9Z,12E-octadecadienoic acid (BioDeep_00000593513)
代谢物信息卡片
9Z,12E-octadecadienoic acid
化学式: C18H32O2 (280.2402172)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCC=CCC=CCCCCCCCC(=O)O
InChI: InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9-
数据库引用编号
6 个数据库交叉引用编号
- ChEBI: CHEBI:86141
- PubChem: 5282797
- Metlin: METLIN34798
- MeSH: Linoleic Acid
- CAS: 2420-42-0
- CAS: 2420-55-5
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rosario Martínez, Cristina Mesas, Ana Guzmán, Milagros Galisteo, María López-Jurado, José Prados, Consolación Melguizo, Francisco Bermúdez, Jesus M Porres. Bioavailability and biotransformation of linolenic acid from basil seed oil as a novel source of omega-3 fatty acids tested on a rat experimental model.
Food & function.
2022 Jul; 13(14):7614-7628. doi:
10.1039/d2fo00672c. [PMID: 35731538] - Nuanyi Liang, Shiva Emami, Kelley T Patten, Anthony E Valenzuela, Christopher D Wallis, Anthony S Wexler, Keith J Bein, Pamela J Lein, Ameer Y Taha. Chronic exposure to traffic-related air pollution reduces lipid mediators of linoleic acid and soluble epoxide hydrolase in serum of female rats.
Environmental toxicology and pharmacology.
2022 Jul; 93(?):103875. doi:
10.1016/j.etap.2022.103875. [PMID: 35550873] - Maria Carolina Borges, Philip C Haycock, Jie Zheng, Gibran Hemani, Michael V Holmes, George Davey Smith, Aroon D Hingorani, Deborah A Lawlor. Role of circulating polyunsaturated fatty acids on cardiovascular diseases risk: analysis using Mendelian randomization and fatty acid genetic association data from over 114,000 UK Biobank participants.
BMC medicine.
2022 06; 20(1):210. doi:
10.1186/s12916-022-02399-w. [PMID: 35692035] - Behnam Tajik, Tomi-Pekka Tuomainen, Masoud Isanejad, Jukka T Salonen, Jyrki K Virtanen. Serum n-6 polyunsaturated fatty acids and risk of atrial fibrillation: the Kuopio Ischaemic Heart Disease Risk Factor Study.
European journal of nutrition.
2022 Jun; 61(4):1981-1989. doi:
10.1007/s00394-021-02780-0. [PMID: 34961890] - Jinkai Liu, Wei Geng, Hanyong Sun, Changan Liu, Fan Huang, Jie Cao, Lei Xia, Hongchuan Zhao, Jianning Zhai, Qing Li, Xiang Zhang, Ming Kuang, Shunli Shen, Qiang Xia, Vincent Wai-Sun Wong, Jun Yu. Integrative metabolomic characterisation identifies altered portal vein serum metabolome contributing to human hepatocellular carcinoma.
Gut.
2022 06; 71(6):1203-1213. doi:
10.1136/gutjnl-2021-325189. [PMID: 34344785] - Francesca Giuffrida, Mathilde Fleith, Amélie Goyer, Tinu Mary Samuel, Isabelle Elmelegy-Masserey, Patric Fontannaz, Cristina Cruz-Hernandez, Sagar K Thakkar, Cathriona Monnard, Carlos Antonio De Castro, Luca Lavalle, Thameur Rakza, Massimo Agosti, Isam Al-Jashi, Almerinda Barroso Pereira, Maria Jose Costeira, Giovanna Marchini, Mireille Vanpee, Tom Stiris, Sylvia Stoicescu, Maria Gorett Silva, Jean-Charles Picaud, Cecilia Martinez-Costa, Magnus Domellöf, Claude Billeaud. Human milk fatty acid composition and its association with maternal blood and adipose tissue fatty acid content in a cohort of women from Europe.
European journal of nutrition.
2022 Jun; 61(4):2167-2182. doi:
10.1007/s00394-021-02788-6. [PMID: 35072787] - Jian Wu, Yanping Xu, Yubao Cui, Mariza Bortolanza, Minjie Wang, Bin Jiang, Meina Yan, Wei Liang, Yiwen Yao, Qiaoling Pan, Jinfeng Yang, Jiong Yu, Dawei Wang, Hongcui Cao, Lanjuan Li. Dynamic changes of serum metabolites associated with infection and severity of patients with acute hepatitis E infection.
Journal of medical virology.
2022 06; 94(6):2714-2726. doi:
10.1002/jmv.27669. [PMID: 35199373] - Nalin Singh, Dongyang Li, Cindy B McReynolds, Christophe Morisseau, Bruce D Hammock. Improved ELISA for linoleate-derived diols in human plasma utilizing a polyHRP-based secondary tracer.
Analytical methods : advancing methods and applications.
2022 05; 14(18):1810-1819. doi:
10.1039/d2ay00272h. [PMID: 35481804] - Kevin Stephenson, Meghan Callaghan-Gillespie, Kenneth Maleta, Minyanga Nkhoma, Matthews George, Hui Gyu Park, Reginald Lee, Iona Humphries-Cuff, R J Scott Lacombe, Donna R Wegner, Richard L Canfield, J Thomas Brenna, Mark J Manary. Low linoleic acid foods with added DHA given to Malawian children with severe acute malnutrition improve cognition: a randomized, triple-blinded, controlled clinical trial.
The American journal of clinical nutrition.
2022 05; 115(5):1322-1333. doi:
10.1093/ajcn/nqab363. [PMID: 34726694] - Michael S Garshick, Robert Block, Kamelia Drenkova, Michael Tawil, Genevieve James, J Thomas Brenna. Statin therapy upregulates arachidonic acid status via enhanced endogenous synthesis in patients with plaque psoriasis.
Prostaglandins, leukotrienes, and essential fatty acids.
2022 05; 180(?):102428. doi:
10.1016/j.plefa.2022.102428. [PMID: 35490599] - Christian B Bergmann, Cindy B McReynolds, Debin Wan, Nalin Singh, Holly Goetzman, Charles C Caldwell, Dorothy M Supp, Bruce D Hammock. sEH-derived metabolites of linoleic acid drive pathologic inflammation while impairing key innate immune cell function in burn injury.
Proceedings of the National Academy of Sciences of the United States of America.
2022 03; 119(13):e2120691119. doi:
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Scientific reports.
2022 03; 12(1):4377. doi:
10.1038/s41598-022-08453-0. [PMID: 35288655] - Sandra Ekström, Emmanouela Sdona, Susanna Klevebro, Jenny Hallberg, Antonios Georgelis, Inger Kull, Erik Melén, Ulf Risérus, Anna Bergström. Dietary intake and plasma concentrations of PUFAs in childhood and adolescence in relation to asthma and lung function up to adulthood.
The American journal of clinical nutrition.
2022 03; 115(3):886-896. doi:
10.1093/ajcn/nqab427. [PMID: 34964829] - Topi Meuronen, Maria A Lankinen, Olli Kärkkäinen, Markku Laakso, Jussi Pihlajamäki, Kati Hanhineva, Ursula Schwab. FADS1 rs174550 genotype and high linoleic acid diet modify plasma PUFA phospholipids in a dietary intervention study.
European journal of nutrition.
2022 Mar; 61(2):1109-1120. doi:
10.1007/s00394-021-02722-w. [PMID: 34718859] - Nirajan Shrestha, Simone Sleep, Tessa Helman, Olivia Holland, James S M Cuffe, Anthony V Perkins, Andrew J McAinch, John P Headrick, Deanne H Hryciw. Maternal diet high in linoleic acid alters offspring fatty acids and cardiovascular function in a rat model.
The British journal of nutrition.
2022 02; 127(4):540-553. doi:
10.1017/s0007114521001276. [PMID: 33858529] - Shuangcui Wang, Jiali Gan, Jingfang Li, Yuli Wang, Jiaqi Zhang, Lili Song, Zhen Yang, Maojuan Guo, Xijuan Jiang. Shengmai Yin formula exerts cardioprotective effects on rats with chronic heart failure via regulating Linoleic Acid metabolism.
Prostaglandins & other lipid mediators.
2022 02; 158(?):106608. doi:
10.1016/j.prostaglandins.2021.106608. [PMID: 34958945] - Raphaël Chouinard-Watkins, Melissa Calleja, Richard P Bazinet, Andrea R Josse. Dairy product consumption is associated with a lowering of linoleic acid within serum TAG in adolescent females with overweight or obesity: a secondary analysis.
The British journal of nutrition.
2022 01; 127(1):68-77. doi:
10.1017/s0007114521001677. [PMID: 34027846] - Kapil Gupta, Christine Toelzer, Maia Kavanagh Williamson, Deborah K Shoemark, A Sofia F Oliveira, David A Matthews, Abdulaziz Almuqrin, Oskar Staufer, Sathish K N Yadav, Ufuk Borucu, Frederic Garzoni, Daniel Fitzgerald, Joachim Spatz, Adrian J Mulholland, Andrew D Davidson, Christiane Schaffitzel, Imre Berger. Structural insights in cell-type specific evolution of intra-host diversity by SARS-CoV-2.
Nature communications.
2022 01; 13(1):222. doi:
10.1038/s41467-021-27881-6. [PMID: 35017512] - Jisoo Park, Hai V Ngo, Hyo-Eon Jin, Kye Wan Lee, Beom-Jin Lee. Hydroxyl Group-Targeted Conjugate and Its Self-Assembled Nanoparticle of Peptide Drug: Effect of Degree of Saturation of Fatty Acids and Modification of Physicochemical Properties.
International journal of nanomedicine.
2022; 17(?):2243-2260. doi:
10.2147/ijn.s356804. [PMID: 35615542] - Ling Huang, Mengyue Li, Guowei Huang. [Quantifiable method of polyunsaturated fatty acids in human plasma by optimized gas chromatography].
Wei sheng yan jiu = Journal of hygiene research.
2021 Nov; 50(6):981-985. doi:
10.19813/j.cnki.weishengyanjiu.2021.06.018. [PMID: 34949327] - Yan Wang, Yiwei Tang, Ye Ji, Wenhui Xu, Naeem Ullah, Haitao Yu, Yixia Wu, Lin Xie. Association between FADS1 rs174547 and levels of long-chain PUFA: a meta-analysis.
The British journal of nutrition.
2021 10; 126(8):1121-1129. doi:
10.1017/s0007114520005103. [PMID: 33331250] - Dennis Winston T Nilsen, Peder Langeland Myhre, Are Kalstad, Erik Berg Schmidt, Harald Arnesen, Ingebjørg Seljeflot. Serum Levels of Dihomo-Gamma (γ)-Linolenic Acid (DGLA) Are Inversely Associated with Linoleic Acid and Total Death in Elderly Patients with a Recent Myocardial Infarction.
Nutrients.
2021 Sep; 13(10):. doi:
10.3390/nu13103475. [PMID: 34684479] - Jacquelyn Cheng, Haim Bar, Elad Tako. Zinc Status Index (ZSI) for Quantification of Zinc Physiological Status.
Nutrients.
2021 Sep; 13(10):. doi:
10.3390/nu13103399. [PMID: 34684398] - Nirajan Shrestha, Steven D Melvin, Daniel R McKeating, Olivia J Holland, James S M Cuffe, Anthony V Perkins, Andrew J McAinch, Deanne H Hryciw. Sex-Specific Differences in Lysine, 3-Hydroxybutyric Acid and Acetic Acid in Offspring Exposed to Maternal and Postnatal High Linoleic Acid Diet, Independent of Diet.
International journal of molecular sciences.
2021 Sep; 22(19):. doi:
10.3390/ijms221910223. [PMID: 34638563] - Neil K Huang, Petra Bůžková, Nirupa R Matthan, Luc Djoussé, Jorge R Kizer, Kenneth J Mukamal, Joseph F Polak, Alice H Lichtenstein. Serum Non-Esterified Fatty Acids, Carotid Artery Intima-Media Thickness and Flow-Mediated Dilation in Older Adults: The Cardiovascular Health Study (CHS).
Nutrients.
2021 Aug; 13(9):. doi:
10.3390/nu13093052. [PMID: 34578930] - Yu Hai-Tao, Guo Zhi-Heng, Chen Yi-Ru, Li Yue-Ting, Zhang Hai-Ying, Liu Ya-Juan, Xie Lin. Gestational diabetes mellitus decreased umbilical cord blood polyunsaturated fatty acids: a meta-analysis of observational studies.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 08; 171(?):102318. doi:
10.1016/j.plefa.2021.102318. [PMID: 34246926] - Teresa Buckner, Lauren A Vanderlinden, Brian C DeFelice, Patrick M Carry, Katerina Kechris, Fran Dong, Oliver Fiehn, Brigitte I Frohnert, Michael Clare-Salzler, Marian Rewers, Jill M Norris. The oxylipin profile is associated with development of type 1 diabetes: the Diabetes Autoimmunity Study in the Young (DAISY).
Diabetologia.
2021 08; 64(8):1785-1794. doi:
10.1007/s00125-021-05457-9. [PMID: 33893822] - Kenta Nishi, Hisako Matsumoto, Noriyuki Tashima, Satoru Terada, Natsuko Nomura, Mariko Kogo, Chie Morimoto, Hironobu Sunadome, Tadao Nagasaki, Tsuyoshi Oguma, Yoshinari Nakatsuka, Kimihiko Murase, Takahisa Kawaguchi, Yasuharu Tabara, Kazuhiro Sonomura, Fumihiko Matsuda, Kazuo Chin, Toyohiro Hirai. Impacts of lipid-related metabolites, adiposity, and genetic background on blood eosinophil counts: the Nagahama study.
Scientific reports.
2021 07; 11(1):15373. doi:
10.1038/s41598-021-94835-9. [PMID: 34321534] - Jacqueline Pontes Monteiro, Carlos A Fuzo, Fábio V Ued, Jim Kaput. Dietary patterns related to zinc and polyunsaturated fatty acids intake are associated with serum linoleic/dihomo-γ-linolenic ratio in NHANES males and females.
Scientific reports.
2021 06; 11(1):12215. doi:
10.1038/s41598-021-91611-7. [PMID: 34108562] - Yue Shen, Yuqi Shen, Xiao Bi, Jiaolun Li, Yingjie Chen, Qiuyu Zhu, Yifeng Wang, Feng Ding. Linoleic acid-modified liposomes for the removal of protein-bound toxins: An in vitro study.
The International journal of artificial organs.
2021 Jun; 44(6):393-403. doi:
10.1177/0391398820968837. [PMID: 33135543] - Nejc Kozar, Kristi Kruusmaa, Marko Bitenc, Rosa Argamasilla, Antonio Adsuar, Iztok Takač, Darja Arko. Identification of Novel Diagnostic Biomarkers in Breast Cancer Using Targeted Metabolomic Profiling.
Clinical breast cancer.
2021 06; 21(3):e204-e211. doi:
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Nutrients.
2021 May; 13(5):. doi:
10.3390/nu13051678. [PMID: 34063343] - Xinyue Huang, Shenglan Yi, Jianping Hu, Ziyu Du, Qingfeng Wang, Zi Ye, Guannan Su, Aize Kijlstra, Peizeng Yang. Linoleic acid inhibits in vitro function of human and murine dendritic cells, CD4+T cells and retinal pigment epithelial cells.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2021 Apr; 259(4):987-998. doi:
10.1007/s00417-020-04972-6. [PMID: 33079282] - Maria A Lankinen, Vanessa D de Mello, Topi Meuronen, Taisa Sallinen, Jyrki Ågren, Kirsi A Virtanen, Markku Laakso, Jussi Pihlajamäki, Ursula Schwab. The FADS1 Genotype Modifies Metabolic Responses to the Linoleic Acid and Alpha-linolenic Acid Containing Plant Oils-Genotype Based Randomized Trial FADSDIET2.
Molecular nutrition & food research.
2021 04; 65(7):e2001004. doi:
10.1002/mnfr.202001004. [PMID: 33548080] - Marie C Conway, Emeir M McSorley, Maria S Mulhern, Toni Spence, Edwin van Wijngaarden, Gene E Watson, Karin Wahlberg, Daniela Pineda, Karin Broberg, Barry W Hyland, Diego F Cobice, J J Strain, Alison J Yeates. The influence of fish consumption on serum n-3 polyunsaturated fatty acid (PUFA) concentrations in women of childbearing age: a randomised controlled trial (the iFish Study).
European journal of nutrition.
2021 Apr; 60(3):1415-1427. doi:
10.1007/s00394-020-02326-w. [PMID: 32725293] - Vanessa Woodard, Melissa Thoene, Matthew Van Ormer, Maranda Thompson, Corrine Hanson, Sathish Kumar Natarajan, Maheswari Mukherjee, Ana Yuil-Valdes, Tara M Nordgren, Arzu Ulu, Kristina Harris Jackson, Ann Anderson-Berry. Intrauterine Transfer of Polyunsaturated Fatty Acids in Mother-Infant Dyads as Analyzed at Time of Delivery.
Nutrients.
2021 Mar; 13(3):. doi:
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Medical oncology (Northwood, London, England).
2021 Mar; 38(4):40. doi:
10.1007/s12032-021-01485-y. [PMID: 33728516] - Nirajan Shrestha, Josif Vidimce, Olivia J Holland, James S M Cuffe, Belinda R Beck, Anthony V Perkins, Andrew J McAinch, Deanne H Hryciw. Maternal and Postnatal High Linoleic Acid Diet Impacts Lipid Metabolism in Adult Rat Offspring in a Sex-Specific Manner.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
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Clinical nutrition (Edinburgh, Scotland).
2021 03; 40(3):1108-1114. doi:
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Biochimica et biophysica acta. Molecular and cell biology of lipids.
2021 03; 1866(3):158870. doi:
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European journal of nutrition.
2021 Mar; 60(2):861-872. doi:
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Clinical nutrition (Edinburgh, Scotland).
2021 03; 40(3):1095-1101. doi:
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Nutrients.
2021 Feb; 13(2):. doi:
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Journal of alternative and complementary medicine (New York, N.Y.).
2021 Feb; 27(2):176-178. doi:
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Clinical nutrition (Edinburgh, Scotland).
2021 02; 40(2):467-475. doi:
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Molecular aspects of medicine.
2021 02; 77(?):100943. doi:
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The Journal of biological chemistry.
2021 Jan; 296(?):100198. doi:
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Nature structural & molecular biology.
2021 01; 28(1):2-7. doi:
10.1038/s41594-020-00544-8. [PMID: 33437043] - Marta Rivera-Pasquel, Mario Flores-Aldana, María-Socorro Parra-Cabrera, Amado David Quezada-Sánchez, Armando García-Guerra, Jorge Maldonado-Hernández. Effect of Milk-Based Infant Formula Fortified with PUFAs on Lipid Profile, Growth and Micronutrient Status of Young Children: A Randomized Double-Blind Clinical Trial.
Nutrients.
2020 Dec; 13(1):. doi:
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European journal of clinical nutrition.
2020 12; 74(12):1707-1717. doi:
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Journal of dairy science.
2020 Dec; 103(12):11889-11910. doi:
10.3168/jds.2020-18735. [PMID: 32981719] - Panos Papandreou, Aristea Gioxari, Dimitrios Ntountaniotis, Olga-Natalia Korda, Maria Skouroliakou, Tania Siahanidou. Administration of an Intravenous Fat Emulsion Enriched with Medium-Chain Triglyceride/ω-3 Fatty Acids is Beneficial Towards Anti-Inflammatory Related Fatty Acid Profile in Preterm Neonates: A Randomized, Double-Blind Clinical Trial.
Nutrients.
2020 Nov; 12(11):. doi:
10.3390/nu12113526. [PMID: 33207743] - Hirohito Tsuboi, Hiroyuki Sakakibara, Masahiro Matsunaga, Asami Tatsumi, Kimiko Yamakawa-Kobayashi, Naoko Yoshida, Kayoko Shimoi. Omega-3 Eicosapentaenoic Acid Is Related to Happiness and a Sense of Fulfillment-A Study among Female Nursing Workers.
Nutrients.
2020 Nov; 12(11):. doi:
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Science (New York, N.Y.).
2020 11; 370(6517):725-730. doi:
10.1126/science.abd3255. [PMID: 32958580] - J Thomas Brenna, Genevieve James, Mark Midei, Frederic Heerinckx, Paldeep Atwal, Peter Milner, Karsten Schmidt, Lex van der Ploeg, Robert Fielding, Mikhail S Shchepinov. Plasma and Red Blood Cell Membrane Accretion and Pharmacokinetics of RT001 (bis-Allylic 11,11-D2-Linoleic Acid Ethyl Ester) during Long Term Dosing in Patients.
Journal of pharmaceutical sciences.
2020 11; 109(11):3496-3503. doi:
10.1016/j.xphs.2020.08.019. [PMID: 32871154] - Xiangnan Ren, Zixing Shao, Wu Fan, Zixuan Wang, Kaiyun Chen, Xuefeng Yu. Untargeted metabolomics reveals the effect of lovastatin on steroid-induced necrosis of the femoral head in rabbits.
Journal of orthopaedic surgery and research.
2020 Oct; 15(1):497. doi:
10.1186/s13018-020-02026-5. [PMID: 33115522] - Qi Tang, Song Cang, Jiao Jiao, Weiwei Rong, Huarong Xu, Kaishun Bi, Qing Li, Ran Liu. Integrated study of metabolomics and gut metabolic activity from ulcerative colitis to colorectal cancer: The combined action of disordered gut microbiota and linoleic acid metabolic pathway might fuel cancer.
Journal of chromatography. A.
2020 Oct; 1629(?):461503. doi:
10.1016/j.chroma.2020.461503. [PMID: 32858455] - William Brewer, Johnathan Harrison, Holly E Saito, Elizabeth M Fozo. Induction of Daptomycin Tolerance in Enterococcus faecalis by Fatty Acid Combinations.
Applied and environmental microbiology.
2020 10; 86(20):. doi:
10.1128/aem.01178-20. [PMID: 32801181] - A Preethika, Suchetha N Kumari, Jayarama Shetty, Vijith Shetty. Plasma fatty acids composition and estimated delta desaturases activity in women with breast cancer.
Journal of cancer research and therapeutics.
2020 Oct; 16(6):1382-1386. doi:
10.4103/jcrt.jcrt_288_19. [PMID: 33342801] - Ji-Seon Yoon, Koji Nishifuji, Toshiro Iwasaki. Supplementation with eicosapentaenoic acid and linoleic acid increases the production of epidermal ceramides in in vitro canine keratinocytes.
Veterinary dermatology.
2020 Oct; 31(5):419-e112. doi:
10.1111/vde.12881. [PMID: 32803908] - Qingfeng Ban, Jianjun Cheng, Xiaomeng Sun, Yunqing Jiang, Mingruo Guo. Effect of feeding type 2 diabetes mellitus rats with synbiotic yogurt sweetened with monk fruit extract on serum lipid levels and hepatic AMPK (5' adenosine monophosphate-activated protein kinase) signaling pathway.
Food & function.
2020 Sep; 11(9):7696-7706. doi:
10.1039/d0fo01860k. [PMID: 32914810] - Jianlong Du, Qiang Chen, Yongnan Li, Xiaojun Xiang, Wei Xu, Kangsen Mai, Qinghui Ai. Activation of the Farnesoid X Receptor (FXR) Suppresses Linoleic Acid-Induced Inflammation in the Large Yellow Croaker (Larimichthys crocea).
The Journal of nutrition.
2020 09; 150(9):2469-2477. doi:
10.1093/jn/nxaa185. [PMID: 32614453] - Souha Hammouda, Imen Ghzaiel, Wided Khamlaoui, Sonia Hammami, Samia Younes Mhenni, Slim Samet, Mohamed Hammami, Amira Zarrouk. Genetic variants in FADS1 and ELOVL2 increase level of arachidonic acid and the risk of Alzheimer's disease in the Tunisian population.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 09; 160(?):102159. doi:
10.1016/j.plefa.2020.102159. [PMID: 32682282] - Dmitry Grapov, Oliver Fiehn, Caitlin Campbell, Carol J Chandler, Dustin J Burnett, Elaine C Souza, Gretchen A Casazza, Nancy L Keim, Gary R Hunter, Jose R Fernandez, W Timothy Garvey, Charles L Hoppel, Mary-Ellen Harper, John W Newman, Sean H Adams. Impact of a weight loss and fitness intervention on exercise-associated plasma oxylipin patterns in obese, insulin-resistant, sedentary women.
Physiological reports.
2020 09; 8(17):e14547. doi:
10.14814/phy2.14547. [PMID: 32869956] - Fuyao Liu, Xiangsheng Zuo, Yi Liu, Yasunori Deguchi, Micheline J Moussalli, Weidong Chen, Peiying Yang, Bo Wei, Lin Tan, Philip L Lorenzi, Shen Gao, Jonathan C Jaoude, Amir Mehdizadeh, Lovie Ann Valentin, Daoyan Wei, Imad Shureiqi. Suppression of Membranous LRP5 Recycling, Wnt/β-Catenin Signaling, and Colon Carcinogenesis by 15-LOX-1 Peroxidation of Linoleic Acid in PI3P.
Cell reports.
2020 08; 32(7):108049. doi:
10.1016/j.celrep.2020.108049. [PMID: 32814052] - Susan Ellul, Wolfgang Marx, Fiona Collier, Richard Saffery, Mimi Tang, David Burgner, John Carlin, Peter Vuillermin, Anne-Louise Ponsonby. Plasma metabolomic profiles associated with infant food allergy with further consideration of other early life factors.
Prostaglandins, leukotrienes, and essential fatty acids.
2020 08; 159(?):102099. doi:
10.1016/j.plefa.2020.102099. [PMID: 32505120] - Chao-Gang Chen, Ping Wang, Zhe-Qing Zhang, Yan-Bin Ye, Shu-Yu Zhuo, Quan Zhou, Yu-Ming Chen, Yi-Xiang Su, Bo Zhang. Effects of plant oils with different fatty acid composition on cardiovascular risk factors in moderately hypercholesteremic Chinese adults: a randomized, double-blinded, parallel-designed trial.
Food & function.
2020 Aug; 11(8):7164-7174. doi:
10.1039/d0fo00875c. [PMID: 32756661] - Charlotte D C C van der Heijden, Rob Ter Horst, Inge C L van den Munckhof, Kiki Schraa, Jacqueline de Graaf, Leo A B Joosten, A H Jan Danser, Mihai G Netea, Jaap Deinum, Joost Rutten, Niels P Riksen. Vasculometabolic and Inflammatory Effects of Aldosterone in Obesity.
The Journal of clinical endocrinology and metabolism.
2020 08; 105(8):. doi:
10.1210/clinem/dgaa356. [PMID: 32529242] - Sheetal Saini, Sarath Kumar Kottarath, Amit Kumar Dinda, Anuradha Dube, Amogh Anant Sahasrabuddhe, Chandreshwar Prasad Thakur, Madhusudan Bhat, Ambak Kumar Rai. Preventive as well as therapeutic significances of linoleic acid in the containment of Leishmania donovani infection.
Biochimie.
2020 Aug; 175(?):13-22. doi:
10.1016/j.biochi.2020.04.024. [PMID: 32439363] - Nirajan Shrestha, Olivia J Holland, Nykola L Kent, Anthony V Perkins, Andrew J McAinch, James S M Cuffe, Deanne H Hryciw. Maternal High Linoleic Acid Alters Placental Fatty Acid Composition.
Nutrients.
2020 Jul; 12(8):. doi:
10.3390/nu12082183. [PMID: 32717842] - Minhao Xie, Jun Yang, Jianan Zhang, Heather L Sherman, Zhenyu Zhang, Lisa M Minter, Bruce D Hammock, Yeonhwa Park, Guodong Zhang. Effects of Linoleic Acid-Rich Diet on Plasma Profiles of Eicosanoids and Development of Colitis in Il-10-/- Mice.
Journal of agricultural and food chemistry.
2020 Jul; 68(29):7641-7647. doi:
10.1021/acs.jafc.0c03024. [PMID: 32594738] - Yong-Jian Liu, Hui Li, Yang Tian, Jun Han, Xin-Yang Wang, Xin-Yu Li, Chao Tian, Pu-Hong Zhang, Yu Hao, Fang Gao, Sheng-Wei Jin. PCTR1 ameliorates lipopolysaccharide-induced acute inflammation and multiple organ damage via regulation of linoleic acid metabolism by promoting FADS1/FASDS2/ELOV2 expression and reducing PLA2 expression.
Laboratory investigation; a journal of technical methods and pathology.
2020 07; 100(7):904-915. doi:
10.1038/s41374-020-0412-9. [PMID: 32123295] - Thomas Hegyi, Barry Weinberger, Naureen Memon, Mary Carayannopoulos, Andrew H Huber, Alan M Kleinfeld. Plasma unbound free fatty acid profiles in premature infants before and after intralipid infusion.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2020 Jul; 33(14):2320-2325. doi:
10.1080/14767058.2018.1548599. [PMID: 30554540] - Kamalita Pertiwi, Leanne K Küpers, Johanna M Geleijnse, Peter L Zock, Anne J Wanders, Herculina S Kruger, Tertia van Zyl, Iolanthé M Kruger, Cornelius M Smuts. Associations of linoleic acid with markers of glucose metabolism and liver function in South African adults.
Lipids in health and disease.
2020 Jun; 19(1):138. doi:
10.1186/s12944-020-01318-3. [PMID: 32546275] - Wenyun Li, Zhichao Kuang, Mengman Zheng, Gengsheng He, Yuwei Liu. Multi-omics integrative analysis to access role of coiled-coil domain-containing 80 in lipid metabolism.
Biochemical and biophysical research communications.
2020 06; 526(3):813-819. doi:
10.1016/j.bbrc.2020.03.121. [PMID: 32273086] - Jay J Cao, Brian R Gregoire, Kim G Michelsen, Matthew J Picklo. Decreasing the Ratio of Dietary Linoleic to α-Linolenic Acid from 10 to 4 by Changing Only the Former Does Not Prevent Adiposity or Bone Deterioration in Obese Mice.
The Journal of nutrition.
2020 06; 150(6):1370-1378. doi:
10.1093/jn/nxaa044. [PMID: 32135009] - Agnieszka Szkudlarek, Michał Wilk, Małgorzata Maciążek-Jurczyk. In Vitro Investigations of Acetohexamide Binding to Glycated Serum Albumin in the Presence of Fatty Acid.
Molecules (Basel, Switzerland).
2020 May; 25(10):. doi:
10.3390/molecules25102340. [PMID: 32429512] - Trudy Voortman, Régine P M Steegers-Theunissen, Nienke E Bergen, Vincent W V Jaddoe, Caspar W N Looman, Jessica C Kiefte-de Jong, Sarah Schalekamp-Timmermans. Validation of a Semi-Quantitative Food-Frequency Questionnaire for Dutch Pregnant Women from the General Population Using the Method or Triads.
Nutrients.
2020 05; 12(5):. doi:
10.3390/nu12051341. [PMID: 32397149] - Cristina Santurino, Bricia López-Plaza, Javier Fontecha, María V Calvo, Laura M Bermejo, David Gómez-Andrés, Carmen Gómez-Candela. Consumption of Goat Cheese Naturally Rich in Omega-3 and Conjugated Linoleic Acid Improves the Cardiovascular and Inflammatory Biomarkers of Overweight and Obese Subjects: A Randomized Controlled Trial.
Nutrients.
2020 May; 12(5):. doi:
10.3390/nu12051315. [PMID: 32380746] - Susan Sergeant, Brian Hallmark, Rasika A Mathias, Tammy L Mustin, Priscilla Ivester, Maggie L Bohannon, Ingo Ruczinski, Laurel Johnstone, Michael C Seeds, Floyd H Chilton. Prospective clinical trial examining the impact of genetic variation in FADS1 on the metabolism of linoleic acid- and ɣ-linolenic acid-containing botanical oils.
The American journal of clinical nutrition.
2020 05; 111(5):1068-1078. doi:
10.1093/ajcn/nqaa023. [PMID: 32167131] - Mandy Ho, G Harvey Anderson, Lin Lin, Richard P Bazinet, Ruslan Kubant. Ethanolamides of essential α-linolenic and linoleic fatty acids suppress short-term food intake in rats.
Food & function.
2020 Apr; 11(4):3066-3072. doi:
10.1039/c9fo02884f. [PMID: 32191234] - Xue Gong, Zhonghan Sun, Zheyong Huang, Qian Zhou, Ziqing Yu, Xueying Chen, Wenqi Shao, Yan Zheng, Yixiu Liang, Shengmei Qin, Yangang Su, Junbo Ge. Circulating metabolite profiles to predict response to cardiac resynchronization therapy.
BMC cardiovascular disorders.
2020 04; 20(1):178. doi:
10.1186/s12872-020-01443-y. [PMID: 32299366] - Madhusmita Nayak, Shiba Shankar Giri, Avinash Pradhan, Mrinal Samanta, Ashis Saha. Effects of dietary α-linolenic acid/linoleic acid ratio on growth performance, tissue fatty acid profile, serum metabolites and Δ6 fad and elovl5 gene expression in silver barb (Puntius gonionotus).
Journal of the science of food and agriculture.
2020 Mar; 100(4):1643-1652. doi:
10.1002/jsfa.10177. [PMID: 31802501] - Anna C Croce, Andrea Ferrigno, Clarissa Berardo, Giovanni Bottiroli, Mariapia Vairetti, Laura G Di Pasqua. Spectrofluorometric Analysis of Autofluorescing Components of Crude Serum from a Rat Liver Model of Ischemia and Reperfusion.
Molecules (Basel, Switzerland).
2020 Mar; 25(6):. doi:
10.3390/molecules25061327. [PMID: 32183261] - Takahisa Mori, Kazuhiro Yoshioka. Features of serum fatty acids in acute ischaemic stroke patients aged 50 years or older.
BMC cardiovascular disorders.
2020 03; 20(1):122. doi:
10.1186/s12872-020-01408-1. [PMID: 32156256] - Maria Carolina Borges, Amand Floriaan Schmidt, Barbara Jefferis, S Goya Wannamethee, Debbie A Lawlor, Mika Kivimaki, Meena Kumari, Tom R Gaunt, Yoav Ben-Shlomo, Therese Tillin, Usha Menon, Rui Providencia, Caroline Dale, Aleksandra Gentry-Maharaj, Alun Hughes, Nish Chaturvedi, Juan Pablo Casas, Aroon D Hingorani. Circulating Fatty Acids and Risk of Coronary Heart Disease and Stroke: Individual Participant Data Meta-Analysis in Up to 16 126 Participants.
Journal of the American Heart Association.
2020 03; 9(5):e013131. doi:
10.1161/jaha.119.013131. [PMID: 32114887] - Q Q Xu, X W Ma, X Y Dong, Z R Tao, L Z Lu, X T Zou. Effects of parental dietary linoleic acid on growth performance, antioxidant capacity, and lipid metabolism in domestic pigeons (Columba livia).
Poultry science.
2020 Mar; 99(3):1471-1482. doi:
10.1016/j.psj.2019.11.002. [PMID: 32111316] - Samarwadee Plianwong, Bindu Thapa, Remant Bahadur Kc, Cezary Kucharski, Theerasak Rojanarata, Hasan Uludağ. Enabling Combinatorial siRNA Delivery against Apoptosis-Related Proteins with Linoleic Acid and α-Linoleic Acid Substituted Low Molecular Weight Polyethylenimines.
Pharmaceutical research.
2020 Feb; 37(3):46. doi:
10.1007/s11095-020-2770-9. [PMID: 32016611] - Kamalita Pertiwi, Anne J Wanders, Marjolein C Harbers, Leanne K Küpers, Sabita S Soedamah-Muthu, Janette de Goede, Peter L Zock, Johanna M Geleijnse. Plasma and Dietary Linoleic Acid and 3-Year Risk of Type 2 Diabetes After Myocardial Infarction: A Prospective Analysis in the Alpha Omega Cohort.
Diabetes care.
2020 02; 43(2):358-365. doi:
10.2337/dc19-1483. [PMID: 31727685] - Poonamjot Deol, Elena Kozlova, Matthew Valdez, Catherine Ho, Ei-Wen Yang, Holly Richardson, Gwendolyn Gonzalez, Edward Truong, Jack Reid, Joseph Valdez, Jonathan R Deans, Jose Martinez-Lomeli, Jane R Evans, Tao Jiang, Frances M Sladek, Margarita C Curras-Collazo. Dysregulation of Hypothalamic Gene Expression and the Oxytocinergic System by Soybean Oil Diets in Male Mice.
Endocrinology.
2020 02; 161(2):. doi:
10.1210/endocr/bqz044. [PMID: 31912136] - Nirajan Shrestha, Simone L Sleep, James S M Cuffe, Olivia J Holland, Andrew J McAinch, Marloes Dekker Nitert, Deanne H Hryciw. Pregnancy and diet-related changes in the maternal gut microbiota following exposure to an elevated linoleic acid diet.
American journal of physiology. Endocrinology and metabolism.
2020 02; 318(2):E276-E285. doi:
10.1152/ajpendo.00265.2019. [PMID: 31846371] - Magdalena Mielczarek-Puta, Dagmara Otto-Ślusarczyk, Alicja Chrzanowska, Agnieszka Filipek, Wojciech Graboń. Telmisartan Influences the Antiproliferative Activity of Linoleic Acid in Human Colon Cancer Cells.
Nutrition and cancer.
2020; 72(1):98-109. doi:
10.1080/01635581.2019.1613552. [PMID: 31094234] - Anandita Pal, Kymberly M Gowdy, Kenneth J Oestreich, Melinda Beck, Saame Raza Shaikh. Obesity-Driven Deficiencies of Specialized Pro-resolving Mediators May Drive Adverse Outcomes During SARS-CoV-2 Infection.
Frontiers in immunology.
2020; 11(?):1997. doi:
10.3389/fimmu.2020.01997. [PMID: 32983141] - Franca Marangoni, Carlo Agostoni, Claudio Borghi, Alberico L Catapano, Hellas Cena, Andrea Ghiselli, Carlo La Vecchia, Giovanni Lercker, Enzo Manzato, Angela Pirillo, Gabriele Riccardi, Patrizia Risé, Francesco Visioli, Andrea Poli. Dietary linoleic acid and human health: Focus on cardiovascular and cardiometabolic effects.
Atherosclerosis.
2020 01; 292(?):90-98. doi:
10.1016/j.atherosclerosis.2019.11.018. [PMID: 31785494] - Eugenia Marbach-Breitrück, Laura Kutzner, Michael Rothe, Robert Gurke, Yannick Schreiber, Pallu Reddanna, Nils-Helge Schebb, Sabine Stehling, Lothar H Wieler, Dagmar Heydeck, Hartmut Kuhn. Functional Characterization of Knock-In Mice Expressing a 12/15-Lipoxygenating Alox5 Mutant Instead of the 5-Lipoxygenating Wild-Type Enzyme.
Antioxidants & redox signaling.
2020 01; 32(1):1-17. doi:
10.1089/ars.2019.7751. [PMID: 31642348] - Tomonori Nakanishi, Kazuhiro Kagamizono, Sayaka Yokoyama, Ryoji Suzuki, Hiroyuki Sakakibara, Laurie Erickson, Satoshi Kawahara. Effects of dietary phytol on tissue accumulation of phytanic acid and pristanic acid and on the tissue lipid profiles in mice.
Animal science journal = Nihon chikusan Gakkaiho.
2020 Jan; 91(1):e13424. doi:
10.1111/asj.13424. [PMID: 32618084] - Marija Knez, Ana Pantovic, Milica Zekovic, Zoran Pavlovic, Maria Glibetic, Manja Zec. Is There a Link between Zinc Intake and Status with Plasma Fatty Acid Profile and Desaturase Activities in Dyslipidemic Subjects?.
Nutrients.
2019 Dec; 12(1):. doi:
10.3390/nu12010093. [PMID: 31905662] - Shuai Yuan, Magnus Bäck, Maria Bruzelius, Amy M Mason, Stephen Burgess, Susanna Larsson. Plasma Phospholipid Fatty Acids, FADS1 and Risk of 15 Cardiovascular Diseases: A Mendelian Randomisation Study.
Nutrients.
2019 Dec; 11(12):. doi:
10.3390/nu11123001. [PMID: 31817859] - Engy Shokry, Roxana Raab, Franca F Kirchberg, Christian Hellmuth, Mario Klingler, Hans Demmelmair, Berthold Koletzko, Olaf Uhl. Prolonged monitoring of postprandial lipid metabolism after a western meal rich in linoleic acid and carbohydrates.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme.
2019 Nov; 44(11):1189-1198. doi:
10.1139/apnm-2018-0798. [PMID: 30893569]