Zidovudine monophosphate (BioDeep_00000593251)

   


代谢物信息卡片


Zidovudine monophosphate

化学式: C10H14N5O7P (347.06308240000004)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)O)N=[N+]=[N-]
InChI: InChI=1S/C10H14N5O7P/c1-5-3-15(10(17)12-9(5)16)8-2-6(13-14-11)7(22-8)4-21-23(18,19)20/h3,6-8H,2,4H2,1H3,(H,12,16,17)(H2,18,19,20)/t6-,7+,8+/m0/s1

描述信息

同义名列表

1 个代谢物同义名

Zidovudine monophosphate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

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文献列表

  • Henrik P Von Euler, Patricio Rivera, Anne-Charlotte Aronsson, Christer Bengtsson, Lars-Olof Hansson, Staffan K Eriksson. Monitoring therapy in canine malignant lymphoma and leukemia with serum thymidine kinase 1 activity--evaluation of a new, fully automated non-radiometric assay. International journal of oncology. 2009 Feb; 34(2):505-10. doi: . [PMID: 19148486]
  • Lucie Durand-Gasselin, Alain Pruvost, Axelle Dehée, Genevieve Vaudre, Marie-Dominique Tabone, Jacques Grassi, Guy Leverger, Antoine Garbarg-Chenon, Henri Bénech, Catherine Dollfus. High levels of zidovudine (AZT) and its intracellular phosphate metabolites in AZT- and AZT-lamivudine-treated newborns of human immunodeficiency virus-infected mothers. Antimicrobial agents and chemotherapy. 2008 Jul; 52(7):2555-63. doi: 10.1128/aac.01130-07. [PMID: 18426897]
  • Yazen Alnouti, Catherine A White, Michael G Bartlett. Simultaneous quantitation of zidovudine and zidovudine monophosphate from plasma, amniotic fluid and tissues by micellar capillary electrophoresis. Biomedical chromatography : BMC. 2004 Oct; 18(8):523-31. doi: 10.1002/bmc.350. [PMID: 15386521]
  • Anders Ohrvik, Maria Lindh, Roland Einarsson, Jacques Grassi, Staffan Eriksson. Sensitive nonradiometric method for determining thymidine kinase 1 activity. Clinical chemistry. 2004 Sep; 50(9):1597-606. doi: 10.1373/clinchem.2003.030379. [PMID: 15247154]
  • I Tong Mak, Lucie F Nedelec, William B Weglicki. Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZT. Cardiovascular toxicology. 2004; 4(2):109-15. doi: 10.1385/ct:4:2:109. [PMID: 15371628]
  • Y Wattanagoon, K Na Bangchang, P G Hoggard, S H Khoo, S E Gibbons, D Phiboonbhanakit, J Karbwang, D J Back. Pharmacokinetics of zidovudine phosphorylation in human immunodeficiency virus-positive thai patients and healthy volunteers. Antimicrobial agents and chemotherapy. 2000 Jul; 44(7):1986-9. doi: 10.1128/aac.44.7.1986-1989.2000. [PMID: 10858368]
  • J H Rodman, P M Flynn, B Robbins, E Jimenez, A D Bardeguez, J F Rodriguez, S Blanchard, A Fridland. Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants. The Journal of infectious diseases. 1999 Dec; 180(6):1844-50. doi: 10.1086/315152. [PMID: 10558940]
  • D Saboulard, L Naesens, D Cahard, A Salgado, R Pathirana, S Velazquez, C McGuigan, E De Clercq, J Balzarini. Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine. Molecular pharmacology. 1999 Oct; 56(4):693-704. doi: . [PMID: 10496951]
  • M E Kuipers, P J Swart, M Witvrouw, J A Esté, D Reymen, E De Clercq, D K Meijer. Anti-HIV-1 activity of combinations and covalent conjugates of negatively charged human serum albumins (NCAs) and AZT. Journal of drug targeting. 1999; 6(5):323-35. doi: 10.3109/10611869908996840. [PMID: 10342381]
  • S M Wintermeyer, M C Nahata, M T Brady, B J Sobol, Venglarcik JS 3rd, R C Baker, J A Hunkler, N M McOwen. Phosphorylated zidovudine concentrations in mononuclear cells in pediatric patients with human immunodeficiency virus infections. Pediatric AIDS and HIV infection. 1997 Apr; 8(2):120-6. doi: . [PMID: 11361778]
  • M G Barry, S H Khoo, G J Veal, P G Hoggard, S E Gibbons, E G Wilkins, O Williams, A M Breckenridge, D J Back. The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites. AIDS (London, England). 1996 Oct; 10(12):1361-7. doi: 10.1097/00002030-199610000-00008. [PMID: 8902065]
  • M E Kuipers, P J Swart, M M Hendriks, D K Meijer. Optimization of the reaction conditions for the synthesis of neoglycoprotein-AZT-monophosphate conjugates. Journal of medicinal chemistry. 1995 Mar; 38(6):883-9. doi: 10.1021/jm00006a005. [PMID: 7699703]
  • M Barry, M Wild, G Veal, D Back, A Breckenridge, R Fox, N Beeching, F Nye, P Carey, D Timmins. Zidovudine phosphorylation in HIV-infected patients and seronegative volunteers. AIDS (London, England). 1994 Aug; 8(8):F1-5. doi: 10.1097/00002030-199408000-00002. [PMID: 7986398]
  • J T Slusher, S K Kuwahara, F M Hamzeh, L D Lewis, D M Kornhauser, P S Lietman. Intracellular zidovudine (ZDV) and ZDV phosphates as measured by a validated combined high-pressure liquid chromatography-radioimmunoassay procedure. Antimicrobial agents and chemotherapy. 1992 Nov; 36(11):2473-7. doi: 10.1128/aac.36.11.2473. [PMID: 1489190]
  • A Namane, C Gouyette, M P Fillion, G Fillion, T Huynh-Dinh. Improved brain delivery of AZT using a glycosyl phosphotriester prodrug. Journal of medicinal chemistry. 1992 Aug; 35(16):3039-44. doi: 10.1021/jm00094a018. [PMID: 1501232]
  • G Molema, R W Jansen, J Visser, P Herdewijn, F Moolenaar, D K Meijer. Neoglycoproteins as carriers for antiviral drugs: synthesis and analysis of protein-drug conjugates. Journal of medicinal chemistry. 1991 Mar; 34(3):1137-41. doi: 10.1021/jm00107a038. [PMID: 2002455]
  • G Molema, R W Jansen, R Pauwels, E de Clercq, D K Meijer. Targeting of antiviral drugs to T4-lymphocytes. Anti-HIV activity of neoglycoprotein-AZTMP conjugates in vitro. Biochemical pharmacology. 1990 Dec; 40(12):2603-10. doi: 10.1016/0006-2952(90)90577-8. [PMID: 1979734]