PERHEXILINE (BioDeep_00000600347)
代谢物信息卡片
PERHEXILINE
化学式: C19H35N (277.2769)
中文名称: 派克昔林
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1CCC(CC1)C(CC2CCCCN2)C3CCCCC3
InChI: InChI=1S/C19H35N/c1-3-9-16(10-4-1)19(17-11-5-2-6-12-17)15-18-13-7-8-14-20-18/h16-20H,1-15H2
描述信息
C78274 - Agent Affecting Cardiovascular System > C270 - Antihypertensive Agent > C333 - Calcium Channel Blocker
C - Cardiovascular system > C08 - Calcium channel blockers > C08E - Non-selective calcium channel blockers
D002317 - Cardiovascular Agents > D002121 - Calcium Channel Blockers
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D000077264 - Calcium-Regulating Hormones and Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
2 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:35553
- KEGGdrug: D08340
- PubChem: 4746
- Metlin: METLIN44340
- DrugBank: DB01074
- ChEMBL: CHEMBL75880
- MeSH: Perhexiline
- CAS: 39648-47-0
- CAS: 10118-35-1
- CAS: 39648-48-1
- CAS: 6621-47-2
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
| 亚细胞结构定位 | 关联基因列表 |
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文献列表
- Mark G Midei, Borje Darpo, Greg Ayers, Randy Brown, Jean-Philippe Couderc, William Daly, Georg Ferber, Philip T Sager, A John Camm. Electrophysiological and ECG Effects of Perhexiline, a Mixed Cardiac Ion Channel Inhibitor, Evaluated in Nonclinical Assays and in Healthy Subjects.
Journal of clinical pharmacology.
2021 12; 61(12):1606-1617. doi:
10.1002/jcph.1934. [PMID: 34214210] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Alessandra Guidi, Greta Petrella, Valentina Fustaino, Fulvio Saccoccia, Sara Lentini, Roberto Gimmelli, Giulia Di Pietro, Alberto Bresciani, Daniel Oscar Cicero, Giovina Ruberti. Drug effects on metabolic profiles of Schistosoma mansoni adult male parasites detected by 1H-NMR spectroscopy.
PLoS neglected tropical diseases.
2020 10; 14(10):e0008767. doi:
10.1371/journal.pntd.0008767. [PMID: 33044962] - Shiva Kant, Pravin Kesarwani, Anthony R Guastella, Praveen Kumar, Stewart F Graham, Katie L Buelow, Ichiro Nakano, Prakash Chinnaiyan. Perhexiline Demonstrates FYN-mediated Antitumor Activity in Glioblastoma.
Molecular cancer therapeutics.
2020 07; 19(7):1415-1422. doi:
10.1158/1535-7163.mct-19-1047. [PMID: 32430486] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Giovanni Licari, Robert W Milne, Andrew A Somogyi, Benedetta C Sallustio. Enantioselectivity in the tissue distribution of perhexiline contributes to different effects on hepatic histology and peripheral neural function in rats.
Pharmacology research & perspectives.
2018 06; 6(3):e00406. doi:
10.1002/prp2.406. [PMID: 29864243] - Zachary J Brown, Qiong Fu, Chi Ma, Michael Kruhlak, Haibo Zhang, Ji Luo, Bernd Heinrich, Su Jong Yu, Qianfei Zhang, Andrew Wilson, Zhen-Dan Shi, Rolf Swenson, Tim F Greten. Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development.
Cell death & disease.
2018 05; 9(6):620. doi:
10.1038/s41419-018-0687-6. [PMID: 29795111] - Patrick Camilleri, Duxi Zhang, Mark Midei, William Daly, James Copp, Cindy Flinn, Carl Luongo, Pirouz Shamszad. The validation of an LC-MS/MS assay for perhexiline and major hydroxy metabolites, and its application to therapeutic monitoring in patient plasma.
Bioanalysis.
2017 Jul; 9(13):1011-1025. doi:
10.4155/bio-2017-0068. [PMID: 28692346] - Harri M Itkonen, Michael Brown, Alfonso Urbanucci, Gregory Tredwell, Chung Ho Lau, Stefan Barfeld, Claire Hart, Ingrid J Guldvik, Mandeep Takhar, Hannelore V Heemers, Nicholas Erho, Katarzyna Bloch, Elai Davicioni, Rita Derua, Etienne Waelkens, James L Mohler, Noel Clarke, Johan V Swinnen, Hector C Keun, Ole P Rekvig, Ian G Mills. Lipid degradation promotes prostate cancer cell survival.
Oncotarget.
2017 Jun; 8(24):38264-38275. doi:
10.18632/oncotarget.16123. [PMID: 28415728] - P-P Liu, J Liu, W-Q Jiang, J S Carew, M A Ogasawara, H Pelicano, C M Croce, Z Estrov, R-H Xu, M J Keating, P Huang. Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline.
Oncogene.
2016 10; 35(43):5663-5673. doi:
10.1038/onc.2016.103. [PMID: 27065330] - Alessandra Guidi, Cristiana Lalli, Emerald Perlas, Giulia Bolasco, Martina Nibbio, Edith Monteagudo, Alberto Bresciani, Giovina Ruberti. Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems.
PLoS neglected tropical diseases.
2016 08; 10(8):e0004928. doi:
10.1371/journal.pntd.0004928. [PMID: 27518281] - Helen Phuong, Bo Y Choi, Cher-Rin Chong, Betty Raman, John D Horowitz. Can Perhexiline Be Utilized Without Long-Term Toxicity? A Clinical Practice Audit.
Therapeutic drug monitoring.
2016 Feb; 38(1):73-8. doi:
10.1097/ftd.0000000000000237. [PMID: 26309031] - Simone Esposito, Elena Bracacel, Martina Nibbio, Roberto Speziale, Laura Orsatti, Maria Veneziano, Edith Monteagudo, Fabio Bonelli. Use of 'dilute-and-shoot' liquid chromatography-high resolution mass spectrometry in preclinical research: application to a DMPK study of perhexiline in mouse plasma.
Journal of pharmaceutical and biomedical analysis.
2016 Jan; 118(?):70-80. doi:
10.1016/j.jpba.2015.10.004. [PMID: 26517851] - Ian S Westley, Giovanni Licari, Benedetta C Sallustio. Validation of a High-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Perhexiline and Cis-Hydroxy-Perhexiline Plasma Concentrations.
Therapeutic drug monitoring.
2015 Dec; 37(6):821-6. doi:
10.1097/ftd.0000000000000207. [PMID: 25774703] - Cher-Rin Chong, Nigel E Drury, Giovanni Licari, Michael P Frenneaux, John D Horowitz, Domenico Pagano, Benedetta C Sallustio. Stereoselective handling of perhexiline: implications regarding accumulation within the human myocardium.
European journal of clinical pharmacology.
2015 Dec; 71(12):1485-91. doi:
10.1007/s00228-015-1934-8. [PMID: 26376650] - Justin D Schumacher, Grace L Guo. Mechanistic review of drug-induced steatohepatitis.
Toxicology and applied pharmacology.
2015 Nov; 289(1):40-7. doi:
10.1016/j.taap.2015.08.022. [PMID: 26344000] - Yanhong Guo, Yanbo Fan, Jifeng Zhang, Gwen A Lomberk, Zhou Zhou, Lijie Sun, Angela J Mathison, Minerva T Garcia-Barrio, Ji Zhang, Lixia Zeng, Lei Li, Subramaniam Pennathur, Cristen J Willer, Daniel J Rader, Raul Urrutia, Y Eugene Chen. Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.
The Journal of clinical investigation.
2015 Oct; 125(10):3819-30. doi:
10.1172/jci79048. [PMID: 26368306] - Claudia Stäubert, Oliver Jay Broom, Anders Nordström. Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism.
Oncotarget.
2015 Aug; 6(23):19706-20. doi:
10.18632/oncotarget.3565. [PMID: 25839160] - Claudia Stäubert, Hasanuzzaman Bhuiyan, Anna Lindahl, Oliver Jay Broom, Yafeng Zhu, Saiful Islam, Sten Linnarsson, Janne Lehtiö, Anders Nordström. Rewired metabolism in drug-resistant leukemia cells: a metabolic switch hallmarked by reduced dependence on exogenous glutamine.
The Journal of biological chemistry.
2015 Mar; 290(13):8348-59. doi:
10.1074/jbc.m114.618769. [PMID: 25697355] - Xiu-Rong Ren, Jiangbo Wang, Takuya Osada, Robert A Mook, Michael A Morse, Larry S Barak, Herbert Kim Lyerly, Wei Chen. Perhexiline promotes HER3 ablation through receptor internalization and inhibits tumor growth.
Breast cancer research : BCR.
2015 Feb; 17(?):20. doi:
10.1186/s13058-015-0528-9. [PMID: 25849870] - Giovanni Licari, Andrew A Somogyi, Robert W Milne, Benedetta C Sallustio. Comparison of CYP2D metabolism and hepatotoxicity of the myocardial metabolic agent perhexiline in Sprague-Dawley and Dark Agouti rats.
Xenobiotica; the fate of foreign compounds in biological systems.
2015 Jan; 45(1):3-9. doi:
10.3109/00498254.2014.942721. [PMID: 25050791] - Abdul Rauf Sheikh, Ian Westley, Benedetta Sallustio, John D Horowitz, John F Beltrame. Interaction of terbinafine (anti-fungal agent) with perhexiline: a case report.
Heart, lung & circulation.
2014 Jun; 23(6):e149-51. doi:
10.1016/j.hlc.2013.11.012. [PMID: 24373912] - Nigel E Drury, Giovanni Licari, Cher-Rin Chong, Neil J Howell, Michael P Frenneaux, John D Horowitz, Domenico Pagano, Benedetta C Sallustio. Relationship between plasma, atrial and ventricular perhexiline concentrations in humans: insights into factors affecting myocardial uptake.
British journal of clinical pharmacology.
2014 May; 77(5):789-95. doi:
10.1111/bcp.12254. [PMID: 24117487] - Nicolas Delattin, Katrijn De Brucker, Katleen Vandamme, Els Meert, Arnaud Marchand, Patrick Chaltin, Bruno P A Cammue, Karin Thevissen. Repurposing as a means to increase the activity of amphotericin B and caspofungin against Candida albicans biofilms.
The Journal of antimicrobial chemotherapy.
2014 Apr; 69(4):1035-44. doi:
10.1093/jac/dkt449. [PMID: 24284780] - Hiroshi Kitoh, Masataka Achiwa, Hiroshi Kaneko, Kenichi Mishima, Masaki Matsushita, Izumi Kadono, John D Horowitz, Benedetta C Sallustio, Kinji Ohno, Naoki Ishiguro. Perhexiline maleate in the treatment of fibrodysplasia ossificans progressiva: an open-labeled clinical trial.
Orphanet journal of rare diseases.
2013 Oct; 8(?):163. doi:
10.1186/1750-1172-8-163. [PMID: 24131551] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Soledad Larrain, Mary E Rinella. A myriad of pathways to NASH.
Clinics in liver disease.
2012 Aug; 16(3):525-48. doi:
10.1016/j.cld.2012.05.009. [PMID: 22824479] - Henrik T Yudate, Toshihiro Kai, Mikio Aoki, Yohsuke Minowa, Toru Yamada, Toru Kimura, Atsushi Ono, Hiroshi Yamada, Yasuo Ohno, Tetsuro Urushidani. Identification of a novel set of biomarkers for evaluating phospholipidosis-inducing potential of compounds using rat liver microarray data measured 24-h after single dose administration.
Toxicology.
2012 May; 295(1-3):1-7. doi:
10.1016/j.tox.2012.02.015. [PMID: 22426296] - Harel Gilutz, Michael P Frenneaux, John D Horowitz. A case series of concomitant treatment of perhexiline with amiodarone.
Therapeutic drug monitoring.
2012 Apr; 34(2):227-31. doi:
10.1097/ftd.0b013e318245e5a6. [PMID: 22322401] - Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
Journal of medicinal chemistry.
2011 Jul; 54(13):4548-58. doi:
10.1021/jm2001629. [PMID: 21599003] - Roger M Beadle, Lynne K Williams, Khaild Abozguia, Kiran Patel, Francisco Leyva Leon, Zaheer Yousef, Anton Wagenmakers, Michael P Frenneaux. Metabolic manipulation in chronic heart failure: study protocol for a randomised controlled trial.
Trials.
2011 Jun; 12(?):140. doi:
10.1186/1745-6215-12-140. [PMID: 21645332] - Simona M Ceccarelli, Odile Chomienne, Marcel Gubler, Arduino Arduini. Carnitine palmitoyltransferase (CPT) modulators: a medicinal chemistry perspective on 35 years of research.
Journal of medicinal chemistry.
2011 May; 54(9):3109-52. doi:
10.1021/jm100809g. [PMID: 21504156] - Liang-Han Ling, William Chik, Paula Averbuj, Purendra K Pati, Aaron L Sverdlov, Doan T M Ngo, Raymond G Morris, Benedetta C Sallustio, John D Horowitz. Effects of aging, renal dysfunction, left ventricular systolic impairment, and weight on steady state pharmacokinetics of perhexiline.
Therapeutic drug monitoring.
2011 Apr; 33(2):251-6. doi:
10.1097/ftd.0b013e31820dd8e9. [PMID: 21383654] - Que Liu, Christen Anderson, Anatoly Broyde, Clara Polizzi, Rayne Fernandez, Alain Baron, David G Parkes. Glucagon-like peptide-1 and the exenatide analogue AC3174 improve cardiac function, cardiac remodeling, and survival in rats with chronic heart failure.
Cardiovascular diabetology.
2010 Nov; 9(?):76. doi:
10.1186/1475-2840-9-76. [PMID: 21080957] - Lionel H Opie, Juhani Knuuti. The adrenergic-fatty acid load in heart failure.
Journal of the American College of Cardiology.
2009 Oct; 54(18):1637-46. doi:
10.1016/j.jacc.2009.07.024. [PMID: 19850204] - Mei Zhang, Grant A Moore, Murray L Barclay, Evan J Begg. Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2009 Oct; 877(27):3025-30. doi:
10.1016/j.jchromb.2009.07.021. [PMID: 19646935] - Yang Wu, David Connors, Lauren Barber, Sukhanya Jayachandra, Umesh M Hanumegowda, Stephen P Adams. Multiplexed assay panel of cytotoxicity in HK-2 cells for detection of renal proximal tubule injury potential of compounds.
Toxicology in vitro : an international journal published in association with BIBRA.
2009 Sep; 23(6):1170-8. doi:
10.1016/j.tiv.2009.06.003. [PMID: 19523510] - Ignasi Barba, Laia Chavarria, Marisol Ruiz-Meana, Maribel Mirabet, Esperanza Agulló, David Garcia-Dorado. Effect of intracellular lipid droplets on cytosolic Ca2+ and cell death during ischaemia-reperfusion injury in cardiomyocytes.
The Journal of physiology.
2009 Mar; 587(Pt 6):1331-41. doi:
10.1113/jphysiol.2008.163311. [PMID: 19188253] - Ju Seop Kang, Min Ho Lee. Overview of therapeutic drug monitoring.
The Korean journal of internal medicine.
2009 Mar; 24(1):1-10. doi:
10.3904/kjim.2009.24.1.1. [PMID: 19270474] - Neetesh Bhandari, David J Figueroa, Jeffrey W Lawrence, David Lee Gerhold. Phospholipidosis assay in HepG2 cells and rat or rhesus hepatocytes using phospholipid probe NBD-PE.
Assay and drug development technologies.
2008 Jun; 6(3):407-19. doi:
10.1089/adt.2007.119. [PMID: 18537465] - Benjamin J Davies, Megan K Herbert, Janet K Coller, Andrew A Somogyi, Robert W Milne, Benedetta C Sallustio. Steady-state pharmacokinetics of the enantiomers of perhexiline in CYP2D6 poor and extensive metabolizers administered Rac-perhexiline.
British journal of clinical pharmacology.
2008 Mar; 65(3):347-54. doi:
10.1111/j.1365-2125.2007.03015.x. [PMID: 17875193] - Antonio C P Chagas, Paulo M M Dourado, Tatiana de Fátima Gonçalves Galvão. Modulation of cardiac metabolism during myocardial ischemia.
Current pharmaceutical design.
2008; 14(25):2563-71. doi:
10.2174/138161208786071236. [PMID: 18991673] - Sally C Inglis, Megan K Herbert, Benjamin J L Davies, Janet K Coller, Heather M James, John D Horowitz, Raymond G Morris, Robert W Milne, Andrew A Somogyi, Benedetta C Sallustio. Effect of CYP2D6 metabolizer status on the disposition of the (+) and (-) enantiomers of perhexiline in patients with myocardial ischaemia.
Pharmacogenetics and genomics.
2007 May; 17(5):305-12. doi:
10.1097/fpc.0b013e32800ffba0. [PMID: 17429312] - Houman Ashrafian, John D Horowitz, Michael P Frenneaux. Perhexiline.
Cardiovascular drug reviews.
2007; 25(1):76-97. doi:
10.1111/j.1527-3466.2007.00006.x. [PMID: 17445089] - Benjamin J Davies, Megan K Herbert, Janet K Coller, Andrew A Somogyi, Robert W Milne, Benedetta C Sallustio. Determination of the 4-monohydroxy metabolites of perhexiline in human plasma, urine and liver microsomes by liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Nov; 843(2):302-9. doi:
10.1016/j.jchromb.2006.06.020. [PMID: 16837252] - Benjamin J Davies, Janet K Coller, Heather M James, Andrew A Somogyi, John D Horowitz, Benedetta C Sallustio. The influence of CYP2D6 genotype on trough plasma perhexiline and cis-OH-perhexiline concentrations following a standard loading regimen in patients with myocardial ischaemia.
British journal of clinical pharmacology.
2006 Mar; 61(3):321-5. doi:
10.1111/j.1365-2125.2005.02570.x. [PMID: 16487226] - Benjamin J Davies, Megan K Herbert, Julie A Culbert, Simon M Pyke, Janet K Coller, Andrew A Somogyi, Robert W Milne, Benedetta C Sallustio. Enantioselective assay for the determination of perhexiline enantiomers in human plasma by liquid chromatography.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2006 Feb; 832(1):114-20. doi:
10.1016/j.jchromb.2005.12.046. [PMID: 16434242] - Leong Lee, Ross Campbell, Michaela Scheuermann-Freestone, Rachel Taylor, Prasad Gunaruwan, Lynne Williams, Houman Ashrafian, John Horowitz, Alan G Fraser, Kieran Clarke, Michael Frenneaux. Metabolic modulation with perhexiline in chronic heart failure: a randomized, controlled trial of short-term use of a novel treatment.
Circulation.
2005 Nov; 112(21):3280-8. doi:
10.1161/circulationaha.105.551457. [PMID: 16301359] - Hiroshi Sawada, Kenji Takami, Satoru Asahi. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.
Toxicological sciences : an official journal of the Society of Toxicology.
2005 Feb; 83(2):282-92. doi:
10.1093/toxsci/kfh264. [PMID: 15342952] - O Beck, N Stephanson, R G Morris, B C Sallustio, P Hjemdahl. Determination of perhexiline and hydroxyperhexiline in plasma by liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2004 Jun; 805(1):87-91. doi:
10.1016/j.jchromb.2004.02.019. [PMID: 15113543] - A Philpott, S Chandy, R Morris, J D Horowitz. Development of a regimen for rapid initiation of perhexiline therapy in acute coronary syndromes.
Internal medicine journal.
2004 Jun; 34(6):361-3. doi:
10.1111/j.1445-5994.2004.00624.x. [PMID: 15228400] - Benjamin J L Davies, Janet K Coller, Heather M James, David Gillis, Andrew A Somogyi, John D Horowitz, Raymond G Morris, Benedetta C Sallustio. Clinical inhibition of CYP2D6-catalysed metabolism by the antianginal agent perhexiline.
British journal of clinical pharmacology.
2004 Apr; 57(4):456-63. doi:
10.1046/j.1365-2125.2003.02033.x. [PMID: 15025744] - Terry E Jones, Raymond G Morris, John D Horowitz. Concentration-time profile for perhexiline and hydroxyperhexiline in patients at steady state.
British journal of clinical pharmacology.
2004 Mar; 57(3):263-9. doi:
10.1046/j.1365-2125.2003.02003.x. [PMID: 14998422] - R Todd Stravitz, Arun J Sanyal. Drug-induced steatohepatitis.
Clinics in liver disease.
2003 May; 7(2):435-51. doi:
10.1016/s1089-3261(03)00027-8. [PMID: 12879993] - N Fabre, E Arrivet, J Trancard, N Bichet, N O Roome, A Prenez, J A Vericat. A new hepatoma cell line for toxicity testing at repeated doses.
Cell biology and toxicology.
2003 Apr; 19(2):71-82. doi:
10.1023/a:1023304005217. [PMID: 12776925] - S R Willoughby, S Stewart, Y Y Chirkov, J A Kennedy, A S Holmes, J D Horowitz. Beneficial clinical effects of perhexiline in patients with stable angina pectoris and acute coronary syndromes are associated with potentiation of platelet responsiveness to nitric oxide.
European heart journal.
2002 Dec; 23(24):1946-54. doi:
10.1053/euhj.2002.3296. [PMID: 12473257] - Benedetta C Sallustio, Ian S Westley, Raymond G Morris. Pharmacokinetics of the antianginal agent perhexiline: relationship between metabolic ratio and steady-state dose.
British journal of clinical pharmacology.
2002 Aug; 54(2):107-14. doi:
10.1046/j.1365-2125.2002.01618.x. [PMID: 12207628] - R Hussein, B G Charles, R G Morris, R L Rasiah. Population pharmacokinetics of perhexiline from very sparse, routine monitoring data.
Therapeutic drug monitoring.
2001 Dec; 23(6):636-43. doi:
10.1097/00007691-200112000-00007. [PMID: 11802096] - M Hamdan, S Urien, H Le Louet, J P Tillement, D Morin. Inhibition of mitochondrial carnitine palmitoyltransferase-1 by a trimetazidine derivative, S-15176.
Pharmacological research.
2001 Aug; 44(2):99-104. doi:
10.1006/phrs.2001.0829. [PMID: 11516258] - S M Killalea, H Krum. Systematic review of the efficacy and safety of perhexiline in the treatment of ischemic heart disease.
American journal of cardiovascular drugs : drugs, devices, and other interventions.
2001; 1(3):193-204. doi:
10.2165/00129784-200101030-00005. [PMID: 14728034] - B C Sallustio, R G Morris. Assessment of interlaboratory performance in the provision of perhexiline therapeutic drug monitoring services in Australia.
Therapeutic drug monitoring.
1999 Aug; 21(4):389-94. doi:
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Molecular and biochemical parasitology.
1997 Dec; 90(1):145-53. doi:
10.1016/s0166-6851(97)00151-5. [PMID: 9497039] - N Grgurinovich. Method for the analysis of perhexiline and its hydroxy metabolite in plasma using high-performance liquid chromatography with precolumn derivatization.
Journal of chromatography. B, Biomedical sciences and applications.
1997 Aug; 696(1):75-80. doi:
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