Diprotin A (BioDeep_00000600331)
代谢物信息卡片
Diprotin A
化学式: C17H31N3O4 (341.23144460000003)
中文名称: 抑二肽素A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(=O)N1CCCC1C(=O)NC(C(C)CC)C(=O)O)N
InChI: InChI=1S/C17H31N3O4/c1-5-10(3)13(18)16(22)20-9-7-8-12(20)15(21)19-14(17(23)24)11(4)6-2/h10-14H,5-9,18H2,1-4H3,(H,19,21)(H,23,24)/t10-,11-,12-,13-,14-/m0/s1
描述信息
D007004 - Hypoglycemic Agents > D054873 - Dipeptidyl-Peptidase IV Inhibitors
D004791 - Enzyme Inhibitors > D011480 - Protease Inhibitors
Diprotin A (Ile-Pro-Ile) is an inhibitor of dipeptidyl peptidase IV (DPP-IV)[1].
同义名列表
2 个代谢物同义名
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:93213
- PubChem: 94701
- Metlin: METLIN44309
- ChEMBL: CHEMBL214381
- CAS: 90614-48-5
- medchemexpress: HY-111174
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Divya Kumar, Vivek K Hamse, K N Neema, Priya Babu Shubha, D M Chetan, Nanjunda Swamy Shivananju. Purification and biochemical characterization of a novel secretory dipeptidyl peptidase IV from porcine serum.
Molecular and cellular biochemistry.
2020 Aug; 471(1-2):71-80. doi:
10.1007/s11010-020-03766-y. [PMID: 32577945] - Feng-Min Xi, Chun-Tong Li, Jun Han, Shi-Shan Yu, Zhi-Jun Wu, Wan-Sheng Chen. Thiophenes, polyacetylenes and terpenes from the aerial parts of Eclipata prostrate.
Bioorganic & medicinal chemistry.
2014 Nov; 22(22):6515-22. doi:
10.1016/j.bmc.2014.06.051. [PMID: 25443644] - P S Unnikrishnan, K Suthindhiran, M A Jayasri. Inhibitory potential of Turbinaria ornata against key metabolic enzymes linked to diabetes.
BioMed research international.
2014; 2014(?):783895. doi:
10.1155/2014/783895. [PMID: 25050371] - C Marchetti, A Di Carlo, F Facchiano, C Senatore, R De Cristofaro, A Luzi, M Federici, M Romani, M Napolitano, M C Capogrossi, A Germani. High mobility group box 1 is a novel substrate of dipeptidyl peptidase-IV.
Diabetologia.
2012 Jan; 55(1):236-44. doi:
10.1007/s00125-011-2213-6. [PMID: 21656024] - Rafaela F Alponti, Paulo F Silveira. Neutral aminopeptidase and dipeptidyl peptidase IV activities in plasma of monosodium glutamate obese and food-deprived rats.
Obesity (Silver Spring, Md.).
2010 Jul; 18(7):1312-7. doi:
10.1038/oby.2009.378. [PMID: 19876009] - Mark Merchant, Stephanie Mead, Charles McAdon, Justin McFatter, Joe Wasilewski. Identification and characterization of dipeptidyl peptidase IV enzyme activity in the American crocodile (Crocodylus acutus).
Veterinary immunology and immunopathology.
2010 Jul; 136(1-2):28-33. doi:
10.1016/j.vetimm.2010.01.005. [PMID: 20227771] - Carlos García-Aparicio, María-Cruz Bonache, Ingrid De Meester, Ana San-Félix, Jan Balzarini, María-José Camarasa, Sonsoles Velazquez. Design and discovery of a novel dipeptidyl-peptidase IV (CD26)-based prodrug approach.
Journal of medicinal chemistry.
2006 Aug; 49(17):5339-51. doi:
10.1021/jm0606490. [PMID: 16913724] - Dwayne N Jackson, Kevin J Milne, Earl G Noble, J Kevin Shoemaker. Neuropeptide Y bioavailability is suppressed in the hindlimb of female Sprague-Dawley rats.
The Journal of physiology.
2005 Oct; 568(Pt 2):573-81. doi:
10.1113/jphysiol.2005.092700. [PMID: 16081487] - Jan Balzarini, Elin Andersson, Dominique Schols, Paul Proost, Jo Van Damme, Bo Svennerholm, Peter Horal, Anders Vahlne. Obligatory involvement of CD26/dipeptidyl peptidase IV in the activation of the antiretroviral tripeptide glycylprolylglycinamide (GPG-NH(2)).
The international journal of biochemistry & cell biology.
2004 Sep; 36(9):1848-59. doi:
10.1016/j.biocel.2004.02.017. [PMID: 15183349] - Seamus J Buckley, Patrick J Collins, Brendan F O'Connor. The purification and characterisation of novel dipeptidyl peptidase IV-like activity from bovine serum.
The international journal of biochemistry & cell biology.
2004 Jul; 36(7):1281-96. doi:
10.1016/j.biocel.2003.02.001. [PMID: 15109572] - J de la Haba-Rodríguez, A Macho, M A Calzado, M V Blázquez, M A Gómez, E E Muñoz, E Aranda. Soluble dipeptidyl peptidase IV (CD-26) in serum of patients with colorectal carcinoma.
Neoplasma.
2002; 49(5):307-11. doi:
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Regulatory peptides.
2001 Jan; 96(3):95-104. doi:
10.1016/s0167-0115(00)00125-7. [PMID: 11111014] - A Wettergren, L Pridal, M Wøjdemann, J J Holst. Amidated and non-amidated glucagon-like peptide-1 (GLP-1): non-pancreatic effects (cephalic phase acid secretion) and stability in plasma in humans.
Regulatory peptides.
1998 Oct; 77(1-3):83-7. doi:
10.1016/s0167-0115(98)00044-5. [PMID: 9809800] - L Juillerat-Jeanneret, J D Aubert, P Leuenberger. Peptidases in human bronchoalveolar lining fluid, macrophages, and epithelial cells: dipeptidyl (amino)peptidase IV, aminopeptidase N, and dipeptidyl (carboxy)peptidase (angiotensin-converting enzyme).
The Journal of laboratory and clinical medicine.
1997 Dec; 130(6):603-14. doi:
10.1016/s0022-2143(97)90110-4. [PMID: 9422334] - J Damas, V Bourdon, J F Liégeois, W H Simmons. Influence of several peptidase inhibitors on the pro-inflammatory effects of substance P, capsaicin and collagenase.
Naunyn-Schmiedeberg's archives of pharmacology.
1996 Nov; 354(5):662-9. doi:
10.1007/bf00170843. [PMID: 8938667] - H Shibuya-Saruta, Y Kasahara, Y Hashimoto. Human serum dipeptidyl peptidase IV (DPPIV) and its unique properties.
Journal of clinical laboratory analysis.
1996; 10(6):435-40. doi:
10.1002/(sici)1098-2825(1996)10:6<435::aid-jcla21>3.0.co;2-x. [PMID: 8951616] - H Shibuya-Saruta, M Sugiyama, Y Kasahara. Colorimetrical rate assay for urinary dipeptidyl peptidase IV (DPPIV) activity using a new substrate.
Journal of clinical laboratory analysis.
1995; 9(2):113-8. doi:
10.1002/jcla.1860090207. [PMID: 7714663] - L H Wang, S Ahmad, I F Benter, A Chow, S Mizutani, P E Ward. Differential processing of substance P and neurokinin A by plasma dipeptidyl(amino)peptidase IV, aminopeptidase M and angiotensin converting enzyme.
Peptides.
1991 Nov; 12(6):1357-64. doi:
10.1016/0196-9781(91)90220-j. [PMID: 1726123]