Divalonic acid (BioDeep_00000600511)

 

Secondary id: BioDeep_00000408230

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


(±)-β-Hydroxy-β-methyl-δ-valerolactone

化学式: C6H10O3 (130.062991)
中文名称: DL-甲瓦龙酸内酯, 4-羟基-4-甲基四氢-2H-吡喃-2-酮
谱图信息: 最多检出来源 Viridiplantae(plant) 2.38%

分子结构信息

SMILES: CC1(CCOC(=O)C1)O
InChI: InChI=1S/C6H10O3/c1-6(8)2-3-9-5(7)4-6/h8H,2-4H2,1H3

描述信息

DL-Mevalonolactone ((±)-Mevalonolactone;Mevalolactone) is the δ-lactone form of mevalonic acid, a precursor in the mevalonate pathway. DL-Mevalonolactone (Mevalonolactone) decreases mitochondrial membrane potential (?Ψm), NAD(P)H content and the capacity to retain Ca2+ in the brain, besides inducing mitochondrial swelling[1][2].

同义名列表

16 个代谢物同义名

(±)-β-Hydroxy-β-methyl-δ-valerolactone; (±) Tetrahydro-4-hydroxy-4-methyl-2H-pyran-2-one; (±)-3-Hydroxy-3-methyl δ-valerolactone; (1)-tetrahydro-4-Hydroxy-4-methyl-2H-pyran-2-one; tetrahydro-4-Hydroxy-4-methyl-2H-pyran-2-one; 4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one; 4-hydroxy-4-methyloxan-2-one; (±)-Mevalonolactone; DL-Mevalonic acid lactone; Mevalonic acid lactone; DL-Mevalonolactone; DL-Mevalolactone; Divalonic acid; MEVALOLACTONE; (±)-Mevalonolactone; 4-Hydroxy-4-methyltetrahydro-2H-pyran-2-one



数据库引用编号

9 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Bin Chen, Nan Lu, KeeSuh Lee, Lei Ye, Chiho Hasegawa, Kazuhisa Maeda. Application of mevalonolactone prevents deterioration of epidermal barrier function by accelerating the lamellar granule lipid transport system. Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI). 2022 Nov; 28(6):804-814. doi: 10.1111/srt.13202. [PMID: 36148627]
  • Roberta Natália Cestari, Juciene Aparecida Caris, Adriana Rocha, Glauco Henrique Balthazar Nardotto, Renê Donizeti Ribeiro de Oliveira, Vera Lucia Lanchote. Plasma mevalonic acid exposure as a pharmacodynamic biomarker of fluvastatin/atorvastatin in healthy volunteers. Journal of pharmaceutical and biomedical analysis. 2020 Apr; 182(?):113128. doi: 10.1016/j.jpba.2020.113128. [PMID: 32004772]
  • Tumelo M Satekge, Olivia Kiabilua, Alta J Terblanche, Meshack Bida, Tahir S Pillay. Mevalonate kinase deficiency masked by cytomegalovirus infection and obscure liver disease. Clinica chimica acta; international journal of clinical chemistry. 2019 Nov; 498(?):122-125. doi: 10.1016/j.cca.2019.08.014. [PMID: 31430439]
  • Cristiane Cecatto, Alexandre Umpierrez Amaral, Janaína Camacho da Silva, Alessandro Wajner, Kálita Dos Santos Godoy, Rafael Teixeira Ribeiro, Aline de Mello Gonçalves, Carmen Regla Vargas, Moacir Wajner. Mevalonolactone disrupts mitochondrial functions and induces permeability transition pore opening in rat brain mitochondria: Implications for the pathogenesis of mevalonic aciduria. Neurochemistry international. 2017 Sep; 108(?):133-145. doi: 10.1016/j.neuint.2017.03.005. [PMID: 28284974]
  • Adam Jozwiak, Agata Lipko, Magdalena Kania, Witold Danikiewicz, Liliana Surmacz, Agnieszka Witek, Jacek Wojcik, Konrad Zdanowski, Cezary Pączkowski, Tadeusz Chojnacki, Jaroslaw Poznanski, Ewa Swiezewska. Modeling of Dolichol Mass Spectra Isotopic Envelopes as a Tool to Monitor Isoprenoid Biosynthesis. Plant physiology. 2017 Jun; 174(2):857-874. doi: 10.1104/pp.17.00036. [PMID: 28385729]
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  • Jenna Waldron, Craig Webster. Liquid chromatography-tandem mass spectrometry method for the measurement of serum mevalonic acid: a novel marker of hydroxymethylglutaryl coenzyme A reductase inhibition by statins. Annals of clinical biochemistry. 2011 May; 48(Pt 3):223-32. doi: 10.1258/acb.2010.010182. [PMID: 21355014]
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