Mephenesin (BioDeep_00000600037)

   

natural product


代谢物信息卡片


Mephenesin

化学式: C10H14O3 (182.0943)
中文名称: 甲酚素
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CC=CC=C1OCC(CO)O
InChI: InChI=1S/C10H14O3/c1-8-4-2-3-5-10(8)13-7-9(12)6-11/h2-5,9,11-12H,6-7H2,1H3

描述信息

M - Musculo-skeletal system > M03 - Muscle relaxants > M03B - Muscle relaxants, centrally acting agents
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
D002491 - Central Nervous System Agents
Mephenesin is an NMDA receptor antagonist and Mephenesin is a central muscle relaxant.

同义名列表

2 个代谢物同义名

Mephenesin; Mephenesin



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Maged H M Sharaf, Dwight D Stiff. Determination of guaifenesin in human serum by capillary gas chromatography and electron capture detection. Journal of pharmaceutical and biomedical analysis. 2004 Jun; 35(4):801-6. doi: 10.1016/j.jpba.2004.01.028. [PMID: 15193724]
  • J F Sheen, G R Her. Analysis of neutral drugs in human plasma by fluoride attachment in liquid chromatography/negative ion electrospray tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2004; 18(17):1911-8. doi: 10.1002/rcm.1561. [PMID: 15329856]
  • P Guinebault, C Colafranceschi, G Bianchetti. Determination of mephenesin in plasma by high-performance liquid chromatography with fluorimetric detection. Journal of chromatography. 1990 May; 507(?):221-5. doi: 10.1016/s0021-9673(01)84197-2. [PMID: 2380289]
  • F Bowser-Riley, S Daniels, W A Hill, E B Smith. An evaluation of the structure-activity relationships of a series of analogues of mephenesin and strychnine on the response to pressure in mice. British journal of pharmacology. 1989 Apr; 96(4):789-94. doi: 10.1111/j.1476-5381.1989.tb11885.x. [PMID: 2743078]
  • N Miki, M Nagano, K Kuriyama. Catalase activates cerebral granylate cyclase in the presence of sodium azide. Biochemical and biophysical research communications. 1976 Oct; 72(3):952-9. doi: 10.1016/s0006-291x(76)80224-0. [PMID: 10917]
  • R J Roberts. Bacterial diseases of farmed fishes. Society for Applied Bacteriology symposium series. 1976; 4(?):55-62. doi: NULL. [PMID: 5781]
  • S Laskowski, J Matyjek, M Koppicz, A Pohorski. [Hemlock poisoning]. Polskie Archiwum Medycyny Wewnetrznej. 1973 Nov; 50(11):1237-9. doi: ". [PMID: 4768252]
  • N C Law. A modern approach for drug identification. The American journal of medical technology. 1973 Jun; 39(6):237-43. doi: NULL. [PMID: 4575337]
  • A R Maass, P L Carey, A E Heming. The effect of SK&F 525-A, 2-diethylaminoethyl-2,2-diphenylvalerate hydrochloride, on the in vivo metabolism of beta-(0-toloxy)-1,2-propanediol. Archives internationales de pharmacodynamie et de therapie. 1969 Jul; 180(1):1-10. doi: NULL. [PMID: 5357005]
  • R Kretzschmar, H J Meyer. [Comparative studies on the anticonvulsant activity of the pyrone compounds of Piper methysticum Forst]. Archives internationales de pharmacodynamie et de therapie. 1969 Feb; 177(2):261-7. doi: . [PMID: 5807167]
  • F Bottari, M F Saettone, M F Serafini. Drug latentiation. The preparation and preliminary pharmacological evaluation of some mephenesin aryloxyacetates. Journal of medicinal chemistry. 1968 Jul; 11(4):904-7. doi: 10.1021/jm00310a054. [PMID: 5671273]
  • S Srebocan, P Stern. The origin of epileptiform seizures caused by oil of Artemisia caerulescens L. The Journal of pharmacy and pharmacology. 1968 Feb; 20(2):160-1. doi: 10.1111/j.2042-7158.1968.tb09712.x. [PMID: 4384546]
  • C H Gallagher, J H Koch, H Hoffman. Electro-myographic studies on sheep injected with the N,N-dimethylated tryptamine alkaloids of Phalaris tuberosa. International journal of neuropharmacology. 1967 May; 6(3):223-8. doi: 10.1016/0028-3908(67)90009-3. [PMID: 5231771]
  • H J Meyer, R Kretzschmar. [Kawa pyrone--a new kind of substance group of central muscle relaxants of the mephenesin type]. Klinische Wochenschrift. 1966 Aug; 44(15):902-3. doi: 10.1007/bf01711971. [PMID: 5992541]
  • A ROOK. SOME CHEMICAL INFLUENCES ON HAIR GROWTH AND PIGMENTATION. The British journal of dermatology. 1965 Mar; 77(?):115-29. doi: 10.1111/j.1365-2133.1965.tb14614.x. [PMID: 14277960]
  • E G HUF, F K COLES, L L EUBANK. Comparative plasma levels of mephenesin, mephenesin carbamate and methocarbamol. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1959 Nov; 102(?):276-7. doi: 10.3181/00379727-102-25218. [PMID: 14403806]
  • J C HONET, T V CASEY, J W RUNYAN. False-positive urinary test for 5-hydroxyindoleacetic acid due to methocarbamol and mephenesin carbamate. The New England journal of medicine. 1959 Jul; 261(4):188-90. doi: 10.1056/nejm195907232610407. [PMID: 13667004]
  • A M MORGAN, E H TRUITT, J M LITTLE. Plasma levels of mephenesin, mephenesin carbamate, guaiacol glyceryl ether, and methocarbamol (AHR-85) after oral and intravenous administration in the dog. Journal of the American Pharmaceutical Association. American Pharmaceutical Association. 1957 Jun; 46(6):374-7. doi: 10.1002/jps.3030460613. [PMID: 13491400]
  • J A ARKINS, P P RUETZ, T L SQUIER. Mephenesin (tolserol) sensitivity with demonstrable skin-sensitizing antibody in the serum. The Journal of allergy. 1957 May; 28(3):247-50. doi: 10.1016/0021-8707(57)90129-6. [PMID: 13428487]
  • I LONDON, R B POET. Comparative plasma levels of mephenesin and its carbamic acid ester. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1957 Jan; 94(1):191. doi: 10.3181/00379727-94-22894. [PMID: 13400909]
  • P E DRESEL, E E UNDERWOOD, A P RICHARDSON. Correlation of plasma level with spinal cord depressant action of mephenesin and its carbamic acid ester. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1954 Jul; 86(3):621-3. doi: 10.3181/00379727-86-21182. [PMID: 13194738]
  • W T SALTER. Therapeutics and toxicology. Annual review of medicine. 1950; 1(?):391-418. doi: 10.1146/annurev.me.01.020150.002135. [PMID: 14771861]
  • T E W GOODIER, C E D GOODHART. Fatal anuria after use of myanesin in anaesthesia. Lancet (London, England). 1949 Jan; 1(6544):183. doi: 10.1016/s0140-6736(49)90469-9. [PMID: 18108015]
  • T F HEWER, R F WOOLMER. Death from renal anoxia after myanesin anaesthesia. Lancet (London, England). 1947 Dec; 2(6486):909. doi: 10.1016/s0140-6736(47)90917-3. [PMID: 18896091]
  • J B WYNGAARDEN, L A WOODS, M H SEEVERS. Plasma levels and urinary excretion of injected myanesin in dogs. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). 1947 Oct; 66(1):256-60. doi: 10.3181/00379727-66-16056. [PMID: 20270747]