Panaxydol (BioDeep_00000594487)

   


代谢物信息卡片


(3r)-8-[(2r,3s)-3-Heptyloxiran-2-yl]oct-1-ene-4,6-diyn-3-ol

化学式: C17H24O2 (260.17762039999997)
中文名称: 人参环氧炔醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(O)(C=C)C#CC#CCC1OC1CCCCCCC
InChI: InChI=1S/C17H24O2/c1-3-5-6-7-10-13-16-17(19-16)14-11-8-9-12-15(18)4-2/h4,15-18H,2-3,5-7,10,13-14H2,1H3

描述信息

A natural product found in Panax ginseng.

同义名列表

5 个代谢物同义名

Panaxydol; (3r)-8-[(2r,3s)-3-Heptyloxiran-2-yl]oct-1-ene-4,6-diyn-3-ol; 9,10-epoxy-heptadeca-1-en-4,6-diyn-3-ol; 9,10-epoxy-1-heptadecen-4,6-diyn-3-ol; FOH 17:6;O



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yueming Wang, Jianwen Li, Yan Wo, Zhengrong Zhou. Panaxydol Derived from Panax notoginseng Promotes Nerve Regeneration after Sciatic Nerve Transection in Rats. Journal of integrative neuroscience. 2022 Jun; 21(4):109. doi: 10.31083/j.jin2104109. [PMID: 35864761]
  • Vartika, Monika Chaudhary, Sameer Suresh Bhagyawant, Nidhi Srivastava. Effects of Prednisolone Derivative and Panaxydol: Biosurfactants on Cell Wall Integrity of Acne-Causing Resistant Bacteria. Cell biochemistry and biophysics. 2022 Mar; 80(1):229-243. doi: 10.1007/s12013-021-01038-0. [PMID: 34709575]
  • Yinxue Guo, Maorong Hu, Juan Ma, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Omar H M Shair, Pingyu Ge. Protective effect of panaxydol against repeated administration of aristolochic acid on renal function and lipid peroxidation products via activating Keap1-Nrf2/ARE pathway in rat kidney. Journal of biochemical and molecular toxicology. 2021 Jan; 35(1):e22619. doi: 10.1002/jbt.22619. [PMID: 32894623]
  • Joon Hyuk Hou, Hyunjung Shin, Kyoung Hwa Jang, Chae Kyu Park, Bonsuk Koo, Hyeji Shin, Soon Hong Yuk, Ki Yong Lee. Anti-acne properties of hydrophobic fraction of red ginseng (Panax ginseng C.A. Meyer) and its active components. Phytotherapy research : PTR. 2019 Mar; 33(3):584-590. doi: 10.1002/ptr.6243. [PMID: 30506753]
  • Jeong-Hun Lee, Dong Gyu Leem, Kyung-Sook Chung, Kyung-Tack Kim, Sang Yoon Choi, Kyung-Tae Lee. Panaxydol Derived from Panax ginseng Inhibits G1 Cell Cycle Progression in Non-small Cell Lung Cancer via Upregulation of Intracellular Ca2+ Levels. Biological & pharmaceutical bulletin. 2018; 41(11):1701-1707. doi: 10.1248/bpb.b18-00447. [PMID: 30381670]
  • Hee Suk Kim, Jang Mi Lim, Joo Young Kim, Yongjin Kim, Serkin Park, Jeongwon Sohn. Panaxydol, a component of Panax ginseng, induces apoptosis in cancer cells through EGFR activation and ER stress and inhibits tumor growth in mouse models. International journal of cancer. 2016 Mar; 138(6):1432-41. doi: 10.1002/ijc.29879. [PMID: 26421996]
  • Nihat Knispel, Elena Ostrozhenkova, Nicholas Schramek, Claudia Huber, Luis M Peña-Rodríguez, Mercedes Bonfill, Javier Palazón, Gesine Wischmann, Rosa M Cusidó, Wolfgang Eisenreich. Biosynthesis of panaxynol and panaxydol in Panax ginseng. Molecules (Basel, Switzerland). 2013 Jul; 18(7):7686-98. doi: 10.3390/molecules18077686. [PMID: 23884121]
  • Haoxin Li, Taryn O'Neill, Duncan Webster, John A Johnson, Christopher A Gray. Anti-mycobacterial diynes from the Canadian medicinal plant Aralia nudicaulis. Journal of ethnopharmacology. 2012 Mar; 140(1):141-4. doi: 10.1016/j.jep.2011.12.048. [PMID: 22234257]
  • Subhasree Ashok Nag, Jiang-Jiang Qin, Wei Wang, Ming-Hai Wang, Hui Wang, Ruiwen Zhang. Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action. Frontiers in pharmacology. 2012; 3(?):25. doi: 10.3389/fphar.2012.00025. [PMID: 22403544]
  • Jie Li, Juan Jiang, Yimin Zheng, Linlin Wang, Yuqing Yang, Yang Hu. [Simultaneous determination of panaxynol and panaxydol in fibrous root of Panax ginseng by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Sep; 36(17):2380-2. doi: . [PMID: 22121807]
  • Stig Purup, Eric Larsen, Lars P Christensen. Differential effects of falcarinol and related aliphatic C(17)-polyacetylenes on intestinal cell proliferation. Journal of agricultural and food chemistry. 2009 Sep; 57(18):8290-6. doi: 10.1021/jf901503a. [PMID: 19694436]
  • Lars P Christensen, Martin Jensen. Biomass and content of ginsenosides and polyacetylenes in American ginseng roots can be increased without affecting the profile of bioactive compounds. Journal of natural medicines. 2009 Apr; 63(2):159-68. doi: 10.1007/s11418-008-0307-3. [PMID: 19085048]
  • Min Cheol Yang, Dong Sang Seo, Sang Un Choi, Young Hyun Park, Kang Ro Lee. Polyacetylenes from the roots of cultivated-wild ginseng and their cytotoxicity in vitro. Archives of pharmacal research. 2008 Feb; 31(2):154-9. doi: 10.1007/s12272-001-1134-1. [PMID: 18365683]
  • Jian Hai, Qi Lin, Yang Lu, Jing Yi, Hao Zhang. Growth inhibition and induction of differentiation by panaxydol in rat C6 glioma cells. Neurological research. 2008 Feb; 30(1):99-105. doi: 10.1179/016164107x228697. [PMID: 17767808]
  • Ji-Hua Liu, Che-Sum Lee, Kit-Ming Leung, Zhong-Kai Yan, Bai-Hua Shen, Zhong-Zhen Zhao, Zhi-Hong Jiang. Quantification of two polyacetylenes in Radix Ginseng and roots of related Panax species using a gas chromatography-mass spectrometric method. Journal of agricultural and food chemistry. 2007 Oct; 55(22):8830-5. doi: 10.1021/jf070735o. [PMID: 17722935]
  • Jian Hai, Qi Lin, Yang Lu, Hao Zhang, Jing Yi. Induction of apoptosis in rat C6 glioma cells by panaxydol. Cell biology international. 2007 Jul; 31(7):711-5. doi: 10.1016/j.cellbi.2007.01.003. [PMID: 17320424]
  • Lars P Christensen, Martin Jensen, Ulla Kidmose. Simultaneous determination of ginsenosides and polyacetylenes in American ginseng root (Panax quinquefolium L.) by high-performance liquid chromatography. Journal of agricultural and food chemistry. 2006 Nov; 54(24):8995-9003. doi: 10.1021/jf062068p. [PMID: 17117783]
  • Malgorzata Baranska, Hartwig Schulz, Lars P Christensen. Structural changes of polyacetylenes in American ginseng root can be observed in situ by using Raman spectroscopy. Journal of agricultural and food chemistry. 2006 May; 54(10):3629-35. doi: 10.1021/jf060422d. [PMID: 19127736]
  • Daisuke Washida, Koichiro Shimomura, Susumu Kitanaka. Polyacetylenes in hairy roots of a panax hybrid. Planta medica. 2003 Dec; 69(12):1163-5. doi: 10.1055/s-2003-818012. [PMID: 14750038]
  • Daisuke Washida, Susumu Kitanaka. Determination of polyacetylenes and ginsenosides in Panax species using high performance liquid chromatography. Chemical & pharmaceutical bulletin. 2003 Nov; 51(11):1314-7. doi: 10.1248/cpb.51.1314. [PMID: 14600381]
  • J Sohn, C H Lee, D J Chung, S H Park, I Kim, W I Hwang. Effect of petroleum ether extract of Panax ginseng roots on proliferation and cell cycle progression of human renal cell carcinoma cells. Experimental & molecular medicine. 1998 Mar; 30(1):47-51. doi: 10.1038/emm.1998.7. [PMID: 9873822]
  • H Matsunaga, T Saita, F Nagumo, M Mori, M Katano. [Relationship between antiproliferative activity of acetylenic alcohol, panaxydol, and its affinity for target cell membrane]. Gan to kagaku ryoho. Cancer & chemotherapy. 1994 Nov; 21(15):2585-9. doi: NULL. [PMID: 7979417]