(5Z,7E)-(1S,3R)-9,10-seco-5,7,10(19),16-cholestatetraen-23-yne-1,3,25-triol (BioDeep_00000598782)
代谢物信息卡片
化学式: C27H38O3 (410.2820798)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: [C@@H]1(O)C(=C)/C(=C\C=C2\[C@]3([H])CC=C([C@@](C)([H])CC#CC(O)(C)C)[C@@]3(C)CCC\2)/C[C@@H](O)C1
InChI: InChI=1S/C27H38O3/c1-18(8-6-14-26(3,4)30)23-12-13-24-20(9-7-15-27(23,24)5)10-11-21-16-22(28)17-25(29)19(21)2/h10-12,18,22,24-25,28-30H,2,7-9,13,15-17H2,1,3-5H3/b20-10+,21-11-/t18-,22-,24+,25+,27-/m1/s1
描述信息
同义名列表
3 个代谢物同义名
1alpha,25-dihydroxy-16,17,23,23,24,24-hexadehydrovitamin D3 / 1alpha,25-dihydroxy-16,17,23,23,24,24-hexadehydrocholecalciferol; (5Z,7E)-(1S,3R)-9,10-seco-5,7,10(19),16-cholestatetraen-23-yne-1,3,25-triol; 1α,25-dihydroxy-16,17,23,23,24,24-hexadehydrovitamin D3 / 1α,25-dihydroxy-16,17,23,23,24,24-hexadehydrocholecalciferol
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Daniel M Albert, Amit Kumar, Stephen A Strugnell, Soesiawati R Darjatmoko, Janice M Lokken, Mary J Lindstrom, Sarit Patel. Effectiveness of vitamin D analogues in treating large tumors and during prolonged use in murine retinoblastoma models.
Archives of ophthalmology (Chicago, Ill. : 1960).
2004 Sep; 122(9):1357-62. doi:
10.1001/archopht.122.9.1357. [PMID: 15364716] - Kurt Lippuner, Romain Perrelet, Jean-Paul Casez, Albrecht Popp, Milan R Uskokovic, Philippe Jaeger. 1,25-(OH)2-16ene-23yne-D3 reduces secondary hyperparathyroidism in uremic rats with little calcemic effect.
Hormone research.
2004; 61(1):7-16. doi:
10.1159/000075191. [PMID: 14646396] - S J Sabet, S R Darjatmoko, M J Lindstrom, D M Albert. Antineoplastic effect and toxicity of 1,25-dihydroxy-16-ene-23-yne-vitamin D3 in athymic mice with Y-79 human retinoblastoma tumors.
Archives of ophthalmology (Chicago, Ill. : 1960).
1999 Mar; 117(3):365-70. doi:
10.1001/archopht.117.3.365. [PMID: 10088815] - C L Wilkerson, S R Darjatmoko, M J Lindstrom, D M Albert. Toxicity and dose-response studies of 1,25-(OH)2-16-ene-23-yne vitamin D3 in transgenic mice.
Clinical cancer research : an official journal of the American Association for Cancer Research.
1998 Sep; 4(9):2253-6. doi:
NULL. [PMID: 9748146] - C Farquharson, J S Rennie, N Loveridge, C C Whitehead. In vivo and in vitro effect of 1,25-dihydroxyvitamin D3 and 1,25-dihydroxy-16-ene-23-yne-vitamin D3 on the proliferation and differentiation of avian chondrocytes: their role in tibial dyschondroplasia.
The Journal of endocrinology.
1996 Mar; 148(3):465-74. doi:
10.1677/joe.0.1480465. [PMID: 8778225] - G G Schwartz, C C Hill, T A Oeler, M J Becich, R R Bahnson. 1,25-Dihydroxy-16-ene-23-yne-vitamin D3 and prostate cancer cell proliferation in vivo.
Urology.
1995 Sep; 46(3):365-9. doi:
10.1016/s0090-4295(99)80221-0. [PMID: 7660511] - A W Norman, I N Sergeev, J E Bishop, W H Okamura. Selective biological response by target organs (intestine, kidney, and bone) to 1,25-dihydroxyvitamin D3 and two analogues.
Cancer research.
1993 Sep; 53(17):3935-42. doi:
NULL. [PMID: 8395333] - R Bouillon, K Allewaert, D Z Xiang, B K Tan, H van Baelen. Vitamin D analogs with low affinity for the vitamin D binding protein: enhanced in vitro and decreased in vivo activity.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1991 Oct; 6(10):1051-7. doi:
10.1002/jbmr.5650061006. [PMID: 1796753] - A S Dusso, L Negrea, S Gunawardhana, S Lopez-Hilker, J Finch, T Mori, Y Nishii, E Slatopolsky, A J Brown. On the mechanisms for the selective action of vitamin D analogs.
Endocrinology.
1991 Apr; 128(4):1687-92. doi:
10.1210/endo-128-4-1687. [PMID: 2004595]