Plerixafor (BioDeep_00000600903)
代谢物信息卡片
1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene, octahydrochloride
化学式: C28H54N8 (502.44712039999996)
中文名称: 普乐沙福
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CNCCNCCCN(CCNC1)CC2=CC=C(C=C2)CN3CCCNCCNCCCNCC3
InChI: InChI=1S/C28H54N8/c1-9-29-15-17-31-13-3-21-35(23-19-33-11-1)25-27-5-7-28(8-6-27)26-36-22-4-14-32-18-16-30-10-2-12-34-20-24-36/h5-8,29-34H,1-4,9-26H2
描述信息
L - Antineoplastic and immunomodulating agents > L03 - Immunostimulants > L03A - Immunostimulants
D000890 - Anti-Infective Agents > D000998 - Antiviral Agents > D044966 - Anti-Retroviral Agents
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C308 - Immunotherapeutic Agent > C63817 - Chemokine Receptor Antagonist
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:125354
- KEGGdrug: D08971
- PubChem: 65015
- Metlin: METLIN45328
- DrugBank: DB06809
- ChEMBL: CHEMBL18442
- CAS: 110078-46-1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Brad Rybinski, Aaron P Rapoport, Ashraf Z Badros, Nancy Hardy, Mehmet Kocoglu. Prolonged Lenalidomide Induction Does Not Significantly Impair Stem Cell Collection in Multiple Myeloma Patients Mobilized With Cyclophosphamide or Plerixafor: A Report From The Covid Era.
Clinical lymphoma, myeloma & leukemia.
2022 Aug; 22(8):e716-e729. doi:
10.1016/j.clml.2022.03.013. [PMID: 35504807] - Mona Vogel, Bettina Möhrle, Vadim Sakk, Andreas Brown, Annette Palmer, Sonja Braumüller, Markus Huber-Lang, Andreas Allgöwer, Jose A Cancelas, Hartmut Geiger. A Limited Role for AMD3100 Induced Stem Cell Mobilization for Modulation of Thoracic Trauma Outcome.
Shock (Augusta, Ga.).
2022 06; 57(6):260-267. doi:
10.1097/shk.0000000000001933. [PMID: 35759306] - Zhi Chen, Xiang Ren, Ruimin Ren, Yonghong Wang, Jiwen Shang. The combination of G-CSF and AMD3100 mobilizes bone marrow-derived stem cells to protect against cisplatin-induced acute kidney injury in mice.
Stem cell research & therapy.
2021 03; 12(1):209. doi:
10.1186/s13287-021-02268-y. [PMID: 33761993] - Chang Li, Kevin A Goncalves, Tamás Raskó, Amit Pande, Sucheol Gil, Zhinan Liu, Zsuzsanna Izsvák, Thalia Papayannopoulou, John C Davis, Hans-Peter Kiem, André Lieber. Single-dose MGTA-145/plerixafor leads to efficient mobilization and in vivo transduction of HSCs with thalassemia correction in mice.
Blood advances.
2021 03; 5(5):1239-1249. doi:
10.1182/bloodadvances.2020003714. [PMID: 33646305] - Xin Zhang, Yi Liu, Lei Dai, Gang Shi, Jie Deng, Qiang Luo, Qian Xie, Lin Cheng, Chunlei Li, Yi Lin, Qingnan Wang, Ping Fan, Hantao Zhang, Xiaolan Su, Shuang Zhang, Yang Yang, Xun Hu, Qiyong Gong, Dechao Yu, Lei Zheng, Hongxin Deng. BATF2 prevents glioblastoma multiforme progression by inhibiting recruitment of myeloid-derived suppressor cells.
Oncogene.
2021 02; 40(8):1516-1530. doi:
10.1038/s41388-020-01627-y. [PMID: 33452462] - W B Duan, X L Dou, L Lei, F R Wang, X J Huang, J Lu. [Analysis of the efficacy and safety of plerixafor combined with G-CSF in plasma cell disease mobilization].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi.
2021 Jan; 42(1):21-26. doi:
10.3760/cma.j.issn.0253-2727.2021.01.005. [PMID: 33677864] - Guoliang Wang, Yanlin Li, Xuhan Meng, Xiao Yang, Yaoyu Xiang. The study of targeted blocking SDF-1/CXCR4 signaling pathway with three antagonists on MMPs, type II collagen, and aggrecan levels in articular cartilage of guinea pigs.
Journal of orthopaedic surgery and research.
2020 May; 15(1):195. doi:
10.1186/s13018-020-01646-1. [PMID: 32471458] - Yahong Liu, Qijian Feng, Jinhua Miao, Qinyu Wu, Shan Zhou, Weiwei Shen, Yanqiu Feng, Fan Fan Hou, Youhua Liu, Lili Zhou. C-X-C motif chemokine receptor 4 aggravates renal fibrosis through activating JAK/STAT/GSK3β/β-catenin pathway.
Journal of cellular and molecular medicine.
2020 04; 24(7):3837-3855. doi:
10.1111/jcmm.14973. [PMID: 32119183] - Langdong Chen, Diya Lv, Shaozhan Wang, Dongyao Wang, Xiaofei Chen, Yue Liu, Zhanying Hong, Zhenyu Zhu, Yan Cao, Yifeng Chai. Surface Plasmon Resonance-Based Membrane Protein-Targeted Active Ingredients Recognition Strategy: Construction and Implementation in Ligand Screening from Herbal Medicines.
Analytical chemistry.
2020 03; 92(5):3972-3980. doi:
10.1021/acs.analchem.9b05479. [PMID: 32045214] - Han-Yu Li, Hong-Chun He, Jing-Feng Song, Yun-Fei Du, Ming Guan, Cheng-Yong Wu. Bone marrow-derived mesenchymal stem cells repair severe acute pancreatitis by secreting miR-181a-5p to target PTEN/Akt/TGF-β1 signaling.
Cellular signalling.
2020 02; 66(?):109436. doi:
10.1016/j.cellsig.2019.109436. [PMID: 31654716] - Hongzhu Tian, Jiushen Pang, Kairong Qin, Weimo Yuan, Jing Kong, Hongjuan Ma, Junzhou He, Xuesong Yang, Yong Luo, Yao Lu, Bingcheng Lin, Tingjiao Liu. A Novel Tissue-Based Liver-Kidney-on-a-Chip Can Mimic Liver Tropism of Extracellular Vesicles Derived from Breast Cancer Cells.
Biotechnology journal.
2020 Feb; 15(2):e1900107. doi:
10.1002/biot.201900107. [PMID: 31473998] - Jiyang Xue, Ruixiang Li, Dingding Gao, Fenghua Chen, Hongjuan Xie. CXCL12/CXCR4 Axis-Targeted Dual-Functional Nano-Drug Delivery System Against Ovarian Cancer.
International journal of nanomedicine.
2020; 15(?):5701-5718. doi:
10.2147/ijn.s257527. [PMID: 32848392] - Wei-Jia Lu, Li Zhou, Fan-Xiang Gao, Yu-Lin Zhou, Zhi Li, Xiao-Juan Zhang, Yang Wang, Jian-Fang Gui. Dynamic and Differential Expression of Duplicated Cxcr4/Cxcl12 Genes Facilitates Antiviral Response in Hexaploid Gibel Carp.
Frontiers in immunology.
2020; 11(?):2176. doi:
10.3389/fimmu.2020.02176. [PMID: 33013914] - Eva Danner, Halvard Bonig, Eliza Wiercinska. Albumin Modifies Responses to Hematopoietic Stem Cell Mobilizing Agents in Mice.
Cells.
2019 12; 9(1):. doi:
10.3390/cells9010004. [PMID: 31861319] - Ilze Adlere, Birgit Caspar, Marta Arimont, Sebastian Dekkers, Kirsten Visser, Jeffrey Stuijt, Chris de Graaf, Michael Stocks, Barrie Kellam, Stephen Briddon, Maikel Wijtmans, Iwan de Esch, Stephen Hill, Rob Leurs. Modulators of CXCR4 and CXCR7/ACKR3 Function.
Molecular pharmacology.
2019 12; 96(6):737-752. doi:
10.1124/mol.119.117663. [PMID: 31548340] - Reena P Thomas, Seema Nagpal, Michael Iv, Scott G Soltys, Sophie Bertrand, Judith S Pelpola, Robyn Ball, Jaden Yang, Vandana Sundaram, Jonathan Lavezo, Donald Born, Hannes Vogel, J Martin Brown, Lawrence D Recht. Macrophage Exclusion after Radiation Therapy (MERT): A First in Human Phase I/II Trial using a CXCR4 Inhibitor in Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2019 12; 25(23):6948-6957. doi:
10.1158/1078-0432.ccr-19-1421. [PMID: 31537527] - Irene M Ghobrial, Chia-Jen Liu, Oksana Zavidij, Abdel K Azab, Rachid Baz, Jacob P Laubach, Yuji Mishima, Philippe Armand, Nikhil C Munshi, Frank Basile, Michael Constantine, James Vredenburgh, Adam Boruchov, Pamela Crilley, Patrick M Henrick, Kalvis T V Hornburg, Houry Leblebjian, Stacey Chuma, Kaitlen Reyes, Kimberly Noonan, Diane Warren, Robert Schlossman, Claudia Paba-Prada, Kenneth C Anderson, Edie Weller, Lorenzo Trippa, Kenneth Shain, Paul G Richardson. Phase I/II trial of the CXCR4 inhibitor plerixafor in combination with bortezomib as a chemosensitization strategy in relapsed/refractory multiple myeloma.
American journal of hematology.
2019 11; 94(11):1244-1253. doi:
10.1002/ajh.25627. [PMID: 31456261] - Alisha Wehdnesday Bernardo Reyes, Lauren Togonon Arayan, Tran Xuan Ngoc Huy, Son Hai Vu, Chang Keun Kang, Wongi Min, Hu Jang Lee, John Hwa Lee, Suk Kim. Chemokine receptor 4 (CXCR4) blockade enhances resistance to bacterial internalization in RAW264.7 cells and AMD3100, a CXCR4 antagonist, attenuates susceptibility to Brucella abortus 544 infection in a murine model.
Veterinary microbiology.
2019 Oct; 237(?):108402. doi:
10.1016/j.vetmic.2019.108402. [PMID: 31585647] - Yan-Yan Fang, Lei Wan, Wen-Zhe Dong, Jian-Ting Wen, Jian Liu. [Effect of triptolide in improving platelet activation in patients with ankylosing spondylitis by regulating VEGFA,SDF-1,CXCR4 pathway].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2019 Aug; 44(16):3520-3525. doi:
10.19540/j.cnki.cjcmm.20181113.001. [PMID: 31602917] - Jean Kwun, Marie Matignon, Miriam Manook, Soulef Guendouz, Vincent Audard, David Kheav, Elsa Poullot, Chantal Gautreau, Brian Ezekian, Diane Bodez, Thibault Damy, Laureline Faivre, Dehbia Menouche, Janghoon Yoon, Jaeberm Park, Karim Belhadj, Dongfeng Chen, Alyssa M Bilewski, John S Yi, Bradley Collins, Mark Stegall, Alton B Farris, Stuart Knechtle, Philippe Grimbert. Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use.
Journal of the American Society of Nephrology : JASN.
2019 07; 30(7):1206-1219. doi:
10.1681/asn.2018121254. [PMID: 31227636] - Hao Tang, Yue Xu, Zijian Zhang, Song Zeng, Wenbo Dong, Wenjiao Jiao, Xiaopeng Hu. SDF‑1/CXCR4 induces epithelial‑mesenchymal transition through activation of the Wnt/β‑catenin signaling pathway in rat chronic allograft nephropathy.
Molecular medicine reports.
2019 May; 19(5):3696-3706. doi:
10.3892/mmr.2019.10045. [PMID: 30896799] - Motomu Tanaka. In Vitro Dynamic Phenotyping for Testing Novel Mobilizing Agents.
Methods in molecular biology (Clifton, N.J.).
2019; 2017(?):11-27. doi:
10.1007/978-1-4939-9574-5_2. [PMID: 31197765] - Eudocia Q Lee, Dan G Duda, Alona Muzikansky, Elizabeth R Gerstner, John G Kuhn, David A Reardon, Lakshmi Nayak, Andrew D Norden, Lisa Doherty, Debra LaFrankie, Jennifer Stefanik, Trupti Vardam, Katrina H Smith, Christine McCluskey, Sarah Gaffey, Tracy T Batchelor, Rakesh K Jain, Patrick Y Wen. Phase I and Biomarker Study of Plerixafor and Bevacizumab in Recurrent High-Grade Glioma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2018 10; 24(19):4643-4649. doi:
10.1158/1078-0432.ccr-18-1025. [PMID: 29941486] - Qingyu Cheng, Laleh Khodadadi, Adriano Taddeo, Jens Klotsche, Bimba F Hoyer, Andreas Radbruch, Falk Hiepe. CXCR4-CXCL12 interaction is important for plasma cell homing and survival in NZB/W mice.
European journal of immunology.
2018 06; 48(6):1020-1029. doi:
10.1002/eji.201747023. [PMID: 29427452] - Renren Bai, Jian Sun, Zhongxing Liang, Younghyoun Yoon, Eric Salgado, Amber Feng, Yoonhyeun Oum, Yuanyuan Xie, Hyunsuk Shim. Anti-inflammatory hybrids of secondary amines and amide-sulfamide derivatives.
European journal of medicinal chemistry.
2018 Apr; 150(?):195-205. doi:
10.1016/j.ejmech.2018.02.085. [PMID: 29529500] - Dian Peng, Bin Cao, Ying-Jun Zhou, Ya-Qiu Long. The chemical diversity and structure-based evolution of non-peptide CXCR4 antagonists with diverse therapeutic potential.
European journal of medicinal chemistry.
2018 Apr; 149(?):148-169. doi:
10.1016/j.ejmech.2018.02.043. [PMID: 29500940] - Rujun Zhai, Yongchun Wang, Le Qi, George Melville Williams, Bin Gao, Guang Song, James F Burdick, Zhaoli Sun. Pharmacological Mobilization of Endogenous Bone Marrow Stem Cells Promotes Liver Regeneration after Extensive Liver Resection in Rats.
Scientific reports.
2018 02; 8(1):3587. doi:
10.1038/s41598-018-21961-2. [PMID: 29483616] - Zi-Fu Li, Xing-Gen Fang, Rui Zhao, Peng-Fei Yang, Qing-Hai Huang, Jian-Min Liu. Stromal cell-derived factor 1α facilitates aneurysm remodeling in elastase-induced rabbit saccular aneurysm.
Cytokine.
2018 02; 102(?):123-130. doi:
10.1016/j.cyto.2017.07.020. [PMID: 28969944] - Salvatore Di Maro, Francesco Saverio Di Leva, Anna Maria Trotta, Diego Brancaccio, Luigi Portella, Michela Aurilio, Stefano Tomassi, Anna Messere, Deborah Sementa, Secondo Lastoria, Alfonso Carotenuto, Ettore Novellino, Stefania Scala, Luciana Marinelli. Structure-Activity Relationships and Biological Characterization of a Novel, Potent, and Serum Stable C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonist.
Journal of medicinal chemistry.
2017 12; 60(23):9641-9652. doi:
10.1021/acs.jmedchem.7b01062. [PMID: 29125295] - Huipeng Li, Xue Yang, Zhanwei Zhou, Kaikai Wang, Chenzi Li, Hongzhi Qiao, David Oupicky, Minjie Sun. Near-infrared light-triggered drug release from a multiple lipid carrier complex using an all-in-one strategy.
Journal of controlled release : official journal of the Controlled Release Society.
2017 09; 261(?):126-137. doi:
10.1016/j.jconrel.2017.06.029. [PMID: 28666728] - Hongyan Mo, Qinyu Wu, Jinhua Miao, Congwei Luo, Xue Hong, Yongping Wang, Lan Tang, Fan Fan Hou, Youhua Liu, Lili Zhou. C-X-C Chemokine Receptor Type 4 Plays a Crucial Role in Mediating Oxidative Stress-Induced Podocyte Injury.
Antioxidants & redox signaling.
2017 08; 27(6):345-362. doi:
10.1089/ars.2016.6758. [PMID: 27960539] - Renren Bai, Zhongxing Liang, Younghyoun Yoon, Eric Salgado, Amber Feng, Saumya Gurbani, Hyunsuk Shim. Novel anti-inflammatory agents targeting CXCR4: Design, synthesis, biological evaluation and preliminary pharmacokinetic study.
European journal of medicinal chemistry.
2017 Aug; 136(?):360-371. doi:
10.1016/j.ejmech.2017.05.030. [PMID: 28521261] - Yonathan Gomez, Dylana Diaz-Solano, Teresa Gledhill, Olga Wittig, Jose Cardier. The effect of G-CSF and AMD3100 on mice treated with streptozotocin: Expansion of alpha-cells and partial islet protection.
Cytokine.
2017 08; 96(?):123-131. doi:
10.1016/j.cyto.2017.04.003. [PMID: 28399484] - Xun-Feng Zou, Jian-Hua Gu, Zi-Lin Cui, Yi-Wei Lu, Chuan Gu. CXC Chemokine Receptor Type 4 Antagonism Ameliorated Allograft Fibrosis in Rat Kidney Transplant Model.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2017 Aug; 15(4):448-452. doi:
10.6002/ect.2016.0071. [PMID: 28585910] - Yuka Mimura-Yamamoto, Hiroshi Shinohara, Taichi Kashiwagi, Toru Sato, Seiji Shioda, Tatsunori Seki. Dynamics and function of CXCR4 in formation of the granule cell layer during hippocampal development.
Scientific reports.
2017 07; 7(1):5647. doi:
10.1038/s41598-017-05738-7. [PMID: 28717168] - Elena Zaitseva, Eugene Zaitsev, Kamran Melikov, Anush Arakelyan, Mariana Marin, Rafael Villasmil, Leonid B Margolis, Gregory B Melikyan, Leonid V Chernomordik. Fusion Stage of HIV-1 Entry Depends on Virus-Induced Cell Surface Exposure of Phosphatidylserine.
Cell host & microbe.
2017 Jul; 22(1):99-110.e7. doi:
10.1016/j.chom.2017.06.012. [PMID: 28704658] - Jae Kim, Krista L Connelly, Ellen M Unterwald, Scott M Rawls. Chemokines and cocaine: CXCR4 receptor antagonist AMD3100 attenuates cocaine place preference and locomotor stimulation in rats.
Brain, behavior, and immunity.
2017 May; 62(?):30-34. doi:
10.1016/j.bbi.2016.08.015. [PMID: 27575003] - Mei Wang, Chunping Wu, Yu Guo, Xiaojuan Cao, Wenwei Zheng, Guo-Kang Fan. The primary growth of laryngeal squamous cell carcinoma cells in vitro is effectively supported by paired cancer-associated fibroblasts alone.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2017 May; 39(5):1010428317705512. doi:
10.1177/1010428317705512. [PMID: 28475003] - Huipeng Li, Kaikai Wang, Xue Yang, Yiwen Zhou, Qineng Ping, David Oupicky, Minjie Sun. Dual-function nanostructured lipid carriers to deliver IR780 for breast cancer treatment: Anti-metastatic and photothermal anti-tumor therapy.
Acta biomaterialia.
2017 04; 53(?):399-413. doi:
10.1016/j.actbio.2017.01.070. [PMID: 28159715] - Silvia Spoerl, Robert Peter, Dagmar Wäscher, Katharina Götze, Mareike Verbeek, Christian Peschel, Angela M Krackhardt. Patients' outcome after rescue plerixafor administration for autologous stem cell mobilization: a single-center retrospective analysis.
Transfusion.
2017 01; 57(1):115-121. doi:
10.1111/trf.13883. [PMID: 27859332] - Siwan Park, Hwanseok Jang, Byung Soo Kim, Changmo Hwang, Gi Seok Jeong, Yongdoo Park. Directional migration of mesenchymal stem cells under an SDF-1α gradient on a microfluidic device.
PloS one.
2017; 12(9):e0184595. doi:
10.1371/journal.pone.0184595. [PMID: 28886159] - Yue Xu, Song Zeng, Qiang Zhang, Zijian Zhang, Xiaopeng Hu. Stem Cell Mobilizers: Novel Therapeutics for Acute Kidney Injury.
Current protein & peptide science.
2017; 18(12):1195-1199. doi:
10.2174/1389203717666160909123135. [PMID: 27634446] - Yue Xu, Qiang Zhang, Wenrui Xue, Song Zeng, Zijian Zhang, Xiaodong Zhang, Xiaopeng Hu. CXC Chemokine Receptor 4 (CXCR4) Antagonist, a Novel Pathway to Prevent Chronic Allograft Nephropathy.
Annals of transplantation.
2016 Nov; 21(?):728-734. doi:
10.12659/aot.899492. [PMID: 27885250] - M Katie Conley-LaComb, Louie Semaan, Rajareddy Singareddy, Yanfeng Li, Elisabeth I Heath, Seongho Kim, Michael L Cher, Sreenivasa R Chinni. Pharmacological targeting of CXCL12/CXCR4 signaling in prostate cancer bone metastasis.
Molecular cancer.
2016 11; 15(1):68. doi:
10.1186/s12943-016-0552-0. [PMID: 27809841] - Semjon Seemann, Amelie Lupp. Administration of AMD3100 in endotoxemia is associated with pro-inflammatory, pro-oxidative, and pro-apoptotic effects in vivo.
Journal of biomedical science.
2016 Oct; 23(1):68. doi:
10.1186/s12929-016-0286-8. [PMID: 27716214] - Satoru Takashima, Hiroki Fujita, Hiromi Fujishima, Tatsunori Shimizu, Takehiro Sato, Tsukasa Morii, Katsushi Tsukiyama, Takuma Narita, Takamune Takahashi, Daniel J Drucker, Yutaka Seino, Yuichiro Yamada. Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy.
Kidney international.
2016 10; 90(4):783-96. doi:
10.1016/j.kint.2016.06.012. [PMID: 27475229] - Salvatore Di Maro, Anna Maria Trotta, Diego Brancaccio, Francesco Saverio Di Leva, Valeria La Pietra, Caterina Ieranò, Maria Napolitano, Luigi Portella, Crescenzo D'Alterio, Rosa Anna Siciliano, Deborah Sementa, Stefano Tomassi, Alfonso Carotenuto, Ettore Novellino, Stefania Scala, Luciana Marinelli. Exploring the N-Terminal Region of C-X-C Motif Chemokine 12 (CXCL12): Identification of Plasma-Stable Cyclic Peptides As Novel, Potent C-X-C Chemokine Receptor Type 4 (CXCR4) Antagonists.
Journal of medicinal chemistry.
2016 Sep; 59(18):8369-80. doi:
10.1021/acs.jmedchem.6b00695. [PMID: 27571038] - X Hu, T Okabayashi, A M Cameron, Y Wang, M Hisada, J Li, L C Raccusen, Q Zheng, R A Montgomery, G M Williams, Z Sun. Chimeric Allografts Induced by Short-Term Treatment With Stem Cell-Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: A Study in Rats.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2016 07; 16(7):2055-65. doi:
10.1111/ajt.13706. [PMID: 26749344] - A M Cameron, R N Wesson, A R Ahmadi, A L Singer, X Hu, T Okabayashi, Y Wang, M Shigoka, Y Fu, W Gao, L C Raccusen, R A Montgomery, G M Williams, Z Sun. Chimeric Allografts Induced by Short-Term Treatment With Stem Cell Mobilizing Agents Result in Long-Term Kidney Transplant Survival Without Immunosuppression: II, Study in Miniature Swine.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2016 07; 16(7):2066-76. doi:
10.1111/ajt.13703. [PMID: 26748958] - Yonghui Dong, Hui Liu, Xuejun Zhang, Fei Xu, Liang Qin, Peng Cheng, Hui Huang, Fengjing Guo, Qing Yang, Anmin Chen. Inhibition of SDF-1α/CXCR4 Signalling in Subchondral Bone Attenuates Post-Traumatic Osteoarthritis.
International journal of molecular sciences.
2016 Jun; 17(6):. doi:
10.3390/ijms17060943. [PMID: 27322244] - Enas Ahmed Hamed, Hanan Sayed Mohamed Farghaly, Asmaa Fathey Abdel Mola, Minerva Kamal Fahmi, Madiha Mohammed Makhlouf, Mohamed Abdullah Balfas. Role of monocyte chemoattractant protein-1, stromal derived factor-1 and retinoic acid in pathophysiology of neuropathic pain in rats.
Journal of basic and clinical physiology and pharmacology.
2016 Jun; 27(4):411-24. doi:
10.1515/jbcpp-2015-0105. [PMID: 26974138] - Federica Lessi, Piero Marson, Anna Colpo, Filippo Marino, Antonio Branca, Tiziana Tison, Fausto Adami. Spontaneous splenic rupture following stem cell mobilization with G-CSF and plerixafor in AL amyloidosis.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.
2016 Apr; 54(2):256-8. doi:
10.1016/j.transci.2015.09.001. [PMID: 26458962] - Xin Liu, Jinyuan Mao, Cheng Han, Shiqiao Peng, Chenyan Li, Ting Jin, Chenling Fan, Zhongyan Shan, Weiping Teng. CXCR4 antagonist AMD3100 ameliorates thyroid damage in autoimmune thyroiditis in NOD.H‑2h⁴ mice.
Molecular medicine reports.
2016 Apr; 13(4):3604-12. doi:
10.3892/mmr.2016.4965. [PMID: 26935473] - Chao Lien Liu, Meghan J Lyle, Simon C Shin, Carol H Miao. Strategies to target long-lived plasma cells for treating hemophilia A inhibitors.
Cellular immunology.
2016 Mar; 301(?):65-73. doi:
10.1016/j.cellimm.2016.01.005. [PMID: 26877251] - Wei-Li Fu, Zhou Xiang, Fu-Guo Huang, Shi-Qiang Cen, Gang Zhong, Xin Duan, Ming Liu, Frankie Leung. Combination of granulocyte colony-stimulating factor and CXCR4 antagonist AMD3100 for effective harvest of endothelial progenitor cells from peripheral blood and in vitro formation of primitive endothelial networks.
Cell and tissue banking.
2016 Mar; 17(1):161-9. doi:
10.1007/s10561-015-9527-4. [PMID: 26224208] - David F Stroncek, Minh Tran, Sue Ellen Frodigh, Virginia David-Ocampo, Jiaqiang Ren, Andre Larochelle, Virginia Sheikh, Irini Sereti, Jeffery L Miller, Kevin Longin, Marianna Sabatino. Preliminary evaluation of a highly automated instrument for the selection of CD34+ cells from mobilized peripheral blood stem cell concentrates.
Transfusion.
2016 Feb; 56(2):511-7. doi:
10.1111/trf.13394. [PMID: 26505619] - Juan Yang, Fengming Zhu, Xiaohui Wang, Weiqi Yao, Meng Wang, Guangchang Pei, Zhizhi Hu, Yujiao Guo, Zhi Zhao, Pengge Wang, Jingyi Mou, Jie Sun, Rui Zeng, Gang Xu, Wenhui Liao, Ying Yao. Continuous AMD3100 Treatment Worsens Renal Fibrosis through Regulation of Bone Marrow Derived Pro-Angiogenic Cells Homing and T-Cell-Related Inflammation.
PloS one.
2016; 11(2):e0149926. doi:
10.1371/journal.pone.0149926. [PMID: 26900858] - R Muralidharan, J Panneerselvam, A Chen, Y D Zhao, A Munshi, R Ramesh. HuR-targeted nanotherapy in combination with AMD3100 suppresses CXCR4 expression, cell growth, migration and invasion in lung cancer.
Cancer gene therapy.
2015 Dec; 22(12):581-90. doi:
10.1038/cgt.2015.55. [PMID: 26494555] - Mohammed M Elayan, Justin G Horowitz, Jose M Magraner, Paul J Shaughnessy, Carlos Bachier. Tbo-Filgrastim versus Filgrastim during Mobilization and Neutrophil Engraftment for Autologous Stem Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2015 Nov; 21(11):1921-5. doi:
10.1016/j.bbmt.2015.05.024. [PMID: 26033279] - Ai-Wu Mao, Ting-Hui Jiang, Xian-Jun Sun, Jian Peng. Application of chemokine receptor antagonist with stents reduces local inflammation and suppresses cancer growth.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.
2015 Nov; 36(11):8637-43. doi:
10.1007/s13277-015-3557-1. [PMID: 26044561] - Jia-Yu Liu, Tsaiyu Chiang, Chun-Hung Liu, Guann-Gen Chern, Ts-Ting Lin, Dong-Yu Gao, Yunching Chen. Delivery of siRNA Using CXCR4-targeted Nanoparticles Modulates Tumor Microenvironment and Achieves a Potent Antitumor Response in Liver Cancer.
Molecular therapy : the journal of the American Society of Gene Therapy.
2015 Nov; 23(11):1772-1782. doi:
10.1038/mt.2015.147. [PMID: 26278330] - Roger Belizaire, David B Sykes, Yi-Bin A Chen, Thomas R Spitzer, Robert S Makar. Difficulties in hematopoietic progenitor cell collection from a patient with TEMPI syndrome and severe iatrogenic iron deficiency.
Transfusion.
2015 Sep; 55(9):2142-8. doi:
10.1111/trf.13125. [PMID: 25911963] - Salvatore Gattillo, Sarah Marktel, Lorenzo Rizzo, Simona Malato, Lucia Malabarba, Milena Coppola, Andrea Assanelli, Raffaella Milani, Tiago De Freitas, Consuelo Corti, Laura Bellio, Fabio Ciceri. Plerixafor on demand in ten healthy family donors as a rescue strategy to achieve an adequate graft for stem cell transplantation.
Transfusion.
2015 Aug; 55(8):1993-2000. doi:
10.1111/trf.13059. [PMID: 25721167] - Yu-Xin Liao, Ze-Ze Fu, Cheng-Hao Zhou, Lian-Cheng Shan, Zhuo-Ying Wang, Fei Yin, Long-Po Zheng, Ying-Qi Hua, Zheng-Dong Cai. AMD3100 reduces CXCR4-mediated survival and metastasis of osteosarcoma by inhibiting JNK and Akt, but not p38 or Erk1/2, pathways in in vitro and mouse experiments.
Oncology reports.
2015 Jul; 34(1):33-42. doi:
10.3892/or.2015.3992. [PMID: 25997540] - Y Wang, J Li, Y Chen, D Oupický. Balancing polymer hydrophobicity for ligand presentation and siRNA delivery in dual function CXCR4 inhibiting polyplexes.
Biomaterials science.
2015 Jul; 3(7):1114-23. doi:
10.1039/c5bm00003c. [PMID: 26146552] - Amy Yuan, Yashang Lee, Uimook Choi, Gilbert Moeckel, Anil Karihaloo. Chemokine receptor Cxcr4 contributes to kidney fibrosis via multiple effectors.
American journal of physiology. Renal physiology.
2015 Mar; 308(5):F459-72. doi:
10.1152/ajprenal.00146.2014. [PMID: 25537742] - Ferhan S Siddiqi, Li-Hao Chen, Suzanne L Advani, Kerri Thai, Sri N Batchu, Tamadher A Alghamdi, Kathryn E White, Manish M Sood, Ian W Gibson, Kim A Connelly, Philip A Marsden, Andrew Advani. CXCR4 promotes renal tubular cell survival in male diabetic rats: implications for ligand inactivation in the human kidney.
Endocrinology.
2015 Mar; 156(3):1121-32. doi:
10.1210/en.2014-1650. [PMID: 25549045] - Sarah Berth, Hector Hugo Caicedo, Tulika Sarma, Gerardo Morfini, Scott T Brady. Internalization and axonal transport of the HIV glycoprotein gp120.
ASN neuro.
2015 Jan; 7(1):. doi:
10.1177/1759091414568186. [PMID: 25636314] - S V Hartimath, A van Waarde, R A J O Dierckx, E F J de Vries. Evaluation of N-[(11)C]methyl-AMD3465 as a PET tracer for imaging of CXCR4 receptor expression in a C6 glioma tumor model.
Molecular pharmaceutics.
2014 Nov; 11(11):3810-7. doi:
10.1021/mp500398r. [PMID: 25094028] - A Zuk, M Gershenovich, Y Ivanova, R T MacFarland, S P Fricker, S Ledbetter. CXCR₄antagonism as a therapeutic approach to prevent acute kidney injury.
American journal of physiology. Renal physiology.
2014 Oct; 307(7):F783-97. doi:
10.1152/ajprenal.00685.2013. [PMID: 25080523] - Kyung-Mee Park, Hyun-Suk Nam, Pankaj Kumar Teotia, Kamal Hany Hussein, Seok-Ho Hong, Jung-Im Yun, Heung-Myong Woo. Kidney injury molecule-1 is involved in the chemotactic migration of mesenchymal stem cells.
In vitro cellular & developmental biology. Animal.
2014 Aug; 50(7):648-55. doi:
10.1007/s11626-013-9731-0. [PMID: 24652046] - Li-Hao Chen, Suzanne L Advani, Kerri Thai, M Golam Kabir, Manish M Sood, Ian W Gibson, Darren A Yuen, Kim A Connelly, Philip A Marsden, Darren J Kelly, Richard E Gilbert, Andrew Advani. SDF-1/CXCR4 signaling preserves microvascular integrity and renal function in chronic kidney disease.
PloS one.
2014; 9(3):e92227. doi:
10.1371/journal.pone.0092227. [PMID: 24637920] - Siddesh V Hartimath, Urszula M Domanska, Annemiek M E Walenkamp, Dierckx Rudi A J O, Erik F J de Vries. [⁹⁹mTc]O₂-AMD3100 as a SPECT tracer for CXCR4 receptor imaging.
Nuclear medicine and biology.
2013 May; 40(4):507-17. doi:
10.1016/j.nucmedbio.2013.02.003. [PMID: 23522974] - Hui-Kuo G Shu, Younghyoun Yoon, Samuel Hong, Kaiming Xu, Huiying Gao, Chunhai Hao, Edilson Torres-Gonzalez, Cardenes Nayra, Mauricio Rojas, Hyunsuk Shim. Inhibition of the CXCL12/CXCR4-axis as preventive therapy for radiation-induced pulmonary fibrosis.
PloS one.
2013; 8(11):e79768. doi:
10.1371/journal.pone.0079768. [PMID: 24244561] - Brian T Garibaldi, Franco R D'Alessio, Jason R Mock, D Clark Files, Eric Chau, Yoshiki Eto, M Bradley Drummond, Neil R Aggarwal, Venkataramana Sidhaye, Landon S King. Regulatory T cells reduce acute lung injury fibroproliferation by decreasing fibrocyte recruitment.
American journal of respiratory cell and molecular biology.
2013 Jan; 48(1):35-43. doi:
10.1165/rcmb.2012-0198oc. [PMID: 23002097] - Longbiao Yao, Janet Heuser-Baker, Oana Herlea-Pana, Ryuji Iida, Qilong Wang, Ming-Hui Zou, Jana Barlic-Dicen. Bone marrow endothelial progenitors augment atherosclerotic plaque regression in a mouse model of plasma lipid lowering.
Stem cells (Dayton, Ohio).
2012 Dec; 30(12):2720-31. doi:
10.1002/stem.1256. [PMID: 23081735] - A I Chen, T Bains, S Murray, R Knight, K Shoop, J Bubalo, C Fowler, S Slater, R T Maziarz. Clinical experience with a simple algorithm for plerixafor utilization in autologous stem cell mobilization.
Bone marrow transplantation.
2012 Dec; 47(12):1526-9. doi:
10.1038/bmt.2012.74. [PMID: 22562080] - Tomonori Takekoshi, Joshua J Ziarek, Brian F Volkman, Sam T Hwang. A locked, dimeric CXCL12 variant effectively inhibits pulmonary metastasis of CXCR4-expressing melanoma cells due to enhanced serum stability.
Molecular cancer therapeutics.
2012 Nov; 11(11):2516-25. doi:
10.1158/1535-7163.mct-12-0494. [PMID: 22869557] - Harold H Bach, Vikas Saini, Todd A Baker, Abhishek Tripathi, Richard L Gamelli, Matthias Majetschak. Initial assessment of the role of CXC chemokine receptor 4 after polytrauma.
Molecular medicine (Cambridge, Mass.).
2012 Sep; 18(?):1056-66. doi:
10.2119/molmed.2011.00497. [PMID: 22634721] - Victor G Kramer, Susan M Schader, Maureen Oliveira, Susan P Colby-Germinario, Daniel A Donahue, Diane N Singhroy, Randy Tressler, Richard D Sloan, Mark A Wainberg. Maraviroc and other HIV-1 entry inhibitors exhibit a class-specific redistribution effect that results in increased extracellular viral load.
Antimicrobial agents and chemotherapy.
2012 Aug; 56(8):4154-60. doi:
10.1128/aac.00409-12. [PMID: 22615275] - D Dunn, P Vikas, M Jagasia, B N Savani. Plerixafor in AL amyloidosis: improved graft composition and faster lymphocyte recovery after auto-SCT in patient with end-stage renal-disease.
Bone marrow transplantation.
2012 Aug; 47(8):1136-7. doi:
10.1038/bmt.2011.226. [PMID: 22080973] - Carlos Bachier, Josh Potter, Grant Potter, Rominna Sugay, Paul Shaughnessy, Kawah Chan, Veronica Jude, Renee Madden, Charles F LeMaistre. High white blood cell concentration in the peripheral blood stem cell product can induce seizures during infusion of autologous peripheral blood stem cells.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation.
2012 Jul; 18(7):1055-60. doi:
10.1016/j.bbmt.2011.12.500. [PMID: 22178402] - K W Douglas, A N Parker, P J Hayden, A Rahemtulla, A D'Addio, R M Lemoli, K Rao, M Maris, A Pagliuca, J Uberti, C Scheid, R Noppeney, G Cook, S W Bokhari, N Worel, G Mikala, T Masszi, R Taylor, J Treisman. Plerixafor for PBSC mobilisation in myeloma patients with advanced renal failure: safety and efficacy data in a series of 21 patients from Europe and the USA.
Bone marrow transplantation.
2012 Jan; 47(1):18-23. doi:
10.1038/bmt.2011.9. [PMID: 21358693] - Verena Kriechbaumer, Alexei Nabok, Robert Widdowson, David P Smith, Ben M Abell. Quantification of ligand binding to G-protein coupled receptors on cell membranes by ellipsometry.
PloS one.
2012; 7(9):e46221. doi:
10.1371/journal.pone.0046221. [PMID: 23049983] - James C Knight, Andrew J Hallett, Andrea Brancale, Stephen J Paisey, Richard W E Clarkson, Peter G Edwards. Evaluation of a fluorescent derivative of AMD3100 and its interaction with the CXCR4 chemokine receptor.
Chembiochem : a European journal of chemical biology.
2011 Nov; 12(17):2692-8. doi:
10.1002/cbic.201100441. [PMID: 21998043] - Ricardo Reyes-Chilpa, Strahil Berkov, Simón Hernández-Ortega, Christopher K Jankowski, Sebastien Arseneau, Imma Clotet-Codina, José A Esté, Carles Codina, Francesc Viladomat, Jaume Bastida. Acetylcholinesterase-inhibiting alkaloids from Zephyranthes concolor.
Molecules (Basel, Switzerland).
2011 Nov; 16(11):9520-33. doi:
10.3390/molecules16119520. [PMID: 22086403] - J Sheng, W-W Cai, N-Y Fang, S-Q Wang, J-J Wu. Role of stromal-derived factor-1
/CXCR4 in neo-intimal repair . Cardiovascular journal of Africa. 2011 Nov; 22(6):313-8. doi:10.5830/cvja-2010-075. [PMID: 22159319] - Alexander Berchanski, Alexander Kalinkovich, Aya Ludin, Tsvee Lapidot, Aviva Lapidot. Insights into the mechanism of enhanced mobilization of hematopoietic progenitor cells and release of CXCL12 by a combination of AMD3100 and aminoglycoside-polyarginine conjugates.
The FEBS journal.
2011 Nov; 278(21):4150-65. doi:
10.1111/j.1742-4658.2011.08348.x. [PMID: 21910828] - T Okabayashi, A M Cameron, M Hisada, R A Montgomery, G M Williams, Z Sun. Mobilization of host stem cells enables long-term liver transplant acceptance in a strongly rejecting rat strain combination.
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.
2011 Oct; 11(10):2046-56. doi:
10.1111/j.1600-6143.2011.03698.x. [PMID: 21883903] - Laura A Wheat, Petra Haberzettl, Jason Hellmann, Shahid P Baba, Matthew Bertke, Jongmin Lee, James McCracken, Timothy E O'Toole, Aruni Bhatnagar, Daniel J Conklin. Acrolein inhalation prevents vascular endothelial growth factor-induced mobilization of Flk-1+/Sca-1+ cells in mice.
Arteriosclerosis, thrombosis, and vascular biology.
2011 Jul; 31(7):1598-606. doi:
10.1161/atvbaha.111.227124. [PMID: 21527748] - Naoya Uchida, Aylin Bonifacino, Allen E Krouse, Mark E Metzger, Gyorgy Csako, Agnes Lee-Stroka, Ross M Fasano, Susan F Leitman, Joseph J Mattapallil, Matthew M Hsieh, John F Tisdale, Robert E Donahue. Accelerated lymphocyte reconstitution and long-term recovery after transplantation of lentiviral-transduced rhesus CD34+ cells mobilized by G-CSF and plerixafor.
Experimental hematology.
2011 Jul; 39(7):795-805. doi:
10.1016/j.exphem.2011.04.002. [PMID: 21549175] - Mizuhiko Terasaki, Yasuo Sugita, Fumiko Arakawa, Yosuke Okada, Koichi Ohshima, Minoru Shigemori. CXCL12/CXCR4 signaling in malignant brain tumors: a potential pharmacological therapeutic target.
Brain tumor pathology.
2011 Apr; 28(2):89-97. doi:
10.1007/s10014-010-0013-1. [PMID: 21210239] - Ming-Yi Shen, Yan-Jun Liu, Ming-Jaw Don, Hsien-Yueh Liu, Zeng-Weng Chen, Clément Mettling, Pierre Corbeau, Chih-Kang Chiang, Yu-Song Jang, Tzu-Hsuan Li, Paul Young, Cicero L T Chang, Yea-Lih Lin, Wen-Chin Yang. Combined phytochemistry and chemotaxis assays for identification and mechanistic analysis of anti-inflammatory phytochemicals in Fallopia japonica.
PloS one.
2011; 6(11):e27480. doi:
10.1371/journal.pone.0027480. [PMID: 22087325] - Paolo Fiorina, Mollie Jurewicz, Andrea Vergani, Alessandra Petrelli, Michele Carvello, Francesca D'Addio, Jonathan G Godwin, Kenneth Law, Erxi Wu, Ze Tian, Gebhard Thoma, Jiri Kovarik, Stefano La Rosa, Carlo Capella, Scott Rodig, Hans-Guenter Zerwes, Mohamed H Sayegh, Reza Abdi. Targeting the CXCR4-CXCL12 axis mobilizes autologous hematopoietic stem cells and prolongs islet allograft survival via programmed death ligand 1.
Journal of immunology (Baltimore, Md. : 1950).
2011 Jan; 186(1):121-31. doi:
10.4049/jimmunol.1000799. [PMID: 21131428] - Russell N Wesson, Andrew M Cameron. Stem cells in acute liver failure.
Advances in surgery.
2011; 45(?):117-30. doi:
10.1016/j.yasu.2011.03.001. [PMID: 21954682] - Anthony L Mark, Zhaoli Sun, Daniel S Warren, Bonnie E Lonze, Matthew K Knabel, George M Melville Williams, Jayme E Locke, Robert A Montgomery, Andrew M Cameron. Stem cell mobilization is life saving in an animal model of acute liver failure.
Annals of surgery.
2010 Oct; 252(4):591-6. doi:
10.1097/sla.0b013e3181f4e479. [PMID: 20881764] - Lee M Morris, Charles A Klanke, Stephanie A Lang, Stefan Pokall, Arturo R Maldonado, Jose F Vuletin, Datis Alaee, Sundeep G Keswani, Foong-Yen Lim, Timothy M Crombleholme. Characterization of endothelial progenitor cells mobilization following cutaneous wounding.
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society.
2010 Jul; 18(4):383-90. doi:
10.1111/j.1524-475x.2010.00596.x. [PMID: 20546555] - Valeria Pinto, Andrea Castelli, Gianluca Gaidano, Annarita Conconi. Safe and effective use of plerixafor plus G-CSF in dialysis-dependent renal failure.
American journal of hematology.
2010 Jun; 85(6):461-2. doi:
10.1002/ajh.21712. [PMID: 20513130] - M Z Ratajczak, H Lee, M Wysoczynski, W Wan, W Marlicz, M J Laughlin, M Kucia, A Janowska-Wieczorek, J Ratajczak. Novel insight into stem cell mobilization-plasma sphingosine-1-phosphate is a major chemoattractant that directs the egress of hematopoietic stem progenitor cells from the bone marrow and its level in peripheral blood increases during mobilization due to activation of complement cascade/membrane attack complex.
Leukemia.
2010 May; 24(5):976-85. doi:
10.1038/leu.2010.53. [PMID: 20357827]