C18-PAF (BioDeep_00000597509)

   


代谢物信息卡片


1-O-Octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine

化学式: C28H58NO7P (551.3951)
中文名称: 1-O-十八烷基-2-乙酰基-sn-甘油-3-磷酸胆碱
谱图信息: 最多检出来源 Homo sapiens(not specific) 50%

分子结构信息

SMILES: CCCCCCCCCCCCCCCCCCOCC(COP(=O)([O-])OCC[N+](C)(C)C)OC(=O)C
InChI: InChI=1S/C28H58NO7P/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-23-33-25-28(36-27(2)30)26-35-37(31,32)34-24-22-29(3,4)5/h28H,6-26H2,1-5H3/t28-/m1/s1

描述信息

D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents

同义名列表

18 个代谢物同义名

1-O-Octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine; 1-O-Stearoyl-2-acetyl-sn-glyceryl-3-phosphorylcholine; 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine; 1-octadecyl-2-acetyl-sn-glycero-3-phosphocholine; Blood platelet activating factor-acether; 1-O-Octadecyl-platelet-activating factor; Platelet activating factor-acether; Blood platelet-activating factor; Platelet-activating factor; C18-PAF-acether; PC(O-18:0/2:0); PAF acether; PC(O-20:0); Ro 14-8161; PC O-20:0; C18-PAF; PAF; GPCho(O-18:0/2:0)



数据库引用编号

6 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(7)

BioCyc(0)

PlantCyc(0)

代谢反应

56 个相关的代谢反应过程信息。

Reactome(56)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表


文献列表

  • Yonggyun Kim, David Stanley. Eicosanoid Signaling in Insect Immunology: New Genes and Unresolved Issues. Genes. 2021 02; 12(2):. doi: 10.3390/genes12020211. [PMID: 33535438]
  • Scott D Ryan, Cory S Harris, Casey L Carswell, John E Baenziger, Steffany A L Bennett. Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons. Journal of lipid research. 2008 Oct; 49(10):2250-8. doi: 10.1194/jlr.m800263-jlr200. [PMID: 18550892]
  • L Callea, M Arese, A Orlandini, C Bargnani, A Priori, F Bussolino. Platelet activating factor is elevated in cerebral spinal fluid and plasma of patients with relapsing-remitting multiple sclerosis. Journal of neuroimmunology. 1999 Feb; 94(1-2):212-21. doi: 10.1016/s0165-5728(98)00246-x. [PMID: 10376955]
  • C Kuenemann-Migeot, F Callais, I Momas, B Festy. Urinary promutagens of smokers: comparison of concentration methods and relation to cigarette consumption. Mutation research. 1996 Jun; 368(2):141-7. doi: 10.1016/0165-1218(96)00004-3. [PMID: 8684404]
  • C Dive, J V Watson, P Workman. Multiparametric flow cytometry of the modulation of tumor cell membrane permeability by developmental antitumor ether lipid SRI 62-834 in EMT6 mouse mammary tumor and HL-60 human promyelocytic leukemia cells. Cancer research. 1991 Feb; 51(3):799-806. doi: ". [PMID: 1988120]
  • F M Clarke, C Orozco, A V Perkins, I Cock. Partial characterization of the PAF-induced soluble factors which mimic the activity of 'early pregnancy factor'. Journal of reproduction and fertility. 1990 Mar; 88(2):459-66. doi: 10.1530/jrf.0.0880459. [PMID: 2109065]
  • J L Olivier, C Chachaty, C Wolf, G Bereziat. Influence of PAF-acether on lecithin-oriented multibilayers monitored by ESR: interaction of PAF-acether with cholesterol. Biochimie. 1989 Jan; 71(1):105-9. doi: 10.1016/0300-9084(89)90139-9. [PMID: 2541796]
  • C Orozco, T Perkins, F M Clarke. Platelet-activating factor induces the expression of early pregnancy factor activity in female mice. Journal of reproduction and fertility. 1986 Nov; 78(2):549-55. doi: 10.1530/jrf.0.0780549. [PMID: 3806515]
  • A C Honey, N Lad, D P Tuffin. Effect of indomethacin and dazoxiben on intravascular platelet aggregation in the anaesthetized rabbit. Thrombosis and haemostasis. 1986 Aug; 56(1):80-5. doi: . [PMID: 3775692]
  • D R Hoffman, J Hajdu, F Snyder. Cytotoxicity of platelet activating factor and related alkyl-phospholipid analogs in human leukemia cells, polymorphonuclear neutrophils, and skin fibroblasts. Blood. 1984 Mar; 63(3):545-52. doi: NULL. [PMID: 6696992]
  • M J Parnham, J Winkelman, H P Hartung, U Hadding. Regulation of the oxidative burst of macrophages by lipid mediators. Agents and actions. Supplements. 1984; 14(?):215-26. doi: ". [PMID: 6433680]
  • G Ostermann, U Till, K Thielmann. Studies on the stimulation of human blood platelets by semi-synthetic platelet-activating factor. Thrombosis research. 1983 Apr; 30(2):127-36. doi: 10.1016/0049-3848(83)90235-9. [PMID: 6408754]
  • P Hadváry, H R Baumgartner. Activation of human and rabbit blood platelets by synthetic structural analogs of platelet activating factor. Thrombosis research. 1983 Apr; 30(2):143-56. doi: 10.1016/0049-3848(83)90237-2. [PMID: 6868019]
  • F M Lai, C A Shepherd, P Cervoni, A Wissner. Hypotensive and vasodilatory activity of (+/-) 1-o-octadecyl-2-acetyl glyceryl-3-phosphorylcholine in the normotensive rat. Life sciences. 1983 Mar; 32(10):1159-66. doi: 10.1016/0024-3205(83)90122-4. [PMID: 6338331]
  • L Touqui, C Jacquemin, B B Vargaftig. Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite. Biochemical and biophysical research communications. 1983 Feb; 110(3):890-3. doi: 10.1016/0006-291x(83)91045-8. [PMID: 6838557]
  • M Sánchez-Crespo, F Alonso, P Iñarrea, V Alvarez, J Egido. Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: evidence for a platelet independent mechanism. Immunopharmacology. 1982 Apr; 4(2):173-85. doi: 10.1016/0162-3109(82)90019-4. [PMID: 7085259]