the prepulse inhibition disruption induced by amphetamine. Psychopharmacology. 2015 Aug; 232(16):3057-65. doi: 10.1007/s00213-015-3945-7. [PMID: 25943166]
  • Katsushi Kumata, Joji Yui, Akiko Hatori, Jun Maeda, Lin Xie, Masanao Ogawa, Tomoteru Yamasaki, Yuji Nagai, Yoko Shimoda, Masayuki Fujinaga, Kazunori Kawamura, Ming-Rong Zhang. Development of [(11)C]MFTC for PET imaging of fatty acid amide hydrolase in rat and monkey brains. ACS chemical neuroscience. 2015 Feb; 6(2):339-46. doi: 10.1021/cn500269g. [PMID: 25398123]
  • Sandra Gouveia-Figueira, Jessica Karlsson, Alessandro Deplano, Sanaz Hashemian, Mona Svensson, Marcus Fredriksson Sundbom, Cenzo Congiu, Valentina Onnis, Christopher J Fowler. Characterisation of (R)-2-(2-Fluorobiphenyl-4-yl)-N-(3-Methylpyridin-2-yl)Propanamide as a Dual Fatty Acid Amide Hydrolase: Cyclooxygenase Inhibitor. PloS one. 2015; 10(9):e0139212. doi: 10.1371/journal.pone.0139212. [PMID: 26406890]
  • Benjamin H Rotstein, Hsiao-Ying Wey, Timothy M Shoup, Alan A Wilson, Steven H Liang, Jacob M Hooker, Neil Vasdev. PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates. Molecular pharmaceutics. 2014 Nov; 11(11):3832-8. doi: 10.1021/mp500316h. [PMID: 25004399]
  • Gaurav Bedse, Roberto Colangeli, Angelo M Lavecchia, Adele Romano, Fabio Altieri, Carlo Cifani, Tommaso Cassano, Silvana Gaetani. Role of the basolateral amygdala in mediating the effects of the fatty acid amide hydrolase inhibitor URB597 on HPA axis response to stress. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 2014 Sep; 24(9):1511-23. doi: 10.1016/j.euroneuro.2014.07.005. [PMID: 25106694]
  • Andrea Chicca, Diego Caprioglio, Alberto Minassi, Vanessa Petrucci, Giovanni Appendino, Orazio Taglialatela-Scafati, Jürg Gertsch. Functionalization of β-caryophyllene generates novel polypharmacology in the endocannabinoid system. ACS chemical biology. 2014 Jul; 9(7):1499-507. doi: 10.1021/cb500177c. [PMID: 24831513]
  • Andrew J Kwilasz, Rehab A Abdullah, Justin L Poklis, Aron H Lichtman, Sidney S Negus. Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats. Behavioural pharmacology. 2014 Apr; 25(2):119-29. doi: 10.1097/fbp.0000000000000023. [PMID: 24583930]
  • Chia-Shan Wu, Daniel Morgan, Chris P Jew, Chris Haskins, Mary-Jeanette Andrews, Emma Leishman, Corinne M Spencer, Traci Czyzyk, Heather Bradshaw, Ken Mackie, Hui-Chen Lu. Long-term consequences of perinatal fatty acid amino hydrolase inhibition. British journal of pharmacology. 2014 Mar; 171(6):1420-34. doi: 10.1111/bph.12500. [PMID: 24730060]
  • Friedrich Felix Hoyer, Mona Khoury, Heike Slomka, Moritz Kebschull, Raissa Lerner, Beat Lutz, Hans Schott, Dieter Lütjohann, Alexandra Wojtalla, Astrid Becker, Andreas Zimmer, Georg Nickenig. Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice. Journal of molecular and cellular cardiology. 2014 Jan; 66(?):126-32. doi: 10.1016/j.yjmcc.2013.11.013. [PMID: 24286707]
  • H Li, J T Wood, K M Whitten, S K Vadivel, S Seng, A Makriyannis, H K Avraham. Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells. British journal of pharmacology. 2013 Oct; 170(3):489-505. doi: 10.1111/bph.12111. [PMID: 23347118]
  • Silvia G Ruginsk, Ernane T Uchoa, Lucila Lk Elias, Jose Antunes-Rodrigues. Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion. Clinical and experimental pharmacology & physiology. 2013 Oct; 40(10):698-705. doi: 10.1111/1440-1681.12155. [PMID: 23875874]
  • Sébastien Lenglet, Aurélien Thomas, Oliver Soehnlein, Fabrizio Montecucco, Fabienne Burger, Graziano Pelli, Katia Galan, Benjamin Cravatt, Christian Staub, Sabine Steffens. Fatty acid amide hydrolase deficiency enhances intraplaque neutrophil recruitment in atherosclerotic mice. Arteriosclerosis, thrombosis, and vascular biology. 2013 Feb; 33(2):215-23. doi: 10.1161/atvbaha.112.300275. [PMID: 23241405]
  • Bingnan Han, Rachel Wright, Aaron M Kirchhoff, Julia A Chester, Bruce R Cooper, Vincent Jo Davisson, Eric Barker. Quantitative LC-MS/MS analysis of arachidonoyl amino acids in mouse brain with treatment of FAAH inhibitor. Analytical biochemistry. 2013 Jan; 432(2):74-81. doi: 10.1016/j.ab.2012.09.031. [PMID: 23044255]
  • Josée Guindon, Yvonne Lai, Sara M Takacs, Heather B Bradshaw, Andrea G Hohmann. Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment. Pharmacological research. 2013 Jan; 67(1):94-109. doi: 10.1016/j.phrs.2012.10.013. [PMID: 23127915]
  • J Allen Crow, Victoria Bittles, Abdolsamad Borazjani, Philip M Potter, Matthew K Ross. Covalent inhibition of recombinant human carboxylesterase 1 and 2 and monoacylglycerol lipase by the carbamates JZL184 and URB597. Biochemical pharmacology. 2012 Nov; 84(9):1215-22. doi: 10.1016/j.bcp.2012.08.017. [PMID: 22943979]
  • Meghan Johnston, Shachi R Bhatt, Surina Sikka, Richard W Mercier, Jay M West, Alexandros Makriyannis, S John Gatley, Richard I Duclos. Assay and inhibition of diacylglycerol lipase activity. Bioorganic & medicinal chemistry letters. 2012 Jul; 22(14):4585-92. doi: 10.1016/j.bmcl.2012.05.101. [PMID: 22738638]
  • Oscar Sasso, Rosalia Bertorelli, Tiziano Bandiera, Rita Scarpelli, Giampiero Colombano, Andrea Armirotti, Guillermo Moreno-Sanz, Angelo Reggiani, Daniele Piomelli. Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions. Pharmacological research. 2012 May; 65(5):553-63. doi: 10.1016/j.phrs.2012.02.012. [PMID: 22420940]
  • D M Kerr, N N Burke, G K Ford, T J Connor, B Harhen, L J Egan, D P Finn, M Roche. Pharmacological inhibition of endocannabinoid degradation modulates the expression of inflammatory mediators in the hypothalamus following an immunological stressor. Neuroscience. 2012 Mar; 204(?):53-63. doi: 10.1016/j.neuroscience.2011.09.032. [PMID: 21952131]
  • Federica Vacondio, Claudia Silva, Alessio Lodola, Caterina Carmi, Silvia Rivara, Andrea Duranti, Andrea Tontini, Silvano Sanchini, Jason R Clapper, Daniele Piomelli, Giorgio Tarzia, Marco Mor. Biphenyl-3-yl alkylcarbamates as fatty acid amide hydrolase (FAAH) inhibitors: steric effects of N-alkyl chain on rat plasma and liver stability. European journal of medicinal chemistry. 2011 Sep; 46(9):4466-73. doi: 10.1016/j.ejmech.2011.07.021. [PMID: 21820769]
  • Tom H Johnston, Philippe Huot, Susan H Fox, James D Wakefield, Kristine A Sykes, Wilmin P Bartolini, G Todd Milne, James P Pearson, Jonathan M Brotchie. Fatty acid amide hydrolase (FAAH) inhibition reduces L-3,4-dihydroxyphenylalanine-induced hyperactivity in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned non-human primate model of Parkinson's disease. The Journal of pharmacology and experimental therapeutics. 2011 Feb; 336(2):423-30. doi: 10.1124/jpet.110.169532. [PMID: 20966038]
  • Linnzi K M Wright, Jing Liu, Anuradha Nallapaneni, Carey N Pope. Behavioral sequelae following acute diisopropylfluorophosphate intoxication in rats: comparative effects of atropine and cannabinomimetics. Neurotoxicology and teratology. 2010 May; 32(3):329-35. doi: 10.1016/j.ntt.2009.12.006. [PMID: 20034559]
  • Andrea De Laurentiis, Javier Fernandez-Solari, Claudia Mohn, Berenice Burdet, María A Zorrilla Zubilete, Valeria Rettori. The hypothalamic endocannabinoid system participates in the secretion of oxytocin and tumor necrosis factor-alpha induced by lipopolysaccharide. Journal of neuroimmunology. 2010 Apr; 221(1-2):32-41. doi: 10.1016/j.jneuroim.2010.02.006. [PMID: 20207018]
  • Murat Oz, Vanaja Jaligam, Sehamuddin Galadari, George Petroianu, Yaroslav M Shuba, Toni S Shippenberg. The endogenous cannabinoid, anandamide, inhibits dopamine transporter function by a receptor-independent mechanism. Journal of neurochemistry. 2010 Mar; 112(6):1454-64. doi: 10.1111/j.1471-4159.2009.06557.x. [PMID: 20050977]
  • Ali Saber-Tehrani, Nima Naderi, Azadeh Hosseini Najarkolaei, Abbas Haghparast, Fereshteh Motamedi. Cannabinoids and their interactions with diazepam on modulation of serum corticosterone concentration in male mice. Neurochemical research. 2010 Jan; 35(1):60-6. doi: 10.1007/s11064-009-0030-9. [PMID: 19590959]
  • Lina Thors, Christopher J Fowler. Effect of nitric oxide donors on membrane tritium accumulation of endocannabinoids and related endogenous lipids. European journal of pharmacology. 2009 Oct; 621(1-3):10-8. doi: 10.1016/j.ejphar.2009.08.028. [PMID: 19715690]
  • Parisa Hasanein, Mohsen Parviz, Mansoor Keshavarz, Ali Roohbakhsh. URB597, an inhibitor of fatty acid amide hydrolase, reduces hyperalgesia in diabetic rats. Canadian journal of physiology and pharmacology. 2009 Jun; 87(6):432-9. doi: 10.1139/y09-026. [PMID: 19526037]
  • Heather B Bradshaw, Neta Rimmerman, Sherry Shu-Jung Hu, Valery M Benton, Jordyn M Stuart, Kim Masuda, Benjamin F Cravatt, David K O'Dell, J Michael Walker. The endocannabinoid anandamide is a precursor for the signaling lipid N-arachidonoyl glycine by two distinct pathways. BMC biochemistry. 2009 May; 10(?):14. doi: 10.1186/1471-2091-10-14. [PMID: 19460156]
  • Kay Ahn, Douglas S Johnson, Mauro Mileni, David Beidler, Jonathan Z Long, Michele K McKinney, Eranthie Weerapana, Nalini Sadagopan, Marya Liimatta, Sarah E Smith, Scott Lazerwith, Cory Stiff, Satwik Kamtekar, Keshab Bhattacharya, Yanhua Zhang, Stephen Swaney, Keri Van Becelaere, Raymond C Stevens, Benjamin F Cravatt. Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain. Chemistry & biology. 2009 Apr; 16(4):411-20. doi: 10.1016/j.chembiol.2009.02.013. [PMID: 19389627]
  • Miriam Melis, Giuliano Pillolla, Antonio Luchicchi, Anna Lisa Muntoni, Sevil Yasar, Steven R Goldberg, Marco Pistis. Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008 Dec; 28(51):13985-94. doi: 10.1523/jneurosci.3221-08.2008. [PMID: 19091987]
  • Michelle Roche, John P Kelly, Maeve O'Driscoll, David P Finn. Augmentation of endogenous cannabinoid tone modulates lipopolysaccharide-induced alterations in circulating cytokine levels in rats. Immunology. 2008 Oct; 125(2):263-71. doi: 10.1111/j.1365-2567.2008.02838.x. [PMID: 18393970]
  • Neta Rimmerman, Heather B Bradshaw, H Velocity Hughes, Jay Shih-Chieh Chen, Sherry Shu-Jung Hu, Douglas McHugh, Eivind Vefring, Jan A Jahnsen, Eric L Thompson, Kim Masuda, Benjamin F Cravatt, Sumner Burstein, Michael R Vasko, Anne L Prieto, David K O'Dell, J Michael Walker. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Molecular pharmacology. 2008 Jul; 74(1):213-24. doi: 10.1124/mol.108.045997. [PMID: 18424551]
  • Boris B Gorzalka, Anna C Morrish, Matthew N Hill. Endocannabinoid modulation of male rat sexual behavior. Psychopharmacology. 2008 Jul; 198(4):479-86. doi: 10.1007/s00213-007-0901-1. [PMID: 17694389]
  • Jacqueline L Blankman, Gabriel M Simon, Benjamin F Cravatt. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chemistry & biology. 2007 Dec; 14(12):1347-56. doi: 10.1016/j.chembiol.2007.11.006. [PMID: 18096503]
  • Marco Bortolato, Regina A Mangieri, Jin Fu, Janet H Kim, Oliver Arguello, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Daniele Piomelli. Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress. Biological psychiatry. 2007 Nov; 62(10):1103-10. doi: 10.1016/j.biopsych.2006.12.001. [PMID: 17511970]
  • Roberto Russo, Jesse Loverme, Giovanna La Rana, Timothy R Compton, Jeff Parrott, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Antonio Calignano, Daniele Piomelli. The fatty acid amide hydrolase inhibitor URB597 (cyclohexylcarbamic acid 3'-carbamoylbiphenyl-3-yl ester) reduces neuropathic pain after oral administration in mice. The Journal of pharmacology and experimental therapeutics. 2007 Jul; 322(1):236-42. doi: 10.1124/jpet.107.119941. [PMID: 17412883]
  • Eric Murillo-Rodríguez, Edgar Vázquez, Diana Millán-Aldaco, Marcela Palomero-Rivero, René Drucker-Colin. Effects of the fatty acid amide hydrolase inhibitor URB597 on the sleep-wake cycle, c-Fos expression and dopamine levels of the rat. European journal of pharmacology. 2007 May; 562(1-2):82-91. doi: 10.1016/j.ejphar.2007.01.076. [PMID: 17336288]
  • Ville A B Palomäki, Marko Lehtonen, Juha R Savinainen, Jarmo T Laitinen. Visualization of 2-arachidonoylglycerol accumulation and cannabinoid CB1 receptor activity in rat brain cryosections by functional autoradiography. Journal of neurochemistry. 2007 May; 101(4):972-81. doi: 10.1111/j.1471-4159.2006.04403.x. [PMID: 17254014]
  • Di Zhang, Anita Saraf, Teodozyi Kolasa, Pramila Bhatia, Guo Zhu Zheng, Meena Patel, Greg S Lannoye, Paul Richardson, Andrew Stewart, John C Rogers, Jorge D Brioni, Carol S Surowy. Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets. Neuropharmacology. 2007 Mar; 52(4):1095-105. doi: 10.1016/j.neuropharm.2006.11.009. [PMID: 17217969]
  • W-S V Ho, M D Randall. Endothelium-dependent metabolism by endocannabinoid hydrolases and cyclooxygenases limits vasorelaxation to anandamide and 2-arachidonoylglycerol. British journal of pharmacology. 2007 Mar; 150(5):641-51. doi: 10.1038/sj.bjp.0707141. [PMID: 17245358]
  • Joohyung Lee, Vincenzo Di Marzo, Jonathan M Brotchie. A role for vanilloid receptor 1 (TRPV1) and endocannabinnoid signalling in the regulation of spontaneous and L-DOPA induced locomotion in normal and reserpine-treated rats. Neuropharmacology. 2006 Sep; 51(3):557-65. doi: 10.1016/j.neuropharm.2006.04.016. [PMID: 16806299]
  • Jessica P Alexander, Benjamin F Cravatt. The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases. Journal of the American Chemical Society. 2006 Aug; 128(30):9699-704. doi: 10.1021/ja062999h. [PMID: 16866524]
  • Alan Saghatelian, Michele K McKinney, Michael Bandell, Ardem Patapoutian, Benjamin F Cravatt. A FAAH-regulated class of N-acyl taurines that activates TRP ion channels. Biochemistry. 2006 Aug; 45(30):9007-15. doi: 10.1021/bi0608008. [PMID: 16866345]
  • Yong-Xin Sun, Kazuhito Tsuboi, Li-Ying Zhao, Yasuo Okamoto, Didier M Lambert, Natsuo Ueda. Involvement of N-acylethanolamine-hydrolyzing acid amidase in the degradation of anandamide and other N-acylethanolamines in macrophages. Biochimica et biophysica acta. 2005 Oct; 1736(3):211-20. doi: 10.1016/j.bbalip.2005.08.010. [PMID: 16154384]
  • Darren Fegley, Silvana Gaetani, Andrea Duranti, Andrea Tontini, Marco Mor, Giorgio Tarzia, Daniele Piomelli. Characterization of the fatty acid amide hydrolase inhibitor cyclohexyl carbamic acid 3'-carbamoyl-biphenyl-3-yl ester (URB597): effects on anandamide and oleoylethanolamide deactivation. The Journal of pharmacology and experimental therapeutics. 2005 Apr; 313(1):352-8. doi: 10.1124/jpet.104.078980. [PMID: 15579492]
  • Sándor Bátkai, Pál Pacher, Douglas Osei-Hyiaman, Svetlana Radaeva, Jie Liu, Judith Harvey-White, László Offertáler, Ken Mackie, M Audrey Rudd, Richard D Bukoski, George Kunos. Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension. Circulation. 2004 Oct; 110(14):1996-2002. doi: 10.1161/01.cir.0000143230.23252.d2. [PMID: 15451779]
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