Perflubron (BioDeep_00000599950)

   


代谢物信息卡片


PERFLUOROOCTYL BROMIDE

化学式: C8BrF17 (497.89119039999997)
中文名称: 1-溴十七氟辛烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(C(C(F)(F)Br)(F)F)(F)F)(F)F)(C(C(C(F)(F)F)(F)F)(F)F)(F)F
InChI: InChI=1S/C8BrF17/c9-7(22,23)5(18,19)3(14,15)1(10,11)2(12,13)4(16,17)6(20,21)8(24,25)26

描述信息

V - Various > V08 - Contrast media > V08C - Magnetic resonance imaging contrast media
C274 - Antineoplastic Agent > C798 - Radiosensitizing Agent
D011838 - Radiation-Sensitizing Agents
D019440 - Anti-Obesity Agents

同义名列表

2 个代谢物同义名

PERFLUOROOCTYL BROMIDE; Perflubron



数据库引用编号

7 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。



文献列表

  • Andrea Berni, Danilo Malandrino, Giovanni Corona, Mario Maggi, Gabriele Parenti, Benedetta Fibbi, Loredana Poggesi, Alessandro Bartoloni, Federico Lavorini, Andrea Fanelli, Giulia Scocchera, Carlo Nozzoli, Adriano Peris, Filippo Pieralli, Riccardo Pini, Andrea Ungar, Alessandro Peri. Serum sodium alterations in SARS CoV-2 (COVID-19) infection: impact on patient outcome. European journal of endocrinology. 2021 May; 185(1):137-144. doi: 10.1530/eje-20-1447. [PMID: 33950864]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Veronica Swystun, Francis H Y Green, John H Dennis, Emmanouil Rampakakis, Gurkeet Lalli, Morenike Fadayomi, Andrea Chiu, Grishma Shrestha, Sharif Galal El Shahat, David Evan Nelson, Tamer Y El Mays, Cora A Pieron, Richard Leigh. A phase IIa proof-of-concept, placebo-controlled, randomized, double-blind, crossover, single-dose clinical trial of a new class of bronchodilator for acute asthma. Trials. 2018 Jun; 19(1):321. doi: 10.1186/s13063-018-2720-6. [PMID: 29914544]
  • Xiao Li, Zhongguo Sui, Xin Li, Wen Xu, Qie Guo, Jialin Sun, Fanbo Jing. Perfluorooctylbromide nanoparticles for ultrasound imaging and drug delivery. International journal of nanomedicine. 2018; 13(?):3053-3067. doi: 10.2147/ijn.s164905. [PMID: 29872293]
  • Francis H Y Green, Richard Leigh, Morenike Fadayomi, Gurkeet Lalli, Andrea Chiu, Grishma Shrestha, Sharif G ElShahat, David Evan Nelson, Tamer Y El Mays, Cora A Pieron, John H Dennis. A phase I, placebo-controlled, randomized, double-blind, single ascending dose-ranging study to evaluate the safety and tolerability of a novel biophysical bronchodilator (S-1226) administered by nebulization in healthy volunteers. Trials. 2016 07; 17(?):361. doi: 10.1186/s13063-016-1489-8. [PMID: 27464582]
  • Tamer Y El Mays, Parichita Choudhury, Richard Leigh, Emmanuel Koumoundouros, Joanne Van der Velden, Grishma Shrestha, Cora A Pieron, John H Dennis, Francis Hy Green, Ken J Snibson. Nebulized perflubron and carbon dioxide rapidly dilate constricted airways in an ovine model of allergic asthma. Respiratory research. 2014 Sep; 15(?):98. doi: 10.1186/s12931-014-0098-x. [PMID: 25355286]
  • Xiao Li, Fei Qin, Li Yang, Liqian Mo, Lei Li, Lianbing Hou. Sulfatide-containing lipid perfluorooctylbromide nanoparticles as paclitaxel vehicles targeting breast carcinoma. International journal of nanomedicine. 2014; 9(?):3971-85. doi: 10.2147/ijn.s67343. [PMID: 25170267]
  • Melissa L Hill, Ivan Gorelikov, Farnaz Niroui, Ronald B Levitin, James G Mainprize, Martin J Yaffe, J A Rowlands, Naomi Matsuura. Towards a nanoscale mammographic contrast agent: development of a modular pre-clinical dual optical/x-ray agent. Physics in medicine and biology. 2013 Aug; 58(15):5215-35. doi: 10.1088/0031-9155/58/15/5215. [PMID: 23851978]
  • Tinghui Yin, Ping Wang, Rongqin Zheng, Bowen Zheng, Du Cheng, Xinling Zhang, Xintao Shuai. Nanobubbles for enhanced ultrasound imaging of tumors. International journal of nanomedicine. 2012; 7(?):895-904. doi: 10.2147/ijn.s28830. [PMID: 22393289]
  • Allison E McDonald, Alex G Ivanov, Rainer Bode, Denis P Maxwell, Steven R Rodermel, Norman P A Hüner. Flexibility in photosynthetic electron transport: the physiological role of plastoquinol terminal oxidase (PTOX). Biochimica et biophysica acta. 2011 Aug; 1807(8):954-67. doi: 10.1016/j.bbabio.2010.10.024. [PMID: 21056542]
  • Ipek Ozcan, Freimar Segura-Sánchez, Kawthar Bouchemal, Murat Sezak, Ozgen Ozer, Tamer Güneri, Gilles Ponchel. Pegylation of poly(γ-benzyl-L-glutamate) nanoparticles is efficient for avoiding mononuclear phagocyte system capture in rats. International journal of nanomedicine. 2010 Dec; 5(?):1103-11. doi: 10.2147/ijn.s15493. [PMID: 21270961]
  • Sun-Joo Lee, Brett Olsen, Paul H Schlesinger, Nathan A Baker. Characterization of perfluorooctylbromide-based nanoemulsion particles using atomistic molecular dynamics simulations. The journal of physical chemistry. B. 2010 Aug; 114(31):10086-96. doi: 10.1021/jp103228c. [PMID: 20684632]
  • Vivian Ojogun, Sandhya M Vyas, Hans-Joachim Lehmler, Barbara L Knutson. Partitioning of homologous nicotinic acid ester prodrugs (nicotinates) into dipalmitoylphosphatidylcholine (DPPC) membrane bilayers. Colloids and surfaces. B, Biointerfaces. 2010 Jun; 78(1):75-84. doi: 10.1016/j.colsurfb.2010.02.015. [PMID: 20227859]
  • Andreas Wemhöner, Irmgard Hackspiel, Nina Hobi, Andrea Ravasio, Thomas Haller, Mario Rüdiger. Effects of perfluorocarbons on surfactant exocytosis and membrane properties in isolated alveolar type II cells. Respiratory research. 2010 May; 11(?):52. doi: 10.1186/1465-9921-11-52. [PMID: 20459693]
  • R Díaz-López, D Libong, N Tsapis, E Fattal, P Chaminade. Quantification of pegylated phospholipids decorating polymeric microcapsules of perfluorooctyl bromide by reverse phase HPLC with a charged aerosol detector. Journal of pharmaceutical and biomedical analysis. 2008 Nov; 48(3):702-7. doi: 10.1016/j.jpba.2008.06.027. [PMID: 18818041]
  • J N Marsh, A Senpan, G Hu, M J Scott, P J Gaffney, S A Wickline, G M Lanza. Fibrin-targeted perfluorocarbon nanoparticles for targeted thrombolysis. Nanomedicine (London, England). 2007 Aug; 2(4):533-43. doi: 10.2217/17435889.2.4.533. [PMID: 17716136]
  • Frédéric Gerber, Marie Pierre Krafft, Thierry F Vandamme. The detrimental effect of serum albumin on the re-spreading of a dipalmitoyl phosphatidylcholine Langmuir monolayer is counteracted by a fluorocarbon gas. Biochimica et biophysica acta. 2007 Mar; 1768(3):490-4. doi: 10.1016/j.bbamem.2006.09.022. [PMID: 17097604]
  • Neelesh R Soman, Jon N Marsh, Michael S Hughes, Gregory M Lanza, Samuel A Wickline. Acoustic activation of targeted liquid perfluorocarbon nanoparticles does not compromise endothelial integrity. IEEE transactions on nanobioscience. 2006 Jun; 5(2):69-75. doi: 10.1109/tnb.2006.875052. [PMID: 16805101]
  • Gregor I Kemming, Franz G Meisner, Christoph J Wojtczyk, Kristian B Packert, Thomas Minor, Manfred Thiel, Jochen Tillmanns, Jens Meier, Daniel Bottino, Peter E Keipert, Simon Faithfull, Oliver P Habler. Oxygent as a top load to colloid and hyperoxia is more effective in resuscitation from hemorrhagic shock than colloid and hyperoxia alone. Shock (Augusta, Ga.). 2005 Sep; 24(3):245-54. doi: 10.1097/01.shk.0000176184.51676.89. [PMID: 16135964]
  • Mitsuhiro Isaka, Ichiro Sakuma, Michiaki Imamura, Yutaka Makino, Shoji Fukushima, Kunihiko Nakai, Norihiko Shiiya, Osamu Kenmotsu, Akira Kitabatake, Keishu Yasuda. Experimental studies on artificial blood usage for hemodilution during cardiopulmonary bypass. Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia. 2005 Aug; 11(4):238-44. doi: NULL. [PMID: 16148870]
  • Mario E G Viana, Guilherme A Sargentelli, André L M Arruda, Budi Wiryawan, Alexandre T Rotta. [The impact of mechanical ventilation strategies that minimize atelectrauma in an experimental model of acute lung injury]. Jornal de pediatria. 2004 May; 80(3):189-96. doi: ". [PMID: 15192761]
  • Yutaka Makino. [Effects of perfluorochemicals on severe hemo-diluted cardiopulmonary bypass in dogs]. [Hokkaido igaku zasshi] The Hokkaido journal of medical science. 2004 Jan; 79(1):41-6. doi: NULL. [PMID: 14978973]
  • Markus Paxian, Steve A Keller, Toan T Huynh, Mark G Clemens. Perflubron emulsion improves hepatic microvascular integrity and mitochondrial redox state after hemorrhagic shock. Shock (Augusta, Ga.). 2003 Nov; 20(5):449-57. doi: 10.1097/01.shk.0000090601.26659.87. [PMID: 14560110]
  • Markus Paxian, Hauke Rensing, Katrin Geckeis, Inge Bauer, Darius Kubulus, Donat R Spahn, Michael Bauer. Perflubron emulsion in prolonged hemorrhagic shock: influence on hepatocellular energy metabolism and oxygen-dependent gene expression. Anesthesiology. 2003 Jun; 98(6):1391-9. doi: 10.1097/00000542-200306000-00014. [PMID: 12766648]
  • Alexandre T Rotta, Björn Gunnarsson, Bradley P Fuhrman, Budi Wiryawan, Lynn J Hernan, David M Steinhorn. Perfluorooctyl bromide (perflubron) attenuates oxidative injury to biological and nonbiological systems. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2003 Apr; 4(2):233-8. doi: 10.1097/01.pcc.0000059729.21375.d0. [PMID: 12749658]
  • Zhengrong Cui, William Fountain, Michael Clark, Michael Jay, Russell J Mumper. Novel ethanol-in-fluorocarbon microemulsions for topical genetic immunization. Pharmaceutical research. 2003 Jan; 20(1):16-23. doi: 10.1023/a:1022234305600. [PMID: 12608531]
  • Cynthia Cox, Robert L Stavis, Marla R Wolfson, Thomas H Shaffer. Long-term tidal liquid ventilation in premature lambs: physiologic, biochemical and histological correlates. Biology of the neonate. 2003; 84(3):232-42. doi: 10.1159/000072307. [PMID: 14504447]
  • Jeffrey F Ellena, Viktor V Obraztsov, Valerie L Cumbea, Catherine M Woods, David S Cafiso. Perfluorooctyl bromide has limited membrane solubility and is located at the bilayer center. Locating small molecules in lipid bilayers through paramagnetic enhancements of NMR relaxation. Journal of medicinal chemistry. 2002 Dec; 45(25):5534-42. doi: 10.1021/jm020278x. [PMID: 12459021]
  • Jon N Marsh, Christopher S Hall, Michael J Scott, Ralph W Fuhrhop, Patrick J Gaffney, Samuel A Wickline, Gregory M Lanza. Improvements in the ultrasonic contrast of targeted perfluorocarbon nanoparticles using an acoustic transmission line model. IEEE transactions on ultrasonics, ferroelectrics, and frequency control. 2002 Jan; 49(1):29-38. doi: 10.1109/58.981381. [PMID: 11833889]
  • Daniel J Weiss, Gary B Baskin, Mary K Shean, James L Blanchard, Jay K Kolls. Use of perflubron to enhance lung gene expression: safety and initial efficacy studies in non-human primates. Molecular therapy : the journal of the American Society of Gene Therapy. 2002 Jan; 5(1):8-15. doi: 10.1006/mthe.2001.0507. [PMID: 11786040]
  • D K Kaul, X Liu, R L Nagel. Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature. Blood. 2001 Nov; 98(10):3128-31. doi: 10.1182/blood.v98.10.3128. [PMID: 11698300]
  • D J Smith, L M Gambone, T Tarara, D R Meays, L A Dellamary, C M Woods, J Weers. Liquid dose pulmonary instillation of gentamicin PulmoSpheres formulations: tissue distribution and pharmacokinetics in rabbits. Pharmaceutical research. 2001 Nov; 18(11):1556-61. doi: 10.1023/a:1013078330485. [PMID: 11758763]
  • C A Cox, A B Cullen, M R Wolfson, T H Shaffer. Intratracheal administration of perfluorochemical-gentamicin suspension: a comparison to intravenous administration in normal and injured lungs. Pediatric pulmonology. 2001 Aug; 32(2):142-51. doi: 10.1002/ppul.1100. [PMID: 11477731]
  • C Reickert, T Pranikoff, M Overbeck, E Kazerooni, K Massey, R Bartlett, R Hirschl. The pulmonary and systemic distribution and elimination of perflubron from adult patients treated with partial liquid ventilation. Chest. 2001 Feb; 119(2):515-22. doi: 10.1378/chest.119.2.515. [PMID: 11171732]
  • B Nakstad, M R Wolfson, T Aspelin, R Lindemann, T H Shaffer, D Fugelseth, T Lyberg. Perfluorochemical liquids do not stimulate endothelin-1 or nitric oxide production in human blood leukocytes. Biology of the neonate. 2001; 80(4):267-72. doi: 10.1159/000047155. [PMID: 11641549]
  • D Nolte, S Pickelmann, M Lang, P Keipert, K Messmer. Compatibility of different colloid plasma expanders with perflubron emulsion: an intravital microscopic study in the hamster. Anesthesiology. 2000 Nov; 93(5):1261-70. doi: 10.1097/00000542-200011000-00020. [PMID: 11046215]
  • R J Noveck, E J Shannon, P T Leese, J S Shorr, K E Flaim, P E Keipert, C M Woods. Randomized safety studies of intravenous perflubron emulsion. II. Effects on immune function in healthy volunteers. Anesthesia and analgesia. 2000 Oct; 91(4):812-22. doi: 10.1097/00000539-200010000-00009. [PMID: 11004031]
  • V V Obraztsov, G G Neslund, E S Kornbrust, S F Flaim, C M Woods. In vitro cellular effects of perfluorochemicals correlate with their lipid solubility. American journal of physiology. Lung cellular and molecular physiology. 2000 May; 278(5):L1018-24. doi: 10.1152/ajplung.2000.278.5.l1018. [PMID: 10781433]
  • K Kawamae, G Pristine, D Chiumello, L N Tremblay, A S Slutsky. Partial liquid ventilation decreases serum tumor necrosis factor-alpha concentrations in a rat acid aspiration lung injury model. Critical care medicine. 2000 Feb; 28(2):479-83. doi: 10.1097/00003246-200002000-00032. [PMID: 10708187]
  • A T Rotta, B Gunnarsson, L J Hernan, B P Fuhrman, D M Steinhorn. Partial liquid ventilation with perflubron attenuates in vivo oxidative damage to proteins and lipids. Critical care medicine. 2000 Jan; 28(1):202-8. doi: 10.1097/00003246-200001000-00033. [PMID: 10667523]
  • A B Cullen, C A Cox, S J Hipp, M R Wolfson, T H Shaffer. Intra-tracheal delivery strategy of gentamicin with partial liquid ventilation. Respiratory medicine. 1999 Nov; 93(11):770-8. doi: 10.1016/s0954-6111(99)90261-5. [PMID: 10603625]
  • A P Shepherd, J M Steinke. CO-oximetry interference by perflubron emulsion: comparison of hemolyzing and nonhemolyzing instruments. Clinical chemistry. 1998 Oct; 44(10):2183-90. doi: 10.1093/clinchem/44.10.2183. [PMID: 9761254]
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  • C J Henry, J W Tyler, T Fields, W G Brewer, N Royer. Accuracy of fluorocrit in determination of blood perflubron concentration. Artificial cells, blood substitutes, and immobilization biotechnology. 1998 May; 26(3):285-92. doi: 10.3109/10731199809117459. [PMID: 9635121]
  • O P Habler, M S Kleen, J W Hutter, A H Podtschaske, M Tiede, G I Kemming, M V Welte, C O Corso, S Batra, P E Keipert, N S Faithfull, K F Messmer. Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs. Transfusion. 1998 Feb; 38(2):145-55. doi: 10.1046/j.1537-2995.1998.38298193096.x. [PMID: 9531945]
  • Z Ma, T G Monk, L T Goodnough, A McClellan, M Gawryl, T Clark, P Moreira, P E Keipert, M G Scott. Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests. Clinical chemistry. 1997 Sep; 43(9):1732-7. doi: . [PMID: 9299968]
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  • P E Keipert, N S Faithfull, J D Bradley, D Y Hazard, J Hogan, M S Levisetti, R M Peters. Enhanced oxygen delivery by perflubron emulsion during acute hemodilution. Artificial cells, blood substitutes, and immobilization biotechnology. 1994; 22(4):1161-7. doi: 10.3109/10731199409138811. [PMID: 7849918]
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  • D J Smith, E S Kornbrust, T A Lane. Phagocytosis of a fluorescently labeled perflubron emulsion by a human monocyte cell line. Artificial cells, blood substitutes, and immobilization biotechnology. 1994; 22(4):1215-21. doi: 10.3109/10731199409138818. [PMID: 7849925]
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