Citiolone (BioDeep_00000600345)
代谢物信息卡片
化学式: C6H9NO2S (159.0353974)
中文名称: DL-N-乙酰高半胱氨酸硫代内酯, 3-乙酰氨基四氢-2-噻吩
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)NC1CCSC1=O
InChI: InChI=1S/C6H9NO2S/c1-4(8)7-5-2-3-10-6(5)9/h5H,2-3H2,1H3,(H,7,8)
描述信息
A - Alimentary tract and metabolism > A05 - Bile and liver therapy > A05B - Liver therapy, lipotropics > A05BA - Liver therapy
C78273 - Agent Affecting Respiratory System > C29767 - Expectorant
C26170 - Protective Agent > C2081 - Hepatoprotective Agent
同义名列表
2 个代谢物同义名
数据库引用编号
8 个数据库交叉引用编号
- ChEBI: CHEBI:94403
- KEGGdrug: D07105
- PubChem: 14520
- Metlin: METLIN44336
- DrugBank: DB13442
- ChEMBL: CHEMBL2104457
- CAS: 17896-21-8
- CAS: 1195-16-0
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - G Papaccio, B De Luca, F A Pisanti. Macrophages and antioxidant status in the NOD mouse pancreas.
Journal of cellular biochemistry.
1998 Dec; 71(4):479-90. doi:
10.1002/(sici)1097-4644(19981215)71:4<479::aid-jcb3>3.0.co;2-6. [PMID: 9827694] - C Bapu, P A Rao, P P Sood. Restoration of methylmercury inhibited adenosine triphosphatases during vitamin and monothiol therapy.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
1998; 17(1):75-80. doi:
NULL. [PMID: 9490323] - M Luque Sánchez, R Romero Ortego, A Moreno Corredor. [Serum sickness type reaction to citiolone].
Atencion primaria.
1995 Sep; 16(5):295-6. doi:
NULL. [PMID: 7578844] - P P Sood, C Bapu, K Vijayalakshmi. Vitamins and monothiols efficacy in the restoration of adenosine nucleotide degradation enzymes altered during methylmercury intoxication.
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer.
1995; 14(2):101-5. doi:
. [PMID: 9372838] - C Bapu, K Vijayalakshmi, P P Sood. Comparison of monothiols and vitamin therapy administered alone or in combinations during methylmercury poisoning.
Bulletin of environmental contamination and toxicology.
1994 Feb; 52(2):182-9. doi:
10.1007/bf00198486. [PMID: 8123976] - P P Sood, K Vijayalakshmi, C Bapu. Ameliorative capacities of vitamins and monothiols administered alone or in combinations in methylmercury mobilisation in nervous and non-nervous tissues of mice.
Cellular and molecular biology (Noisy-le-Grand, France).
1993 Mar; 39(2):213-9. doi:
. [PMID: 8513276] - S M Naqvi, M Hasan. Acetylhomocysteine thiolactone protection against phosphamidon-induced alteration of regional superoxide dismutase activity in the central nervous system and its correlation with altered lipid peroxidation.
Indian journal of experimental biology.
1992 Sep; 30(9):850-2. doi:
. [PMID: 1478721] - K Vijayalakshmi, C Bapu, P P Sood. Differential effects of methylmercury, thiols, and vitamins on galactosidases of nervous and non-nervous tissues.
Bulletin of environmental contamination and toxicology.
1992 Jul; 49(1):71-7. doi:
10.1007/bf00193343. [PMID: 1327315] - I Flechner, K Maruta, V Burkart, K Kawai, H Kolb, U Kiesel. Effects of radical scavengers on the development of experimental diabetes.
Diabetes research (Edinburgh, Scotland).
1990 Feb; 13(2):67-73. doi:
". [PMID: 2091872] - B A Burdick, T W Esders, J R Schaeffer, S Lynn. Polymeric thiols as enzyme activators of serum creatine phosphokinase.
Applied biochemistry and biotechnology.
1987 Sep; 16(?):145-56. doi:
10.1007/bf02798363. [PMID: 3504127] - F A Pisanti, M de Nicola Giudici, E Aloj Totaro, P Russo. Effects of bonellin on lipids.
Life sciences.
1986 Mar; 38(10):923-7. doi:
10.1016/0024-3205(86)90260-2. [PMID: 2869393] - F Galeone, F Salvadorini, M Guarguaglini, P Saba. Effect of intravenous injection of CDP-choline, S-adenosyl-methionine and citiolone in subjects with hyperlipemia.
Artery.
1979 Feb; 5(2):157-69. doi:
NULL. [PMID: 231953] - J SCHOLTHOLT. [Behavior of serum bilirubin and serum enzymes in acute viral hepatitis during therapy with Reducdyn].
Therapie der Gegenwart.
1962 Jun; 101(?):264-7. doi:
NULL. [PMID: 13909149]