MG-132 (BioDeep_00000600918)
代谢物信息卡片
Benzyl n-[(2s)-4-methyl-1-[[(2r)-4-methyl-1-[[(2s)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate
化学式: C26H41N3O5 (475.3046)
中文名称: MG-132, L-亮氨酰胺，N-[（苯基甲氧基）羰基]-L-亮氨酰-N-[（1S）-1-甲酰基-3-甲基丁基]
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1
InChI: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)
描述信息
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D015853 - Cysteine Proteinase Inhibitors
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2160 - Proteasome Inhibitor
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors > D007976 - Leupeptins
D000970 - Antineoplastic Agents
C471 - Enzyme Inhibitor
同义名列表
7 个代谢物同义名
Z-Leu-leu-leu-al; MG-132; Benzyl n-[(2s)-4-methyl-1-[[(2r)-4-methyl-1-[[(2s)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate; benzyl N-[(2S)-4-methyl-1-[[(2S)-4-methyl-1-[[(2S)-4-methyl-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]amino]-1-oxopentan-2-yl]carbamate; N-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide; (S)-MG132; L-Leucinamide,n-[(phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:75142
- ChEBI: CHEBI:191090
- PubChem: 462382
- PubChem: 45103781
- PubChem: 6914692
- Metlin: METLIN45357
- ChEMBL: CHEMBL64925
- ChEMBL: CHEMBL1090713
- CAS: 1211877-36-9
- CAS: 133407-82-6
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
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Science advances.
2018 03; 4(3):eaar2631. doi:
10.1126/sciadv.aar2631. [PMID: 29532034] - Dan Yang, Zhong-Quan Cheng, Liu Yang, Bo Hou, Jing Yang, Xiao-Nian Li, Cheng-Ting Zi, Fa-Wu Dong, Zheng-Hua Liu, Jun Zhou, Zhong-Tao Ding, Jiang-Miao Hu. Seco-Dendrobine-Type Alkaloids and Bioactive Phenolics from Dendrobium findlayanum.
Journal of natural products.
2018 02; 81(2):227-235. doi:
10.1021/acs.jnatprod.7b00150. [PMID: 29338260] - Wenhao Zhao, Yinghua Ji, Shuhua Wu, Xiaofang Ma, Shuo Li, Feng Sun, Zhaobang Cheng, Yijun Zhou, Yongjian Fan. Single amino acid in V2 encoded by TYLCV is responsible for its self-interaction, aggregates and pathogenicity.
Scientific reports.
2018 02; 8(1):3561. doi:
10.1038/s41598-018-21446-2. [PMID: 29476063] - Nicholas W West, Edward M Golenberg. Gender-specific expression of GIBBERELLIC ACID INSENSITIVE is critical for unisexual organ initiation in dioecious Spinacia oleracea.
The New phytologist.
2018 02; 217(3):1322-1334. doi:
10.1111/nph.14919. [PMID: 29226967] - Kozo Ohkusu-Tsukada, Daiki Ito, Kimimasa Takahashi. The Role of Proteasome Inhibitor MG132 in 2,4-Dinitrofluorobenzene-Induced Atopic Dermatitis in NC/Nga Mice.
International archives of allergy and immunology.
2018; 176(2):91-100. doi:
10.1159/000488155. [PMID: 29669333] - Saeed Jahandideh, Shohreh Khatami, Ali Eslami Far, Mehdi Kadivar. Anti-inflammatory effects of human embryonic stem cell-derived mesenchymal stem cells secretome preconditioned with diazoxide, trimetazidine and MG-132 on LPS-induced systemic inflammation mouse model.
Artificial cells, nanomedicine, and biotechnology.
2018; 46(sup2):1178-1187. doi:
10.1080/21691401.2018.1481862. [PMID: 29929400] - Wenjuan Tang, Sunyinyan Tang, Hongdong Wang, Zhijuan Ge, Dalong Zhu, Yan Bi. Insulin restores UCP3 activity and decreases energy surfeit to alleviate lipotoxicity in skeletal muscle.
International journal of molecular medicine.
2017 Dec; 40(6):2000-2010. doi:
10.3892/ijmm.2017.3169. [PMID: 29039450] - Jibiao Li, Cheng Chen, Yuan Li, David J Matye, Yifeng Wang, Wen-Xing Ding, Tiangang Li. Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes.
Biochimica et biophysica acta. Molecular basis of disease.
2017 11; 1863(11):2924-2933. doi:
10.1016/j.bbadis.2017.08.012. [PMID: 28844948] - Sergii Domanskyi, Justin W Nicholatos, Joshua E Schilling, Vladimir Privman, Sergiy Libert. SIRT6 knockout cells resist apoptosis initiation but not progression: a computational method to evaluate the progression of apoptosis.
Apoptosis : an international journal on programmed cell death.
2017 Nov; 22(11):1336-1343. doi:
10.1007/s10495-017-1412-0. [PMID: 28856570] - Filomena Fiorito, Valentina Iovane, Antonietta Cantiello, Annarosaria Marullo, Luisa De Martino, Giuseppe Iovane. MG-132 reduces virus release in Bovine herpesvirus-1 infection.
Scientific reports.
2017 10; 7(1):13306. doi:
10.1038/s41598-017-13717-1. [PMID: 29042667] - Ting Li, Xin Chen, Xiao-Yang Dai, Bin Wei, Qin-Jie Weng, Xiuping Chen, De-Fang Ouyang, Ru Yan, Zhang-Jian Huang, Hu-Lin Jiang, Hong Zhu, Jin-Jian Lu. Novel Hsp90 inhibitor platycodin D disrupts Hsp90/Cdc37 complex and enhances the anticancer effect of mTOR inhibitor.
Toxicology and applied pharmacology.
2017 09; 330(?):65-73. doi:
10.1016/j.taap.2017.07.006. [PMID: 28711525] - Hsi-Chin Wu, Ing-Shiow Lay, Marthandam Asokan Shibu, Tsung-Jung Ho, Shiu-Min Cheng, Chih-Hao Lin, Tran Duc Dung, Long-Bin Jeng, Vijaya Padma Viswanadha, Chih-Yang Huang. Zanthoxylum avicennae extract enhances GSK-3β to attenuate β-catenin via phosphatase 2A to block metastatic effects of HA22T cells and hepatocellular carcinoma xenografted nude mice.
Environmental toxicology.
2017 Sep; 32(9):2133-2143. doi:
10.1002/tox.22426. [PMID: 28548306] - Liang Shi, Guoqing Zhang, Zhiyong Zheng, Bin Lu, Lili Ji. Andrographolide reduced VEGFA expression in hepatoma cancer cells by inactivating HIF-1α: The involvement of JNK and MTA1/HDCA.
Chemico-biological interactions.
2017 Aug; 273(?):228-236. doi:
10.1016/j.cbi.2017.06.024. [PMID: 28651835] - Meng Yan, Lifang Feng, Yanhui Shi, Junnan Wang, Yan Liu, Fengmei Li, Baoxin Li. Mechanism of As2O3-Induced Action Potential Prolongation and Using hiPS-CMs to Evaluate the Rescue Efficacy of Drugs With Different Rescue Mechanism.
Toxicological sciences : an official journal of the Society of Toxicology.
2017 08; 158(2):379-390. doi:
10.1093/toxsci/kfx098. [PMID: 28521025] - Janusz Ligeza, Paulina Marona, Natalia Gach, Barbara Lipert, Katarzyna Miekus, Waclaw Wilk, Janusz Jaszczynski, Andrzej Stelmach, Agnieszka Loboda, Jozef Dulak, Wojciech Branicki, Janusz Rys, Jolanta Jura. MCPIP1 contributes to clear cell renal cell carcinomas development.
Angiogenesis.
2017 Aug; 20(3):325-340. doi:
10.1007/s10456-017-9540-2. [PMID: 28197812] - Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Wei Song, Xue Qiao, Gulnar Sabir, Min Ye. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
Bioorganic & medicinal chemistry.
2017 07; 25(14):3706-3713. doi:
10.1016/j.bmc.2017.05.009. [PMID: 28522265] - Jae Yun Moon, Su Jin Choi, Cheol Ho Heo, Hwan Myung Kim, Hye Sun Kim. α-Syntrophin stabilizes catalase to reduce endogenous reactive oxygen species levels during myoblast differentiation.
The FEBS journal.
2017 07; 284(13):2052-2065. doi:
10.1111/febs.14103. [PMID: 28485891] - Roberta Ramos Coelho, Paulo Vieira, José Dijair Antonino de Souza Júnior, Cristina Martin-Jimenez, Lieven De Veylder, Julie Cazareth, Gilbert Engler, Maria Fatima Grossi-de-Sa, Janice de Almeida Engler. Exploiting cell cycle inhibitor genes of the KRP family to control root-knot nematode induced feeding sites in plants.
Plant, cell & environment.
2017 Jul; 40(7):1174-1188. doi:
10.1111/pce.12912. [PMID: 28103637] - Anne Rietz, Hongxia Li, Kevin M Quist, Jonathan J Cherry, Christian L Lorson, Barrington G Burnett, Nicholas L Kern, Alyssa N Calder, Melanie Fritsche, Hrvoje Lusic, Patrick J Boaler, Sungwoon Choi, Xuechao Xing, Marcie A Glicksman, Gregory D Cuny, Elliot J Androphy, Kevin J Hodgetts. Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy.
Journal of medicinal chemistry.
2017 06; 60(11):4594-4610. doi:
10.1021/acs.jmedchem.6b01885. [PMID: 28481536] - Susanne Jennek, Sonnhild Mittag, Juliane Reiche, Julie K Westphal, Stefanie Seelk, Max J Dörfel, Thorsten Pfirrmann, Karlheinz Friedrich, Anja Schütz, Udo Heinemann, Otmar Huber. Tricellulin is a target of the ubiquitin ligase Itch.
Annals of the New York Academy of Sciences.
2017 06; 1397(1):157-168. doi:
10.1111/nyas.13349. [PMID: 28436082] - Ali Akoumi, Taha Haffar, Maria Mousterji, Robert Scott Kiss, Nicolas Bousette. Palmitate mediated diacylglycerol accumulation causes endoplasmic reticulum stress, Plin2 degradation, and cell death in H9C2 cardiomyoblasts.
Experimental cell research.
2017 05; 354(2):85-94. doi:
10.1016/j.yexcr.2017.03.032. [PMID: 28336294] - Bojan Bujisic, Aude De Gassart, Rémy Tallant, Olivier Demaria, Léa Zaffalon, Sonia Chelbi, Michel Gilliet, Francesco Bertoni, Fabio Martinon. Impairment of both IRE1 expression and XBP1 activation is a hallmark of GCB DLBCL and contributes to tumor growth.
Blood.
2017 04; 129(17):2420-2428. doi:
10.1182/blood-2016-09-741348. [PMID: 28167662] - Haiyang Yu, Yu Zhang, Dong Zhang, Yanxi Lu, Haixia He, Fucong Zheng, Meng Wang. Identification of a Ribose-Phosphate Pyrophosphokinase that Can Interact In Vivo with the Anaphase Promoting Complex/Cyclosome.
International journal of molecular sciences.
2017 Mar; 18(4):. doi:
10.3390/ijms18040617. [PMID: 28358323] - Aneta Żabka, Konrad Winnicki, Justyna Teresa Polit, Janusz Maszewski. Sanguinarine-induced oxidative stress and apoptosis-like programmed cell death(AL-PCD) in root meristem cells of Allium cepa.
Plant physiology and biochemistry : PPB.
2017 Mar; 112(?):193-206. doi:
10.1016/j.plaphy.2017.01.004. [PMID: 28088021] - Kai Li, Shuai Ji, Wei Song, Yi Kuang, Yan Lin, Shunan Tang, Zexu Cui, Xue Qiao, Siwang Yu, Min Ye. Glycybridins A-K, Bioactive Phenolic Compounds from Glycyrrhiza glabra.
Journal of natural products.
2017 02; 80(2):334-346. doi:
10.1021/acs.jnatprod.6b00783. [PMID: 28140583] - Bharat P Bashyal, E M Kithsiri Wijeratne, Joseph Tillotson, A Elizabeth Arnold, Eli Chapman, A A Leslie Gunatilaka. Chlorinated Dehydrocurvularins and Alterperylenepoxide A from Alternaria sp. AST0039, a Fungal Endophyte of Astragalus lentiginosus.
Journal of natural products.
2017 02; 80(2):427-433. doi:
10.1021/acs.jnatprod.6b00960. [PMID: 28139929] - Madoka Chinen, Elissa P Lei. Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway.
Biochemical and biophysical research communications.
2017 02; 483(3):951-957. doi:
10.1016/j.bbrc.2017.01.039. [PMID: 28087276] - Elizabeth G Bromfield, R John Aitken, Eileen A McLaughlin, Brett Nixon. Proteolytic degradation of heat shock protein A2 occurs in response to oxidative stress in male germ cells of the mouse.
Molecular human reproduction.
2017 02; 23(2):91-105. doi:
10.1093/molehr/gaw074. [PMID: 27932549] - Abhijeet K Choudhary, Chinmoy S Dey. Nuclear co-repressor (NCoR) is required to maintain insulin sensitivity in C2 C12 myotubes.
Cell biology international.
2017 Feb; 41(2):204-212. doi:
10.1002/cbin.10711. [PMID: 27935220] - Po-Hao Hsu, Yu-Ting Ma, Ya-Ching Fang, Jing-Jia Huang, Yu-Ling Gan, Pei-Tzu Chang, Guey-Mei Jow, Chih-Yung Tang, Chung-Jiuan Jeng. Cullin 7 mediates proteasomal and lysosomal degradations of rat Eag1 potassium channels.
Scientific reports.
2017 01; 7(?):40825. doi:
10.1038/srep40825. [PMID: 28098200] - Lili Kong, Yangwei Wang, Manyu Luo, Yi Tan, Wenpeng Cui, Lining Miao. Prevention of Streptozotocin-Induced Diabetic Nephropathy by MG132: Possible Roles of Nrf2 and IκB.
Oxidative medicine and cellular longevity.
2017; 2017(?):3671751. doi:
10.1155/2017/3671751. [PMID: 28373900] - Yuichiro Izumi, Hideki Inoue, Yushi Nakayama, Koji Eguchi, Yukiko Yasuoka, Naomi Matsuo, Hiroshi Nonoguchi, Yutaka Kakizoe, Takashige Kuwabara, Masashi Mukoyama. TSS-Seq analysis of low pH-induced gene expression in intercalated cells in the renal collecting duct.
PloS one.
2017; 12(8):e0184185. doi:
10.1371/journal.pone.0184185. [PMID: 28859164] - Mitsuaki Tokumaru, Fumi Adachi, Makoto Toda, Yasuko Ito-Inaba, Fumiko Yazu, Yoshihiro Hirosawa, Yoichi Sakakibara, Masahito Suiko, Tomohiro Kakizaki, Takehito Inaba. Ubiquitin-Proteasome Dependent Regulation of the GOLDEN2-LIKE 1 Transcription Factor in Response to Plastid Signals.
Plant physiology.
2017 01; 173(1):524-535. doi:
10.1104/pp.16.01546. [PMID: 27821720] - Cody S Shirriff, John J Heikkila. Characterization of cadmium chloride-induced BiP accumulation in Xenopus laevis A6 kidney epithelial cells.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2017 Jan; 191(?):117-128. doi:
10.1016/j.cbpc.2016.10.003. [PMID: 27746171] - Jeong Ah Hwang, Nok Hyun Park, Yong Joo Na, Hae Kwang Lee, John Hwan Lee, Yong Jin Kim, Chang Seok Lee. Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase.
Biological & pharmaceutical bulletin.
2017; 40(4):535-539. doi:
10.1248/bpb.b16-00834. [PMID: 28381809] - Gwang Hun Park, Hun Min Song, Jin Boo Jeong. The coffee diterpene kahweol suppresses the cell proliferation by inducing cyclin D1 proteasomal degradation via ERK1/2, JNK and GKS3β-dependent threonine-286 phosphorylation in human colorectal cancer cells.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2016 Sep; 95(?):142-8. doi:
10.1016/j.fct.2016.07.008. [PMID: 27424123] - Qin Li, Xianzong Shi, Shengjian Ye, Sheng Wang, Ron Chan, Troy Harkness, Hong Wang. A short motif in Arabidopsis CDK inhibitor ICK1 decreases the protein level, probably through a ubiquitin-independent mechanism.
The Plant journal : for cell and molecular biology.
2016 09; 87(6):617-28. doi:
10.1111/tpj.13223. [PMID: 27233081] - Hang Lu, Xue-Feng Yang, Xiao-Qing Tian, Shou-Long Tang, Lian-Qian Li, Shuang Zhao, Hua-Chuan Zheng. The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells.
Oncotarget.
2016 Aug; 7(35):56508-56525. doi:
10.18632/oncotarget.10643. [PMID: 27447743] - Yasuyuki Yamada, Fumihiko Sato. Tyrosine phosphorylation and protein degradation control the transcriptional activity of WRKY involved in benzylisoquinoline alkaloid biosynthesis.
Scientific reports.
2016 08; 6(?):31988. doi:
10.1038/srep31988. [PMID: 27552928] - Nian-Hua Zhang, Rui-Qing Peng, Ya Ding, Xiao-Shi Zhang. Rejection of adenovirus infection is independent of coxsackie and adenovirus receptor expression in cisplatin-resistant human lung cancer cells.
Oncology reports.
2016 Aug; 36(2):715-20. doi:
10.3892/or.2016.4870. [PMID: 27373420] - Kamonshanok Kraidith, Saovaros Svasti, Jarinthorn Teerapornpuntakit, Jim Vadolas, Rattana Chaimana, Sarawut Lapmanee, Panan Suntornsaratoon, Nateetip Krishnamra, Suthat Fucharoen, Narattaphol Charoenphandhu. Hepcidin and 1,25(OH)2D3 effectively restore Ca2+ transport in β-thalassemic mice: reciprocal phenomenon of Fe2+ and Ca2+ absorption.
American journal of physiology. Endocrinology and metabolism.
2016 07; 311(1):E214-23. doi:
10.1152/ajpendo.00067.2016. [PMID: 27245334] - Luo-Sheng Wan, Rui Chu, Xing-Rong Peng, Guo-Lei Zhu, Mu-Yuan Yu, Lei Li, Lin Zhou, Shuang-Yang Lu, Jin-Run Dong, Zhi-Run Zhang, Yan Li, Ming-Hua Qiu. Pepluane and Paraliane Diterpenoids from Euphorbia peplus with Potential Anti-inflammatory Activity.
Journal of natural products.
2016 06; 79(6):1628-34. doi:
10.1021/acs.jnatprod.6b00206. [PMID: 27203291] - Hyo Jin Park, Tae Hee Kim, So Won Kim, Shin Hye Noh, Kyeong Jee Cho, Choe Choi, Eun Young Kwon, Yang Ji Choi, Heon Yung Gee, Ji Ha Choi. Functional characterization of ABCB4 mutations found in progressive familial intrahepatic cholestasis type 3.
Scientific reports.
2016 06; 6(?):26872. doi:
10.1038/srep26872. [PMID: 27256251] - Nicholas P Gladman, Richard S Marshall, Kwang-Hee Lee, Richard D Vierstra. The Proteasome Stress Regulon Is Controlled by a Pair of NAC Transcription Factors in Arabidopsis.
The Plant cell.
2016 06; 28(6):1279-96. doi:
10.1105/tpc.15.01022. [PMID: 27194708]
