sulfaphenazole (BioDeep_00000598266)
代谢物信息卡片
sulfaphenazole
化学式: C15H14N4O2S (314.0837424)
中文名称: 磺胺苯吡唑
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C(C=C1)N2C(=CC=N2)NS(=O)(=O)C3=CC=C(C=C3)N
InChI: InChI=1S/C15H14N4O2S/c16-12-6-8-14(9-7-12)22(20,21)18-15-10-11-17-19(15)13-4-2-1-3-5-13/h1-11,18H,16H2
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01E - Sulfonamides and trimethoprim > J01ED - Long-acting sulfonamides
S - Sensory organs > S01 - Ophthalmologicals > S01A - Antiinfectives > S01AB - Sulfonamides
C254 - Anti-Infective Agent > C29739 - Sulfonamide Anti-Infective Agent
D000890 - Anti-Infective Agents > D013424 - Sulfanilamides
同义名列表
1 个代谢物同义名
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:77780
- KEGGdrug: D01954
- KEGGdrug: D70410
- PubChem: 5335
- Metlin: METLIN4101
- DrugBank: DB06729
- ChEMBL: CHEMBL1109
- MeSH: Sulfaphenazole
- CAS: 1420043-53-3
- CAS: 526-08-9
- RefMet: Sulfaphenazole
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qiuying Zhang, Hui Liu, Dongmei Wu, Hongyan Yu, Kun Wang, Weijie Jiao, Xu Zhao. Methysticin Acts as a Mechanism-Based Inactivator of Cytochrome P450 2C9.
Chemical research in toxicology.
2022 06; 35(6):1117-1124. doi:
10.1021/acs.chemrestox.2c00098. [PMID: 35583123] - Mercedes Muñoz, Elvira López-Oliva, Estéfano Pinilla, Claudia Rodríguez, María Pilar Martínez, Cristina Contreras, Alfonso Gómez, Sara Benedito, Javier Sáenz-Medina, Luis Rivera, Dolores Prieto. Differential contribution of renal cytochrome P450 enzymes to kidney endothelial dysfunction and vascular oxidative stress in obesity.
Biochemical pharmacology.
2022 01; 195(?):114850. doi:
10.1016/j.bcp.2021.114850. [PMID: 34822809] - Han Ju, N Arul Murugan, Lingxin Hou, Ping Li, Laura Guizzo, Ying Zhang, Chiara Bertagnin, Xiujie Kong, Dongwei Kang, Ruifang Jia, Xiuli Ma, Ruikun Du, Vasanthanathan Poongavanam, Arianna Loregian, Bing Huang, Xinyong Liu, Peng Zhan. Identification of C5-NH2 Modified Oseltamivir Derivatives as Novel Influenza Neuraminidase Inhibitors with Highly Improved Antiviral Activities and Favorable Druggability.
Journal of medicinal chemistry.
2021 12; 64(24):17992-18009. doi:
10.1021/acs.jmedchem.1c01366. [PMID: 34735766] - Ying-Chao Duan, Lin-Feng Jin, Hong-Mei Ren, Shao-Jie Zhang, Yue-Jiao Liu, Yong-Tao Xu, Zi-Hao He, Yu Song, Hang Yuan, Shu-Hui Chen, Yuan-Yuan Guan. Design, synthesis, and biological evaluation of novel dual inhibitors targeting lysine specific demethylase 1 (LSD1) and histone deacetylases (HDAC) for treatment of gastric cancer.
European journal of medicinal chemistry.
2021 Aug; 220(?):113453. doi:
10.1016/j.ejmech.2021.113453. [PMID: 33957387] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tong Zhao, Qing Meng, Zhuosen Sun, Yanyu Chen, Wei Ai, Zean Zhao, Dongwei Kang, Yue Dong, Ruipeng Liang, Ting Wu, Jianxin Pang, Xinyong Liu, Peng Zhan. Novel Human Urate Transporter 1 Inhibitors as Hypouricemic Drug Candidates with Favorable Druggability.
Journal of medicinal chemistry.
2020 10; 63(19):10829-10854. doi:
10.1021/acs.jmedchem.0c00223. [PMID: 32897699] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Xianbao Shi, Gang Zhang, Guangbo Ge, Zhe Guo, Yonggui Song, Dan Su, Lina Shan. In Vitro Metabolism of Auriculasin and Its Inhibitory Effects on Human Cytochrome P450 and UDP-Glucuronosyltransferase Enzymes.
Chemical research in toxicology.
2019 10; 32(10):2125-2134. doi:
10.1021/acs.chemrestox.9b00307. [PMID: 31515991] - Shizhen Zhao, Peng Wei, Mengya Wu, Xiangqian Zhang, Liyu Zhao, Xiaolin Jiang, Chenzhou Hao, Xin Su, Dongmei Zhao, Maosheng Cheng. Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51.
Bioorganic & medicinal chemistry.
2018 07; 26(12):3242-3253. doi:
10.1016/j.bmc.2018.04.054. [PMID: 29748145] - Everett J Perkins, Maria Posada, P Kellie Turner, Jill Chappell, Wee Teck Ng, Chris Twelves. Physiologically Based Pharmacokinetic Modelling of Cytochrome P450 2C9-Related Tolbutamide Drug Interactions with Sulfaphenazole and Tasisulam.
European journal of drug metabolism and pharmacokinetics.
2018 06; 43(3):355-367. doi:
10.1007/s13318-017-0447-5. [PMID: 29119333] - Baoli Li, Shuaishuai Ni, Fei Mao, Feifei Chen, Yifu Liu, Hanwen Wei, Wenhua Chen, Jin Zhu, Lefu Lan, Jian Li. Novel Terminal Bipheny-Based Diapophytoene Desaturases (CrtN) Inhibitors as Anti-MRSA/VISR/LRSA Agents with Reduced hERG Activity.
Journal of medicinal chemistry.
2018 01; 61(1):224-250. doi:
10.1021/acs.jmedchem.7b01300. [PMID: 29243920] - Shizhen Zhao, Xiangqian Zhang, Peng Wei, Xin Su, Liyu Zhao, Mengya Wu, Chenzhou Hao, Chunchi Liu, Dongmei Zhao, Maosheng Cheng. Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents.
European journal of medicinal chemistry.
2017 Sep; 137(?):96-107. doi:
10.1016/j.ejmech.2017.05.043. [PMID: 28558334] - Mercedes Muñoz, Maria Elvira López-Oliva, Estéfano Pinilla, María Pilar Martínez, Ana Sánchez, Claudia Rodríguez, Albino García-Sacristán, Medardo Hernández, Luis Rivera, Dolores Prieto. CYP epoxygenase-derived H2O2 is involved in the endothelium-derived hyperpolarization (EDH) and relaxation of intrarenal arteries.
Free radical biology & medicine.
2017 05; 106(?):168-183. doi:
10.1016/j.freeradbiomed.2017.02.031. [PMID: 28212823] - Brian Metcalf, Chihyuan Chuang, Kobina Dufu, Mira P Patel, Abel Silva-Garcia, Carl Johnson, Qing Lu, James R Partridge, Larysa Patskovska, Yury Patskovsky, Steven C Almo, Matthew P Jacobson, Lan Hua, Qing Xu, Stephen L Gwaltney, Calvin Yee, Jason Harris, Bradley P Morgan, Joyce James, Donghong Xu, Athiwat Hutchaleelaha, Kumar Paulvannan, Donna Oksenberg, Zhe Li. Discovery of GBT440, an Orally Bioavailable R-State Stabilizer of Sickle Cell Hemoglobin.
ACS medicinal chemistry letters.
2017 Mar; 8(3):321-326. doi:
10.1021/acsmedchemlett.6b00491. [PMID: 28337324] - Heng-Yen Wang, Yajuan Qin, Huiying Li, Linda J Roman, Pavel Martásek, Thomas L Poulos, Richard B Silverman. Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
Journal of medicinal chemistry.
2016 05; 59(10):4913-25. doi:
10.1021/acs.jmedchem.6b00273. [PMID: 27050842] - Minsoo Han, Chiman Song, Nakcheol Jeong, Hoh-Gyu Hahn. Exploration of 3-Aminoazetidines as Triple Reuptake Inhibitors by Bioisosteric Modification of 3-α-Oxyazetidine.
ACS medicinal chemistry letters.
2014 Sep; 5(9):999-1004. doi:
10.1021/ml500187a. [PMID: 25221656] - Jun Yun, Minsoo Han, Chiman Song, Seung Hoon Cheon, Kihang Choi, Hoh-Gyu Hahn. Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors.
Bioorganic & medicinal chemistry letters.
2014 Aug; 24(15):3234-7. doi:
10.1016/j.bmcl.2014.06.026. [PMID: 24974340] - Haiyan Liu, Li Liu, Jia Li, Dan Mei, Ru Duan, Nan Hu, Haifang Guo, Zeyu Zhong, Xiaodong Liu. Combined contributions of impaired hepatic CYP2C11 and intestinal breast cancer resistance protein activities and expression to increased oral glibenclamide exposure in rats with streptozotocin-induced diabetes mellitus.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Jun; 40(6):1104-12. doi:
10.1124/dmd.111.043513. [PMID: 22393122] - Sayuri Hama, Yasuhiro Ishihara, Masatomo Watanabe, Sonoko Danjo, Yu Nakamura, Kouichi Itoh. Effects of sulfaphenazole after collagenase-induced experimental intracerebral hemorrhage in rats.
Biological & pharmaceutical bulletin.
2012; 35(10):1849-53. doi:
10.1248/bpb.b12-00525. [PMID: 23037177] - John H K Yeung, Penelope M Y Or. Polysaccharide peptides from Coriolus versicolor competitively inhibit tolbutamide 4-hydroxylation in specific human CYP2C9 isoform and pooled human liver microsomes.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Oct; 18(13):1170-5. doi:
10.1016/j.phymed.2011.06.002. [PMID: 21757329] - Maribel Reyes, Leslie Z Benet. Effects of uremic toxins on transport and metabolism of different biopharmaceutics drug disposition classification system xenobiotics.
Journal of pharmaceutical sciences.
2011 Sep; 100(9):3831-42. doi:
10.1002/jps.22640. [PMID: 21618544] - Robert T Jacobs, Bakela Nare, Stephen A Wring, Matthew D Orr, Daitao Chen, Jessica M Sligar, Matthew X Jenks, Robert A Noe, Tana S Bowling, Luke T Mercer, Cindy Rewerts, Eric Gaukel, Jennifer Owens, Robin Parham, Ryan Randolph, Beth Beaudet, Cyrus J Bacchi, Nigel Yarlett, Jacob J Plattner, Yvonne Freund, Charles Ding, Tsutomu Akama, Y-K Zhang, Reto Brun, Marcel Kaiser, Ivan Scandale, Robert Don. SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis.
PLoS neglected tropical diseases.
2011 Jun; 5(6):e1151. doi:
10.1371/journal.pntd.0001151. [PMID: 21738803] - Bruce P Burnett, Lakshmi Pillai, Alessandra Bitto, Francesco Squadrito, Robert M Levy. Evaluation of CYP450 inhibitory effects and steady-state pharmacokinetics of genistein in combination with cholecalciferol and citrated zinc bisglycinate in postmenopausal women.
International journal of women's health.
2011; 3(?):139-50. doi:
10.2147/ijwh.s19309. [PMID: 21792336] - Vijay M Kale, Chin-ju J Hsiao, Urs A Boelsterli. Nimesulide-induced electrophile stress activates Nrf2 in human hepatocytes and mice but is not sufficient to induce hepatotoxicity in Nrf2-deficient mice.
Chemical research in toxicology.
2010 May; 23(5):967-76. doi:
10.1021/tx100063z. [PMID: 20405857] - Yuka Kimura, Hideyuki Ito, Tsutomu Hatano. Effects of mace and nutmeg on human cytochrome P450 3A4 and 2C9 activity.
Biological & pharmaceutical bulletin.
2010; 33(12):1977-82. doi:
10.1248/bpb.33.1977. [PMID: 21139236] - Yasuhiro Ishihara, Masaya Sekine, Ai Hamaguchi, Yusuke Kobayashi, Takashi Harayama, Mikio Nakazawa, Norio Shimamoto. Effects of sulfaphenazole derivatives on cardiac ischemia-reperfusion injury: association of cytochrome P450 activity and infarct size.
Journal of pharmacological sciences.
2010; 113(4):335-42. doi:
10.1254/jphs.10103fp. [PMID: 20644334] - Soo H Bae, Soo K Bae, Myung G Lee. Effect of hepatic CYP inhibitors on the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in rats in vitro and in vivo.
The Journal of pharmacy and pharmacology.
2009 Dec; 61(12):1637-42. doi:
10.1211/jpp/61.12.0008. [PMID: 19958586] - Hao Chen, Michael Zientek, Mehran Jalaie, Yanhua Zhang, Christopher Bigge, Abdul Mutlib. Characterization of cytochrome P450-mediated bioactivation of a compound containing the chemical scaffold, 4,5-dihydropyrazole-1-carboxylic acid-(4-chlorophenyl amide), to a chemically reactive p-chlorophenyl isocyanate intermediate in human liver microsomes.
Chemical research in toxicology.
2009 Sep; 22(9):1603-12. doi:
10.1021/tx900167y. [PMID: 19697924] - Yasuhiro Ishihara, Masaya Sekine, Mikio Nakazawa, Norio Shimamoto. Suppression of myocardial ischemia-reperfusion injury by inhibitors of cytochrome P450 in rats.
European journal of pharmacology.
2009 Jun; 611(1-3):64-71. doi:
10.1016/j.ejphar.2009.03.069. [PMID: 19356728] - Frederique Bravin, Radu C Duca, Patrick Balaguer, Marcel Delaforge. In vitro cytochrome p450 formation of a mono-hydroxylated metabolite of zearalenone exhibiting estrogenic activities: possible occurrence of this metabolite in vivo.
International journal of molecular sciences.
2009 Apr; 10(4):1824-37. doi:
10.3390/ijms10041824. [PMID: 19468341] - Limin Wang, Rajan Gill, Theresa L Pedersen, Laura J Higgins, John W Newman, John C Rutledge. Triglyceride-rich lipoprotein lipolysis releases neutral and oxidized FFAs that induce endothelial cell inflammation.
Journal of lipid research.
2009 Feb; 50(2):204-13. doi:
10.1194/jlr.m700505-jlr200. [PMID: 18812596] - Simon Lucas, Ralf Heim, Christina Ries, Katarzyna E Schewe, Barbara Birk, Rolf W Hartmann. In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives.
Journal of medicinal chemistry.
2008 Dec; 51(24):8077-87. doi:
10.1021/jm800888q. [PMID: 19049427] - Tae Inoue, Kayoko Nitta, Kazumi Sugihara, Toru Horie, Shigeyuki Kitamura, Shigeru Ohta. CYP2C9-catalyzed metabolism of S-warfarin to 7-hydroxywarfarin in vivo and in vitro in chimeric mice with humanized liver.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Dec; 36(12):2429-33. doi:
10.1124/dmd.108.022830. [PMID: 18784266] - Xi-lan Tang, Ai-hua Liang, Chang-an Yu, Ting Liu, Yong Zhao, Chun-yu Cao, Chun-ying Li, Yan Yi, Ran Hao. [Effects of cytochrome P450 isozymes on aristolochic acid renal cytotoxicity].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2008 Sep; 33(17):2164-9. doi:
. [PMID: 19066067] - Miao Hao, Yuqing Zhao, Peizhan Chen, He Huang, Hong Liu, Hualiang Jiang, Ruiwen Zhang, Hui Wang. Structure-activity relationship and substrate-dependent phenomena in effects of ginsenosides on activities of drug-metabolizing P450 enzymes.
PloS one.
2008 Jul; 3(7):e2697. doi:
10.1371/journal.pone.0002697. [PMID: 18628990] - C Henoumont, V Henrotte, S Laurent, L Vander Elst, R N Muller. Synthesis of a new gadolinium complex with a high affinity for human serum albumin and its manifold physicochemical characterization by proton relaxation rate analysis, NMR diffusometry and electrospray mass spectrometry.
Journal of inorganic biochemistry.
2008 Apr; 102(4):721-30. doi:
10.1016/j.jinorgbio.2007.10.017. [PMID: 18096235] - Dian-lei Wang, Yan Liang, Wei-dong Chen, Lin Xie, Guang-ji Wang, Xiao-dong Liu. Identification of ginkgolide B metabolites in urine and rat liver cytochrome P450 enzymes responsible for their formation in vitro.
Acta pharmacologica Sinica.
2008 Mar; 29(3):376-84. doi:
10.1111/j.1745-7254.2008.00758.x. [PMID: 18298904] - Praveen Rajendran, Manu Jaggi, Manoj K Singh, Rama Mukherjee, Anand C Burman. Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity.
Investigational new drugs.
2008 Feb; 26(1):25-34. doi:
10.1007/s10637-007-9081-4. [PMID: 17851638] - Shahrzad Elmi, Nada A Sallam, Mohammad M Rahman, Xiaowei Teng, Arwen L Hunter, Farzad Moien-Afshari, Majid Khazaei, David J Granville, Ismail Laher. Sulfaphenazole treatment restores endothelium-dependent vasodilation in diabetic mice.
Vascular pharmacology.
2008 Jan; 48(1):1-8. doi:
10.1016/j.vph.2007.09.001. [PMID: 17974492] - Hong C Shen, Fa-Xiang Ding, Silvi Luell, Michael J Forrest, Ester Carballo-Jane, Kenneth K Wu, Tsuei-Ju Wu, Kang Cheng, Larissa C Wilsie, Mihajlo L Krsmanovic, Andrew K Taggart, Ning Ren, Tian-Quan Cai, Qiaolin Deng, Qing Chen, Junying Wang, Michael S Wolff, Xinchun Tong, Tom G Holt, M Gerard Waters, Milton L Hammond, James R Tata, Steven L Colletti. Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
Journal of medicinal chemistry.
2007 Dec; 50(25):6303-6. doi:
10.1021/jm700942d. [PMID: 17994679] - Zhong Jian Cheng, Yan-Fen Jiang, Hong Ding, David Severson, Chris R Triggle. Vascular dysfunction in type 2 diabetic TallyHo mice: role for an increase in the contribution of PGH2/TxA2 receptor activation and cytochrome p450 products.
Canadian journal of physiology and pharmacology.
2007 Mar; 85(3-4):404-12. doi:
10.1139/y07-010. [PMID: 17612649] - Aleksi Tornio, Pertti J Neuvonen, Janne T Backman. The CYP2C8 inhibitor gemfibrozil does not increase the plasma concentrations of zopiclone.
European journal of clinical pharmacology.
2006 Aug; 62(8):645-51. doi:
10.1007/s00228-006-0155-6. [PMID: 16832679] - Jerzy Bełtowski, Grazyna Wójcicka, Anna Jamroz-Wiśniewska. Role of nitric oxide and endothelium-derived hyperpolarizing factor (EDHF) in the regulation of blood pressure by leptin in lean and obese rats.
Life sciences.
2006 May; 79(1):63-71. doi:
10.1016/j.lfs.2005.12.041. [PMID: 16455110] - Hayley S Brown, Aleksandra Galetin, David Hallifax, J Brian Houston. Prediction of in vivo drug-drug interactions from in vitro data : factors affecting prototypic drug-drug interactions involving CYP2C9, CYP2D6 and CYP3A4.
Clinical pharmacokinetics.
2006; 45(10):1035-50. doi:
10.2165/00003088-200645100-00006. [PMID: 16984215] - Dermot F McGinnity, James Tucker, Steve Trigg, Robert J Riley. Prediction of CYP2C9-mediated drug-drug interactions: a comparison using data from recombinant enzymes and human hepatocytes.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Nov; 33(11):1700-7. doi:
10.1124/dmd.105.005884. [PMID: 16081671] - J Vriens, G Owsianik, B Fisslthaler, M Suzuki, A Janssens, T Voets, C Morisseau, B D Hammock, I Fleming, R Busse, B Nilius. Modulation of the Ca2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium.
Circulation research.
2005 Oct; 97(9):908-15. doi:
10.1161/01.res.0000187474.47805.30. [PMID: 16179585] - Dae Y Lee, Shin J Lee, Myung G Lee. Effects of enzyme inducers and inhibitors on the pharmacokinetics of intravenous torasemide in rats.
International journal of pharmaceutics.
2005 Jul; 298(1):38-46. doi:
10.1016/j.ijpharm.2005.03.014. [PMID: 15890479] - Jun Taniguchi, Hideo Honda, Yoichi Shibusawa, Takeshi Iwata, Yoko Notoya. Alteration in endothelial function and modulation by treatment with pioglitazone in rabbit renal artery from short-term hypercholesterolemia.
Vascular pharmacology.
2005 Jun; 43(1):47-55. doi:
10.1016/j.vph.2005.03.005. [PMID: 15953770] - Ji-Hong Shon, Young-Ran Yoon, Min-Jung Kim, Kyoung-Ah Kim, Young-Chae Lim, Kwang-Hyeon Liu, Dong-Hoon Shin, Chung Han Lee, In-June Cha, Jae-Gook Shin. Chlorpropamide 2-hydroxylation is catalysed by CYP2C9 and CYP2C19 in vitro: chlorpropamide disposition is influenced by CYP2C9, but not by CYP2C19 genetic polymorphism.
British journal of clinical pharmacology.
2005 May; 59(5):552-63. doi:
10.1111/j.1365-2125.2005.02364.x. [PMID: 15842554] - Jens Passauer, Frank Pistrosch, Grit Lässig, Kay Herbrig, Eckhart Büssemaker, Peter Gross, Ingrid Fleming. Nitric oxide- and EDHF-mediated arteriolar tone in uremia is unaffected by selective inhibition of vascular cytochrome P450 2C9.
Kidney international.
2005 May; 67(5):1907-12. doi:
10.1111/j.1523-1755.2005.00289.x. [PMID: 15840038] - Shigeru Furuta, Emiko Kamada, Takeshi Omata, Tohru Sugimoto, Yoshihiro Kawabata, Keiko Yonezawa, Xiaochun Cheryl Wu, Tadashi Kurimoto. Drug-drug interactions of Z-338, a novel gastroprokinetic agent, with terfenadine, comparison with cisapride, and involvement of UGT1A9 and 1A8 in the human metabolism of Z-338.
European journal of pharmacology.
2004 Aug; 497(2):223-31. doi:
10.1016/j.ejphar.2004.06.040. [PMID: 15306208] - Yune-Fang Ueng, Chih-Hang Hsieh, Ming-Jaw Don, Chin-Wen Chi, Li-Kang Ho. Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation.
Chemical research in toxicology.
2004 Aug; 17(8):1151-6. doi:
10.1021/tx030055p. [PMID: 15310247] - Stephan Fichtlscherer, Stefanie Dimmeler, Susanne Breuer, Rudi Busse, Andreas M Zeiher, Ingrid Fleming. Inhibition of cytochrome P450 2C9 improves endothelium-dependent, nitric oxide-mediated vasodilatation in patients with coronary artery disease.
Circulation.
2004 Jan; 109(2):178-83. doi:
10.1161/01.cir.0000105763.51286.7f. [PMID: 14662709] - Lavinia Cantoni, Rea Valaperta, Xavier Ponsoda, José V Castell, Davide Barelli, Milena Rizzardini, Alessandra Mangolini, Lisa Hauri, Pia Villa. Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity.
Journal of hepatology.
2003 Jun; 38(6):776-83. doi:
10.1016/s0168-8278(03)00095-3. [PMID: 12763371] - R Hyland, B C Jones, D A Smith. Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole.
Drug metabolism and disposition: the biological fate of chemicals.
2003 May; 31(5):540-7. doi:
10.1124/dmd.31.5.540. [PMID: 12695341] - Eckhart Büssemaker, Rüdiger Popp, Jochen Binder, Rudi Busse, Ingrid Fleming. Characterization of the endothelium-derived hyperpolarizing factor (EDHF) response in the human interlobar artery.
Kidney international.
2003 May; 63(5):1749-55. doi:
10.1046/j.1523-1755.2003.00910.x. [PMID: 12675850] - L Zou, M R Harkey, G L Henderson. Effects of herbal components on cDNA-expressed cytochrome P450 enzyme catalytic activity.
Life sciences.
2002 Aug; 71(13):1579-89. doi:
10.1016/s0024-3205(02)01913-6. [PMID: 12127912] - Michael Potente, U Ruth Michaelis, Beate Fisslthaler, Rudi Busse, Ingrid Fleming. Cytochrome P450 2C9-induced endothelial cell proliferation involves induction of mitogen-activated protein (MAP) kinase phosphatase-1, inhibition of the c-Jun N-terminal kinase, and up-regulation of cyclin D1.
The Journal of biological chemistry.
2002 May; 277(18):15671-6. doi:
10.1074/jbc.m110806200. [PMID: 11867622] - Lars Brachtendorf, Alexander Jetter, K Tobias Beckurts, Arnulf H Hölscher, Uwe Fuhr. Cytochrome P450 enzymes contributing to demethylation of maprotiline in man.
Pharmacology & toxicology.
2002 Mar; 90(3):144-9. doi:
10.1034/j.1600-0773.2002.900306.x. [PMID: 12071336] - G Colmenarejo, A Alvarez-Pedraglio, J L Lavandera. Cheminformatic models to predict binding affinities to human serum albumin.
Journal of medicinal chemistry.
2001 Dec; 44(25):4370-8. doi:
10.1021/jm010960b. [PMID: 11728183] - S A Cherstniakova, D Bi, D R Fuller, J Z Mojsiak, J M Collins, L R Cantilena. Metabolism of vanoxerine, 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazine, by human cytochrome P450 enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
2001 Sep; 29(9):1216-20. doi:
. [PMID: 11502731] - R S Obach. Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.
Drug metabolism and disposition: the biological fate of chemicals.
2000 Sep; 28(9):1069-76. doi:
. [PMID: 10950851] - S Kanamitsu, K Ito, Y Sugiyama. Quantitative prediction of in vivo drug-drug interactions from in vitro data based on physiological pharmacokinetics: use of maximum unbound concentration of inhibitor at the inlet to the liver.
Pharmaceutical research.
2000 Mar; 17(3):336-43. doi:
10.1023/a:1007509324428. [PMID: 10801223] - F Kamali, D E Ball, W S McLaughlin, R A Seymour. Phenytoin metabolism to 5-(4-hydroxyphenyl)-5-phenylhydantoin (HPPH) in man, cat and rat in vitro and in vivo, and susceptibility to phenytoin-induced gingival overgrowth.
Journal of periodontal research.
1999 Apr; 34(3):145-53. doi:
10.1111/j.1600-0765.1999.tb02235.x. [PMID: 10384402] - T Ogiso, M Iwaki, H Tanaka, E Kobayashi, T Tanino, A Sawada, S Uno. Pharmacokinetic drug interactions between ampiroxicam and sulfaphenazole in rats.
Biological & pharmaceutical bulletin.
1999 Feb; 22(2):191-6. doi:
10.1248/bpb.22.191. [PMID: 10077440] - W M Zweers-Zeilmaker, S Wildschut, R F Witkamp, A S Van Miert. The effect of sulfaphenazole and sulfadoxine on tolbutamide disposition in dwarf goats (Caprus hircus aegagrus).
Research in veterinary science.
1997 Nov; 63(3):269-72. doi:
10.1016/s0034-5288(97)90032-1. [PMID: 9491455] - D Busse, J Cosme, P Beaune, H K Kroemer, M Eichelbaum. Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans.
Naunyn-Schmiedeberg's archives of pharmacology.
1995 Dec; 353(1):116-21. doi:
10.1007/bf00168924. [PMID: 8750925] - T B Vree, E W Beneken Kolmer, Y A Hekster. High pressure liquid chromatographic analysis and preliminary pharmacokinetics of sulfaphenazole and its N2-glucuronide and N4-acetyl metabolites in plasma and urine of man.
Pharmaceutisch weekblad. Scientific edition.
1990 Dec; 12(6):243-6. doi:
10.1007/bf01967825. [PMID: 2091020] - M E Veronese, J O Miners, D Randles, D Gregov, D J Birkett. Validation of the tolbutamide metabolic ratio for population screening with use of sulfaphenazole to produce model phenotypic poor metabolizers.
Clinical pharmacology and therapeutics.
1990 Mar; 47(3):403-11. doi:
10.1038/clpt.1990.46. [PMID: 2311340] - M Otagiri, H Nakamura, Y Imamura, U Matsumoto, J Fleitman, J H Perrin. Effect of pH and small inorganic ions on binding of sulfadimethoxine and sulfaphenazole to human serum albumin measured by circular dichroism.
Chemical & pharmaceutical bulletin.
1989 May; 37(5):1401-3. doi:
10.1248/cpb.37.1401. [PMID: 2630108] - O Sugita, Y Sawada, Y Sugiyama, T Iga, M Hanano. Effect of sulfaphenazole on tolbutamide distribution in rabbits: analysis of interspecies differences in tissue distribution of tolbutamide.
Journal of pharmaceutical sciences.
1984 May; 73(5):631-4. doi:
10.1002/jps.2600730513. [PMID: 6737237] - D B Back, B K Park, J F Tjia, S N Newby. Sulphaphenazole and drug oxidation in man.
British journal of clinical pharmacology.
1983 Oct; 16(4):460-1. doi:
10.1111/j.1365-2125.1983.tb02199.x. [PMID: 6626444] - O Sugita, Y Sawada, Y Sugiyama, T Iga, M Hanano. Prediction of drug-drug interaction from in vitro plasma protein binding and metabolism. A study of tolbutamide-sulfonamide interaction in rats.
Biochemical pharmacology.
1981 Dec; 30(24):3347-54. doi:
10.1016/0006-2952(81)90611-0. [PMID: 7326045] - T Kawamura, N Yagi, H Sugawara, K Yamahata, M Takada. Efficacy of hemodialysis and the effects of certain displacing agents on plasma protein binding of sulfamethoxazole and sulfaphenazole in patients with chronic renal failure.
Chemical & pharmaceutical bulletin.
1980 Jan; 28(1):268-76. doi:
10.1248/cpb.28.268. [PMID: 7363373] - I Polacek, H Mühlbauer. The effect of displacement from protein binding on serum and tissue fluid levels of cephazolin.
Biopharmaceutics & drug disposition.
1980 Jan; 1(3):127-32. doi:
10.1002/bdd.2510010307. [PMID: 7448339] - S Soback, U Lamminsivu. The effect of protein-binding on the excretion of three sulphonamide preparations in the milk of dairy cows, examined by chemical and microbiological methods.
Nordisk veterinaermedicin.
1979 Jul; 31(7-8):309-15. doi:
NULL. [PMID: 386251] - K F Brown, M J Crooks. Displacement of tolbutamide, glibencalmide and chlorpropamide from serum albumin by anionic drugs.
Biochemical pharmacology.
1976 May; 25(10):1175-8. doi:
10.1016/0006-2952(76)90365-8. [PMID: 820348] - D R Varma, R K Gupta, S Gupta. Prothrombin response to phenindione during hypoalbuminaemia.
British journal of clinical pharmacology.
1975 Oct; 2(5):467-8. doi:
10.1111/j.1365-2125.1975.tb00558.x. [PMID: 1233073] - N Loreau, C Lepreux, R Ardaillou. Calcitonin-sensitive adenylate cyclase in rat renal tubular membranes.
The Biochemical journal.
1975 Sep; 150(3):305-14. doi:
10.1042/bj1500305. [PMID: 2153] - O K Faber, H T Mouridsen, L Skovsted. The effect of chloramphenicol and sulphaphenazole on the biotransformation of cyclophosphamide in man.
British journal of clinical pharmacology.
1975 Jun; 2(3):281-5. doi:
10.1111/j.1365-2125.1975.tb01589.x. [PMID: 791322] - W R Fair, D E Govan, G W Friedland, R A Filly. Urinary tract infections in children. Part I-- Young girls with non-refluxing ureters.
The Western journal of medicine.
1974 Nov; 121(5):366-73. doi:
NULL. [PMID: 4617970] - B Hellman. Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells.
Metabolism: clinical and experimental.
1974 Sep; 23(9):839-46. doi:
10.1016/0026-0495(74)90117-6. [PMID: 4212254] - W Eckhardt, R Rudolph, H Sauer, W R Schubert, D Undeutsch. [Pharmacological interference of glibornuride with sulfaphenazole, phenylbutazone, and phenprocoumon in man].
Arzneimittel-Forschung.
1972 Dec; 22(?):Suppl 12A:2212. doi:
NULL. [PMID: 4679251] - T Fujita. Hydrophobic bonding of sulfonamide drugs with serum albumin.
Journal of medicinal chemistry.
1972 Oct; 15(10):1049-56. doi:
10.1021/jm00280a014. [PMID: 4672194] - M Ueda, K Orita, T Koizumi. Studies on metabolism of drugs. 13. Quantitative separation of metabolites in human urine after oral administration of sulfisomezole and sulfaphenazole.
Chemical & pharmaceutical bulletin.
1972 Sep; 20(9):2047-50. doi:
10.1248/cpb.20.2047. [PMID: 4645223] - J Kampmann, J M Hansen, K Siersboek-Nielsen, H Laursen. Effect of some drugs on penicillin half-life in blood.
Clinical pharmacology and therapeutics.
1972 Jul; 13(4):516-9. doi:
10.1002/cpt1972134516. [PMID: 5042368] - C F Chignell, E S Vesell, D K Starkweather, C M Berlin. The binding of sulfaphenazole to fetal, neonatal, and adult human plasma albumin.
Clinical pharmacology and therapeutics.
1971 Nov; 12(6):897-901. doi:
10.1002/cpt1971126897. [PMID: 5134994] - M Ueda, K Orita, T Koizumi. Studies on metabolism of drugs. XI. A new metabolite of sulfaphenazole in man.
Chemical & pharmaceutical bulletin.
1971 Oct; 19(10):2046-9. doi:
10.1248/cpb.19.2046. [PMID: 5137275] - W Falk, E Weikmann. [Poisoning in children. Analysis of 642 treated children].
Wiener klinische Wochenschrift.
1969 Nov; 81(48):867-73. doi:
". [PMID: 5362156] - J Krieglstein. [Plasma protein binding of drugs].
Klinische Wochenschrift.
1969 Nov; 47(21):1125-30. doi:
10.1007/bf01483741. [PMID: 4909984] - L K Christensen, M Kristensen. [Drug induced changes of the blood glucose lowering effect of oral hypoglycemic agents].
Acta diabetologica latina.
1969 Sep; 6 Suppl 1(?):116-36. doi:
NULL. [PMID: 4190079] - M J Mattila, H Tiitinen, E Alhava. Acetylation pattern of different sulphonamides in rapid and slow isoniazid inactivators.
Annales medicinae experimentalis et biologiae Fenniae.
1969; 47(4):308-15. doi:
NULL. [PMID: 5384058] - A Rossolini, C Panero, P Puglisi, C Pindinelli. [Serum sulfonamide curve in children treated with a new sulfonamide-pyrazole compound in rectal administration].
Minerva pediatrica.
1967 Oct; 19(40):1822-7. doi:
NULL. [PMID: 5606443] - H M Solomon, J J Schrogie. The effect of various drugs on the binding of warfarin-14C to human albumin.
Biochemical pharmacology.
1967 Jul; 16(7):1219-26. doi:
10.1016/0006-2952(67)90153-0. [PMID: 6053595] - D S Shrotri, M B Gharpure. Effect of insulin on the metabolism of sulfonamides.
Archives internationales de pharmacodynamie et de therapie.
1967 May; 167(1):237-44. doi:
NULL. [PMID: 6035101] - T Seki, T Segawa, T Komatsu, T Nakagome. Biological properties of 4-sulfanilamido-3,6-dimethoxypyridazine (CS-61)--a new sulfonamide.
Arzneimittel-Forschung.
1965 Dec; 15(12):1441-5. doi:
NULL. [PMID: 4960234] - O Jardetzky, N G Wade-Jardetzky. On the mechanism of the binding of sulfonamides to bovine serum albumin.
Molecular pharmacology.
1965 Nov; 1(3):214-30. doi:
NULL. [PMID: 5842823] - W Riess, K Schmid, H Keberle. [On the metabolism of sulfaphenazol (Orisul)].
Klinische Wochenschrift.
1965 Jul; 43(13):740-4. doi:
10.1007/bf01707074. [PMID: 5826385] - Z PLACKOVA, J WAGNER, I M HAIS. [COMPARISON OF THE FATE OF VARIOUS PYRIDAZINE SULFONAMIDES IN THE ANIMAL BODY].
Ceskoslovenska farmacie.
1963 Jun; 12(?):239-42. doi:
NULL. [PMID: 14076174]