Ferrous Fumarate (BioDeep_00000597633)
代谢物信息卡片
化学式: C4H2FeO4 (169.9302482)
中文名称: 延胡索酸亚铁, 富马酸亚铁
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(=CC(=O)[O-])C(=O)[O-].[Fe+2]
InChI: /q
描述信息
B - Blood and blood forming organs > B03 - Antianemic preparations > B03A - Iron preparations > B03AA - Iron bivalent, oral preparations
D018977 - Micronutrients > D014131 - Trace Elements
同义名列表
数据库引用编号
7 个数据库交叉引用编号
- ChEBI: CHEBI:31607
- KEGGdrug: D01194
- PubChem: 6433164
- Metlin: METLIN4026
- DrugBank: DB14491
- CAS: 7705-12-6
- CAS: 141-01-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Ambra Giorgetti, Frederike M D Husmann, Christophe Zeder, Isabelle Herter-Aeberli, Michael B Zimmermann. Prebiotic Galacto-Oligosaccharides and Fructo-Oligosaccharides, but Not Acacia Gum, Increase Iron Absorption from a Single High-Dose Ferrous Fumarate Supplement in Iron-Depleted Women.
The Journal of nutrition.
2022 04; 152(4):1015-1021. doi:
10.1093/jn/nxac003
. [PMID: 35015879] - Frederike M D Husmann, Laura Stierli, Dominic S Bräm, Christophe Zeder, Stefanie D Krämer, Michael B Zimmermann, Isabelle Herter-Aeberli. Kinetics of iron absorption from ferrous fumarate with and without galacto-oligosaccharides determined from stable isotope appearance curves in women.
The American journal of clinical nutrition.
2022 03; 115(3):949-957. doi:
10.1093/ajcn/nqab361
. [PMID: 34726703] - Akkarach Bumrungpert, Patcharanee Pavadhgul, Theera Piromsawasdi, M R Mozafari. Efficacy and Safety of Ferrous Bisglycinate and Folinic Acid in the Control of Iron Deficiency in Pregnant Women: A Randomized, Controlled Trial.
Nutrients.
2022 Jan; 14(3):. doi:
10.3390/nu14030452
. [PMID: 35276810] - Vickie S Braithwaite, Martin N Mwangi, Kerry S Jones, Ayşe Y Demir, Ann Prentice, Andrew M Prentice, Pauline E A Andang'o, Hans Verhoef. Antenatal iron supplementation, FGF23, and bone metabolism in Kenyan women and their offspring: secondary analysis of a randomized controlled trial.
The American journal of clinical nutrition.
2021 05; 113(5):1104-1114. doi:
10.1093/ajcn/nqaa417
. [PMID: 33675347] - Samuel Kofi Tchum, Fareed Kow Arthur, Bright Adu, Samuel Asamoah Sakyi, Latifatu Alhassan Abubakar, Dorcas Atibilla, Seeba Amenga-Etego, Felix Boakye Oppong, Francis Dzabeng, Benjamin Amoani, Thomas Gyan, Emmanuel Arhin, Kwaku Poku-Asante. Impact of iron fortification on anaemia and iron deficiency among pre-school children living in Rural Ghana.
PloS one.
2021; 16(2):e0246362. doi:
10.1371/journal.pone.0246362
. [PMID: 33571267] - Muhammad Azrai Abu, Azniza Suriati Borhan, Abdul Kadir Abdul Karim, Mohd Faizal Ahmad, Zaleha Abdullah Mahdy. Comparison between Iberet Folic® and Zincofer® in treatment of iron deficiency anaemia in pregnancy.
Hormone molecular biology and clinical investigation.
2020 Dec; 42(1):49-56. doi:
10.1515/hmbci-2020-0034
. [PMID: 33781008] - Wendy Schijns, Abel Boerboom, Margot de Bruyn Kops, Christel de Raaff, Bart van Wagensveld, Frits J Berends, Ignace M C Janssen, Cees J H M van Laarhoven, Hans de Boer, Edo O Aarts. A randomized controlled trial comparing oral and intravenous iron supplementation after Roux-en-Y gastric bypass surgery.
Clinical nutrition (Edinburgh, Scotland).
2020 12; 39(12):3779-3785. doi:
10.1016/j.clnu.2020.04.010
. [PMID: 32402684] - Ana A Márquez, Ignasi Sirés, Enric Brillas, José L Nava. Mineralization of Methyl Orange azo dye by processes based on H2O2 electrogeneration at a 3D-like air-diffusion cathode.
Chemosphere.
2020 Nov; 259(?):127466. doi:
10.1016/j.chemosphere.2020.127466
. [PMID: 32615456] - Frederike M D Jeroense, Christophe Zeder, Michael B Zimmermann, Isabelle Herter-Aeberli. Acute Consumption of Prebiotic Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate, but not from Ferrous Sulfate and Ferric Pyrophosphate: Stable Iron Isotope Studies in Iron-Depleted Young Women.
The Journal of nutrition.
2020 09; 150(9):2391-2397. doi:
10.1093/jn/nxaa199
. [PMID: 32692367] - Ndèye Fatou Ndiaye, Nicole Idohou-Dossou, Simone Bürkli, Adama Diouf, Cheikh Loucoubar, Amadou Tidiane Guiro, Michael Bruce Zimmermann, Salimata Wade, Diego Moretti. Polyphenol-rich tea decreases iron absorption from fortified wheat bread in Senegalese mother-child pairs and bioavailability of ferrous fumarate is sharply lower in children.
European journal of clinical nutrition.
2020 08; 74(8):1221-1228. doi:
10.1038/s41430-020-0601-z
. [PMID: 32203231] - Xiaolin Yao, Xiaoxue Yao, Kai Xu, Kao Wu, Fatang Jiang, Katsuyoshi Nishinari, Glyn O Phillips. Iron encapsulated microstructured gel beads using an emulsification-gelation technique for an alginate-caseinate matrix.
Food & function.
2020 May; 11(5):3811-3822. doi:
10.1039/c9fo02184a
. [PMID: 32329495] - Yu Lin, Xugang Shu, Zhihuan Fu, Hongchao Hu, Wen-Xiong Wang, Sheng Gong. Influences of different Fe sources on Fe bioavailability and homeostasis in SD rats.
Animal science journal = Nihon chikusan Gakkaiho.
2019 Oct; 90(10):1377-1387. doi:
10.1111/asj.13254
. [PMID: 31436009] - Frederike M D Jeroense, Ladina Michel, Christophe Zeder, Isabelle Herter-Aeberli, Michael B Zimmermann. Consumption of Galacto-Oligosaccharides Increases Iron Absorption from Ferrous Fumarate: A Stable Iron Isotope Study in Iron-Depleted Young Women.
The Journal of nutrition.
2019 05; 149(5):738-746. doi:
10.1093/jn/nxy327
. [PMID: 31004135] - Kazuya Takasawa, Chikako Takaeda, Takashi Wada, Norishi Ueda. Optimal Serum Ferritin Levels for Iron Deficiency Anemia during Oral Iron Therapy (OIT) in Japanese Hemodialysis Patients with Minor Inflammation and Benefit of Intravenous Iron Therapy for OIT-Nonresponders.
Nutrients.
2018 Mar; 10(4):. doi:
10.3390/nu10040428
. [PMID: 29596361] - Daniela Paganini, Mary A Uyoga, Guus A M Kortman, Colin I Cercamondi, Diego Moretti, Tanja Barth-Jaeggi, Clarissa Schwab, Jos Boekhorst, Harro M Timmerman, Christophe Lacroix, Simon Karanja, Michael B Zimmermann. Prebiotic galacto-oligosaccharides mitigate the adverse effects of iron fortification on the gut microbiome: a randomised controlled study in Kenyan infants.
Gut.
2017 11; 66(11):1956-1967. doi:
10.1136/gutjnl-2017-314418
. [PMID: 28774885] - Dominik Glinz, Rita Wegmüller, Mamadou Ouattara, Victorine G Diakité, Grant J Aaron, Lorenz Hofer, Michael B Zimmermann, Lukas G Adiossan, Jürg Utzinger, Eliézer K N'Goran, Richard F Hurrell. Iron Fortified Complementary Foods Containing a Mixture of Sodium Iron EDTA with Either Ferrous Fumarate or Ferric Pyrophosphate Reduce Iron Deficiency Anemia in 12- to 36-Month-Old Children in a Malaria Endemic Setting: A Secondary Analysis of a Cluster-Randomized Controlled Trial.
Nutrients.
2017 Jul; 9(7):. doi:
10.3390/nu9070759
. [PMID: 28708072] - Katarzyna Kordas, Aditi Roy, Patricia López, Gonzalo García-Vargas, Mariano E Cebrián, Eunice Vera-Aguilar, Jorge L Rosado. Iron and Zinc Supplementation Does Not Impact Urinary Arsenic Excretion in Mexican School Children.
The Journal of pediatrics.
2017 06; 185(?):205-210.e1. doi:
10.1016/j.jpeds.2017.02.040
. [PMID: 28343659] - Shruti B Bhavi, Purushottam B Jaju. Intravenous iron sucrose v/s oral ferrous fumarate for treatment of anemia in pregnancy. A randomized controlled trial.
BMC pregnancy and childbirth.
2017 May; 17(1):137. doi:
10.1186/s12884-017-1313-9
. [PMID: 28482869] - Emily M Teshome, Pauline E A Andang'o, Victor Osoti, Sofie R Terwel, Walter Otieno, Ayşe Y Demir, Andrew M Prentice, Hans Verhoef. Daily home fortification with iron as ferrous fumarate versus NaFeEDTA: a randomised, placebo-controlled, non-inferiority trial in Kenyan children.
BMC medicine.
2017 04; 15(1):89. doi:
10.1186/s12916-017-0839-z
. [PMID: 28449690] - Ghada Abdel Fattah Abdel Moety, Ahmed Mahmoud Ali, Reham Fouad, Wafaa Ramadan, Doaa Shafie Belal, Hisham Mamdouh Haggag. Amino acid chelated iron versus an iron salt in the treatment of iron deficiency anemia with pregnancy: A randomized controlled study.
European journal of obstetrics, gynecology, and reproductive biology.
2017 Mar; 210(?):242-246. doi:
10.1016/j.ejogrb.2017.01.003
. [PMID: 28073037] - Martin N Mwangi, Johanna M Roth, Menno R Smit, Laura Trijsburg, Alice M Mwangi, Ayşe Y Demir, Jos P M Wielders, Petra F Mens, Jaco J Verweij, Sharon E Cox, Andrew M Prentice, Inge D Brouwer, Huub F J Savelkoul, Pauline E A Andang'o, Hans Verhoef. Effect of Daily Antenatal Iron Supplementation on Plasmodium Infection in Kenyan Women: A Randomized Clinical Trial.
JAMA.
2015 Sep; 314(10):1009-20. doi:
10.1001/jama.2015.9496
. [PMID: 26348751] - Ivy Song, Julie Borland, Niki Arya, Brian Wynne, Stephen Piscitelli. Pharmacokinetics of dolutegravir when administered with mineral supplements in healthy adult subjects.
Journal of clinical pharmacology.
2015 May; 55(5):490-6. doi:
10.1002/jcph.439
. [PMID: 25449994] - Korinna Kloepfer, Pirmin Schmid, Walter A Wuillemin, Axel Rüfer. Reference values for oral iron absorption of bivalent iron in healthy volunteers.
Swiss medical weekly.
2015; 145(?):w14063. doi:
10.4414/smw.2015.14063
. [PMID: 25612208] - Kazuya Takasawa, Chikako Takaeda, Teiryo Maeda, Norishi Ueda. Hepcidin-25, mean corpuscular volume, and ferritin as predictors of response to oral iron supplementation in hemodialysis patients.
Nutrients.
2014 Dec; 7(1):103-18. doi:
10.3390/nu7010103
. [PMID: 25551249] - María N García-Casal, Irene Leets. Carotenoids, but not vitamin A, improve iron uptake and ferritin synthesis by Caco-2 cells from ferrous fumarate and NaFe-EDTA.
Journal of food science.
2014 Apr; 79(4):H706-12. doi:
10.1111/1750-3841.12374
. [PMID: 24665932] - Zhengyuan Wang, Jianqin Sun, Lu Wang, Min Zong, Yanqiu Chen, Yifan Lin, Danfeng Xu, Jingjing Jiang, Yiru Pan, Jianhua Piao, Zhenwu Huang, Xiaoguang Yang. [Effect of iron supplementation on iron deficiency anemia of childbearing age women in Shanghai].
Wei sheng yan jiu = Journal of hygiene research.
2012 Jan; 41(1):51-5. doi:
NULL
. [PMID: 22443058] - L Adhikary, S Acharya. Efficacy of IV iron compared to oral iron for increment of haemoglobin level in anemic chronic kidney disease patients on erythropoietin therapy.
JNMA; journal of the Nepal Medical Association.
2011 Jul; 51(183):133-6. doi:
10.31729/jnma.32
. [PMID: 22922860] - Ekhard E Ziegler, Samuel J Fomon, Steven E Nelson, Janice M Jeter, Richard C Theuer. Dry cereals fortified with electrolytic iron or ferrous fumarate are equally effective in breast-fed infants.
The Journal of nutrition.
2011 Feb; 141(2):243-8. doi:
10.3945/jn.110.127266
. [PMID: 21178077] - Yao Olive Li, Divya Yadava, Kit Lan Lo, Levente L Diosady, Annie S Wesley. Feasibility and optimization study of using cold-forming extrusion process for agglomerating and microencapsulating ferrous fumarate for salt double fortification with iodine and iron.
Journal of microencapsulation.
2011; 28(7):639-49. doi:
10.3109/02652048.2011.604434
. [PMID: 21824067] - Kimberly S Balay, Keli M Hawthorne, Penni D Hicks, Ian J Griffin, Zhensheng Chen, Mark Westerman, Steven A Abrams. Orange but not apple juice enhances ferrous fumarate absorption in small children.
Journal of pediatric gastroenterology and nutrition.
2010 May; 50(5):545-50. doi:
10.1097/mpg.0b013e3181b1848f
. [PMID: 20639713] - Min Lu, Martin H Cohen, Dwaine Rieves, Richard Pazdur. FDA report: Ferumoxytol for intravenous iron therapy in adult patients with chronic kidney disease.
American journal of hematology.
2010 May; 85(5):315-9. doi:
10.1002/ajh.21656
. [PMID: 20201089] - Michael B Zimmermann, Mary Harrington, Salvador Villalpando, Richard F Hurrell. Nonheme-iron absorption in first-degree relatives is highly correlated: a stable-isotope study in mother-child pairs.
The American journal of clinical nutrition.
2010 Mar; 91(3):802-7. doi:
10.3945/ajcn.2009.28800
. [PMID: 20016013] - Yao Olive Li, Levente L Diosady, Annie S Wesley. Iron in vitro bioavailability and iodine storage stability in double-fortified salt.
Food and nutrition bulletin.
2009 Dec; 30(4):327-35. doi:
10.1177/156482650903000403
. [PMID: 20496622] - Michael B Zimmermann, Barbara Troesch, Ralf Biebinger, Ines Egli, Christophe Zeder, Richard F Hurrell. Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin.
The American journal of clinical nutrition.
2009 Nov; 90(5):1280-7. doi:
10.3945/ajcn.2009.28129
. [PMID: 19740974] - Lena Davidsson, Shafiqual Alam Sarker, Kazi Asif Jamil, Shamima Sultana, Richard Hurrell. Regular consumption of a complementary food fortified with ascorbic acid and ferrous fumarate or ferric pyrophosphate is as useful as ferrous sulfate in maintaining hemoglobin concentrations >105 g/L in young Bangladeshi children.
The American journal of clinical nutrition.
2009 Jun; 89(6):1815-20. doi:
10.3945/ajcn.2008.27353
. [PMID: 19403640] - Eman Khedr, Sherifa A Hamed, Esam Elbeih, Hala El-Shereef, Yousreyia Ahmad, Safaa Ahmed. Iron states and cognitive abilities in young adults: neuropsychological and neurophysiological assessment.
European archives of psychiatry and clinical neuroscience.
2008 Dec; 258(8):489-96. doi:
10.1007/s00406-008-0822-y
. [PMID: 18574611] - Maria Andersson, Prashanth Thankachan, Sumithra Muthayya, Ramakrishna B Goud, Anura V Kurpad, Richard F Hurrell, Michael B Zimmermann. Dual fortification of salt with iodine and iron: a randomized, double-blind, controlled trial of micronized ferric pyrophosphate and encapsulated ferrous fumarate in southern India.
The American journal of clinical nutrition.
2008 Nov; 88(5):1378-87. doi:
10.3945/ajcn.2008.26149
. [PMID: 18996875] - Martha E van Stuijvenberg, Cornelius M Smuts, Carl J Lombard, Muhammad A Dhansay. Fortifying brown bread with sodium iron EDTA, ferrous fumarate, or electrolytic iron does not affect iron status in South African schoolchildren.
The Journal of nutrition.
2008 Apr; 138(4):782-6. doi:
10.1093/jn/138.4.782
. [PMID: 18356335] - Sukyung Woo, Wojciech Krzyzanski, Anne-Marie Duliege, Richard B Stead, William J Jusko. Population pharmacokinetics and pharmacodynamics of peptidic erythropoiesis receptor agonist (ERA) in healthy volunteers.
Journal of clinical pharmacology.
2008 Jan; 48(1):43-52. doi:
10.1177/0091270007309702
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The Journal of pediatrics.
2007 Jul; 151(1):23-8. doi:
10.1016/j.jpeds.2007.02.016
. [PMID: 17586185] - Pankaj Sarkate, Amrapali Patil, Shashank Parulekar, N N Rege, B D Samant, Jaisen Lokhande, Ashwaria Gupta, Kamlakar Kulkarni. A randomised double-blind study comparing sodium feredetate with ferrous fumarate in anaemia in pregnancy.
Journal of the Indian Medical Association.
2007 May; 105(5):278, 280-1, 284. doi:
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. [PMID: 17915799] - S Navas-Carretero, B Sarriá, A M Pérez-Granados, S Schoppen, M Izquierdo-Pulido, M P Vaquero. A comparative study of iron bioavailability from cocoa supplemented with ferric pyrophosphate or ferrous fumarate in rats.
Annals of nutrition & metabolism.
2007; 51(3):204-7. doi:
10.1159/000104138
. [PMID: 17587790] - Håkan Flink, Ake Tegelberg, Mari Thörn, Folke Lagerlöf. Effect of oral iron supplementation on unstimulated salivary flow rate: a randomized, double-blind, placebo-controlled trial.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.
2006 Oct; 35(9):540-7. doi:
10.1111/j.1600-0714.2006.00450.x
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Annals of hematology.
2006 Sep; 85(9):567-73. doi:
10.1007/s00277-006-0141-1
. [PMID: 16733739] - Kari Erichsen, Rune J Ulvik, Gunnar Nysaeter, Jack Johansen, Jens Ostborg, Arnold Berstad, Rolf K Berge, Trygve Hausken. Oral ferrous fumarate or intravenous iron sucrose for patients with inflammatory bowel disease.
Scandinavian journal of gastroenterology.
2005 Sep; 40(9):1058-65. doi:
10.1080/00365520510023198
. [PMID: 16165718] - Kari Erichsen, Anne Marita Milde, Gülen Arslan, Lars Helgeland, Oddrun Anita Gudbrandsen, Rune J Ulvik, Rolf K Berge, Trygve Hausken, Arnold Berstad. Low-dose oral ferrous fumarate aggravated intestinal inflammation in rats with DSS-induced colitis.
Inflammatory bowel diseases.
2005 Aug; 11(8):744-8. doi:
10.1097/01.mib.0000174374.83601.86
. [PMID: 16043990] - Ta-Chih Liu, Shen-Fung Lin, Chao-Sung Chang, Wen-Chi Yang, Tyen-Po Chen. Comparison of a combination ferrous fumarate product and a polysaccharide iron complex as oral treatments of iron deficiency anemia: a Taiwanese study.
International journal of hematology.
2004 Dec; 80(5):416-20. doi:
10.1532/ijh97.a10409
. [PMID: 15646652] - Mélody C Tondeur, Claudia S Schauer, Anna L Christofides, Kwaku P Asante, Samuel Newton, Robert E Serfass, Stanley H Zlotkin. Determination of iron absorption from intrinsically labeled microencapsulated ferrous fumarate (sprinkles) in infants with different iron and hematologic status by using a dual-stable-isotope method.
The American journal of clinical nutrition.
2004 Nov; 80(5):1436-44. doi:
10.1093/ajcn/80.5.1436
. [PMID: 15531698] - P Nielsen. A comment. Ferrous fumarate deteriorated plasma antioxidant status in patients with Crohn disease.
Scandinavian journal of gastroenterology.
2004 Aug; 39(8):801; author reply 801. doi:
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The British journal of nutrition.
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Przeglad lekarski.
2004; 61(7):751-4. doi:
NULL
. [PMID: 15792014] - K Erichsen, T Hausken, R J Ulvik, A Svardal, A Berstad, R K Berge. Ferrous fumarate deteriorated plasma antioxidant status in patients with Crohn disease.
Scandinavian journal of gastroenterology.
2003 May; 38(5):543-8. doi:
10.1080/00365520310000771
. [PMID: 12795468] - Stanley Zlotkin, Kojo Yeboah Antwi, Claudia Schauer, George Yeung. Use of microencapsulated iron(II) fumarate sprinkles to prevent recurrence of anaemia in infants and young children at high risk.
Bulletin of the World Health Organization.
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Food and nutrition bulletin.
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Journal of the Indian Medical Association.
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Revista de gastroenterologia de Mexico.
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Bollettino chimico farmaceutico.
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European journal of haematology.
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British journal of haematology.
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Journal of internal medicine.
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