Mestanolone (BioDeep_00000598635)

   


代谢物信息卡片


17beta-hydroxy-17-methyl-androstan-3-one

化学式: C20H32O2 (304.24021719999996)
中文名称: 美雄诺龙
谱图信息: 最多检出来源 Homo sapiens(lipidomics) 96%

分子结构信息

SMILES: C1[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@](C)(O)CC[C@@]4([H])[C@]3([H])CC[C@@]2([H])CC(=O)C1
InChI: InChI=1S/C20H32O2/c1-18-9-6-14(21)12-13(18)4-5-15-16(18)7-10-19(2)17(15)8-11-20(19,3)22/h13,15-17,22H,4-12H2,1-3H3/t13-,15+,16-,17-,18-,19-,20-/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C2360 - Anabolic Steroid
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones

同义名列表

3 个代谢物同义名

Mestanolone; 17beta-hydroxy-17-methyl-androstan-3-one; ST 20:1;O2



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Tayyebeh Madrakian, Abbas Afkhami, Mohammad Rahimi, Mazaher Ahmadi, Mohammad Soleimani. Preconcentration and spectrophotometric determination of oxymetholone in the presence of its main metabolite (mestanolone) using modified maghemite nanoparticles in urine sample. Talanta. 2013 Oct; 115(?):468-73. doi: 10.1016/j.talanta.2013.05.056. [PMID: 24054620]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Masayuki Yamada, Sugako Aramaki, Masahiko Kurosawa, Isao Kijima-Suda, Koichi Saito, Hiroyuki Nakazawa. Simultaneous doping analysis of main urinary metabolites of anabolic steroids in horse by ion-trap gas chromatography-tandem mass spectrometry. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2008 Sep; 24(9):1199-204. doi: 10.2116/analsci.24.1199. [PMID: 18781036]
  • Masayuki Yamada, Sugako Aramaki, Masahiko Kurosawa, Koichi Saito, Hiroyuki Nakazawa. Detection of urinary metabolites common to structurally related 17alpha-alkyl anabolic steroids in horses and application to doping tests in racehorses: methandienone, methandriol, and oxymetholone. Journal of analytical toxicology. 2008 Jun; 32(5):387-91. doi: 10.1093/jat/32.5.387. [PMID: 18544225]
  • J L Hoffmann, R G Thomason, D M Lee, J L Brill, B B Price, G J Carr, D J Versteeg. Hepatic gene expression profiling using GeneChips in zebrafish exposed to 17alpha-methyldihydrotestosterone. Aquatic toxicology (Amsterdam, Netherlands). 2008 Apr; 87(2):69-80. doi: 10.1016/j.aquatox.2008.01.012. [PMID: 18339436]
  • Masayuki Yamada, Sugako Aramaki, Toshimasa Okayasu, Tomoo Hosoe, Masahiko Kurosawa, Isao Kijima-Suda, Koichi Saito, Hiroyuki Nakazawa. Identification and quantification of metabolites common to 17alpha-methyltestosterone and mestanolone in horse urine. Journal of pharmaceutical and biomedical analysis. 2007 Sep; 45(1):125-133. doi: 10.1016/j.jpba.2007.06.020. [PMID: 17709226]
  • Ralph Urbatzka, Sergio Bottero, Alberta Mandich, Ilka Lutz, Werner Kloas. Endocrine disrupters with (anti)estrogenic and (anti)androgenic modes of action affecting reproductive biology of Xenopus laevis: I. Effects on sex steroid levels and biomarker expression. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2007 Jan; 144(4):310-8. doi: 10.1016/j.cbpc.2006.10.008. [PMID: 17157075]
  • Natasha L Hungerford, Benoît Sortais, Corrine G Smart, Andrew R McKinney, Damon D Ridley, Allen M Stenhouse, Craig J Suann, Kellie J Munn, Martin N Sillence, Malcolm D McLeod. Analysis of anabolic steroids in the horse: development of a generic ELISA for the screening of 17alpha-alkyl anabolic steroid metabolites. The Journal of steroid biochemistry and molecular biology. 2005 Aug; 96(3-4):317-34. doi: 10.1016/j.jsbmb.2005.03.007. [PMID: 16040239]
  • F Molano, A Saborido, J Delgado, M Morán, A Megías. Rat liver lysosomal and mitochondrial activities are modified by anabolic-androgenic steroids. Medicine and science in sports and exercise. 1999 Feb; 31(2):243-50. doi: 10.1097/00005768-199902000-00007. [PMID: 10063813]
  • M S Fitzpatrick, W L Gale, C B Schreck. Binding characteristics of an androgen receptor in the ovaries of coho salmon, Oncorhynchus kisutch. General and comparative endocrinology. 1994 Sep; 95(3):399-408. doi: 10.1006/gcen.1994.1139. [PMID: 7821777]
  • A Saborido, F Molano, A Megías. Effect of training and anabolic-androgenic steroids on drug metabolism in rat liver. Medicine and science in sports and exercise. 1993 Jul; 25(7):815-22. doi: 10.1249/00005768-199307000-00010. [PMID: 8350704]
  • R Gragera, A Saborido, F Molano, L Jiménez, E Muñiz, A Megías. Ultrastructural changes induced by anabolic steroids in liver of trained rats. Histology and histopathology. 1993 Jul; 8(3):449-55. doi: NULL. [PMID: 8358156]
  • H Bi, R Massé. Studies on anabolic steroids--12. Epimerization and degradation of anabolic 17 beta-sulfate-17 alpha-methyl steroids in human: qualitative and quantitative GC/MS analysis. The Journal of steroid biochemistry and molecular biology. 1992 Jun; 42(5):533-46. doi: 10.1016/0960-0760(92)90267-m. [PMID: 1616883]
  • R Massé, H G Bi, C Ayotte, P Du, H Gélinas, R Dugal. Studies on anabolic steroids. V. Sequential reduction of methandienone and structurally related steroid A-ring substituents in humans: gas chromatographic-mass spectrometric study of the corresponding urinary metabolites. Journal of chromatography. 1991 Jan; 562(1-2):323-40. doi: NULL. [PMID: 2026703]
  • J F Templeton, C C Jackson. Metabolism of 17 alpha-methyl-5 beta-dihydrotestosterone in the rabbit. Steroids. 1983 Apr; 41(4):493-500. doi: 10.1016/0039-128x(83)90089-2. [PMID: 6658887]