fluprostenol (BioDeep_00000600029)

   


代谢物信息卡片


(+)-9α,11α,15R-trihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid

化学式: C23H29F3O6 (458.191613)
中文名称: (+)-氟丁烯醇, 氟前列醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(C(C1O)C=CC(COC2=CC=CC(=C2)C(F)(F)F)O)CC=CCCCC(=O)O)O
InChI: InChI=1S/C23H29F3O6/c24-23(25,26)15-6-5-7-17(12-15)32-14-16(27)10-11-19-18(20(28)13-21(19)29)8-3-1-2-4-9-22(30)31/h1,3,5-7,10-12,16,18-21,27-29H,2,4,8-9,13-14H2,(H,30,31)/b3-1-,11-10+/t16-,18-,19-,20+,21-/m1/s1

描述信息

D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
D012102 - Reproductive Control Agents > D008186 - Luteolytic Agents
C78568 - Prostaglandin Analogue

同义名列表

3 个代谢物同义名

(+)-Fluprostenol; fluprostenol; (+)-9α,11α,15R-trihydroxy-16-(3-(trifluoromethyl)phenoxy)-17,18,19,20-tetranor-prosta-5Z,13E-dien-1-oic acid



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Steven K Engle, David E Watson. Natriuretic Peptides as Cardiovascular Safety Biomarkers in Rats: Comparison With Blood Pressure, Heart Rate, and Heart Weight. Toxicological sciences : an official journal of the Society of Toxicology. 2016 Feb; 149(2):458-72. doi: 10.1093/toxsci/kfv240. [PMID: 26609138]
  • Ko Fujimori, Fumio Amano. Niacin promotes adipogenesis by reducing production of anti-adipogenic PGF2α through suppression of C/EBPβ-activated COX-2 expression. Prostaglandins & other lipid mediators. 2011 Apr; 94(3-4):96-103. doi: 10.1016/j.prostaglandins.2011.01.002. [PMID: 21236357]
  • Jinshan Cao, Tatsuro Nakamura, Takio Kitazawa, Naoko Yamashiki, Tsubasa Yamamoto, Tetsuro Taneike. Characterization of prostanoid receptors present on adrenergic neurons innervating the porcine uterine longitudinal muscle. Prostaglandins & other lipid mediators. 2008 Jun; 86(1-4):26-34. doi: 10.1016/j.prostaglandins.2008.02.002. [PMID: 18403225]
  • K M Rice, S Uddemarri, D H Desai, R G Morrison, R Harris, G L Wright, E R Blough. PGF2alpha-associated vascular smooth muscle hypertrophy is ROS dependent and involves the activation of mTOR, p70S6k, and PTEN. Prostaglandins & other lipid mediators. 2008 Feb; 85(1-2):49-57. doi: 10.1016/j.prostaglandins.2007.10.009. [PMID: 18160324]
  • B A McCue, M M Cason, M A Curtis, R D Faulkner, D C Dahlin. Determination of travoprost and travoprost free acid in human plasma by electrospray HPLC/MS/MS. Journal of pharmaceutical and biomedical analysis. 2002 Apr; 28(2):199-208. doi: 10.1016/s0731-7085(01)00644-6. [PMID: 11929662]
  • K Noguchi, H Endo, H Kondo, I Ishikawa. Prostaglandin F2alpha upregulates interleukin-6 production in human gingival fibroblasts. Journal of periodontal research. 2001 Apr; 36(2):80-7. doi: 10.1034/j.1600-0765.2001.360203.x. [PMID: 11327082]
  • D F Woodward, A H Krauss, J Chen, D W Gil, K M Kedzie, C E Protzman, L Shi, R Chen, H A Krauss, A Bogardus, H T Dinh, L A Wheeler, S W Andrews, R M Burk, T Gac, M B Roof, M E Garst, L J Kaplan, G Sachs, K L Pierce, J W Regan, R A Ross, M F Chan. Replacement of the carboxylic acid group of prostaglandin f(2alpha) with a hydroxyl or methoxy substituent provides biologically unique compounds. British journal of pharmacology. 2000 Aug; 130(8):1933-43. doi: 10.1038/sj.bjp.0703462. [PMID: 10952685]
  • R D Gauw, P J Stoffolano, D L Kuhlenbeck, V S Patel, S M Garver, T R Baker, K R Wehmeyer. Semi-automated 96-well solid-phase extraction and gas chromatography-negative chemical ionization tandem mass spectrometry for the trace analysis of fluprostenol in rat plasma. Journal of chromatography. B, Biomedical sciences and applications. 2000 Jul; 744(2):283-91. doi: 10.1016/s0378-4347(00)00254-1. [PMID: 10993516]
  • T H Eichhold, D L Kuhlenbeck, T R Baker, M E Stella, J S Amburgey, M A deLong, J R Hartke, C A Cruze, S A Pierce, K R Wehmeyer. Use of short high-performance liquid chromatography columns and tandem-mass spectrometry for the rapid analysis of a prostaglandin analog, fluprostenol, in rat plasma. Journal of chromatography. B, Biomedical sciences and applications. 2000 May; 741(2):213-20. doi: 10.1016/s0378-4347(00)00093-1. [PMID: 10872591]
  • M Abramovitz, M Adam, Y Boie, M Carrière, D Denis, C Godbout, S Lamontagne, C Rochette, N Sawyer, N M Tremblay, M Belley, M Gallant, C Dufresne, Y Gareau, R Ruel, H Juteau, M Labelle, N Ouimet, K M Metters. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs. Biochimica et biophysica acta. 2000 Jan; 1483(2):285-93. doi: 10.1016/s1388-1981(99)00164-x. [PMID: 10634944]
  • L E Anderson, M K Schultz, M C Wiltbank. Prostaglandin moieties that determine receptor binding specificity in the bovine corpus luteum. Journal of reproduction and fertility. 1999 May; 116(1):133-41. doi: 10.1530/jrf.0.1160133. [PMID: 10505064]
  • J Chen, D F Woodward, Y D Yuan, K Marshall, J Senior. Prostanoid-induced contraction of the rabbit isolated uterus is mediated by FP receptors. Prostaglandins & other lipid mediators. 1998 Apr; 55(5-6):387-94. doi: 10.1016/s0090-6980(98)00034-3. [PMID: 9653775]
  • P W Bravo, P J Bazan, M H Troedsson, P R Villalta, J P Garnica. Induction of parturition in alpacas and subsequent survival of neonates. Journal of the American Veterinary Medical Association. 1996 Nov; 209(10):1760-2. doi: NULL. [PMID: 8921038]
  • M Silver, J C Ousey, F E Dudan, A L Fowden, J Knox, R S Cash, P D Rossdale. Studies on equine prematurity 2: Post natal adrenocortical activity in relation to plasma adrenocorticotrophic hormone and catecholamine levels in term and premature foals. Equine veterinary journal. 1984 Jul; 16(4):278-86. doi: 10.1111/j.2042-3306.1984.tb01927.x. [PMID: 6090119]
  • F Broughton Pipkin, J C Ousey, C P Wallace, P D Rossdale. Studies on equine prematurity 4: Effect of salt and water loss on the renin-angiotensin-aldosterone system in the newborn foal. Equine veterinary journal. 1984 Jul; 16(4):292-7. doi: 10.1111/j.2042-3306.1984.tb01929.x. [PMID: 6383811]
  • A L Fowden, M Silver, L Ellis, J Ousey, P D Rossdale. Studies on equine prematurity 3: Insulin secretion in the foal during the perinatal period. Equine veterinary journal. 1984 Jul; 16(4):286-91. doi: 10.1111/j.2042-3306.1984.tb01928.x. [PMID: 6383810]
  • J C Ousey, F E Dudan, P D Rossdale, M Silver. Effects of fluprostenol administration in mares during late pregnancy. Equine veterinary journal. 1984 Jul; 16(4):264-9. doi: 10.1111/j.2042-3306.1984.tb01924.x. [PMID: 6090118]
  • W van Leeuwen, P A Noden, S J Dieleman. Induced abortion with two prostaglandin F2 alpha analogues in mares: plasma progesterone changes. The veterinary quarterly. 1983 Jul; 5(3):97-100. doi: 10.1080/01652176.1983.9693880. [PMID: 6636502]
  • L M Williams, M Hollingsworth, M Dukes, I D Morris. Fluprostenol-induced softening of the cervix of the pregnant rat. The Journal of endocrinology. 1983 May; 97(2):283-90. doi: 10.1677/joe.0.0970283. [PMID: 6304223]
  • D P Leadon, P D Rossdale, L B Jeffcott, W R Allen. A comparison of agents for inducing parturition in mares in the pre-viable and premature periods of gestation. Journal of reproduction and fertility. Supplement. 1982; 32(?):597-602. doi: NULL. [PMID: 6962901]
  • D I Chapman, M S Moss, P W Tomlinson, M P Harrison, P J Simmons. The disposition and metabolism of the synthetic prostaglandin fluprostenol (ICI 81,008) in the horse. Xenobiotica; the fate of foreign compounds in biological systems. 1980 Sep; 10(9):715-23. doi: 10.3109/00498258009108378. [PMID: 7445532]
  • M A Taverne, G C van der Weyden, P Fontijne, S J Dieleman, R L Pashen, W R Allen. In-vivo myometrial electrical activity in the cyclic mare. Journal of reproduction and fertility. 1979 Jul; 56(2):521-32. doi: 10.1530/jrf.0.0560521. [PMID: 573325]
  • P D Rossdale, R L Pashen, L B Jeffcott. The use of synthetic prostaglandin analogue (fluprostenol) to induce foaling. Journal of reproduction and fertility. Supplement. 1979; ?(27):521-9. doi: NULL. [PMID: 289831]