Spermine NONOate (BioDeep_00000600525)
代谢物信息卡片
Spermine NONOate
化学式: C10H26N6O2 (262.2117136)
中文名称: 精胺氮氧化加合物
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CCN(CCCN)[N+](=NO)[O-])CNCCCN
InChI: InChI=1S/C10H26N6O2/c11-5-3-8-13-7-1-2-9-15(10-4-6-12)16(18)14-17/h13,17H,1-12H2/b16-14-
描述信息
D002317 - Cardiovascular Agents > D020030 - Nitric Oxide Donors
同义名列表
1 个代谢物同义名
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Casandra M Monzon, Jeffrey L Garvin. Claudin-19 mediates the effects of NO on the paracellular pathway in thick ascending limbs.
American journal of physiology. Renal physiology.
2019 08; 317(2):F411-F418. doi:
10.1152/ajprenal.00065.2019. [PMID: 31166708] - Juan Pablo Nicola, Victoria Peyret, Magalí Nazar, Jorge Miguel Romero, Ariel Maximiliano Lucero, María del Mar Montesinos, José Luis Bocco, Claudia Gabriela Pellizas, Ana María Masini-Repiso. S-Nitrosylation of NF-κB p65 Inhibits TSH-Induced Na(+)/I(-) Symporter Expression.
Endocrinology.
2015 Dec; 156(12):4741-54. doi:
10.1210/en.2015-1192. [PMID: 26587909] - Vimal Veeriah, Uttara Saran, Akila Swaminathan, Uma Maheswari Balaguru, Pradeep Thangaraj, Shunmugam Nagarajan, Vinoth Kumar Rajendran, Suvro Chatterjee. Cadmium-induced embryopathy: nitric oxide rescues teratogenic effects of cadmium.
Toxicological sciences : an official journal of the Society of Toxicology.
2015 Mar; 144(1):90-104. doi:
10.1093/toxsci/kfu258. [PMID: 25490952] - Mingzhu Wu, Fangquan Wang, Chen Zhang, Yanjie Xie, Bin Han, Jingjing Huang, Wenbiao Shen. Heme oxygenase-1 is involved in nitric oxide- and cGMP-induced α-Amy2/54 gene expression in GA-treated wheat aleurone layers.
Plant molecular biology.
2013 Jan; 81(1-2):27-40. doi:
10.1007/s11103-012-9979-x. [PMID: 23090695] - Thais de Castro Barbosa, Lake Q Jiang, Juleen R Zierath, Maria Tereza Nunes. L-Arginine enhances glucose and lipid metabolism in rat L6 myotubes via the NO/ c-GMP pathway.
Metabolism: clinical and experimental.
2013 Jan; 62(1):79-89. doi:
10.1016/j.metabol.2012.06.011. [PMID: 22889511] - Leone F Mattioli, Naomi B Holloway, James H Thomas, John G Wood. Fructose, but not dextrose, induces leukocyte adherence to the mesenteric venule of the rat by oxidative stress.
Pediatric research.
2010 Apr; 67(4):352-6. doi:
10.1203/pdr.0b013e3181d00c41. [PMID: 20032812] - Ursula Rauen, Tongju Li, Herbert de Groot. Inhibitory and enhancing effects of NO on H(2)O(2) toxicity: dependence on the concentrations of NO and H(2)O(2).
Free radical research.
2007 Apr; 41(4):402-12. doi:
10.1080/10715760601097631. [PMID: 17454122] - C N Hall, J Garthwaite. Inactivation of nitric oxide by rat cerebellar slices.
The Journal of physiology.
2006 Dec; 577(Pt 2):549-67. doi:
10.1113/jphysiol.2006.118380. [PMID: 16973697] - Joseph Satriano, Lucinda Wead, Anna Cardus, Aihua Deng, Gerry R Boss, Scott C Thomson, Roland C Blantz. Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation.
American journal of physiology. Renal physiology.
2006 Nov; 291(5):F1078-82. doi:
10.1152/ajprenal.00043.2006. [PMID: 16705150] - Karen T Elvers, Guanghui Wu, Nicola J Gilberthorpe, Robert K Poole, Simon F Park. Role of an inducible single-domain hemoglobin in mediating resistance to nitric oxide and nitrosative stress in Campylobacter jejuni and Campylobacter coli.
Journal of bacteriology.
2004 Aug; 186(16):5332-41. doi:
10.1128/jb.186.16.5332-5341.2004. [PMID: 15292134] - Stephen Wedgwood, Stephen M Black. Molecular mechanisms of nitric oxide-induced growth arrest and apoptosis in fetal pulmonary arterial smooth muscle cells.
Nitric oxide : biology and chemistry.
2003 Dec; 9(4):201-10. doi:
10.1016/j.niox.2003.11.005. [PMID: 14996427] - Charles Henry Cottart, Valérie Nivet-Antoine, Louis Do, Ghassan Al-Massarani, Geneviéve Descamps, François Xavier-Galen, Jean-Pierre Clot. Hepatic cytoprotection by nitric oxide and the cGMP pathway after ischaemia-reperfusion in the rat.
Nitric oxide : biology and chemistry.
2003 Sep; 9(2):57-63. doi:
10.1016/j.niox.2003.09.003. [PMID: 14623171] - Nam-Hee Jung, Hong Pyo Kim, Bum-Rae Kim, Seok Ho Cha, Gyeong A Kim, Hunjoo Ha, Young Eun Na, Young-Nam Cha. Evidence for heme oxygenase-1 association with caveolin-1 and -2 in mouse mesangial cells.
IUBMB life.
2003 Sep; 55(9):525-32. doi:
10.1080/15216540310001620968. [PMID: 14658758] - S D Chauhan, G Seggara, P A Vo, R J Macallister, A J Hobbs, A Ahluwalia. Protection against lipopolysaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2003 Apr; 17(6):773-5. doi:
10.1096/fj.02-0668fje. [PMID: 12586741] - Hao Zhang, Kalpana Bhargava, Agnes Keszler, Jimmy Feix, Neil Hogg, Joy Joseph, B Kalyanaraman. Transmembrane nitration of hydrophobic tyrosyl peptides. Localization, characterization, mechanism of nitration, and biological implications.
The Journal of biological chemistry.
2003 Mar; 278(11):8969-78. doi:
10.1074/jbc.m211561200. [PMID: 12519728] - J P Scharsack, D Steinhagen, C Kleczka, J O Schmidt, W Körting, R D Michael, W Leibold, H J Schuberth. The haemoflagellate Trypanoplasma borreli induces the production of nitric oxide, which is associated with modulation of carp (Cyprinus carpio L.) leucocyte functions.
Fish & shellfish immunology.
2003 Mar; 14(3):207-22. doi:
10.1006/fsim.2002.0430. [PMID: 12681277] - Joan Torras, Immaculada Herrero-Fresneda, Nuria Lloberas, Marta Riera, Josep Ma Cruzado, Josep Ma Grinyó. Promising effects of ischemic preconditioning in renal transplantation.
Kidney international.
2002 Jun; 61(6):2218-27. doi:
10.1046/j.1523-1755.2002.00360.x. [PMID: 12028463] - Rui Mesquita, Bruno Piçarra, Carlota Saldanha, J Martins e Silva. Nitric oxide effects on human erythrocytes structural and functional properties--an in vitro study.
Clinical hemorheology and microcirculation.
2002; 27(2):137-47. doi:
NULL. [PMID: 12237483] - K B Sandau, J Fandrey, B Brüne. Accumulation of HIF-1alpha under the influence of nitric oxide.
Blood.
2001 Feb; 97(4):1009-15. doi:
10.1182/blood.v97.4.1009. [PMID: 11159530] - R Mesquita, I Pires, C Saldanha, J Martins-Silva. Effects of acetylcholine and spermineNONOate on erythrocyte hemorheologic and oxygen carrying properties.
Clinical hemorheology and microcirculation.
2001; 25(3-4):153-63. doi:
NULL. [PMID: 11847418] - W Korytowski, M Zareba, A W Girotti. Inhibition of free radical-mediated cholesterol peroxidation by diazeniumdiolate-derived nitric oxide: effect of release rate on mechanism of action in a membrane system.
Chemical research in toxicology.
2000 Dec; 13(12):1265-74. doi:
10.1021/tx000160o. [PMID: 11123968] - M Liang, A J Croatt, K A Nath. Mechanisms underlying induction of heme oxygenase-1 by nitric oxide in renal tubular epithelial cells.
American journal of physiology. Renal physiology.
2000 Oct; 279(4):F728-35. doi:
10.1152/ajprenal.2000.279.4.f728. [PMID: 10997923] - M Belén Herrero, S Chatterjee, L Lefièvre, E de Lamirande, C Gagnon. Nitric oxide interacts with the cAMP pathway to modulate capacitation of human spermatozoa.
Free radical biology & medicine.
2000 Sep; 29(6):522-36. doi:
10.1016/s0891-5849(00)00339-7. [PMID: 11025196] - B Hinz, H Schröder. The nitric oxide donor SIN-1 is free of tolerance and maintains its cyclic GMP stimulatory potency in nitrate-tolerant LLC-PK1 cells.
Pharmaceutical research.
1999 May; 16(5):633-6. doi:
10.1023/a:1018804003745. [PMID: 10350003] - H Ohshima, I Celan, L Chazotte, B Pignatelli, H F Mower. Analysis of 3-nitrotyrosine in biological fluids and protein hydrolyzates by high-performance liquid chromatography using a postseparation, on-line reduction column and electrochemical detection: results with various nitrating agents.
Nitric oxide : biology and chemistry.
1999; 3(2):132-41. doi:
10.1006/niox.1999.0216. [PMID: 10369183] - B Hinz, H Schröder. Vitamin C attenuates nitrate tolerance independently of its antioxidant effect.
FEBS letters.
1998 May; 428(1-2):97-9. doi:
10.1016/s0014-5793(98)00506-7. [PMID: 9645484] - J Pfeilschifter, A Huwiler. Nitric oxide stimulates stress-activated protein kinases in glomerular endothelial and mesangial cells.
FEBS letters.
1996 Oct; 396(1):67-70. doi:
10.1016/0014-5793(96)01070-8. [PMID: 8906868] - I Y Haddad, S Zhu, J Crow, E Barefield, T Gadilhe, S Matalon. Inhibition of alveolar type II cell ATP and surfactant synthesis by nitric oxide.
The American journal of physiology.
1996 Jun; 270(6 Pt 1):L898-906. doi:
10.1152/ajplung.1996.270.6.l898. [PMID: 8764213] - N H Garcia, B A Stoos, O A Carretero, J L Garvin. Mechanism of the nitric oxide-induced blockade of collecting duct water permeability.
Hypertension (Dallas, Tex. : 1979).
1996 Mar; 27(3 Pt 2):679-83. doi:
10.1161/01.hyp.27.3.679. [PMID: 8613224] - A Zini, E De Lamirande, C Gagnon. Low levels of nitric oxide promote human sperm capacitation in vitro.
Journal of andrology.
1995 Sep; 16(5):424-31. doi:
NULL. [PMID: 8575982] - N Hogg, A Struck, S P Goss, N Santanam, J Joseph, S Parthasarathy, B Kalyanaraman. Inhibition of macrophage-dependent low density lipoprotein oxidation by nitric-oxide donors.
Journal of lipid research.
1995 Aug; 36(8):1756-62. doi:
". [PMID: 7595096] - B A Stoos, N H Garcia, J L Garvin. Nitric oxide inhibits sodium reabsorption in the isolated perfused cortical collecting duct.
Journal of the American Society of Nephrology : JASN.
1995 Jul; 6(1):89-94. doi:
10.1681/asn.v6189. [PMID: 7579075] - S P Goss, N Hogg, B Kalyanaraman. The antioxidant effect of spermine NONOate in human low-density lipoprotein.
Chemical research in toxicology.
1995 Jul; 8(5):800-6. doi:
10.1021/tx00047a021. [PMID: 7548764]